Letter - Clinical
Phacomatosis cesio-flammeo-marmorata: report of a rare association
Luciane Zagonel
, Mônica Vannucci Nunes Lipay, Glaucos Ricardo Paraluppi, Célia Antônia Xavier de Moraes Alves
Corresponding author
Department of Dermatology, Faculty of Medicine of Jundiaí, Jundiaí, SP, Brazil
Read
2525
Timeswas read the article
908
Total PDF
1617
Total HTML
Share statistics
array:23 [ "pii" => "S0365059623002799" "issn" => "03650596" "doi" => "10.1016/j.abd.2022.09.019" "estado" => "S300" "fechaPublicacion" => "2024-05-01" "aid" => "884" "copyright" => "Sociedade Brasileira de Dermatologia" "copyrightAnyo" => "2023" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "pt" => array:18 [ "pii" => "S266627522400002X" "issn" => "26662752" "doi" => "10.1016/j.abdp.2024.01.002" "estado" => "S300" "fechaPublicacion" => "2024-05-01" "aid" => "884" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "pt" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Cartas ‐ Caso clínico</span>" "titulo" => "Facomatose cesio‐flammea‐marmorata: relato desta rara associação" "tienePdf" => "pt" "tieneTextoCompleto" => "pt" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "462" "paginaFinal" => "464" ] ] "contieneTextoCompleto" => array:1 [ "pt" => true ] "contienePdf" => array:1 [ "pt" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1466 "Ancho" => 2508 "Tamanyo" => 174721 ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Aos 6 meses de vida, extensas manchas mongólicas. Escleras acinzentas.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Luciane Zagonel, Mônica Vannucci Nunes Lipay, Glaucos Ricardo Paraluppi, Célia Antônia Xavier de Moraes Alves" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Luciane" "apellidos" => "Zagonel" ] 1 => array:2 [ "nombre" => "Mônica Vannucci Nunes" "apellidos" => "Lipay" ] 2 => array:2 [ "nombre" => "Glaucos Ricardo" "apellidos" => "Paraluppi" ] 3 => array:2 [ "nombre" => "Célia Antônia Xavier de Moraes" "apellidos" => "Alves" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0365059623002799" "doi" => "10.1016/j.abd.2022.09.019" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059623002799?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S266627522400002X?idApp=UINPBA00008Z" "url" => "/26662752/0000009900000003/v1_202404300449/S266627522400002X/v1_202404300449/pt/main.assets" ] ] "itemSiguiente" => array:18 [ "pii" => "S0365059624000126" "issn" => "03650596" "doi" => "10.1016/j.abd.2023.02.011" "estado" => "S300" "fechaPublicacion" => "2024-05-01" "aid" => "898" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter - Dermatopathology</span>" "titulo" => "An unusual Wolf’s isotopic response: myelodysplastic syndrome with acute myeloid leukemia developed on herpes zoster lesions" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "465" "paginaFinal" => "467" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 946 "Ancho" => 3341 "Tamanyo" => 728315 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Negative immunohistochemical staining for CD20 (A), Myeloperoxidase (MPO) (B) and CD117 (C) (×200).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Yu Zhu, Wei Wu" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Yu" "apellidos" => "Zhu" ] 1 => array:2 [ "nombre" => "Wei" "apellidos" => "Wu" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275224000183" "doi" => "10.1016/j.abdp.2024.02.011" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275224000183?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059624000126?idApp=UINPBA00008Z" "url" => "/03650596/0000009900000003/v1_202404281408/S0365059624000126/v1_202404281408/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0365059624000175" "issn" => "03650596" "doi" => "10.1016/j.abd.2022.11.007" "estado" => "S300" "fechaPublicacion" => "2024-05-01" "aid" => "903" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter - Clinical</span>" "titulo" => "Multiple familial trichoepithelioma: report of a disfiguring case" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "459" "paginaFinal" => "461" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1777 "Ancho" => 2925 "Tamanyo" => 428803 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Multiple confluent, normochromic, shiny, well-defined papules and nodules, measuring 0.5 to 2 cm in diameter, located predominantly and symmetrically on the central face; (B) Dermoscopy: arboriform vessels, chrysalises and milium pseudocysts over pink areas.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Thais Florence Duarte Nogueira, Stefanie Gallotti Borges Carneiro, Larissa Jacom Abdulmassih Wood, José Roberto Pereira Pegas" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Thais Florence Duarte" "apellidos" => "Nogueira" ] 1 => array:2 [ "nombre" => "Stefanie Gallotti Borges" "apellidos" => "Carneiro" ] 2 => array:2 [ "nombre" => "Larissa Jacom Abdulmassih" "apellidos" => "Wood" ] 3 => array:2 [ "nombre" => "José Roberto Pereira" "apellidos" => "Pegas" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275224000201" "doi" => "10.1016/j.abdp.2024.02.013" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275224000201?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059624000175?idApp=UINPBA00008Z" "url" => "/03650596/0000009900000003/v1_202404281408/S0365059624000175/v1_202404281408/en/main.assets" ] "en" => array:18 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter - Clinical</span>" "titulo" => "Phacomatosis cesio-flammeo-marmorata: report of a rare association" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "462" "paginaFinal" => "464" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Luciane Zagonel, Mônica Vannucci Nunes Lipay, Glaucos Ricardo Paraluppi, Célia Antônia Xavier de Moraes Alves" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Luciane" "apellidos" => "Zagonel" "email" => array:1 [ 0 => "celiaalves@g.fmj.br" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Mônica Vannucci Nunes" "apellidos" => "Lipay" ] 2 => array:2 [ "nombre" => "Glaucos Ricardo" "apellidos" => "Paraluppi" ] 3 => array:2 [ "nombre" => "Célia Antônia Xavier de Moraes" "apellidos" => "Alves" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Department of Dermatology, Faculty of Medicine of Jundiaí, Jundiaí, SP, Brazil" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1466 "Ancho" => 2508 "Tamanyo" => 174721 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0180" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A and B: At six months of life, extensive mongolian spots and gray sclerae.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Phacomatosis pigmentovascularis (PPV) is a rare congenital anomaly characterized by the presence of vascular and pigmentary lesions. The present case describes a rare association of congenital telangiectatic cutis marmorata, nevus flammeus and aberrant mongolian spots. These findings do not allow it to be classified under any item of the classification of PPV, except for the proposed name phacomatosis cesio-flammeo-marmorata.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">A late preterm baby was born from a dichorionic and diamniotic twin pregnancy to non-consanguineous parents; the mother had SARS-CoV-2 during an otherwise uneventful pregnancy and childbirth. The twin brother presented no alterations. Since birth, the reported brother however showed an erythematous lesion affecting almost the entire facial region, compatible with nevus flammeus. There was also a reticular pattern erythema on the right side of the body with clear demarcation in the anterior midline, compatible with cutis marmorata telangiectatica congenita, and extensive blue-gray macules on the lower limbs, gluteal area and back, compatible with mongolian spots. He also had grayish sclerae bilaterally and a slight asymmetry in the circumference of the lower limbs. The vascular lesions became more intense while crying or after exposure to cold (<a class="elsevierStyleCrossRefs" href="#fig0005">Figs. 1 and 2</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">An echocardiogram and transfontanellar, and abdominal ultrasonography were performed, which showed no alterations. The neurological, ophthalmic, and orthopedic evaluations showed no abnormalities. Dermatological ultrasonography identified subcutaneous tissue hypoplasia in the right leg compared to the contralateral limb.</p><p id="par0020" class="elsevierStylePara elsevierViewall">The whole exome sequencing in peripheral blood identified a probably pathogenic heterozygous variant in the COL17A1 gene, (c.3277+1G>A), in addition to a pathogenic heterozygous variant in the HBB gene, (c.20A>T: p., Glu7Val) attributing betalassemia minor.</p><p id="par0025" class="elsevierStylePara elsevierViewall">At the time of this publication, the patient is one year old, showing normal neuropsychomotor development and partial improvement of the vascular lesions. The diagnosis of phacomatosis pigmentovascularis was made; however, the findings do not completely align with the current criteria, which made the classification challenging. The name phacomatosis cesio-flammeo-marmorata has already been proposed in the literature, with seven cases identified to date,<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> which show heterogeneity of characteristics and one case with the described triad associated with nevus of Ota and anemic nevus.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Phacomatosis</span><p id="par0030" class="elsevierStylePara elsevierViewall">PPV is a group of rare congenital syndromes characterized by the combination of capillary malformations and pigmented lesions, associated or not with systemic manifestations. Initially, it was classified into four types according to the phenotype (I - Nevus flammeus and nevus pigmentosus or verrucous; II - flammeus +/- anemic and mongolian spots; III - flammeus +/- anemic and spilus; IV - flammeus +/- anemic and spilus with mongolian spot) and subtypes (a –cutaneous involvement only; b – systemic involvement). Happle<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> reclassified it into phacomatosis cesioflamea, cesiomarmorata, spilorosea, and unclassified, with or without systemic manifestations.</p><p id="par0035" class="elsevierStylePara elsevierViewall">The syndrome pathogenesis is not well understood. The GNAG and GNA11 genes have been associated with some cases.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> The COL17A1 gene, identified in the patient of the present case, encodes collagen XVII, essential in epidermal stabilization, and, to the best of the authors knowledge, this is the first time that possibly pathogenic variants have been identified in this gene in a patient with these characteristics. This gene is related to epidermolysis bullosa; however, it does not have 100% penetrance, which may explain the lack of the expected phenotype. The patient does not have skin fragility so far.</p><p id="par0040" class="elsevierStylePara elsevierViewall">The diagnosis of PPV is clinical; however, the classification is challenging when it does not meet all the criteria or if there is an overlap between them, which is why it has been proposed that the combination of the three conditions found in this patient merit a distinct classification as phacomatosis cesio-flammeo-marmorata.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The investigation of ocular and neurological involvement is generally recommended,<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> as well as other tests, depending on clinical suspicion.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Financial support</span><p id="par0045" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Authors’ contributions</span><p id="par0050" class="elsevierStylePara elsevierViewall">Luciane Zagonel: Approval of the final version of the manuscript; drafting and editing of the manuscript; critical review of the literature.</p><p id="par0055" class="elsevierStylePara elsevierViewall">Mônica Vannucci Nunes Lipay: Approval of the final version of the manuscript; drafting and editing of the manuscript; critical review of the literature.</p><p id="par0060" class="elsevierStylePara elsevierViewall">Glaucos Ricardo Paraluppi: Approval of the final version of the manuscript; critical review of the manuscript; intellectual participation in the propaedeutic and/or therapeutic conduct of the studied case.</p><p id="par0065" class="elsevierStylePara elsevierViewall">Célia Antônia Xavier de Moraes Alves: Approval of the final version of the manuscript; critical review of the manuscript; intellectual participation in the propaedeutic and/or therapeutic conduct of the studied case.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conflicts of interest</span><p id="par0070" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:6 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Phacomatosis" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Financial support" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Authors’ contributions" ] 3 => array:2 [ "identificador" => "sec0020" "titulo" => "Conflicts of interest" ] 4 => array:2 [ "identificador" => "xack741447" "titulo" => "Acknowledgment" ] 5 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2022-06-29" "fechaAceptado" => "2022-09-07" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Study conducted at the Faculty of Medicine of Jundiaí, Jundiaí, SP, Brazil.</p>" ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1566 "Ancho" => 2508 "Tamanyo" => 204744 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0175" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A and B: At 28 days of life, congenital telangiectatic cutis, aberrant mongolian spots and nevus flammeus on the face.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1466 "Ancho" => 2508 "Tamanyo" => 174721 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0180" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A and B: At six months of life, extensive mongolian spots and gray sclerae.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "New case of phacomatosis cesio-flammeo-marmorata: the time is right to review the classification for phacomatosis pigmentovascularis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A.S. Chehad" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/ijd.14612" "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2019" "volumen" => "58" "paginaInicial" => "e237" "paginaFinal" => "e240" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31463930" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The case of a boy with nevus of ota, extensive Mongolian spot, nevus flammeus, nevus anemicus and cutis marmorata telangectasica congenita: A unique instance of phacomatosis pigmento-vascularis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H. Ma" 1 => "M. Liao" 2 => "S. Qiu" 3 => "R. Luo" 4 => "R. Lu" 5 => "C. Lu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1590/abd1806-4841.20153466" "Revista" => array:6 [ "tituloSerie" => "An Bras Dermatol" "fecha" => "2015" "volumen" => "90" "paginaInicial" => "10" "paginaFinal" => "12" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26312661" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Phacomatosis pigmentovascularis revisted and reclassified" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R. Happle" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/archderm.141.3.385" "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "2005" "volumen" => "141" "paginaInicial" => "385" "paginaFinal" => "388" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15781681" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mosaic activating mutations in GNA11 and GNAQ are associated with phakomatosis pigmentovascularis and extensive dermal melanocytoses" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.C. Thomas" 1 => "Z. Zeng" 2 => "J.B. Rivière" 3 => "R. O’Shaughnessy" 4 => "L. Al- Olabi" 5 => "J. St-Onge" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jid.2015.11.027" "Revista" => array:6 [ "tituloSerie" => "J Invest Dermatol" "fecha" => "2016" "volumen" => "136" "paginaInicial" => "770" "paginaFinal" => "778" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26778290" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extracutaneous manifestations in phacomatosis cesioflammea and cesiomarmorata: case series and literature review" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Kumar" 1 => "D.B. Zastrow" 2 => "E.J. Kravets" 3 => "D. Beleford" 4 => "M.R.Z. Ruzhnikov" 5 => "M.E. Grove" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ajmg.a.61134" "Revista" => array:7 [ "tituloSerie" => "Am J Med Genet A" "fecha" => "2019" "volumen" => "179" "paginaInicial" => "966" "paginaFinal" => "977" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30920161" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1364661322001668" "estado" => "S300" "issn" => "13646613" ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack741447" "titulo" => "Acknowledgment" "texto" => "<p id="par0075" class="elsevierStylePara elsevierViewall">To Dr. Rosa Sigrist.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/03650596/0000009900000003/v1_202404281408/S0365059623002799/v1_202404281408/en/main.assets" "Apartado" => array:4 [ "identificador" => "95153" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letter - Clinical" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009900000003/v1_202404281408/S0365059623002799/v1_202404281408/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059623002799?idApp=UINPBA00008Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 14 | 10 | 24 |
| 2024 October | 130 | 86 | 216 |
| 2024 September | 159 | 97 | 256 |
| 2024 August | 196 | 125 | 321 |
| 2024 July | 170 | 113 | 283 |
| 2024 June | 206 | 68 | 274 |
| 2024 May | 390 | 96 | 486 |
| 2024 April | 133 | 90 | 223 |
| 2024 March | 92 | 70 | 162 |
| 2024 February | 96 | 110 | 206 |
| 2024 January | 31 | 43 | 74 |
