Letter - Therapy
Recalcitrant folliculitis decalvans successfully controlled with adalimumab
José Ramos
, António Magarreiro Silva, Ana Marta António, João Alves
Corresponding author
Dermatology and Venereology Department, Hospital Garcia de Orta EPE, Almada, Portugal
Read
2925
Timeswas read the article
889
Total PDF
2036
Total HTML
Share statistics
array:23 [ "pii" => "S0365059624000394" "issn" => "03650596" "doi" => "10.1016/j.abd.2024.02.001" "estado" => "S300" "fechaPublicacion" => "2024-05-01" "aid" => "925" "copyright" => "Sociedade Brasileira de Dermatologia" "copyrightAnyo" => "2024" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "pt" => array:18 [ "pii" => "S2666275224000444" "issn" => "26662752" "doi" => "10.1016/j.abdp.2024.03.012" "estado" => "S300" "fechaPublicacion" => "2024-05-01" "aid" => "925" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "pt" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Cartas ‐ Terapia</span>" "titulo" => "Foliculite decalvante recalcitrante controlada com sucesso com adalimumabe" "tienePdf" => "pt" "tieneTextoCompleto" => "pt" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "480" "paginaFinal" => "482" ] ] "contieneTextoCompleto" => array:1 [ "pt" => true ] "contienePdf" => array:1 [ "pt" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figura 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 2211 "Ancho" => 2925 "Tamanyo" => 867764 ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Exame clínico (A, B e C) e tricoscopia (D) após o tratamento.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "José Ramos, António Magarreiro Silva, Ana Marta António, João Alves" "autores" => array:4 [ 0 => array:2 [ "nombre" => "José" "apellidos" => "Ramos" ] 1 => array:2 [ "nombre" => "António Magarreiro" "apellidos" => "Silva" ] 2 => array:2 [ "nombre" => "Ana Marta" "apellidos" => "António" ] 3 => array:2 [ "nombre" => "João" "apellidos" => "Alves" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0365059624000394" "doi" => "10.1016/j.abd.2024.02.001" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059624000394?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275224000444?idApp=UINPBA00008Z" "url" => "/26662752/0000009900000003/v1_202404300449/S2666275224000444/v1_202404300449/pt/main.assets" ] ] "itemSiguiente" => array:18 [ "pii" => "S0365059624000084" "issn" => "03650596" "doi" => "10.1016/j.abd.2023.07.003" "estado" => "S300" "fechaPublicacion" => "2024-05-01" "aid" => "895" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter - Therapy</span>" "titulo" => "Selective JAK 1 inhibition with upadacitinib as a potential treatment for coexistent severe atopic dermatitis and alopecia areata" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "483" "paginaFinal" => "484" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 852 "Ancho" => 1508 "Tamanyo" => 167516 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0020" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Resolution of patch of alopecia areata after 16-weeks of Upadacitnib 15 mg daily.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Guilherme Muzy" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Guilherme" "apellidos" => "Muzy" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S266627522400016X" "doi" => "10.1016/j.abdp.2024.02.009" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S266627522400016X?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059624000084?idApp=UINPBA00008Z" "url" => "/03650596/0000009900000003/v1_202404281408/S0365059624000084/v1_202404281408/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "S0365059624000254" "issn" => "03650596" "doi" => "10.1016/j.abd.2023.06.011" "estado" => "S300" "fechaPublicacion" => "2024-05-01" "aid" => "911" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter - Tropical/Infectious and parasitic dermatology</span>" "titulo" => "<span class="elsevierStyleItalic">Tinea corporis</span> caused by <span class="elsevierStyleItalic">Trichophyton benhamiae</span>: report of the first case transmitted by guinea pig in Brazil" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "475" "paginaFinal" => "479" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1091 "Ancho" => 1675 "Tamanyo" => 328208 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Direct mycological examination: skin desquamation containing septate, branched hyaline hyphae and arthroconidia. KOH 40% (×100).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Cristiana Ludwig Schneider Longo, Flávio Marcondes Hercules, Fábio Silva de Azevedo, Adriana Lúcia Pires Ferreira, Rosane Orofino-Costa" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Cristiana Ludwig Schneider" "apellidos" => "Longo" ] 1 => array:2 [ "nombre" => "Flávio Marcondes" "apellidos" => "Hercules" ] 2 => array:2 [ "nombre" => "Fábio Silva de" "apellidos" => "Azevedo" ] 3 => array:2 [ "nombre" => "Adriana Lúcia Pires" "apellidos" => "Ferreira" ] 4 => array:2 [ "nombre" => "Rosane" "apellidos" => "Orofino-Costa" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275224000304" "doi" => "10.1016/j.abdp.2024.02.021" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275224000304?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059624000254?idApp=UINPBA00008Z" "url" => "/03650596/0000009900000003/v1_202404281408/S0365059624000254/v1_202404281408/en/main.assets" ] "en" => array:17 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter - Therapy</span>" "titulo" => "Recalcitrant folliculitis decalvans successfully controlled with adalimumab" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "480" "paginaFinal" => "482" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "José Ramos, António Magarreiro Silva, Ana Marta António, João Alves" "autores" => array:4 [ 0 => array:4 [ "nombre" => "José" "apellidos" => "Ramos" "email" => array:1 [ 0 => "jalramos@campus.ul.pt" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "António Magarreiro" "apellidos" => "Silva" ] 2 => array:2 [ "nombre" => "Ana Marta" "apellidos" => "António" ] 3 => array:2 [ "nombre" => "João" "apellidos" => "Alves" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Dermatology and Venereology Department, Hospital Garcia de Orta EPE, Almada, Portugal" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1236 "Ancho" => 2925 "Tamanyo" => 1106474 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0025" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) In the vertical sections: a lymphohistiocytic infiltrate with neutrophils, at the perivascular and periadnexal level, with fibrosis of the dermis is observed. (B) In horizontal sections: there is a perifollicular lymphohistiocytic infiltrate with neutrophils mainly in the upper zones of the follicle with concentric perifollicular and interfollicular fibrosis, with loss of sebaceous glands. PAS and Giemsa stainings excluded microorganisms in the observed samples (Hematoxylin & eosin, ×40 [A], [B] Hematoxylin & eosin, ×100).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Folliculitis Decalvans (FD) is a primary cicatricial neutrophilic alopecia that affects young adults, mainly men, with a typically chronic and relapsing course. The pathogenesis remains unclear, current evidence suggests that in patients with genetic predisposition, there is an altered interrelationship between local immunity and the microbiome (mainly colonization by <span class="elsevierStyleItalic">Staphylococcus aureus</span>) culminating in chronic stimulation of T-cell homing.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a> Clinically, it starts with pruriginous or painful plaques in the vertex, with tufts of hairs and perifollicular crusts, which leads to the permanent destruction of hair follicular stem cell structure and subsequent replacement with fibrous tissue. Treatment of FD is challenging, characterized by prolonged courses of medications and frequent relapse after suspension.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The therapeutic goals should be focused on controlling outbreaks and preventing the irreversible progression of alopecia.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Herein we report a case of FD with extensive involvement in the scalp whose disease control was only obtained with adalimumab.</p><p id="par0015" class="elsevierStylePara elsevierViewall">A 39-year-old-male with a personal history of bronchial asthma and ischemic transient stroke at 22 years of age as a complication of renovascular hypertension, was previously followed in the Dermatology department of our hospital with a diagnosis of FD, with a histopathological examination of a scalp biopsy compatible with the diagnosis (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Back then, in 2015, in addition to topical and intralesional corticosteroids, he was treated with various regimens of doxycycline, and rifampicin/clindamycin with initial clinical improvement, but once the medication was stopped, relapses were observed. After one year, he started missing appointments and lost follow-ups. For about five years, he had irregular appointments in private Dermatology and was treated with several cycles of doxycycline and clindamycin. In November 2021, he returned to our consultation, with clinical worsening. He was quite symptomatic, with continuous pain that affected his quality of life. He also mentioned that there had been a decreasing response to oral antibiotics in recent years. Clinical observation revealed extensive involvement of the scalp, with multiple-scarring alopecic patches with inflammatory active lesions in the borders, characterized by follicular pustules, tufting of hairs, and hemorrhagic crusts (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>A, 2B, and 2C). On trichoscopy, there was diffuse erythema, alongside capillary tufts, follicular pustules, and perifollicular scale (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>D). Laboratory tests were found to be normal. He started treatment with oral isotretinoin and azithromycin. After six months, given an absence of a response, the medication was suspended and changed to adalimumab (dosing regimen of 160<span class="elsevierStyleHsp" style=""></span>mg subcutaneously on day 1, 80<span class="elsevierStyleHsp" style=""></span>mg starting on day 15, and 40<span class="elsevierStyleHsp" style=""></span>mg weekly starting from day 29). Disease control was achieved after three months of therapy. The patient has been treated with adalimumab for the last 15 months with only one flare observed during this period, which was successfully resolved with the addition of doxycycline (already suspended). In the last appointment, he was asymptomatic with no active lesions at clinical and trichoscopy examinations (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Tumor necrosis factor is a cytokine whose role as a mediator of inflammatory processes has been widely described, and that is commonly encountered in neutrophilic dermatoses. The inhibition of tumor necrosis factor-α with biological treatment has been successfully used in many of these diseases, with a positive outcome.<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,5</span></a> This case illustrates the difficulties faced when treating FD and supports existing evidence, based on clinical case series, regarding the efficacy of adalimumab in the treatment of refractory FD.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0025" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors’ contributions</span><p id="par0030" class="elsevierStylePara elsevierViewall">José Ramos: Approval of the final version of the manuscript; preparation and writing of the manuscript; Manuscript critical review.</p><p id="par0035" class="elsevierStylePara elsevierViewall">António Magarreiro Silva: Approval of the final version of the manuscript; manuscript critical review.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Ana Marta António: Approval of the final version of the manuscript; manuscript critical review.</p><p id="par0045" class="elsevierStylePara elsevierViewall">João Alves: Approval of the final version of the manuscript; manuscript critical review.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Financial support" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Authors’ contributions" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Conflicts of interest" ] 3 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2024-02-12" "fechaAceptado" => "2024-02-26" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Study conducted at the Hospital Garcia de Orta EPE, Almada, Portugal.</p>" ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1236 "Ancho" => 2925 "Tamanyo" => 1106474 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0025" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) In the vertical sections: a lymphohistiocytic infiltrate with neutrophils, at the perivascular and periadnexal level, with fibrosis of the dermis is observed. (B) In horizontal sections: there is a perifollicular lymphohistiocytic infiltrate with neutrophils mainly in the upper zones of the follicle with concentric perifollicular and interfollicular fibrosis, with loss of sebaceous glands. PAS and Giemsa stainings excluded microorganisms in the observed samples (Hematoxylin & eosin, ×40 [A], [B] Hematoxylin & eosin, ×100).</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2189 "Ancho" => 2925 "Tamanyo" => 1088351 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0030" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Clinical aspect (A, B, and C) and trichoscopy (D) - examination before treatment with adalimumab.</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 2211 "Ancho" => 2925 "Tamanyo" => 867764 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0035" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Clinical aspect (A, B, and C) and trichoscopy (D) - examination after the treatment.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Folliculitis decalvans" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "N. Otberg" 1 => "H. Kang" 2 => "A.A. Alzolibani" 3 => "J. Shapiro" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1529-8019.2008.00204.x" "Revista" => array:6 [ "tituloSerie" => "Dermatol Ther." "fecha" => "2008" "volumen" => "21" "paginaInicial" => "238" "paginaFinal" => "244" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18715292" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Folliculitis decalvans: a multicentre review of 82 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Vaño-Galván" 1 => "A.M. Molina-Ruiz" 2 => "P. Fernandez-Crehuet" 3 => "A.R. Rodrigues-Barata" 4 => "S. Arias-Santiago" 5 => "C. Serrano-Falcón" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jdv.12993" "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol." "fecha" => "2015" "volumen" => "29" "paginaInicial" => "1750" "paginaFinal" => "1757" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25682915" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Therapy-recalcitrant folliculitis decalvans controlled successfully with adalimumab" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.M. Alhameedy" 1 => "A.M. Alsantali" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4103/ijt.ijt_92_19" "Revista" => array:6 [ "tituloSerie" => "Int J Trichology." "fecha" => "2019" "volumen" => "11" "paginaInicial" => "241" "paginaFinal" => "243" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32030059" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adalimumab for treatment of pyoderma gangrenosum" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.G. Pomerantz" 1 => "M.E. Husni" 2 => "E. Mody" 3 => "A.A. Qureshi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2007.08212.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol." "fecha" => "2007" "volumen" => "157" "paginaInicial" => "1274" "paginaFinal" => "1275" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17916198" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "3 cases of dissecting cellulitis of the scalp treated with adalimumab: control of inflammation within residual structural disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.A. Navarini" 1 => "R.M. Trüeb" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/archdermatol.2010.16" "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol." "fecha" => "2010" "volumen" => "146" "paginaInicial" => "517" "paginaFinal" => "520" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20231491" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Refractory folliculitis decalvans treated with adalimumab: a case series of 23 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M. Iorizzo" 1 => "M. Starace" 2 => "S. Vano-Galvan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2022.02.044" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol." "fecha" => "2022" "volumen" => "87" "paginaInicial" => "666" "paginaFinal" => "669" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35245565" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03650596/0000009900000003/v1_202404281408/S0365059624000394/v1_202404281408/en/main.assets" "Apartado" => array:4 [ "identificador" => "96904" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letter – Therapy" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009900000003/v1_202404281408/S0365059624000394/v1_202404281408/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059624000394?idApp=UINPBA00008Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 30 | 6 | 36 |
| 2024 October | 239 | 92 | 331 |
| 2024 September | 265 | 103 | 368 |
| 2024 August | 298 | 134 | 432 |
| 2024 July | 248 | 116 | 364 |
| 2024 June | 236 | 98 | 334 |
| 2024 May | 505 | 191 | 696 |
| 2024 April | 189 | 138 | 327 |
| 2024 March | 26 | 11 | 37 |
