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(a) Fotomicroscopia do melanoma <span class="elsevierStyleItalic">in situ</span> da perna esquerda demonstrando atipias citológicas intensas e disseminação pagetoide exuberante (Hematoxilina & eosina, 100<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>). (b) Positividade imuno‐histoquímica de HMB45 nas células neoplásicas em ambos os componentes epidérmico e dérmico do melanoma invasivo da região do abdome (Hematoxilina & eosina, 100<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Marcelo Moreno, Maria Luiza Mukai Franciosi, Lucas Faria Abrahão‐Machado" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Marcelo" "apellidos" => "Moreno" ] 1 => array:2 [ "nombre" => "Maria Luiza Mukai" "apellidos" => "Franciosi" ] 2 => array:2 [ "nombre" => "Lucas Faria" "apellidos" => "Abrahão‐Machado" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0365059623000454" "doi" => "10.1016/j.abd.2021.12.011" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059623000454?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S266627522300053X?idApp=UINPBA00008Z" "url" => "/26662752/0000009800000004/v2_202307101646/S266627522300053X/v2_202307101646/pt/main.assets" ] ] "itemSiguiente" => array:18 [ "pii" => "S0365059623000491" "issn" => "03650596" "doi" => "10.1016/j.abd.2022.05.006" "estado" => "S300" "fechaPublicacion" => "2023-07-01" "aid" => "730" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter – Dermatopathology</span>" "titulo" => "Blastic plasmacytoid dendritic cell neoplasm: diagnostic difficulty and proposed flowchart for histopathological diagnosis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "559" "paginaFinal" => "563" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1109 "Ancho" => 2508 "Tamanyo" => 273220 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Violaceous plaque on the lower dorsal region. (B) Infiltrated erythematous nodules and plaques on the forehead.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Gabriel Taylor Castolde, Alexandre Lizardo Lourenço Pontes, Gabriel Macedo Cortopassi, José Cândido Caldeira Xavier-Júnior" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Gabriel Taylor" "apellidos" => "Castolde" ] 1 => array:2 [ "nombre" => "Alexandre Lizardo Lourenço" "apellidos" => "Pontes" ] 2 => array:2 [ "nombre" => "Gabriel Macedo" "apellidos" => "Cortopassi" ] 3 => array:2 [ "nombre" => "José Cândido Caldeira" "apellidos" => "Xavier-Júnior" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275223000577" "doi" => "10.1016/j.abdp.2023.03.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275223000577?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059623000491?idApp=UINPBA00008Z" "url" => "/03650596/0000009800000004/v1_202307031010/S0365059623000491/v1_202307031010/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "S0365059623000594" "issn" => "03650596" "doi" => "10.1016/j.abd.2021.08.017" "estado" => "S300" "fechaPublicacion" => "2023-07-01" "aid" => "740" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter - Clinical</span>" "titulo" => "Radiation recall dermatitis induced by ibuprofen" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "554" "paginaFinal" => "556" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1406 "Ancho" => 1675 "Tamanyo" => 540482 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The histopathology revealed intraepidermal vesiculation, papillary dermal edema, and perivascular inflammatory infiltrate in the upper dermis (Hematoxylin & eosin, ×100).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Li-wen Zhang, Juan Wu, Lu Zheng, Tao Chen" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Li-wen" "apellidos" => "Zhang" ] 1 => array:2 [ "nombre" => "Juan" "apellidos" => "Wu" ] 2 => array:2 [ "nombre" => "Lu" "apellidos" => "Zheng" ] 3 => array:2 [ "nombre" => "Tao" "apellidos" => "Chen" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275223000863" "doi" => "10.1016/j.abdp.2023.03.018" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275223000863?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059623000594?idApp=UINPBA00008Z" "url" => "/03650596/0000009800000004/v1_202307031010/S0365059623000594/v1_202307031010/en/main.assets" ] "en" => array:17 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter - Clinical</span>" "titulo" => "Synchronous and metachronous melanomas diagnosed at early stages in a patient with dysplastic nevus syndrome" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "556" "paginaFinal" => "558" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Marcelo Moreno, Maria Luiza Mukai Franciosi, Lucas Faria Abrahão-Machado" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Marcelo" "apellidos" => "Moreno" "email" => array:1 [ 0 => "marcelo.moreno@uffs.edu.br" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Maria Luiza Mukai" "apellidos" => "Franciosi" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Lucas Faria" "apellidos" => "Abrahão-Machado" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Faculty of Medicine, Universidade Federal da Fronteira Sul, Chapecó, SC, Brazil" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Pathology Consultancy, Private Practice, Botucatu, SP, Brazil" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1895 "Ancho" => 1675 "Tamanyo" => 314789 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0030" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A superficial spreading melanoma, with 0.5mm Breslow’s thickness on the right hypochondrium region: (a) Clinical appearance and location of the lesion (arrow). (b) Dermoscopy showing areas of atypical pigmented network (black arrow), area with reticulated hypopigmentation (yellow arrow); and depigmented/amorphous central area with intermingled linear and irregular vessels (blue arrow).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 34-year-old male patient, phototype II, according to the Fitzpatrick classification, with clinically dysplastic multiple nevi, was surgically treated in 2019 for a superficial spreading cutaneous melanoma with 0.45mm Breslow's thickness, on the lumbar region. He had no family history of melanoma and was referred for photo-dermoscopy/total body mapping (TBM) with the inclusion of all pigmented lesions. For that purpose, macroscopic photos of the patient's skin surface were taken in standard positions. A Canon EOS T7i® camera with EF 50<span class="elsevierStyleHsp" style=""></span>mm lens (f/1.4 USM aperture) was used to obtain the photos. The camera was attached to the set of hardware that constitutes the Fotofinder Dermoscope 1000®. The images were generated using Medicam full HD 1000®, with non-polarized light, and aqueous gel was used on the interface between the skin and the lens. Afterwards, all lesions were analyzed considering the qualitative method of “pattern analysis”.</p><p id="par0010" class="elsevierStylePara elsevierViewall">A total of 645 melanocytic lesions were documented. Of these, nine showed dermoscopic findings with indication for additional histopathology. Suspicious melanocytic lesions were submitted to excision and three new melanomas were diagnosed: 1) A superficial spreading melanoma, with 0.5mm Breslow's thickness, on the right hypochondrium region (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>); <span class="elsevierStyleItalic">in situ</span> melanoma on the left flank (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>) and an <span class="elsevierStyleItalic">in situ</span> melanoma on the left leg (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). The other six lesions were diagnosed as dysplastic nevi (marked dysplasia).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">On histopathology, the atypical nevi showed components of junctional and dermal melanocytic cells (compound nevi) with architectural disarray and asymmetry, in addition to cytological atypia and subepidermal fibroplasia. In the lesions diagnosed as <span class="elsevierStyleItalic">in situ</span> melanoma (flank and left leg), in addition to more intense cytological atypia, significant pagetoid dissemination was observed; however, without dermal invasion. The superficial spreading melanoma (abdominal region) showed intense cytological atypia, characterized by pleomorphism and nuclear hyperchromasia, exuberant pagetoid dissemination, and dermal invasion foci with atypical mitotic figures. Immunohistochemistry showed HMB45 positivity in neoplastic cells in both the epidermal and dermal components, indicating the absence of maturation and enhancing the invasive component, unlike what is seen in benign melanocytic lesions (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>).</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Discussion</span><p id="par0020" class="elsevierStylePara elsevierViewall">To consider the diagnosis of dysplastic nevus syndrome (DNS) in an individual, a personal or family history of melanoma (in at least one first- or second-degree relative) is necessary, associated with the presence of many nevi; some of them clinically atypical (more than 100 nevi, with at least one nevus measuring more than 8<span class="elsevierStyleHsp" style=""></span>mm, or one clinically atypical nevus larger than 5<span class="elsevierStyleHsp" style=""></span>mm).<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a> The patient described here had a previous personal history of melanoma, in addition to clinical criteria for the diagnosis of DNS. People with DNS are at high risk for developing cutaneous melanoma (up to 150-fold higher than the general population).<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,3</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Performing the TBM with digital photo-dermoscopy in patients with DNS is an important strategy for the early diagnosis of melanoma and, consequently, the reduction of mortality associated with this neoplasm.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3–5</span></a> In this population, approximately 34% to 61% of melanomas are detected exclusively by follow-up with TBM.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6,7</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">There is no consensus on how to perform TBM, and all identified pigmented lesions may be included, or only those with clinical and/or dermoscopic suspicion, previously selected according to the ABCD rule criteria or by alterations detected in the initial dermoscopic exam. Including all lesions in TBM requires more time for the acquisition and dermoscopic analysis of the images, but it can increase accuracy, mainly in lesions without clinical suspicion and the ones that do not show characteristics requiring complementary histopathology.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8,9</span></a> At the same time, by analyzing the dermoscopic patterns of all lesions, it is possible to select, with more stringency, the ones that should be included in the subsequent follow-up assessment, in addition to defining the best period for the next examination (three months, six months or 12 months).<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> In the reported clinical case, although the patient had no family history of melanoma, he had more than 600 melanocytic lesions, several of which with clinical and dermoscopic characteristics of dysplastic nevi (in addition to a previous personal history of melanoma). Diagnosis of the two <span class="elsevierStyleItalic">in situ</span> melanomas (mainly the one located on the left leg) was only possible due to the criterion of including all pigmented skin lesions in the initial digital documentation.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Financial support</span><p id="par0035" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Authors' contributions</span><p id="par0040" class="elsevierStylePara elsevierViewall">Marcelo Moreno: Design and planning of the study; data collection, or data analysis and interpretation; drafting and editing of the manuscript or critical review of important intellectual content; collection, analysis, and interpretation of data; effective participation in research orientation; intellectual participation in the propaedeutic and/or therapeutic conduct of the studied cases; critical review of the literature; approval of the final version of the manuscript.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Maria Luiza Mukai Franciosi: Drafting and editing of the manuscript or critical review of important intellectual content; critical review of the literature.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Lucas Faria Abrahão-Machado: Drafting and editing of the manuscript or critical review of important intellectual content; collection, analysis, and interpretation of data; intellectual participation in the propaedeutic and/or therapeutic conduct of the studied cases; approval of the final version of the manuscript.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conflicts of interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:5 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Discussion" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Financial support" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Authors' contributions" ] 3 => array:2 [ "identificador" => "sec0020" "titulo" => "Conflicts of interest" ] 4 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2021-09-27" "fechaAceptado" => "2021-12-20" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Study conducted at the Medical Course, Universidade Federal da Fronteira Sul, Chapecó, SC, Brazil.</p>" ] ] "multimedia" => array:4 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1895 "Ancho" => 1675 "Tamanyo" => 314789 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0030" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A superficial spreading melanoma, with 0.5mm Breslow’s thickness on the right hypochondrium region: (a) Clinical appearance and location of the lesion (arrow). (b) Dermoscopy showing areas of atypical pigmented network (black arrow), area with reticulated hypopigmentation (yellow arrow); and depigmented/amorphous central area with intermingled linear and irregular vessels (blue arrow).</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1881 "Ancho" => 1675 "Tamanyo" => 241204 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0035" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">In situ</span> melanoma on the left flank: (a) Clinical aspect of the melanoma, showing characteristics similar to other adjacent lesions (blue arrow). (b) On dermoscopy, an irregular pigmented network can be observed (black arrows), associated with reticulated hypopigmentation or inverted network (blue arrow); and peripheral punctiform blood vessels (green arrow).</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1876 "Ancho" => 1675 "Tamanyo" => 218271 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0040" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">In situ</span> melanoma on the anteromedial region of the left lower limb: (a) Clinical aspect of lesion measuring 1.5<span class="elsevierStyleHsp" style=""></span>mm (blue arrow), with light brown color, similar to other pigmented lesions on both lower limbs. (b) Dermoscopy of the lesion, showing a somewhat symmetrical lesion, light brown in color, containing peripheral globules with irregular distribution and sizes (black arrow); linear, comma shaped and intermingled globular shaped vessels (white arrow).</p>" ] ] 3 => array:8 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 2521 "Ancho" => 1675 "Tamanyo" => 473684 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0045" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Histopathology: (a) <span class="elsevierStyleItalic">In situ</span> melanoma on the left leg showing intense cytological atypia and exuberant pagetoid dissemination (Hematoxylin & eosin, ×100). (b) HMB45 immunohistochemical positivity in neoplastic cells in both the epidermal and dermal components of the invasive melanoma on the abdominal region (×100).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:9 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dysplastic nevus syndrome: a phenotypic association of sporadic cutaneous melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D.E. Elder" 1 => "L.I. Goldman" 2 => "S.C. Goldman" 3 => "M.H. Greene" 4 => "W.H. Clark Jr" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/1097-0142(19801015)46:8<1787::aid-cncr2820460816>3.0.co;2-s" "Revista" => array:6 [ "tituloSerie" => "Cancer." 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