Letter - Dermatopathology
A unique case of a lymphoproliferative disorder affecting the skin and uterine cervix on a male transgender
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(A) Hematoxilina & eosina (40<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>) mostrando agregados linfoides em padrão nodular e folicular. (B) Ki67 (200<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>) com falta de polarização dentro dos folículos neoplásicos. (C) CD20 (40<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>) destacando as células B esboçando folículos. (D) CD3<span class="elsevierStyleSup">+</span> nas células ao redor dos folículos linfoides. (E) Bcl6<span class="elsevierStyleSup">+</span> fraco, mas assemelhando‐se às células CD20<span class="elsevierStyleSup">+</span>. (F) Bcl2<span class="elsevierStyleSup">−</span> (40<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>) nos folículos linfoides, com distribuição semelhante às células CD3<span class="elsevierStyleSup">+</span></p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Jade Cury‐Martins, Marcelo A. Giannotti, Denis Miyashiro, Juliana Pereira, José Antonio Sanches" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Jade" "apellidos" => "Cury‐Martins" ] 1 => array:2 [ "nombre" => "Marcelo A." 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(B) A potato piece of 2<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>1.5<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>0.5<span class="elsevierStyleHsp" style=""></span>cm with a slit made in it by means of a scalpel. (C) The piece of potato, with the tissue inside. (D) Longitudinal section demonstrating the components of the nail apparatus. Hematoxylin & eosin, original magnification ×40.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Laura Bertanha, Cristina Diniz Borges Figueira de Mello, Ingrid Iara Damas, Rafael Fantelli Stelini, Nilton Di Chiacchio, Maria Letícia Cintra" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Laura" "apellidos" => "Bertanha" ] 1 => array:2 [ "nombre" => "Cristina Diniz Borges Figueira" "apellidos" => "de Mello" ] 2 => array:2 [ "nombre" => "Ingrid Iara" "apellidos" => "Damas" ] 3 => array:2 [ "nombre" => "Rafael Fantelli" "apellidos" => "Stelini" ] 4 => array:2 [ "nombre" => "Nilton" "apellidos" => "Di Chiacchio" ] 5 => array:2 [ "nombre" => "Maria Letícia" "apellidos" => "Cintra" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275223002199" "doi" => "10.1016/j.abdp.2023.09.001" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275223002199?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059623001897?idApp=UINPBA00008Z" "url" => "/03650596/0000009900000001/v1_202401040817/S0365059623001897/v1_202401040817/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0365059623001952" "issn" => "03650596" "doi" => "10.1016/j.abd.2022.06.008" "estado" => "S300" "fechaPublicacion" => "2024-01-01" "aid" => "830" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "article" "crossmark" => 1 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter - Clinical</span>" "titulo" => "Pigmented squamous cell carcinoma in a non-photo-exposed area of an indigenous woman" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "131" "paginaFinal" => "134" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 865 "Ancho" => 3341 "Tamanyo" => 803440 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0325" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Histopathology of the excisional biopsy. (A) Invasive cutaneous neoplasm consisting of atypical and pleomorphic cells with clear eosinophilic cytoplasm and pleomorphic nuclei with abundant keratinization (Hematoxylin & eosin, ×100). (B) Pigment deposits (Hematoxylin & eosin, ×40). (C) At higher magnification, keratinocyte atypia and pigment deposits (Hematoxylin & eosin, ×400).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Luana Amaral de Moura, Lucia Martins Diniz, Emilly Neves Souza, Lucas Amaral de Moura" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Luana Amaral de" "apellidos" => "Moura" ] 1 => array:2 [ "nombre" => "Lucia Martins" "apellidos" => "Diniz" ] 2 => array:2 [ "nombre" => "Emilly Neves" "apellidos" => "Souza" ] 3 => array:2 [ "nombre" => "Lucas Amaral de" "apellidos" => "Moura" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275223002266" "doi" => "10.1016/j.abdp.2023.09.008" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275223002266?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059623001952?idApp=UINPBA00008Z" "url" => "/03650596/0000009900000001/v1_202401040817/S0365059623001952/v1_202401040817/en/main.assets" ] "en" => array:18 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter - Dermatopathology</span>" "titulo" => "A unique case of a lymphoproliferative disorder affecting the skin and uterine cervix on a male transgender" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "135" "paginaFinal" => "139" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Jade Cury-Martins, Marcelo A. Giannotti, Denis Miyashiro, Juliana Pereira, José Antonio Sanches" "autores" => array:5 [ 0 => array:4 [ "nombre" => "Jade" "apellidos" => "Cury-Martins" "email" => array:1 [ 0 => "jadecury@yahoo.com.br" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Marcelo A." "apellidos" => "Giannotti" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Denis" "apellidos" => "Miyashiro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Juliana" "apellidos" => "Pereira" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "José Antonio" "apellidos" => "Sanches" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Department of Dermatology, Universidade de São Paulo, São Paulo, SP, Brazil" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Pathology, Universidade de São Paulo, São Paulo, SP, Brazil" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Department of Hematology, Universidade de São Paulo, São Paulo, SP, Brazil" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2777 "Ancho" => 3341 "Tamanyo" => 1384224 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">(A‒H) Skin histopathology: (Hematoxylin & eosin, ×10 and ×200), there is a “bottom-heavy” infiltrate of small lymphocytes, with a nodular growth pattern and no epidermal alterations; CD20 (×10) highlighting neoplastic B-cells; CD3 (×10) showing the associated rich T-cell infiltrate; CD21 showing areas with follicle outlines; Bcl2 positive (×10) in B and T cells; Bcl6 positive (×10 and ×40) inside and outside the germinal centers</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Extranodal lymphomas account for 25%-35% of all Non-Hodgkin's lymphomas (NHL). The most common site of involvement is the gastrointestinal tract, followed by the skin.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Primary cutaneous follicular center lymphoma (FCL) is the most common form of cutaneous B-cell lymphoma, accounting for 50%-60% of cases.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,4</span></a> It affects mainly adults, and has an excellent prognosis and a specific five-year survival of more than 95%.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Extracutaneous spread is extremely rare, but recurrences are frequent.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Primary female genital system lymphoma (PFGSL) is extremely rare, accounting for 0.2%‒1.1% of all extranodal lymphomas, with an estimated number of 165 new cases annually in the USA.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Secondary involvement by nodal lymphoma is more frequent. The most commonly affected site is the ovary, followed by the uterine cervix, and the most common histopathological subtype is diffuse large B-cell lymphoma, followed by follicular lymphoma.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,5,6</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Regarding the risk factors, it is suggested that a possible chronic antigenic stimulus may have a causal role, but no factor has been well established yet. In cutaneous B-cell marginal zone lymphomas, a relationship with <span class="elsevierStyleItalic">Borrelia burgdorferi</span> has been suggested, but this association has not been confirmed.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Regarding transgender individuals, the question of the role of hormonal stimulation in the development of neoplasms is important. For hormone-dependent neoplasms, such as breast cancer, this risk exists; for NHL there is a hypothesis of a hormonal role in some studies, but this relationship is suggested for female hormone replacement, but is not described for male hormones, as would be the case in transgender men, as in the case described below.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The authors describe a 42-year-old male transgender patient, without comorbidities, who presented to the Dermatology Outpatient Clinic with an asymptomatic, slow-growing, infiltrated, erythematous tumor, measuring 3 cm in the left preauricular region (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Histopathology disclosed an infiltrate of small lymphocytes, with a “bottom-heavy” nodular growth pattern, and no epidermal alterations. The neoplastic cells were CD20+ and CD10 and MUM1 negative; with CD21 staining in the lymphoid follicles; BCL6+ both inside (more evident) and outside the follicles; BCL2+ in B and T cells; CD3 and CD5 revealed a background of reactive T cells but were negative in atypical cells (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Polymerase chain reaction (PCR) showed monoclonality for the IgH gene in the B cell population. A diagnosis of FCL was made and no evidence of extracutaneous disease was found after staging with CT scans of the chest, abdomen, pelvis and cervix, and a bone marrow biopsy. The patient was treated with intralesional corticosteroids with a complete response (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Regarding gender identity, the patient started a hormonal transition (with testosterone) at the age of 40 years. Two years after the diagnosis of cutaneous lymphoma, the patient continued the transition by undergoing a total hystero-salpingo-oophorectomy. Histopathology of the uterine cervix disclosed lymphoid aggregates in a nodular, follicular pattern, with a phenotype similar to that of the skin lesion (CD20+, CD23 highlighting nodules, in a background rich in T CD3+ and CD5+ cells, weak BCL6+, with a strong similarity to the distribution of CD20+, CD10-, MUM-, Bcl2- cells in the germinal center, and resembling the distribution of CD3+ and KI67 cells, with lack of polarization inside the neoplastic follicles; <a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). PCR analysis for immunoglobulin was inconclusive. The investigation of the t(14;18) translocation in paraffin-embedded tissue, both in the cervix and the skin of the face, was negative. The patient had no B symptoms and no signs of residual disease on PET-CT staging and a new bone marrow biopsy, thus, clinical follow-up without additional treatment was chosen.</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Two years later, a new cutaneous nodule on the right thorax, with the same clinical aspect as the one on the face, was surgically excised, and presented histopathologic findings again compatible with the diagnosis of FCL (<a class="elsevierStyleCrossRef" href="#fig0005">Figs. 1</a> C and D). The patient has been in complete remission for two years.</p><p id="par0040" class="elsevierStylePara elsevierViewall">After several multidisciplinary discussions, no conclusion could be reached on the unification of the cutaneous and uterine findings. Initially, the diagnosis of FCL was made. However, extracutaneous spread of FCL is rare and, when present, is more frequent to local lymph nodes.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> No previous description of spread to the uterine cervix was found.</p><p id="par0045" class="elsevierStylePara elsevierViewall">One possibility would be a primary nodal lymphoma secondarily affecting the skin and cervix. However, no signs of nodal involvement were found when staging with tomography and later through PET-CT, nor disease in the bone marrow biopsy, at the time of the diagnosis in the skin and cervix. Additionally, nodal lymphomas are usually Bcl2 positive in germinal centers.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">This led to a third proposition of two different primary extranodal follicular B-cell lymphomas: an FCL and a PFGSL. Also, for this association, no previous description was found.</p><p id="par0055" class="elsevierStylePara elsevierViewall">Another possibility would be that the involvement of the uterine cervix represents a pseudolymphoma. Lymphoma-like lesions of the cervix were first described in 1985, and there are other rare reports.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,10</span></a> Au et al. described three cases of uterine cervix B-cell lymphomas, but upon review concluded that two of the three were, in fact, pseudolymphomas. The reported cases usually regressed spontaneously when the biopsy was repeated. As possible diagnostic clues for pseudolymphoma, a more superficial distribution of the infiltrate is suggested, with heterogeneity of lymphoid cells and absence of masses or ulcerations, but this can also occur in indolent lymphomas. It can be suggested that the detection of the immunoglobulin gene rearrangement by PCR helps to differentiate these two diseases since the lymphoma is usually clonal while the pseudolymphoma, as a reactional and non-neoplastic process, is expected to be polyclonal. However, previous studies have shown that clonal rearrangement can also be detected in benign conditions, reported, for instance, in 50% of benign gastric lymphoid hyperplasia cases and 41% of benign lymphoepithelial lesions of the salivary glands.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11,12</span></a> Thus, even though it is not conclusive, it could be one more tool to help (but not define) the diagnosis. Unfortunately, in the current case, clonal detection in the paraffin-embedded uterine cervix sample was inconclusive.</p><p id="par0060" class="elsevierStylePara elsevierViewall">Although a definitive diagnosis was not possible, the authors describe the association of two rare lymphoproliferative diseases and the diagnostic pitfalls of this group of diseases.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0065" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors' contributions</span><p id="par0070" class="elsevierStylePara elsevierViewall">Jade Cury-Martins: Approval of the final version of the manuscript; design and planning of the study; drafting and editing of the manuscript; collection, analysis, and interpretation of data; effective participation in research orientation; critical review of the literature; critical review of the manuscript.</p><p id="par0075" class="elsevierStylePara elsevierViewall">Marcelo Abrante Giannotti: Approval of the final version of the manuscript; collection, analysis, and interpretation of data; critical review of the manuscript.</p><p id="par0080" class="elsevierStylePara elsevierViewall">Denis Miyashiro: Approval of the final version of the manuscript; collection, analysis, and interpretation of data; critical review of the manuscript.</p><p id="par0085" class="elsevierStylePara elsevierViewall">Juliana Pereira: Approval of the final version of the manuscript; collection, analysis, and interpretation of data; critical review of the manuscript.</p><p id="par0090" class="elsevierStylePara elsevierViewall">Jose Antonio Sanches: Approval of the final version of the manuscript; collection, analysis, and interpretation of data; effective participation in research orientation; critical review of the manuscript.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0095" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Financial support" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Authors' contributions" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Conflicts of interest" ] 3 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2022-06-13" "fechaAceptado" => "2023-02-25" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Study conducted at the Hospital das Clínicas, Universidade de São Paulo, São Paulo, SP, Brazil.</p>" ] ] "apendice" => array:1 [ 0 => array:1 [ "seccion" => array:1 [ 0 => array:4 [ "apendice" => "<p id="par0105" class="elsevierStylePara elsevierViewall">The following is Supplementary data to this article:<elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>" "etiqueta" => "Appendix A" "titulo" => "Supplementary data" "identificador" => "sec0025" ] ] ] ] "multimedia" => array:4 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3178 "Ancho" => 1675 "Tamanyo" => 629978 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical photo: (A) erythematous, infiltrated, asymptomatic, slow-growing tumor measuring 3 cm on the left preauricular region; (B) there was complete resolution after the use of topical and intralesional corticosteroids. (C) Erythematous nodule on the left breast and (D) resolution with scarring after excision</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2777 "Ancho" => 3341 "Tamanyo" => 1384224 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">(A‒H) Skin histopathology: (Hematoxylin & eosin, ×10 and ×200), there is a “bottom-heavy” infiltrate of small lymphocytes, with a nodular growth pattern and no epidermal alterations; CD20 (×10) highlighting neoplastic B-cells; CD3 (×10) showing the associated rich T-cell infiltrate; CD21 showing areas with follicle outlines; Bcl2 positive (×10) in B and T cells; Bcl6 positive (×10 and ×40) inside and outside the germinal centers</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 2892 "Ancho" => 3008 "Tamanyo" => 1516822 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">(A‒F) Uterine cervix histopathology (Hematoxylin & eosin, ×40), showing lymphoid aggregates in a nodular and follicular pattern; Ki67 (×200) with lack of polarization inside the neoplastic follicles; CD20 (×40) highlighting B cells outlining follicles; CD3 positive in cells around lymphoid follicles; weakly Bcl6 positive cells, but resembling CD20 positive cells; Bcl2 negative reaction (×40) in lymphoid follicles, with a distribution similar to CD3+ cells</p>" ] ] 3 => array:5 [ "identificador" => "upi0005" "tipo" => "MULTIMEDIAECOMPONENTE" "mostrarFloat" => false "mostrarDisplay" => true "Ecomponente" => array:2 [ "fichero" => "mmc1.docx" "ficheroTamanyo" => 15839 ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:12 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary lymphoma of the female genital tract: An analysis of 697 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D. Nasioudis" 1 => "P.N. Kampaktsis" 2 => "M. Frey" 3 => "S.S. Witkin" 4 => "K. Holcomb" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ygyno.2017.02.043" "Revista" => array:6 [ "tituloSerie" => "Gynecol Oncol." "fecha" => "2017" "volumen" => "145" "paginaInicial" => "305" "paginaFinal" => "309" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28284518" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Willemze" 1 => "L. Cerroni" 2 => "W. Kempf" 3 => "E. Berti" 4 => "F. Facchetti" 5 => "S.H. Swerdlow" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1182/blood-2018-11-881268" "Revista" => array:6 [ "tituloSerie" => "Blood." "fecha" => "2019" "volumen" => "133" "paginaInicial" => "1703" "paginaFinal" => "1714" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30635287" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary cutaneous B-cell lymphomas with large cell predominance-primary cutaneous follicle center lymphoma, diffuse large B-cell lymphoma, leg type and intravascular large B-cell lymphoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C.B. Hope" 1 => "L.B. Pincus" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/j.semdp.2016.11.006" "Revista" => array:6 [ "tituloSerie" => "Semin Diagn Pathol." "fecha" => "2017" "volumen" => "34" "paginaInicial" => "85" "paginaFinal" => "98" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28065463" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary cutaneous follicle center lymphoma associated with an extracutaneous dissemination: a cytogenetic finding of potential prognostic value" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Subramaniyam" 1 => "C.M. Magro" 2 => "S. Gogineni" 3 => "W. Tam" 4 => "S. Mathew" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1309/AJCPV3F9BEFCTAOQ" "Revista" => array:7 [ "tituloSerie" => "Am J Clin Pathol." "fecha" => "2015" "volumen" => "144" "paginaInicial" => "805" "paginaFinal" => "810" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26486746" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0735109713060282" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary B-cell lymphoma of the uterine cervix: Presentation in Pap-test slide and cervical biopsy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G. Yang" 1 => "J. Deisch" 2 => "M. Tavares" 3 => "Q. Haixia" 4 => "C. Cobb" 5 => "A.S. Raza" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/dc.23627" "Revista" => array:6 [ "tituloSerie" => "Diagn Cytopathol." "fecha" => "2017" "volumen" => "45" "paginaInicial" => "235" "paginaFinal" => "238" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27863160" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gynecologic cancer screening in the transgender male population and its current challenges" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.M. Patel" 1 => "S. Dolitsky" 2 => "G.A. Bachman" 3 => "A. Buckley de Meritens" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Maturitas." "fecha" => "2019" "volumen" => "129" "paginaInicial" => "40" "paginaFinal" => "44" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exploring the causes of cutaneous B-cell lymphoma: we should learn from the Lyme disease experience" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L. Naldi" 1 => "C. Minelli" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000051554" "Revista" => array:6 [ "tituloSerie" => "Dermatology." "fecha" => "2000" "volumen" => "201" "paginaInicial" => "353" "paginaFinal" => "355" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11146350" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reproductive factors and non-Hodgkin lymphoma: a systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L. Costas" 1 => "S. de Sanjosé" 2 => "C. Infante-Rivard" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.critrevonc.2014.07.004" "Revista" => array:6 [ "tituloSerie" => "Crit Rev Oncol Hematol." "fecha" => "2014" "volumen" => "92" "paginaInicial" => "181" "paginaFinal" => "193" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25132165" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bcl-2, Bcl-6 and CD10 expression in cutaneous B-cell lymphoma: further support for a follicle centre cell origin and differential diagnostic significance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.J. Hoefnagel" 1 => "M.H. Vermeer" 2 => "P.M. Jansen" 3 => "G.J. Fleuren" 4 => "C.J. Meijer" 5 => "R. Willemze" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2003.05649.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol." "fecha" => "2003" "volumen" => "149" "paginaInicial" => "1183" "paginaFinal" => "1191" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14674895" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary B-cell lymphoma and lymphoma-like lesions of the uterine cervix" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "W.Y. Au" 1 => "B.C. Chan" 2 => "L.P. Chung" 3 => "C. Choy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Hematol." "fecha" => "2003" "volumen" => "73" "paginaInicial" => "176" "paginaFinal" => "179" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Distinct B-cell clonal bands in Helicobacter pylori gastritis with lymphoid hyperplasia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Saxena" 1 => "O. Moshynska" 2 => "R. Kanthan" 3 => "M. Bhutani" 4 => "A.W. Maksymiuk" 5 => "B.E. Lukie" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/(SICI)1096-9896(200001)190:1<47::AID-PATH506>3.0.CO;2-O" "Revista" => array:6 [ "tituloSerie" => "J Pathol." "fecha" => "2000" "volumen" => "190" "paginaInicial" => "47" "paginaFinal" => "54" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10640991" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Salivary gland lymphoid infiltrates associated with lymphoepithelial lesions: a clinicopathologic, immunophenotypic, and genotypic study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P.G. Quintana" 1 => "S.B. Kapadia" 2 => "D.W. Bahler" 3 => "J.T. Johnson" 4 => "S.H. Swerdlow" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0046-8177(97)90161-1" "Revista" => array:6 [ "tituloSerie" => "Hum Pathol." "fecha" => "1997" "volumen" => "28" "paginaInicial" => "850" "paginaFinal" => "861" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9224756" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03650596/0000009900000001/v1_202401040817/S0365059623001940/v1_202401040817/en/main.assets" "Apartado" => array:4 [ "identificador" => "95152" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letter - Dermatopathology" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009900000001/v1_202401040817/S0365059623001940/v1_202401040817/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059623001940?idApp=UINPBA00008Z" ]
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