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3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">A genetic study revealed a mutation in the ERCC2 gene&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">What is your diagnosis&#63;</span><p id="par0095" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">a&#41;</span><p id="par0020" class="elsevierStylePara elsevierViewall">Xeroderma Pigmentosum</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">b&#41;</span><p id="par0025" class="elsevierStylePara elsevierViewall">Trichothiodystrophy</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">c&#41;</span><p id="par0030" class="elsevierStylePara elsevierViewall">Menkes disease</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">d&#41;</span><p id="par0035" class="elsevierStylePara elsevierViewall">Cockayne syndrome</p></li></ul></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Discussion</span><p id="par0040" class="elsevierStylePara elsevierViewall">Based on clinical presentation&#44; trichological and genetic examination&#44; the diagnosis of trichothiodystrophy was established&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Trichothiodystrophy &#40;TTD&#41; is a heterogeneous group of neuroectodermal disorders with an autosomal recessive inheritance&#44; although a few cases with possible X-linked transmission have been reported&#46; The photosensitive form of TTD is caused by mutations in XPB&#44; XPD&#44; or p8&#47;TTDA genes&#44; which encode subunits of TFIIH transcription&#47;repair factor&#46; Non-photosensitive form of TTD is genetically heterogeneous&#44; being TTDN1 gene the one described in a small proportion of patients&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In photosensitive TTD&#44; the most frequently described is XPD &#40;ERCC2&#41; mutation&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> which is also involved in the pathogenesis of xeroderma pigmentosum &#40;XP&#41; and Cockayne syndrome&#44; although&#44; unlike XP&#44; there is no predisposition to cutaneous malignancies&#46; XP&#44; Cockayne syndrome&#44; and TTD are an example of the phenomenon called clinical heterogeneity&#44; in which mutations in one gene &#40;in this case XPD&#41; may result in distinct diseases or variants&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Clinical features of patients with TTD vary widely in nature and severity&#44; and the single common feature in all patients is fragile hair &#40;short&#44; unruly&#44; fragile hair of the scalp&#44; eyebrows&#44; and eyelashes&#41; due to abnormally low sulfur content&#46; In addition&#44; a wide spectrum of other clinical symptoms that usually affect organs of ectodermal and neuroectodermal origin may be present&#44; such as intellectual and growth retardation&#44; ichthyosis&#44; short stature&#44; decreased fertility&#44; neurologic and ocular abnormalities and&#44; in some cases&#44; recurrent infections&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> as in the case of our patient&#46; Approximately half of the patients present photosensitivity&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">When examined under a polarized microscope&#44; hair samples constantly show striking bright and dark transverse banding or &#8220;tiger tail pattern&#8221;&#44; and they often exhibit an undulating&#44; irregular contour in all hairs &#40;differently from pseudo-tiger tail banding&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> Trichoschisis and trichorrhexis nodosa-like defects are also distinctive hair shaft abnormalities in TTD though not always present&#46; In contrast to TTD&#44; other patients with similar defects in DNA repair and mutations in the XPD gene do not show true &#8220;tiger tail banding&#8221;&#46; A &#8220;pseudo-tiger tail banding&#8221; can be observed in segments of normal shafts&#44; but the banding pattern is usually less pronounced and less regular than the bright and dark banding observed in TTD patients&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> In fact&#44; characteristic microscopic hair findings distinguish trichothiodystrophy from other conditions with congenital alopecia or hypotrichosis&#46; For example&#44; patients with Menkes disease typically present &#8220;kinky hairs&#8221; with twists around their long axis at irregular intervals in the shaft when observed under a light microscope&#44; also known as pili torti&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">In conclusion&#44; analysis of the hair under a polarized microscope is considered a very useful diagnostic marker in trichothiodystrophy since it shares clinical and genetic characteristics with other neuroectodermal syndromes&#46; Diagnosis can be made on the basis of clinical and trichological examination with a polarizing and light microscope&#44; although a genetic study may be helpful&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Financial support</span><p id="par0065" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Authors&#39; contributions</span><p id="par0070" class="elsevierStylePara elsevierViewall">Irene L&#243;pez Riquelme&#58; Critical review of the literature&#59; writing of the manuscript&#59; final approval of the final version of the manuscript&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Alberto Andamoyo Casta&#241;eda&#58; Critical review of the literature&#59; writing of the manuscript&#59; final approval of the final version of the manuscript&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Elisabeth G&#243;mez Moyano&#58; Intellectual participation in the propaedeutic conduct of the case&#59; final approval of the final version of the manuscript&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">&#193;ngel Vera Casa&#241;o&#58; Intellectual participation in the propaedeutic conduct of the case&#59; final approval of the final version of the manuscript&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conflicts of interest</span><p id="par0090" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trichothiodystrophy&#58; from basic mechanisms to clinical implications"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Stefanini"
                            1 => "E&#46; Botta"
                            2 => "M&#46; Lanzafame"
                            3 => "D&#46; Orioli"
                          ]
                        ]
                      ]
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                    0 => array:2 [
                      "doi" => "10.1016/j.dnarep.2009.10.005"
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                        "tituloSerie" => "DNA Repair&#46;"
                        "fecha" => "2010"
                        "volumen" => "9"
                        "paginaInicial" => "2"
                        "paginaFinal" => "10"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19931493"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Novel ERCC2 mutation in two siblings with trichothiodystrophy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Lund"
                            1 => "S&#46; Stein"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1111/pde.13882"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Dermatol&#46;"
                        "fecha" => "2019"
                        "volumen" => "36"
                        "paginaInicial" => "668"
                        "paginaFinal" => "671"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31282071"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A multistep approach to the diagnosis of rare genodermatoses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "I&#46; Tantcheva-Po&#243;"
                            1 => "V&#46; Oji"
                            2 => "C&#46; Has"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ddg.13140_g"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dtsch Dermatol Ges&#46;"
                        "fecha" => "2016"
                        "volumen" => "14"
                        "paginaInicial" => "969"
                        "paginaFinal" => "986"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27767281"
                            "web" => "Medline"
                          ]
                        ]
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                    ]
                  ]
                ]
              ]
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                    0 => array:2 [
                      "titulo" => "Trichothiodystrophy&#58; a systematic review of 112 published cases characterises a wide spectrum of clinical manifestations"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
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                            2 => "K&#46; Kraemer"
                            3 => "J&#46; DiGiovanna"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/jmg.2008.058743"
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                        "tituloSerie" => "J Med Genet&#46;"
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                        "paginaFinal" => "621"
                        "link" => array:1 [
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                            2 => "A&#46; Morris"
                            3 => "R&#46; Schiffmann"
                            4 => "V&#46;H&#46; Price"
                            5 => "E&#46; Menefee"
                          ]
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                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
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                        "paginaInicial" => "224"
                        "paginaFinal" => "232"
                        "link" => array:1 [
                          0 => array:2 [
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                            "web" => "Medline"
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                  ]
                ]
              ]
            ]
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              "etiqueta" => "6"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Trichothiodystrophy&#46; Hair examination as a diagnostic tool"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L&#46;K&#46; Hansen"
                            1 => "K&#46; Wulff"
                            2 => "F&#46; Brandrup"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ugeskr Laeger&#46;"
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                        "paginaInicial" => "1949"
                        "paginaFinal" => "1952"
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                    ]
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                      "titulo" => "Light microscopic examination of scalp hair samples as an aid in the diagnosis of paediatric disorders&#58; retrospective review of more than 300 cases from a single centre"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
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                            2 => "M&#46; Malone"
                            3 => "N&#46;J&#46; Sebire"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
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                        "volumen" => "58"
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                        "paginaFinal" => "1298"
                        "link" => array:1 [
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Letter - Clinical
Case for diagnosis. Hair analysis in a child with delayed psychomotor development and fragile and brittle hair: Trichothiodystrophy
Irene López Riquelme
Corresponding author
lopezriquelmeirene@uma.es

Corresponding author.
, Alberto Andamoyo Castañeda, Elisabeth Gómez Moyano, Ángel Vera Casaño
Department of Dermatology, Hospital Regional Universitario de Málaga, Málaga, Spain
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    "titulo" => "Case for diagnosis&#46; Hair analysis in a child with delayed psychomotor development and fragile and brittle hair&#58; Trichothiodystrophy"
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Examination of the hair under a polarized microscope&#58; trichoscisis with typical &#8220;tiger-tail pattern&#8221;&#46; Note the alternating dark and light transverse banding&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 4-year-old female child presented to the Dermatology Department with short&#44; thin&#44; and fragile hair since birth &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; She also presented important xerosis and eczematous plaques in her back&#44; trunk&#44; and scalp and photosensitivity&#46; The patient also had short stature&#44; severe myopia&#44; delayed psychomotor development&#44; and recurrent respiratory infections&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Examination of the hair under a polarized light microscope showed fine hair and trichoscisis with typical alternating dark and light transverse banding&#44; called &#8220;tiger-tail pattern&#8221; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41; and an irregular surface &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">A genetic study revealed a mutation in the ERCC2 gene&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">What is your diagnosis&#63;</span><p id="par0095" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">a&#41;</span><p id="par0020" class="elsevierStylePara elsevierViewall">Xeroderma Pigmentosum</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">b&#41;</span><p id="par0025" class="elsevierStylePara elsevierViewall">Trichothiodystrophy</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">c&#41;</span><p id="par0030" class="elsevierStylePara elsevierViewall">Menkes disease</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">d&#41;</span><p id="par0035" class="elsevierStylePara elsevierViewall">Cockayne syndrome</p></li></ul></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Discussion</span><p id="par0040" class="elsevierStylePara elsevierViewall">Based on clinical presentation&#44; trichological and genetic examination&#44; the diagnosis of trichothiodystrophy was established&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Trichothiodystrophy &#40;TTD&#41; is a heterogeneous group of neuroectodermal disorders with an autosomal recessive inheritance&#44; although a few cases with possible X-linked transmission have been reported&#46; The photosensitive form of TTD is caused by mutations in XPB&#44; XPD&#44; or p8&#47;TTDA genes&#44; which encode subunits of TFIIH transcription&#47;repair factor&#46; Non-photosensitive form of TTD is genetically heterogeneous&#44; being TTDN1 gene the one described in a small proportion of patients&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In photosensitive TTD&#44; the most frequently described is XPD &#40;ERCC2&#41; mutation&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> which is also involved in the pathogenesis of xeroderma pigmentosum &#40;XP&#41; and Cockayne syndrome&#44; although&#44; unlike XP&#44; there is no predisposition to cutaneous malignancies&#46; XP&#44; Cockayne syndrome&#44; and TTD are an example of the phenomenon called clinical heterogeneity&#44; in which mutations in one gene &#40;in this case XPD&#41; may result in distinct diseases or variants&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Clinical features of patients with TTD vary widely in nature and severity&#44; and the single common feature in all patients is fragile hair &#40;short&#44; unruly&#44; fragile hair of the scalp&#44; eyebrows&#44; and eyelashes&#41; due to abnormally low sulfur content&#46; In addition&#44; a wide spectrum of other clinical symptoms that usually affect organs of ectodermal and neuroectodermal origin may be present&#44; such as intellectual and growth retardation&#44; ichthyosis&#44; short stature&#44; decreased fertility&#44; neurologic and ocular abnormalities and&#44; in some cases&#44; recurrent infections&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> as in the case of our patient&#46; Approximately half of the patients present photosensitivity&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">When examined under a polarized microscope&#44; hair samples constantly show striking bright and dark transverse banding or &#8220;tiger tail pattern&#8221;&#44; and they often exhibit an undulating&#44; irregular contour in all hairs &#40;differently from pseudo-tiger tail banding&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> Trichoschisis and trichorrhexis nodosa-like defects are also distinctive hair shaft abnormalities in TTD though not always present&#46; In contrast to TTD&#44; other patients with similar defects in DNA repair and mutations in the XPD gene do not show true &#8220;tiger tail banding&#8221;&#46; A &#8220;pseudo-tiger tail banding&#8221; can be observed in segments of normal shafts&#44; but the banding pattern is usually less pronounced and less regular than the bright and dark banding observed in TTD patients&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> In fact&#44; characteristic microscopic hair findings distinguish trichothiodystrophy from other conditions with congenital alopecia or hypotrichosis&#46; For example&#44; patients with Menkes disease typically present &#8220;kinky hairs&#8221; with twists around their long axis at irregular intervals in the shaft when observed under a light microscope&#44; also known as pili torti&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">In conclusion&#44; analysis of the hair under a polarized microscope is considered a very useful diagnostic marker in trichothiodystrophy since it shares clinical and genetic characteristics with other neuroectodermal syndromes&#46; Diagnosis can be made on the basis of clinical and trichological examination with a polarizing and light microscope&#44; although a genetic study may be helpful&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Financial support</span><p id="par0065" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Authors&#39; contributions</span><p id="par0070" class="elsevierStylePara elsevierViewall">Irene L&#243;pez Riquelme&#58; Critical review of the literature&#59; writing of the manuscript&#59; final approval of the final version of the manuscript&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Alberto Andamoyo Casta&#241;eda&#58; Critical review of the literature&#59; writing of the manuscript&#59; final approval of the final version of the manuscript&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Elisabeth G&#243;mez Moyano&#58; Intellectual participation in the propaedeutic conduct of the case&#59; final approval of the final version of the manuscript&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">&#193;ngel Vera Casa&#241;o&#58; Intellectual participation in the propaedeutic conduct of the case&#59; final approval of the final version of the manuscript&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conflicts of interest</span><p id="par0090" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Trichothiodystrophy&#58; from basic mechanisms to clinical implications"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Stefanini"
                            1 => "E&#46; Botta"
                            2 => "M&#46; Lanzafame"
                            3 => "D&#46; Orioli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.dnarep.2009.10.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "DNA Repair&#46;"
                        "fecha" => "2010"
                        "volumen" => "9"
                        "paginaInicial" => "2"
                        "paginaFinal" => "10"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19931493"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Novel ERCC2 mutation in two siblings with trichothiodystrophy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Lund"
                            1 => "S&#46; Stein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/pde.13882"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Dermatol&#46;"
                        "fecha" => "2019"
                        "volumen" => "36"
                        "paginaInicial" => "668"
                        "paginaFinal" => "671"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31282071"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A multistep approach to the diagnosis of rare genodermatoses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "I&#46; Tantcheva-Po&#243;"
                            1 => "V&#46; Oji"
                            2 => "C&#46; Has"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ddg.13140_g"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dtsch Dermatol Ges&#46;"
                        "fecha" => "2016"
                        "volumen" => "14"
                        "paginaInicial" => "969"
                        "paginaFinal" => "986"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27767281"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trichothiodystrophy&#58; a systematic review of 112 published cases characterises a wide spectrum of clinical manifestations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Faghri"
                            1 => "D&#46; Tamura"
                            2 => "K&#46; Kraemer"
                            3 => "J&#46; DiGiovanna"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/jmg.2008.058743"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Med Genet&#46;"
                        "fecha" => "2008"
                        "volumen" => "45"
                        "paginaInicial" => "609"
                        "paginaFinal" => "621"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18603627"
                            "web" => "Medline"
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                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Characterization of tiger tail banding and hair shaft abnormalities in trichothiodystrophy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Liang"
                            1 => "K&#46;H&#46; Kraemer"
                            2 => "A&#46; Morris"
                            3 => "R&#46; Schiffmann"
                            4 => "V&#46;H&#46; Price"
                            5 => "E&#46; Menefee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2004.09.013"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2005"
                        "volumen" => "52"
                        "paginaInicial" => "224"
                        "paginaFinal" => "232"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15692466"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trichothiodystrophy&#46; Hair examination as a diagnostic tool"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L&#46;K&#46; Hansen"
                            1 => "K&#46; Wulff"
                            2 => "F&#46; Brandrup"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ugeskr Laeger&#46;"
                        "fecha" => "1993"
                        "volumen" => "155"
                        "paginaInicial" => "1949"
                        "paginaFinal" => "1952"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
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Article information
ISSN: 03650596
Original language: English
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