Letter - Clinical
Familiar white sponge nevus
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(B) Plaque with a whitish, velvety surface on the dorsal tongue.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">White sponge nevus is a rare and benign disease with autosomal dominant inheritance and variable penetrance, primarily affecting the oral mucosa. It is found in approximately one in 200,000 people. This condition was initially described by Hyde in 1909 and presents as white or grey patches with a spongy appearance. These patches, typically located on the buccal mucosa bilaterally, do not peel off when scraped. They also appear on the lips, alveolar ridges, and the floor of the mouth.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a> We herein present two affected members of a single family.</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 61-year-old woman, with no significant medical or surgical history, sought consultation due to the presence of asymptomatic lesions in the oral mucosa that had been present since childhood. Examination revealed plaques with diffuse borders, that were non-infiltrated and with a whitish, velvety surface. These were located bilaterally on the buccal mucosa and the dorsal tongue. The lesions could not be removed by scraping and no other skin or mucosal lesions were observed (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Her 23-year-old son also sought consultation for the presence of similar, asymptomatic lesions that had been present since birth. The lesions were of the same characteristics, affecting the bilateral buccal mucosa and the dorsal tongue (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">A punch biopsy was performed on one of the lesions on the 61-year-old patient's buccal mucosa. It showed moderate acanthosis with regular elongation of crests and intracellular edema, alongside foci of parakeratosis and some dyskeratotic cells displaying paranuclear eosinophilic condensations. Only the upper layers were affected. In the underlying chorion, a few slightly dilated capillaries and a mild, nonspecific perivascular chronic infiltrate were observed. The Periodic Acid-Schiff (PAS) technique did not reveal any fungi (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). Both clinical and histopathological findings were consistent with the diagnosis of familial white sponge nevus. Neither patient wished to receive any treatment as they had no symptoms or clinical complaints.</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">White sponge nevus is a benign and rare keratinopathy, primarily affecting the oral mucosa. It was first described by Hyde in 1909 and Cannon coined the term “white sponge nevus” in 1935. Although it follows an autosomal dominant transmission pattern with incomplete penetrance, there have been reported cases without a family history.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–3</span></a> The most frequently associated mutations are found in the genes encoding Cytokeratins 4 (KRT4) and 13 (KRT13).<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,5</span></a> Lesions usually appear during childhood or adolescence without a preference for either sex. They present as asymptomatic white or greyish plaques, asymmetrical, with irregular borders and a spongy appearance, and are usually found bilaterally in the oral mucosa. Lesions may also appear on the nasal, esophageal, vaginal or rectal mucosae.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Both cases in the present report had bilateral lesions on the buccal mucosa and on the dorsal tongue. The diagnosis can be made with a detailed patient history and meticulous clinical examination. A histopathological analysis may be performed purely to corroborate the initial diagnosis.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> The main histological findings include the presence of acanthosis with intercellular edema and vacuolization, as well as parakeratotic or orthokeratotic hyperkeratosis in the superficial layers. This entity may resemble a wide spectrum of oral disorders that may present as diffuse white plaques. The differential diagnosis should include oral candidiasis, frictional leukokeratosis, leukoedema, leukoplakia, lichen planus, and even squamous cell carcinoma. The manifestation of the lesions, including the plaque dimensions, the affected areas, and their distribution, may change with time. To date, no standard treatment exists, although various therapies such as topical and oral tetracyclines and chlorhexidine rinses have been tried with variable results. The beneficial effect of tetracycline may stem from the modulation of epithelial keratinization. Vitamins (like beta-carotene and topical applications of retinoic acid), antihistamines, and laser ablation have also been employed.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3,7</span></a> Specific treatment is not generally required because this condition is benign and not expected to progress malignantly.</p><p id="par0030" class="elsevierStylePara elsevierViewall">In conclusion, we describe two new cases of familial white sponge nevus, a rare entity that should be considered in the differential diagnosis of other “white” oral lesions with potential malignancy. Adults may display oral manifestations of white sponge nevus that clinically resemble other whitish oral lesions, which can lead to a delayed diagnosis based on microscopic findings. Early and accurate diagnosis of the condition is crucial to prevent the application of unnecessary treatments.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0035" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors’ contributions</span><p id="par0040" class="elsevierStylePara elsevierViewall">Camino Prada-García: The study concept and design; data collection, analysis, and interpretation of data; writing of the manuscript or critical review of important intellectual content; effective participation in the research guidance; intellectual participation in the propaedeutic and/or therapeutic conduct of the studied cases; critical review of the literature; final approval of the final version of the manuscript.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Asunción González-Morán: The study concept and design, analysis and interpretation of data; writing of the manuscript or critical review of important intellectual content; intellectual participation in the propaedeutic and/or therapeutic conduct of the studied cases; critical review of the literature; final approval of the final version of the manuscript.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Xenia Pérez-González: The study concept and design; data collection, analysis, and interpretation of data; intellectual participation in the propaedeutic and/or therapeutic conduct of the studied cases; final approval of the final version of the manuscript.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Financial support" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Authors’ contributions" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Conflicts of interest" ] 3 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2023-07-29" "fechaAceptado" => "2023-08-16" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Study conducted at the Complejo Asistencial Universitario de León, León, Spain.</p>" ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1685 "Ancho" => 2508 "Tamanyo" => 495593 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Whitish lesions on the buccal mucosa. (B) Plaque with a whitish, velvety surface on the dorsal tongue.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1651 "Ancho" => 2508 "Tamanyo" => 671385 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">(A) Her son with a well-demarcated white patch present on the buccal mucosa. (B) Plaque with a whitish and a spongy appearance on the dorsal tongue.</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 994 "Ancho" => 3341 "Tamanyo" => 997690 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">(A) Photomicrograph from Hematoxylin & eosin stained from the left buccal mucosa sample of the 61-year-old woman demonstrating moderate acanthosis with regular elongation of crests and intracellular edema (Hematoxylin & eosin, ×40). (B) Some dyskeratotic cells displaying paranuclear eosinophilic condensations (Hematoxylin & eosin, ×400).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:7 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Successful treatment of white sponge nevus with oral doxycycline: a case report and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E. Amores-Martín" 1 => "G. Melé-Ninot" 2 => "E. Del Alcázar Viladomiu" 3 => "M.T. Fernández-Figueras" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Actas Dermosifiliogr (Engl Ed)." 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| Year/Month | Html | Total | |
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