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as well as pain on wrist flexion&#46; Electroneuromyography showed severe sensorimotor axonal neuropathy of the median nerve&#44; which affected its distal segment&#44; with an absence of potential in the nerve conduction test&#46; X-rays of the hands showed osteolysis of the distal phalanx of the index fingers&#46; A wrist magnetic resonance imaging showed bilateral thickening of the median nerve in the retinaculum &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A and B&#41;&#44; with normal thickness outside this region &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>C&#41;&#44; whereas the ulnar nerves showed a normal appearance&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><span id="sec1005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect1005">What&#8217;s your diagnosis&#63;</span><p id="par0015" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">a&#41;</span><p id="par0020" class="elsevierStylePara elsevierViewall">Leprosy</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">b&#41;</span><p id="par0025" class="elsevierStylePara elsevierViewall">Diabetic neuropathy</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">c&#41;</span><p id="par0030" class="elsevierStylePara elsevierViewall">Ulcerative carpal tunnel syndrome</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">d&#41;</span><p id="par0035" class="elsevierStylePara elsevierViewall">Dermatitis artefacta</p></li></ul></p></span><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Discussion</span><p id="par0040" class="elsevierStylePara elsevierViewall">Carpal tunnel syndrome &#40;CTS&#41; is a focal mononeuropathy caused by compression of the median nerve as it goes through the osteofibrous carpal tunnel&#46; In the case reported herein&#44; the nerve measured 18&#46;7&#8239;mm<span class="elsevierStyleSup">2</span> in the left retinaculum and 22&#46;1&#8239;mm<span class="elsevierStyleSup">2</span> in the right one&#44; with normal size being up to 15&#8239;mm<span class="elsevierStyleSup">2</span>&#59; measurements above 19&#8239;mm<span class="elsevierStyleSup">2</span> are considered a severe form of the disease&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The idiopathic form of CTS occurs more often in women aged between 40 and 60 years&#44; and in half of the cases it is bilateral&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> similar to the case described herein&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Secondary forms are caused by trauma&#44; such as dislocation of the carpal bones&#44; or by joint alterations in the wrist&#44; such as osteoarthritis or inflammatory arthritis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Cutaneous involvement in CTS is rare&#44; having been described as an ulcerative-mutilating form in 1979 by Bouvier&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> with some reports in the dermatological literature&#44;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#8211;6</span></a> which are generally described as ulcerative or ulcerative-mutilating forms&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">There is a Portuguese report of nine cases in a retrospective study&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> confirmed by electromyography&#46; All of them started with paresthesia in the second and third fingers and one case had nocturnal pain&#46; All radiographed cases &#40;one-third&#41; had osteolysis of the distal phalanges&#46; Seven cases &#40;77&#37;&#41; had ulcerations on the second and third fingers&#44; also similar to the case described herein&#44; and two cases had ulceration in only one finger&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The lesions observed in this patient are characteristic of peripheral neuropathy&#44; with a clear background and callused edges and without pain&#44; probably aggravated by the patient&#8217;s professional activity&#46; CTS should be suspected whenever there is involvement restricted to the second and third fingers&#44; and the thumb is usually spared&#44; as it has combined innervation of the radial nerve&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">It is relevant in dermatology to know about this disease&#44; given the important differential diagnosis with leprosy &#40;although it cannot be completely ruled out&#41;&#44; so these cases can be referred for orthopedic evaluation and treatment&#44; which can be conservative or surgical&#44; with retinaculotomy&#44; which gave good results in this patient&#46;&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Financial support</span><p id="par0075" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Authors&#8217; contributions</span><p id="par0080" class="elsevierStylePara elsevierViewall">Hiram Larangeira de Almeida Jr&#46;&#58; Approval of the final version of the manuscript&#59; design and planning of the study&#59; drafting and editing of the manuscript&#59; collection&#44; analysis and interpretation of data&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Fernanda Pinto Garcia&#58; Approval of the final version of the manuscript&#59; design and planning of the study&#59; drafting and editing of the manuscript&#59; collection&#44; analysis and interpretation of data&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Laura de Moraes Gomes&#58; Approval of the final version of the manuscript&#59; drafting and editing of the manuscript&#59; collection&#44; analysis and interpretation of data&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Ant&#244;nia Larangeira de Almeida&#58; Approval of the final version of the manuscript&#59; design and planning of the study&#59; drafting and editing of the manuscript&#59; collection&#44; analysis and interpretation of data&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conflicts of interest</span><p id="par0100" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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Letter - Clinical
Case for diagnosis. Bilateral ulcerations on the distal phalanges of the second and third fingers - Ulcerative carpal tunnel syndrome
Hiram Larangeira de Almeida Jr.a,b,
Corresponding author
hiramalmeidajr@hotmail.com

Corresponding author.
, Fernanda Pinto Garciac, Laura de Moraes Gomesd, Antônia Larangeira de Almeidab
a Department of Dermatology, Universidade Católica de Pelotas, Pelotas, RS, Brazil
b Department of Dermatology, Universidade Federal de Pelotas, Pelotas, RS, Brazil
c Hospital Erasto Gaertner, Curitiba, RS, Brazil
d Department of Radiology, Universidade Federal de Pelotas, Pelotas, RS, Brazil
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as well as pain on wrist flexion&#46; Electroneuromyography showed severe sensorimotor axonal neuropathy of the median nerve&#44; which affected its distal segment&#44; with an absence of potential in the nerve conduction test&#46; X-rays of the hands showed osteolysis of the distal phalanx of the index fingers&#46; A wrist magnetic resonance imaging showed bilateral thickening of the median nerve in the retinaculum &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A and B&#41;&#44; with normal thickness outside this region &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>C&#41;&#44; whereas the ulnar nerves showed a normal appearance&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><span id="sec1005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect1005">What&#8217;s your diagnosis&#63;</span><p id="par0015" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">a&#41;</span><p id="par0020" class="elsevierStylePara elsevierViewall">Leprosy</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">b&#41;</span><p id="par0025" class="elsevierStylePara elsevierViewall">Diabetic neuropathy</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">c&#41;</span><p id="par0030" class="elsevierStylePara elsevierViewall">Ulcerative carpal tunnel syndrome</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">d&#41;</span><p id="par0035" class="elsevierStylePara elsevierViewall">Dermatitis artefacta</p></li></ul></p></span><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Discussion</span><p id="par0040" class="elsevierStylePara elsevierViewall">Carpal tunnel syndrome &#40;CTS&#41; is a focal mononeuropathy caused by compression of the median nerve as it goes through the osteofibrous carpal tunnel&#46; In the case reported herein&#44; the nerve measured 18&#46;7&#8239;mm<span class="elsevierStyleSup">2</span> in the left retinaculum and 22&#46;1&#8239;mm<span class="elsevierStyleSup">2</span> in the right one&#44; with normal size being up to 15&#8239;mm<span class="elsevierStyleSup">2</span>&#59; measurements above 19&#8239;mm<span class="elsevierStyleSup">2</span> are considered a severe form of the disease&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The idiopathic form of CTS occurs more often in women aged between 40 and 60 years&#44; and in half of the cases it is bilateral&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> similar to the case described herein&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Secondary forms are caused by trauma&#44; such as dislocation of the carpal bones&#44; or by joint alterations in the wrist&#44; such as osteoarthritis or inflammatory arthritis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Cutaneous involvement in CTS is rare&#44; having been described as an ulcerative-mutilating form in 1979 by Bouvier&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> with some reports in the dermatological literature&#44;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#8211;6</span></a> which are generally described as ulcerative or ulcerative-mutilating forms&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">There is a Portuguese report of nine cases in a retrospective study&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> confirmed by electromyography&#46; All of them started with paresthesia in the second and third fingers and one case had nocturnal pain&#46; All radiographed cases &#40;one-third&#41; had osteolysis of the distal phalanges&#46; Seven cases &#40;77&#37;&#41; had ulcerations on the second and third fingers&#44; also similar to the case described herein&#44; and two cases had ulceration in only one finger&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The lesions observed in this patient are characteristic of peripheral neuropathy&#44; with a clear background and callused edges and without pain&#44; probably aggravated by the patient&#8217;s professional activity&#46; CTS should be suspected whenever there is involvement restricted to the second and third fingers&#44; and the thumb is usually spared&#44; as it has combined innervation of the radial nerve&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">It is relevant in dermatology to know about this disease&#44; given the important differential diagnosis with leprosy &#40;although it cannot be completely ruled out&#41;&#44; so these cases can be referred for orthopedic evaluation and treatment&#44; which can be conservative or surgical&#44; with retinaculotomy&#44; which gave good results in this patient&#46;&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Financial support</span><p id="par0075" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Authors&#8217; contributions</span><p id="par0080" class="elsevierStylePara elsevierViewall">Hiram Larangeira de Almeida Jr&#46;&#58; Approval of the final version of the manuscript&#59; design and planning of the study&#59; drafting and editing of the manuscript&#59; collection&#44; analysis and interpretation of data&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Fernanda Pinto Garcia&#58; Approval of the final version of the manuscript&#59; design and planning of the study&#59; drafting and editing of the manuscript&#59; collection&#44; analysis and interpretation of data&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Laura de Moraes Gomes&#58; Approval of the final version of the manuscript&#59; drafting and editing of the manuscript&#59; collection&#44; analysis and interpretation of data&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Ant&#244;nia Larangeira de Almeida&#58; Approval of the final version of the manuscript&#59; design and planning of the study&#59; drafting and editing of the manuscript&#59; collection&#44; analysis and interpretation of data&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conflicts of interest</span><p id="par0100" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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ISSN: 03650596
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