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(B) Dermoscopy (×10 magnification) showing round whitish-yellow structures in a cobblestone pattern (3), telangiectasias (4), arboriform vessels (5) and rounded whitish-yellow papules with central umbilication and crown vessels (6).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ingrid Priscila Ribeiro Paes Ferraz, Gustavo Carvalho, Juliana Casagrande Tavoloni Braga, Rafaela Brito de Paula, André Molina" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Ingrid Priscila Ribeiro Paes" "apellidos" => "Ferraz" ] 1 => array:2 [ "nombre" => "Gustavo" "apellidos" => "Carvalho" ] 2 => array:2 [ "nombre" => "Juliana Casagrande Tavoloni" "apellidos" => "Braga" ] 3 => array:2 [ "nombre" => "Rafaela Brito de" "apellidos" => "Paula" ] 4 => array:2 [ "nombre" => "André" "apellidos" => "Molina" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275224001693" "doi" => "10.1016/j.abdp.2024.07.014" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275224001693?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059624001491?idApp=UINPBA00008Z" "url" => "/03650596/0000009900000006/v1_202410230911/S0365059624001491/v1_202410230911/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "S0365059624001545" "issn" => "03650596" "doi" => "10.1016/j.abd.2023.12.006" "estado" => "S300" "fechaPublicacion" => "2024-11-01" "aid" => "1001" "documento" => "article" "crossmark" => 1 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter - Clinical</span>" "titulo" => "A case of psoriasiform eruption developed during imatinib therapy" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "953" "paginaFinal" => "956" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2371 "Ancho" => 3175 "Tamanyo" => 1116399 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Psoriasiform lesions on the buttocks. (B) Similar lesions on the lower legs. (C) Histological findings revealed slight parakeratosis with a slightly flattened epidermis. Inflammatory cell infiltration was observed around blood vessels and stroma in the superficial dermis, accompanied by red blood cell extravasation. The inflammatory cells were eosinophils as well as lymphocytes and histiocytes. (Hematoxylin & eosin, ×200). (D) After treatment, the skin rash was partially improved.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Yukina Watanabe, Tomoko Hiraiwa, Mikio Ohtsuka, Toshiyuki Yamamoto" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Yukina" "apellidos" => "Watanabe" ] 1 => array:2 [ "nombre" => "Tomoko" "apellidos" => "Hiraiwa" ] 2 => array:2 [ "nombre" => "Mikio" "apellidos" => "Ohtsuka" ] 3 => array:2 [ "nombre" => "Toshiyuki" "apellidos" => "Yamamoto" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275224001747" "doi" => "10.1016/j.abdp.2024.07.019" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275224001747?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059624001545?idApp=UINPBA00008Z" "url" => "/03650596/0000009900000006/v1_202410230911/S0365059624001545/v1_202410230911/en/main.assets" ] "en" => array:17 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter - Clinical</span>" "titulo" => "Acquired ichthyosis as a messenger to gastric diffuse large B-cell lymphoma" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">Dear Editor,</span>" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "956" "paginaFinal" => "957" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "İrfan Yavaşoğlu, Atakan Turgutkaya, Canten Tataroğlu, Ali Zahit Bolaman" "autores" => array:4 [ 0 => array:3 [ "nombre" => "İrfan" "apellidos" => "Yavaşoğlu" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:4 [ "nombre" => "Atakan" "apellidos" => "Turgutkaya" "email" => array:1 [ 0 => "atakanturgutkaya@yahoo.com.tr" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 2 => array:3 [ "nombre" => "Canten" "apellidos" => "Tataroğlu" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Ali Zahit" "apellidos" => "Bolaman" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Division of Hematology, Aydin Adnan Menderes University Medical Faculty, Aydin, Turkey" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Division of Pathology, Aydin Adnan Menderes University Medical Faculty, Aydın, Turkey" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1801 "Ancho" => 1675 "Tamanyo" => 203170 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Polygon-shaped brown, grey, or white scales on the forearm. (B) Resolution after the treatment.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 50-year-old male patient presented with recurrent bloody vomiting. In the endoscopic examination, a tumoral lesion was detected in the gastric antrum. Immediate gastrectomy was performed due to perforation. Histopathological examination diagnosed a triple-expressor gastric Diffuse Large B-Cell Lymphoma (DLBCL) [Bcl-2 focal (60%), Bcl-6 focal (40%), C-Myc (10%), CD10 focal (70%)]. The Ki-67 index was positive at 60%. A stool examination of the Helicobacter pylori antigen was negative. PET-CT demonstrated no involvement at the operation (gastrectomy) site.</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient had been complaining of itchy, polygon-shaped brown, gray, and white scales on the whole-body skin, more prominently on the extremities, for 2 years. At the same time, the skin was very dry and thickened (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). There was no similar history in the patient’s family. The patient was started on R-CHOEP (Rituximab, Doxorubicin, Vincristine, Etoposide, Cyclophosphamide, and Prednisolone) chemotherapy. Also, a skin biopsy was performed. In the skin tissue hyperkeratosis, papillomatosis, mild acanthosis, and absent granular layer were noted. Perivascular mononuclear cell infiltration was observed in the superficial dermis (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). At the end of chemotherapy, skin findings improved (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Ichthyosis presents as rough, dry, skin with a large plate-like scale, and it can either be hereditary or acquired. Acquired Ichthyosis is defined in neoplastic disorders (Hodgkin's lymphoma, anaplastic large cell lymphoma, multiple myeloma, mycosis fungoides, POEMS [polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes] syndrome, Kaposi's sarcoma, leiomyosarcoma, etc). Also, it is known to be associated with malnutrition, infections (HIV, Human T-lymphotropic virus), hypothyroidism, celiac disease, autoimmune conditions, sarcoidosis, graft-versus-host disease, and drug intake (hydroxyurea, allopurinol, vemurafenib, cholesterol-lowering medications, etc.). It is assumed that ichthyosis can be caused by impaired epidermal lipogenesis and production of transforming growth factor-α by tumor cells and impaired vitamin A metabolism.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a> According to the best of our knowledge, our case is the first ichthyosis as a precursor to gastric DLBCL.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0020" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors’ contributions</span><p id="par0025" class="elsevierStylePara elsevierViewall">İrfan Yavaşoğlu: Design and planning of the study; Data collection, or analysis and interpretation of data; Drafting and editing of the manuscript or critical review of important intellectual content; Collection, analysis, and interpretation of data; Critical review of the literature; Approval of the final version of the manuscript.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Atakan Turgutkaya: Data collection, or analysis and interpretation of data; Drafting and editing of the manuscript or critical review of important intellectual content; Collection, analysis, and interpretation of data; Critical review of the literature.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Canten Tataroğlu: Data collection, analysis, and interpretation of data; Drafting and editing of the manuscript or critical review of important intellectual content.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Ali Zahit Bolaman: Design and planning of the study; Data collection, or analysis and interpretation of data; Drafting and editing of the manuscript or critical review of important intellectual content; Collection, analysis, and interpretation of data; Critical review of the literature; Approval of the final version of the manuscript.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Financial support" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Authors’ contributions" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Conflicts of interest" ] 3 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2023-06-19" "fechaAceptado" => "2023-08-16" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Study conducted at the Aydin Adnan Menderes University Medical Faculty, Aydın, Turkey.</p>" ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1801 "Ancho" => 1675 "Tamanyo" => 203170 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Polygon-shaped brown, grey, or white scales on the forearm. (B) Resolution after the treatment.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1266 "Ancho" => 1683 "Tamanyo" => 783203 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Orthohyperkeratosis, absence of granular cell layer and mild acanthosis are observed in the epidermis. In the upper dermis is a mild perivascular lymphocytic infiltrate (Hematoxylin & eosin, ×200).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:2 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ichthyosis: a harbinger of lymphoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "K. Mishra" 1 => "A. Jandial" 2 => "K. Gupta" 3 => "G. Prakash" 4 => "P. Malhotra" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "BMJ Case Rep" "fecha" => "2018" "volumen" => "2018" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Beware of underlying malignancy: acquired ichthyosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.P. Word" 1 => "R. Cayce" 2 => "A.G. Pandya" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.amjmed.2013.12.009" "Revista" => array:6 [ "tituloSerie" => "Am J Med" "fecha" => "2014" "volumen" => "127" "paginaInicial" => "202" "paginaFinal" => "204" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24355352" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03650596/0000009900000006/v1_202410230911/S0365059624001442/v1_202410230911/en/main.assets" "Apartado" => array:4 [ "identificador" => "95153" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letter - Clinical" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009900000006/v1_202410230911/S0365059624001442/v1_202410230911/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059624001442?idApp=UINPBA00008Z" ]
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