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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Eruptive collagenoma is a rare connective tissue nevus&#44; which presents with asymptomatic&#44; multiple&#44; discrete&#44; firm&#44; slightly elevated&#44; skin-colored&#44; or reddish papules on the trunk and extremities&#46; We describe herein a rare case of eruptive collagenoma on the back of a juvenile patient with Down syndrome&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 14-year-old boy with Down syndrome and a previous history of anorectal anomaly visited our Dermatology Department&#44; complaining of asymptomatic eruption on his back&#46; He had no family history of connective tissue nevi&#46; Physical examination showed several red-brown or whitish papules on his back &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; There were no eruptions in other locations&#46; One of the papules was removed under local anesthesia&#46; A biopsy specimen revealed relatively well-circumscribed areas with increased collagenous fibers in the upper to mid-dermis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&#41;&#46; Lack of elastic fibers as compared with surrounding dermis was observed in Elastica Masson &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>B&#41;&#44; Elastica van Gieson and Weigert staining&#46; A diagnosis of collagenoma was made&#46; No specific treatment was given&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Several cutaneous manifestations are associated with Down syndrome&#44; including atopic eczema&#44; seborrheic eczema&#44; alopecia areata&#44; vitiligo&#44; psoriasis&#44; tinea&#44; syringoma&#44; and milia-like calcinosis cutis&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> By contrast&#44; connective tissue disorders such as collagenoma&#44; connective tissue nevi&#44; anetoderma&#44; and elastosis perforans serpiginosa&#44; are rare&#46; Eruptive or solitary collagenoma is rarely seen in patients with Down syndrome&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a> Among the previously reported 5 patients and our patient&#44; 2 were male&#44; and 3 were pediatric patients&#59; and age ranged between 7 and 47 years old&#46; The affected sites were the neck&#44; chest&#44; back&#44; abdomen&#44; buttock&#44; groin&#44; sacrococcygeal region&#44; thighs&#44; hands&#44; and arms&#46; Four patients developed multiple lesions&#44; while 2 patients developed solitary lesions&#46; The etiology of collagenoma in Down syndrome remains unknown&#59; however&#44; premature aging due to impaired DNA repair or altered free radical metabolism may be involved&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The genetic locus for superoxide dismutase&#44; a key enzyme in free radical metabolism is located in chromosome 21&#46; Moreover&#44; in the skin of fetuses with trisomy 21&#44; overexpression of COL6A1&#44; and irregular arrangement of type VI collagen were observed&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Differential diagnosis mainly includes papular elastorrhexis and nevus anelasticus&#46; Papular elastorrhexis occurs during the first or second decades of life and presents with asymptomatic&#44; small&#44; non-follicular&#44; creamy-white papules on the chest&#44; abdomen&#44; and back&#46; Histopathology shows fragmented elastic fibers&#46; Nevus anelasticus is an acquired nevus characterized by perifollicular papules and histopathologically&#44; fragmentation or loss of elastic fibers&#46; Collagenomas can be found in association with hereditable conditions such as Multiple Endocrine Neoplasia type 1 &#40;MEN1&#41;&#46; The present case did not have either a family history of MEN1 or tumors of parathyroid glands&#44; endocrine pancreas and anterior pituitary&#46;</p><p id="par1020" class="elsevierStylePara elsevierViewall">In conclusion&#44; we report a rare case of eruptive collagenoma in an adolescent patient with Down syndrome&#46; Further studies are necessary to elucidate the mechanism of collagenoma in association with Down syndrome&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0025" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors&#8217; contributions</span><p id="par0030" class="elsevierStylePara elsevierViewall">Yasunobu Kato&#58; Played a role in conception&#44; design&#44; analysis&#44; and approval&#59; read and approved the final version of the manuscript&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Toshiyuki Yamamoto&#58; Played a role in conception&#44; analysis&#44; writing&#44; and approval&#59; read and approved the final version of the manuscript&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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Case Letter
Eruptive collagenoma in a juvenile patient with Down syndrome
Yasunobu Kato, Toshiyuki Yamamoto
Corresponding author
toyamade@fmu.ac.jp

Corresponding author.
Department of Dermatology, Fukushima Medical University, Fukushima, Japan
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Eruptive collagenoma is a rare connective tissue nevus&#44; which presents with asymptomatic&#44; multiple&#44; discrete&#44; firm&#44; slightly elevated&#44; skin-colored&#44; or reddish papules on the trunk and extremities&#46; We describe herein a rare case of eruptive collagenoma on the back of a juvenile patient with Down syndrome&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 14-year-old boy with Down syndrome and a previous history of anorectal anomaly visited our Dermatology Department&#44; complaining of asymptomatic eruption on his back&#46; He had no family history of connective tissue nevi&#46; Physical examination showed several red-brown or whitish papules on his back &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; There were no eruptions in other locations&#46; One of the papules was removed under local anesthesia&#46; A biopsy specimen revealed relatively well-circumscribed areas with increased collagenous fibers in the upper to mid-dermis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&#41;&#46; Lack of elastic fibers as compared with surrounding dermis was observed in Elastica Masson &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>B&#41;&#44; Elastica van Gieson and Weigert staining&#46; A diagnosis of collagenoma was made&#46; No specific treatment was given&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Several cutaneous manifestations are associated with Down syndrome&#44; including atopic eczema&#44; seborrheic eczema&#44; alopecia areata&#44; vitiligo&#44; psoriasis&#44; tinea&#44; syringoma&#44; and milia-like calcinosis cutis&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> By contrast&#44; connective tissue disorders such as collagenoma&#44; connective tissue nevi&#44; anetoderma&#44; and elastosis perforans serpiginosa&#44; are rare&#46; Eruptive or solitary collagenoma is rarely seen in patients with Down syndrome&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a> Among the previously reported 5 patients and our patient&#44; 2 were male&#44; and 3 were pediatric patients&#59; and age ranged between 7 and 47 years old&#46; The affected sites were the neck&#44; chest&#44; back&#44; abdomen&#44; buttock&#44; groin&#44; sacrococcygeal region&#44; thighs&#44; hands&#44; and arms&#46; Four patients developed multiple lesions&#44; while 2 patients developed solitary lesions&#46; The etiology of collagenoma in Down syndrome remains unknown&#59; however&#44; premature aging due to impaired DNA repair or altered free radical metabolism may be involved&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The genetic locus for superoxide dismutase&#44; a key enzyme in free radical metabolism is located in chromosome 21&#46; Moreover&#44; in the skin of fetuses with trisomy 21&#44; overexpression of COL6A1&#44; and irregular arrangement of type VI collagen were observed&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Differential diagnosis mainly includes papular elastorrhexis and nevus anelasticus&#46; Papular elastorrhexis occurs during the first or second decades of life and presents with asymptomatic&#44; small&#44; non-follicular&#44; creamy-white papules on the chest&#44; abdomen&#44; and back&#46; Histopathology shows fragmented elastic fibers&#46; Nevus anelasticus is an acquired nevus characterized by perifollicular papules and histopathologically&#44; fragmentation or loss of elastic fibers&#46; Collagenomas can be found in association with hereditable conditions such as Multiple Endocrine Neoplasia type 1 &#40;MEN1&#41;&#46; The present case did not have either a family history of MEN1 or tumors of parathyroid glands&#44; endocrine pancreas and anterior pituitary&#46;</p><p id="par1020" class="elsevierStylePara elsevierViewall">In conclusion&#44; we report a rare case of eruptive collagenoma in an adolescent patient with Down syndrome&#46; Further studies are necessary to elucidate the mechanism of collagenoma in association with Down syndrome&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0025" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors&#8217; contributions</span><p id="par0030" class="elsevierStylePara elsevierViewall">Yasunobu Kato&#58; Played a role in conception&#44; design&#44; analysis&#44; and approval&#59; read and approved the final version of the manuscript&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Toshiyuki Yamamoto&#58; Played a role in conception&#44; analysis&#44; writing&#44; and approval&#59; read and approved the final version of the manuscript&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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Article information
ISSN: 03650596
Original language: English
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