Letter - Clinical
Cutaneous plasmacytoma: a rare manifestation of multiple myeloma
Larissa Helena Marques Carrai
, Elaine Cristina Faria Abrahão Machado, Luiza Castro, Livia Matida Gontijo
Corresponding author
Pontifícia Universidade Católica de Campinas, Campinas, SP, Brazil
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Clinical</span>" "titulo" => "Cutaneous plasmacytoma: a rare manifestation of multiple myeloma" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "454" "paginaFinal" => "456" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Larissa Helena Marques Carrai, Elaine Cristina Faria Abrahão Machado, Luiza Castro, Livia Matida Gontijo" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Larissa Helena Marques" "apellidos" => "Carrai" "email" => array:1 [ 0 => "dralarissa.carrai.dermatologia@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Elaine Cristina Faria Abrahão" "apellidos" => "Machado" ] 2 => array:2 [ "nombre" => "Luiza" "apellidos" => "Castro" ] 3 => array:2 [ "nombre" => "Livia Matida" "apellidos" => "Gontijo" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Pontifícia Universidade Católica de Campinas, Campinas, SP, Brazil" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 2276 "Ancho" => 3341 "Tamanyo" => 667602 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Diffuse positivity for C138 in tumor cells (A); diffuse intense KAPPA positivity in the lesion (B); focal positive CD79A (C); focal positive CD79A – higher magnification (D).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Cutaneous metastases result from the spread of a tumor to the skin through lymphatic or vascular embolization, direct implantation during surgery, or involvement of the skin through contiguity. Studies indicate a frequency of 0.7%-10.4%, mainly secondary to visceral neoplasms.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The primary neoplasms most often associated with skin metastasis include breast cancer, lung cancer, and melanoma.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> There are few reported cases of cutaneous metastasis from multiple myeloma (MM), the main topic in this case report. Skin involvement associated with MM occurs in less than 10% of cases.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Due to the rarity of this manifestation, as well as the importance of its correct diagnosis, the present report describes a patient with MM and cutaneous metastasis after disease recurrence.</p><p id="par0015" class="elsevierStylePara elsevierViewall">A 49-year-old female patient had been diagnosed with MM 12 years before. She underwent several treatments, including a bone marrow transplant. She had a painless lesion on her right leg that had been developing for three months. She had a history of excision of a tumor in the right tibia with prosthetic reconstruction in the previous year. On examination, she had two well-defined, erythematous tumors with regular contours, located on the right pre-tibial region, measuring up to 3 cm (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). At the site of the orthopedic prosthesis scar, she had an erythematous, hardened, and painless nodule measuring approximately 2 cm, adhered to deep planes (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). The pathological analysis of an incisional biopsy was compatible with a neoplasm of large, poorly differentiated cells, of probable metastatic origin (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Immunohistochemistry was positive for CD79a, CD138 and Kappa, confirming the diagnosis of MM skin metastasis (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). In a joint decision with hematology, radiotherapy was chosen due to the poor prognosis. However, the patient moved to another city and was lost to follow-up at the service.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Cutaneous involvement by MM is a rare event, and cutaneous metastasis can appear in any area of the skin, most frequently the trunk, extremities, and face.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Frequently, multiple lesions are observed, although solitary lesions have also been recorded.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Cutaneous metastatic lesions of MM are classified into non-specific ones, which are more common: secondary amyloidosis, alopecia, pyoderma gangrenosum, flat xanthomas, anhidrosis, sclerodermiform lesions, lichen myxedematosus, among others, and specific ones, which represent the spread of multiple myeloma in the final stage of the disease: secondary plasmacytomas that occur by direct extension to the skin from underlying bone lesions, such as in the case described in the present report, or by lymphatic and/or hematogenous spread.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,4</span></a> They present as erythematous nodules, ulcerated or not, or plaques measuring up to 5 cm in diameter. Around 50% of the patients die within six months of the diagnosis. Cutaneous plasmacytomas can also appear in patients without a previous diagnosis of MM and are then called primary cutaneous plasmacytomas.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Therefore, a thorough dermatological examination is essential for the early diagnosis of cutaneous metastases from multiple myeloma. Thus, it becomes possible not only to optimize patient treatment but also to corroborate the importance of dermatologists because of their responsibility in the diagnosis and follow-up of patients with severe systemic diseases.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0035" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors’ contributions</span><p id="par0040" class="elsevierStylePara elsevierViewall">Larissa Helena Marques Carrai: Design and planning of the study; drafting and editing of the manuscript; collection, analysis and interpretation of data; critical review of the literature.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Elaine Cristina Faria Abrahão Machado: Design and planning of the study; drafting and editing of the manuscript; collection, analysis and interpretation of data; critical review of the literature.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Livia Matida Gontijo: Approval of the final version of the manuscript; effective participation in research orientation; drafting and editing of the manuscript; collection, analysis and interpretation of data; critical review of the manuscript.</p><p id="par0055" class="elsevierStylePara elsevierViewall">Luiza Castro: Design and planning of the study; drafting and editing of the manuscript; collection, analysis and interpretation of data; critical review of the literature.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Financial support" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Authors’ contributions" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Conflicts of interest" ] 3 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2022-10-05" "fechaAceptado" => "2022-10-27" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "⋆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Study conducted at the Pontifícia Universidade Católica de Campinas, Campinas, SP, Brazil.</p>" ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2071 "Ancho" => 1508 "Tamanyo" => 218494 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Erythematous tumors on the right pre-tibial region.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1334 "Ancho" => 3341 "Tamanyo" => 703559 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Immunohistochemistry. Diffuse infiltration of the dermis by atypical cells (A); dermal infiltration by large, poorly differentiated cells, suggestive of plasma cells – greater magnification (B).</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 2276 "Ancho" => 3341 "Tamanyo" => 667602 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Diffuse positivity for C138 in tumor cells (A); diffuse intense KAPPA positivity in the lesion (B); focal positive CD79A (C); focal positive CD79A – higher magnification (D).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:4 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metástase cutânea de câncer de mama: relato de caso e revisão da literatura" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.A. Marques" 1 => "A.S. Shibata" 2 => "D.S. Martins" 3 => "H.A. Miot" 4 => "M.E.A. Marques" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Diagn Tratamento" "fecha" => "2008" "volumen" => "13" "paginaInicial" => "164" "paginaFinal" => "168" "itemHostRev" => array:3 [ "pii" => "S2215036614702755" "estado" => "S300" "issn" => "22150366" ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metástases cutâneas como apresentação de câncer de pulmão: relato de caso" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.S.B. Machado" 1 => "G.S. Borges" 2 => "G.C. Felippe" 3 => "M. Ribeiro" 4 => "F. Zamboni" 5 => "K. 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Brito" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "J Dermatolog Clin Res" "fecha" => "2014" "volumen" => "2" "paginaInicial" => "1022" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mieloma múltiplo com plasmocitomas cutâneos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D.A.F. Souza" 1 => "T.H.P. Freitas" 2 => "P. Helena" 3 => "R.A.P. Paes" 4 => "H. Müller" 5 => "V.T.M. Hungria" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "An Bras Dermatol" "fecha" => "2004" "volumen" => "79" "paginaInicial" => "581" "paginaFinal" => "585" "itemHostRev" => array:3 [ "pii" => "S0165178114005320" "estado" => "S300" "issn" => "01651781" ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03650596/0000009900000003/v1_202404281408/S0365059624000230/v1_202404281408/en/main.assets" "Apartado" => array:4 [ "identificador" => "95153" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letter - Clinical" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009900000003/v1_202404281408/S0365059624000230/v1_202404281408/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059624000230?idApp=UINPBA00008Z" ]
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| 2024 July | 217 | 111 | 328 |
| 2024 June | 240 | 108 | 348 |
| 2024 May | 395 | 152 | 547 |
| 2024 April | 165 | 90 | 255 |
| 2024 March | 103 | 59 | 162 |
| 2024 February | 20 | 14 | 34 |
