Letter - Clinical
A case of basal cell carcinoma arising in the umbilicus
Maki Takada
, Tatsuhiko Mori, Yuka Hanami, Toshiyuki Yamamoto
Corresponding author
Department of Dermatology, Fukushima Medical University, Fukushima, Japan
Read
3895
Timeswas read the article
1621
Total PDF
2274
Total HTML
Share statistics
array:24 [ "pii" => "S0365059622002884" "issn" => "03650596" "doi" => "10.1016/j.abd.2021.05.023" "estado" => "S300" "fechaPublicacion" => "2023-03-01" "aid" => "681" "copyright" => "Sociedade Brasileira de Dermatologia" "copyrightAnyo" => "2022" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "pt" => array:19 [ "pii" => "S2666275222003009" "issn" => "26662752" "doi" => "10.1016/j.abdp.2022.12.011" "estado" => "S300" "fechaPublicacion" => "2023-03-01" "aid" => "681" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "pt" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta ‐ Caso Clínico</span>" "titulo" => "Caso de carcinoma basocelular localizado na cicatriz umbilical" "tienePdf" => "pt" "tieneTextoCompleto" => "pt" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "243" "paginaFinal" => "244" ] ] "contieneTextoCompleto" => array:1 [ "pt" => true ] "contienePdf" => array:1 [ "pt" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1111 "Ancho" => 3341 "Tamanyo" => 410046 ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Carcinoma basocelular na cicatriz umbilical apresentando‐se clinicamente como lesão única, pigmentada de cor escura, medindo 15<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>7<span class="elsevierStyleHsp" style=""></span>mm, com leve descamação. (B) O carcinoma basocelular na cicatriz umbilical mostrou grandes ninhos ovais azul‐acinzentados sem rede pigmentada à dermatoscopia.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Maki Takada, Tatsuhiko Mori, Yuka Hanami, Toshiyuki Yamamoto" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Maki" "apellidos" => "Takada" ] 1 => array:2 [ "nombre" => "Tatsuhiko" "apellidos" => "Mori" ] 2 => array:2 [ "nombre" => "Yuka" "apellidos" => "Hanami" ] 3 => array:2 [ "nombre" => "Toshiyuki" "apellidos" => "Yamamoto" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0365059622002884" "doi" => "10.1016/j.abd.2021.05.023" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059622002884?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275222003009?idApp=UINPBA00008Z" "url" => "/26662752/0000009800000002/v1_202302281436/S2666275222003009/v1_202302281436/pt/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S0365059622002720" "issn" => "03650596" "doi" => "10.1016/j.abd.2021.02.016" "estado" => "S300" "fechaPublicacion" => "2023-03-01" "aid" => "665" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter - Clinical</span>" "titulo" => "A case of Bowen’s disease possibly attributed to chronic stimulation by a metal wristwatch" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "245" "paginaFinal" => "246" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1229 "Ancho" => 3341 "Tamanyo" => 1189501 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0100" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">(A) Low power view of a biopsy specimen from the wrist shows irregular acanthosis and full-thickness dysplasia of the epidermis without infiltration of atypical cells into the dermis. (Hematoxylin & eosin, ×100). (B) Higher magnification shows the epidermis with hyperchromatic nuclei, atypia, and numerous mitoses. (Hematoxylin & eosin, ×200).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Maki Takada, Masato Ishikawa, Yuka Hanami, Toshiyuki Yamamoto" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Maki" "apellidos" => "Takada" ] 1 => array:2 [ "nombre" => "Masato" "apellidos" => "Ishikawa" ] 2 => array:2 [ "nombre" => "Yuka" "apellidos" => "Hanami" ] 3 => array:2 [ "nombre" => "Toshiyuki" "apellidos" => "Yamamoto" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275222002843" "doi" => "10.1016/j.abdp.2022.11.029" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275222002843?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059622002720?idApp=UINPBA00008Z" "url" => "/03650596/0000009800000002/v1_202302171515/S0365059622002720/v1_202302171515/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0365059622002938" "issn" => "03650596" "doi" => "10.1016/j.abd.2022.06.003" "estado" => "S300" "fechaPublicacion" => "2023-03-01" "aid" => "686" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:9 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter - Research</span>" "titulo" => "Real-life clinical practice with omalizumab in 134 patients with refractory chronic spontaneous urticaria: a single-center experience" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "240" "paginaFinal" => "242" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Elçin Akdaş, Esra Adışen, Murat Orhan Öztaş, Ahmet Burhan Aksakal, Nilsel İlter, Ayla Gülekon" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Elçin" "apellidos" => "Akdaş" ] 1 => array:2 [ "nombre" => "Esra" "apellidos" => "Adışen" ] 2 => array:2 [ "nombre" => "Murat Orhan" "apellidos" => "Öztaş" ] 3 => array:2 [ "nombre" => "Ahmet Burhan" "apellidos" => "Aksakal" ] 4 => array:2 [ "nombre" => "Nilsel" "apellidos" => "İlter" ] 5 => array:2 [ "nombre" => "Ayla" "apellidos" => "Gülekon" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275222003071" "doi" => "10.1016/j.abdp.2022.12.018" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275222003071?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059622002938?idApp=UINPBA00008Z" "url" => "/03650596/0000009800000002/v1_202302171515/S0365059622002938/v1_202302171515/en/main.assets" ] "en" => array:17 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter - Clinical</span>" "titulo" => "A case of basal cell carcinoma arising in the umbilicus" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "243" "paginaFinal" => "244" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Maki Takada, Tatsuhiko Mori, Yuka Hanami, Toshiyuki Yamamoto" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Maki" "apellidos" => "Takada" "email" => array:1 [ 0 => "takadamk@fmu.ac.jp" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Tatsuhiko" "apellidos" => "Mori" ] 2 => array:2 [ "nombre" => "Yuka" "apellidos" => "Hanami" ] 3 => array:2 [ "nombre" => "Toshiyuki" "apellidos" => "Yamamoto" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Department of Dermatology, Fukushima Medical University, Fukushima, Japan" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1273 "Ancho" => 3341 "Tamanyo" => 2000565 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0080" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">(A) Basal cell carcinoma in the umbilicus was excised, and histopathological examination revealed nests of tumor cells connected to the superficial dermis (Hematoxylin & eosin ×100). (B) Higher magnification shows a small number of melanin deposits in the tumor. (Hematoxylin & eosin, ×400).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Basal cell carcinoma (BCC) is one of the most common cutaneous malignant tumors, and more than half of BCCs arise in sun-exposed areas such as the head and neck region.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Here the authors report a rare case of BCC arising in the umbilicus.</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 72-year-old man was referred to the present study’s hospital, complaining of a pigmented lesion in his umbilicus that appeared one year previously. Physical examination revealed a solitary 15<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>7<span class="elsevierStyleHsp" style=""></span>mm pigmented nodule (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>Aa). Dermoscopy showed large blue-gray ovoid nests and the lack of a pigmented network (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B). A diagnosis of BCC was made based on biopsy findings. He underwent surgical excision of the tumor with a 3-mm margin under local anesthesia. Both the deep and peripheral margins were tumor-free. Pathological findings of the excised lesions revealed atypical cells that formed nests extending from the epidermis with a palisading pattern. The nests connected to the superficial dermis without apparent invasion, with an artifactual cleft occurring around the nest (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). A small number of melanin deposits was observed in the tumor, but not in the stroma. HMB-45, MALT-1, and S-100 were positive in some of the tumor cells. Positive alcian blue and colloidal iron staining revealed mucin deposition in the stroma surrounding the tumor nests. The postoperative course was uneventful, and there was no evidence of recurrence 6 months after surgery.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Primary umbilical malignancies are rare. Malignant skin tumors affecting the umbilicus include adenocarcinoma of urachal elements, BCC, malignant melanoma, ectopic Paget’s disease, mycosis fungoides, and squamous cell carcinoma.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Previous literature reported that among 112 umbilical tumors, 48 were malignant and 64 were benign.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Among the 48 malignant tumors, 40 were metastases from other organs (the stomach, pancreas, intestines, ovaries, etc.), and 8 were primary malignant tumors (7.1%). Among the 8 primary malignancies, malignant melanoma was the most frequent (4 cases), followed by BCC (2 cases, 1.8%).<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Among 518 surgical cases of BCC in the hospital from 2004 to 2020, none involved the umbilicus, and this is the first case. The frequency was estimated to be 0.2% (1/518). According to a survey of BCC in 2010 in Japan,<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> 1162 of 1578 BCC cases (73.6%) arose in the head and neck region, while 3 (0.2%) arose in the umbilicus. To the best of our knowledge, there are 16 previously reported cases of BCC arising in the umbilicus.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> These included 5 men and 11 women, 2.2 times more common in women, and the most common histologic subtype was nodular (9/16), followed by superficial type (3/16). The present case was the superficial type. Pigmented BCC, in which melanin is microscopically detected in the tumor, surrounding stroma, or both, was observed in 2 of the 16 cases. This case clinically presented with a brownish or pigmented nodule, and histopathologically, a small number of melanin deposits was observed in the tumor, but not in the stroma. It has been reported that 48.5% of superficial BCCs occur on the trunk.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Therefore, the superficial type may not be rare in the BCC of the umbilicus. According to a previous report, most patients with BCC had a surgical excision, and the prognosis was generally favorable.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Sun exposure is a risk factor for BCC, but umbilical BCC is not associated with a history of prolonged sun exposure to the area. BCC occurring in the umbilicus is exceedingly rare, but the prognosis after surgery is good. When BCC is suspected, dermoscopy and biopsy should be undertaken.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0020" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors’ contributions</span><p id="par0025" class="elsevierStylePara elsevierViewall">Maki Takada wrote the initial draft of the manuscript. Toshiyuki Yamamoto assisted in the preparation of the manuscript. Tatsuhiko Mori and Yuka Hanami performed data collection, analysis, and interpretation. All authors have read and approved the final version of the manuscript.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Financial support" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Authors’ contributions" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Conflicts of interest" ] 3 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2021-03-11" "fechaAceptado" => "2021-05-19" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Study conducted at the Department of Dermatology, Fukushima Medical University, Fukushima, Japan.</p>" ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1111 "Ancho" => 3341 "Tamanyo" => 410046 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0075" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Basal cell carcinoma in the umbilicus appeared clinically as a single black pigmented lesion of 15<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>7<span class="elsevierStyleHsp" style=""></span>mm in size, with slight scaling. (B) Basal cell carcinoma in the umbilicus showed large blue-gray oval nests with no pigmented network on dermoscopy.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1273 "Ancho" => 3341 "Tamanyo" => 2000565 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0080" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">(A) Basal cell carcinoma in the umbilicus was excised, and histopathological examination revealed nests of tumor cells connected to the superficial dermis (Hematoxylin & eosin ×100). (B) Higher magnification shows a small number of melanin deposits in the tumor. (Hematoxylin & eosin, ×400).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Differences in age and body site distribution of the histological subtypes of basal cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.M. Christopher" 1 => "W.K. John" 2 => "P.D. Abraham" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1997" "volumen" => "133" "paginaInicial" => "593" "paginaFinal" => "596" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9158412" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Umbilical and periumbilical dermatoses" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.K. Christopher" 1 => "H.P. Tess" 2 => "M.T. Megha" 3 => "R.G. John" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2015.02.1100" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2015" "volumen" => "72" "paginaInicial" => "1066" "paginaFinal" => "1073" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25840731" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tumors of the umbilicus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.S. Willard" 1 => "B. Elson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s12885-018-4825-4" "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1965" "volumen" => "18" "paginaInicial" => "907" "paginaFinal" => "915" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30241469" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A nationwide survey of basal cell carcinoma in Japan" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Y. Ishii" 1 => "M. Sakaino" 2 => "Y. Fujisawa" 3 => "Y. Nakamura" 4 => "Y. Kawachi" 5 => "F. Otsuka" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Skin Cancer" "fecha" => "2013" "volumen" => "28" "paginaInicial" => "205" "paginaFinal" => "211" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Basal cell carcinoma of the umbilicus: A comprehensive literature review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "N. Saisindhu" 1 => "R. Philip" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.7759/cureus.770" "Revista" => array:5 [ "tituloSerie" => "Cureus" "fecha" => "2016" "volumen" => "8" "paginaInicial" => "e770" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27738570" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03650596/0000009800000002/v1_202302171515/S0365059622002884/v1_202302171515/en/main.assets" "Apartado" => array:4 [ "identificador" => "95153" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letter - Clinical" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009800000002/v1_202302171515/S0365059622002884/v1_202302171515/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059622002884?idApp=UINPBA00008Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 13 | 8 | 21 |
| 2024 October | 95 | 86 | 181 |
| 2024 September | 140 | 118 | 258 |
| 2024 August | 155 | 145 | 300 |
| 2024 July | 143 | 123 | 266 |
| 2024 June | 130 | 86 | 216 |
| 2024 May | 116 | 60 | 176 |
| 2024 April | 117 | 98 | 215 |
| 2024 March | 102 | 78 | 180 |
| 2024 February | 124 | 71 | 195 |
| 2024 January | 100 | 55 | 155 |
| 2023 December | 77 | 63 | 140 |
| 2023 November | 77 | 104 | 181 |
| 2023 October | 66 | 75 | 141 |
| 2023 September | 94 | 82 | 176 |
| 2023 August | 137 | 32 | 169 |
| 2023 July | 81 | 47 | 128 |
| 2023 June | 58 | 40 | 98 |
| 2023 May | 65 | 26 | 91 |
| 2023 April | 109 | 39 | 148 |
| 2023 March | 126 | 71 | 197 |
| 2023 February | 89 | 55 | 144 |
| 2023 January | 28 | 42 | 70 |
| 2022 December | 32 | 17 | 49 |
Show all
