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Clinical</span>" "titulo" => "Unilateral linear syringoma on the right chest and arm" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "263" "paginaFinal" => "265" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Danyi Huang, Yanqing Chen, Jianjian Li, Han Ma" "autores" => array:4 [ 0 => array:3 [ "nombre" => "Danyi" "apellidos" => "Huang" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "fn0005" ] ] ] 1 => array:3 [ "nombre" => "Yanqing" "apellidos" => "Chen" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "fn0005" ] ] ] 2 => array:2 [ "nombre" => "Jianjian" "apellidos" => "Li" ] 3 => array:4 [ "nombre" => "Han" "apellidos" => "Ma" "email" => array:1 [ 0 => "drmahan@sina.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Department of Dermatology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, China" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1119 "Ancho" => 1675 "Tamanyo" => 190890 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0070" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Closer look on the right chest. There is a wound after skin biopsy at the bottom.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 25-year-old man presented to the dermatology department with an 8-year history of yellowish-brown skin lesions on his right chest, axilla, and arm. The lesions first appeared on the right chest and increased in number and size gradually, showing a linear distribution, with no pain or itching. He was otherwise healthy with no other special medical history. Physical examination revealed a yellowish-brown firm, smooth papules and plaques on his right chest, axilla, and arm, ranging from 1 to 10<span class="elsevierStyleHsp" style=""></span>mm in diameter (Figs. <a class="elsevierStyleCrossRef" href="#fig0005">1</a>–<a class="elsevierStyleCrossRef" href="#fig0020">4</a>). The distribution of the lesions followed Blaschko's lines. Histopathology showed multiple small tubules, cysts, and nests forming by epithelial proliferation, with some of them morphologically like a comma or a tadpole, in the superficial dermis (<a class="elsevierStyleCrossRef" href="#fig0025">Fig. 5</a>). A diagnosis of sporadic linear syringoma was made. As it is a benign disease with no malignant potential, the patient has been followed up regularly without any treatment.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><elsevierMultimedia ident="fig0025"></elsevierMultimedia><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Discussion</span><p id="par0010" class="elsevierStylePara elsevierViewall">Syringoma is a benign neoplasm that derives from eccrine sweat gland ducts. The typical clinical manifestation is single or multiple skin-color or yellowish papules on the lower eyelid, 1 to 3<span class="elsevierStyleHsp" style=""></span>mm in size. Friedman and Butler classified syringoma into 4 clinical variants: generalized forms, localized forms, familial forms and variants associated with Down’s syndrome.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Differential diagnosis of syringoma based on a variety of clinical manifestations includes milia, xanthoma, hidrocystoma, trichoepithelioma, and flat warts, especially for the eyelids; other considerations include cutaneous mastocytosis, fibrofolliculomas, vellus hair cysts, angiofibroma, and fibroelastic papulosis, lichen planus, steatocystoma multiplex, eruptive vellus hair cysts, disseminated granuloma annulare, secondary syphilis and so on.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,3</span></a> Diagnosis can be confirmed by typical histopathologic manifestations.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Though syringoma is a common ailment, the pathogenesis remains unclear, some investigators have suggested that syringomas may be caused by hormonal factors.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> The linear arrangement along Blascko’s lines is unusual and indicated the genetic association in pathogenesis.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> However, we could not find any congenital abnormalities in the present case.</p><p id="par0020" class="elsevierStylePara elsevierViewall">As we all know, syringoma rarely shows the unilateral or linear distribution. There have been only 4 reports of unilateral linear syringoma, all involving the upper trunk and limb.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6–9</span></a> We learned from previously reported cases that linear syringoma usually presents clinically quite similar to ordinary syringoma. Nevertheless, in the present case, the size of most skin lesions was larger than the usual size and the color was different, which reminds dermatologists of the necessity to consider syringoma in the differential diagnosis of unilateral linear papular or plaque skin lesions.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Financial support</span><p id="par0025" class="elsevierStylePara elsevierViewall">This work is supported by <span class="elsevierStyleGrantSponsor" id="gs0005">Medical Science and Technology Research Projects in Guangdong Province</span> (<span class="elsevierStyleGrantNumber" refid="gs0005">A2021365</span>) and <span class="elsevierStyleGrantSponsor" id="gs0010">Science and Technology Plan Projects of Zhuhai</span> (<span class="elsevierStyleGrantNumber" refid="gs0010">ZH2202200003HJL</span>).</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Authors' contributions</span><p id="par0030" class="elsevierStylePara elsevierViewall">Danyi Huang took effective participation in research orientation and completed the preparation and writing of the manuscript. Yanqing Chen was in charge of the data collection, analysis and interpretation. Jianjian Li helped with data collection. Han Ma formed the study conception and planning and approved the final version of the manuscript.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conflicts of interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:5 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Discussion" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Financial support" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Authors' contributions" ] 3 => array:2 [ "identificador" => "sec0020" "titulo" => "Conflicts of interest" ] 4 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2021-08-26" "fechaAceptado" => "2021-09-10" "NotaPie" => array:2 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Study conducted at the Department of Dermatology, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai (ZH), Guangdong (GD), China (CHN).</p>" ] 1 => array:3 [ "etiqueta" => "1" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Danyi Huang and Yanqing Chen contributed equally to this work.</p>" "identificador" => "fn0005" ] ] "multimedia" => array:5 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1402 "Ancho" => 1675 "Tamanyo" => 213274 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0065" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Physical examination revealed yellowish-brown firm, smooth papules, and plaques on his right chest. Distribution of the lesions followed Blaschko's lines.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1119 "Ancho" => 1675 "Tamanyo" => 190890 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0070" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Closer look on the right chest. There is a wound after skin biopsy at the bottom.</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1119 "Ancho" => 1675 "Tamanyo" => 154914 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0075" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Lesions on the axilla.</p>" ] ] 3 => array:8 [ "identificador" => "fig0020" "etiqueta" => "Fig. 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1119 "Ancho" => 1675 "Tamanyo" => 110828 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0080" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Lesions on the right upper limb.</p>" ] ] 4 => array:8 [ "identificador" => "fig0025" "etiqueta" => "Fig. 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 1055 "Ancho" => 1675 "Tamanyo" => 294863 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0085" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Histopathology showed multiple small tubules, cysts, and nest forming by epithelial proliferation, with some of them morphologically like a comma or a tadpole, in the superficial dermis (Hematoxilin & eosin, X40).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:9 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Syringoma presenting as milia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.J. 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Year/Month | Html | Total | |
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2024 November | 41 | 6 | 47 |
2024 October | 213 | 85 | 298 |
2024 September | 211 | 93 | 304 |
2024 August | 221 | 146 | 367 |
2024 July | 226 | 117 | 343 |
2024 June | 160 | 69 | 229 |
2024 May | 124 | 65 | 189 |
2024 April | 172 | 85 | 257 |
2024 March | 103 | 73 | 176 |
2024 February | 128 | 77 | 205 |
2024 January | 66 | 59 | 125 |
2023 December | 67 | 58 | 125 |
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2023 October | 64 | 80 | 144 |
2023 September | 83 | 73 | 156 |
2023 August | 64 | 22 | 86 |
2023 July | 60 | 36 | 96 |
2023 June | 96 | 51 | 147 |
2023 May | 80 | 60 | 140 |
2023 April | 90 | 49 | 139 |
2023 March | 111 | 101 | 212 |
2023 February | 95 | 59 | 154 |
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2022 December | 46 | 38 | 84 |
2022 November | 38 | 51 | 89 |