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Sebaceous nevus of Jadassohn: review and clinical-surgical approach
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However, recent studies suggest the association of a post-zygotic somatic mutation related to the <span class="elsevierStyleItalic">HRAS</span> (chromosome 11p15), <span class="elsevierStyleItalic">NRAS</span> (chromosome 1p13) and <span class="elsevierStyleItalic">KRAS</span> (chromosome 12p12) genes<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,6</span></a> in the genesis of this condition, as they condition the cell proliferation process.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6,7</span></a> The clinical manifestation occurs as plaques with partial or complete alopecia, with a linear or oval shape, and color ranging from skin-colored, to yellowish-orange or brownish-black, with a smooth, nipple-like or verrucous appearance, depending on the degree of lesion development.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,8,9</span></a> The commonly affected regions include the scalp, followed by the preauricular area, face, and cervical regions. However, several studies have reported its occurrence in other less frequent areas, such as mucosa, trunk and extremities, so that, when found in these sites, the lesions are distributed following the orientation of the Blaschko lines.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,3,10</span></a> Nevus sebaceous may be related to extracutaneous manifestations affecting different organs and, in this case, it constitutes a more complex clinical picture, being called linear nevus syndrome or Schimmelpenning-Feuerstein-Mims syndrome.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,6</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objective</span><p id="par0010" class="elsevierStylePara elsevierViewall">The present study aims to report the main aspects of nevus sebaceous and nevus sebaceous of Jadassohn syndrome, outlining their characteristics, clinical manifestations and emphasizing therapeutic alternatives.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Method</span><p id="par0015" class="elsevierStylePara elsevierViewall">This is a literature review study, with a narrative focus. A search was carried out on the PubMed database in May 2021, restricting the results to the last five years (2016‒2021), with the following expressions in English: “Nevus sebaceous”, “sebaceous nevus”, “syndrome Schimmelpenning” and “sebaceous nevus Jadassohn”.</p><p id="par0020" class="elsevierStylePara elsevierViewall">The following inclusion criterion was employed: articles strictly related to the topic. The screening of articles was based on titles and/or abstracts, availability of the full article and publications in English, Portuguese, Spanish and French. The articles that did not meet the previously established criteria were removed. A total of 128 articles were found and, of these, 64 were selected and 64 were excluded. Of the 64 selected articles, after reading and critical analysis, 24 were chosen to be included in the present study. Subsequently, in order to broaden the study perspective, the works by Happle,<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> Basu et al.,<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> McCalmont<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and Kang et al.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> were also included.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Historical background</span><p id="par0025" class="elsevierStylePara elsevierViewall">In 1895, the German dermatologist Josef Jadassohn described the organoid nevus, which is a subclassification of the epidermal nevus, as a congenital malformation involving adnexal structures, mainly the sebaceous glands.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,14–16</span></a> Subsequently, in 1957, Gustav Schimmelpenning performed the evaluation of a patient with skin lesions and neurological impairment manifestations caused by cranial malformation and, due to the fact that this condition did not correspond to any other previously described clinical picture, Schimmelpenning categorized it as a neurocutaneous phakomatosis.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,11</span></a> In 1962 Feuerstein and Mims reported a case of a linear nevus associated with seizures and intellectual disability symptoms.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Since then, the so-called classic triad used for the diagnosis has been created, which consists of neurological impairment, seizures, and intellectual disability, associated with the presence of a nevus sebaceus.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> However, subsequent studies have shown that the extracutaneous manifestations of the Schimmelpenning-Feuerstein-Mims syndrome are much more diverse.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Case report</span><p id="par0030" class="elsevierStylePara elsevierViewall">An 18-year-old male patient, healthy and with no other complaints, was evaluated for a unilateral congenital lesion on the left retroauricular region. Physical examination revealed a linear lesion consisting of pigmented papules, slightly reddish and brownish in color, with a verrucous appearance and well-defined borders (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Clinical evaluation disclosed no lesion progression, except for the patient's own physical growth. Systemic evaluation revealed no abnormalities. The patient wanted the lesion removed for aesthetic reasons and because of repeated trauma. Moreover, there was a parental concern due to the positive history of the death of a family member due to melanoma, who also had nevi. The lesion was surgically excised in an outpatient setting, with a safety margin of 5 mm up to the level of the muscular fascia (<a class="elsevierStyleCrossRefs" href="#fig0010">Figs. 2 and 3</a>), with primary closure (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">The anatomopathological evaluation disclosed mild hyperkeratosis, accompanied by acanthosis due to the increased thickness of the epidermis. Moreover, there was papillomatosis demonstrated by intense sinuosity of the dermo-epidermal junction and clinically corroborated by the verrucous aspect of the lesion (<a class="elsevierStyleCrossRef" href="#fig0025">Fig. 5</a>). Hyperplasia of the sebaceous glands was also observed, with these adnexal structures localized more closely to the surface of the skin (<a class="elsevierStyleCrossRefs" href="#fig0030">Figs. 6 and 7</a>). Therefore, the histopathological findings were consistent with nevus sebaceus.</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia><elsevierMultimedia ident="fig0030"></elsevierMultimedia><elsevierMultimedia ident="fig0035"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Epidemiology</span><p id="par0040" class="elsevierStylePara elsevierViewall">The incidence of nevus sebaceus in newborns is estimated at 0.1% to 0.3%,<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> with no predilection for sex or ethnicity.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,12</span></a> Although familial cases have been described, the lesion manifests randomly.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> Regarding the main areas of involvement, 62.5% of the lesions are found on the scalp, 24.5% on the cephalic segment, 4.7% on the trunk, and 4.2% on the cervical region.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> In addition to aesthetic impairment, one of the major concerns related to this disease is associated related to its capacity to generate secondary neoplasms.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> Studies indicate that this phenomenon occurs in approximately 10% to 20% of the cases, mostly in patients over 40 years of age.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12,19</span></a> However, most secondary neoplasms are benign, so only approximately 3% of cases have some degree of malignancy and are considered rare incidences.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> The most frequent malignant tumors include basal cell carcinoma (1.1%) and squamous cell carcinoma (0.57%), followed by sebaceous carcinoma and apocrine carcinoma.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> Secondary neoplasms with lower incidence rates reported in the literature include sebaceous carcinoma, squamous cell carcinoma, microcystic carcinoma, and melanoma.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,15,16,19</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Clinical presentation</span><p id="par0045" class="elsevierStylePara elsevierViewall">Nevus sebaceous is present since birth or shortly thereafter.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,16</span></a> The clinical manifestation of the lesions can be subdivided into three stages or phases of clinical evolution based on the morphological appearance and age group of the affected individual, even though age does not have a definite relationship with the clinical manifestations.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> The first stage corresponds to the disease manifestation after birth and extends throughout childhood, a period in which it appears as a disc-shaped lesion or small associated spots, smooth or partially hairless, ranging in color from pale skin color, slightly yellowish, yellowish-pink, yellowish-orange, or brown.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6,15</span></a> During puberty, the second stage is characterized by hyperplasia of the sebaceous glands and other adnexal structures due to hormonal influence.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6,15</span></a> Studies have indicated the presence of androgen receptors in nevus sebaceous,<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> so that lesions take on a verrucous appearance and a more intense color, due to the processes of hyperkeratosis, papillomatosis, and acanthosis.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6,14,15</span></a> Finally, the third stage is seen in the adulthood, when there is a higher risk of secondary neoplasm development.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6,15</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">A linear nevus is usually reported in Schimmelpenning-Feuerstein-Mims syndrome and, as a component of multisystemic disorders, which have been previously described in a wide variety of organs, such as the nervous, ocular, cardiovascular, muscular, urogenital systems, and bones, among others.<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14,15,22,23</span></a> Aiming to facilitate the identification and clinical diagnosis, <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the main disorders that have been previously identified and related to Schimmelpenning-Feuerstein-Mims syndrome, among which the most frequently reported in the literature are: hypophosphatemic rickets, intellectual disability, and cognitive impairment, coloboma and strabismus.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,11,22</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Histopathological findings</span><p id="par0055" class="elsevierStylePara elsevierViewall">Regarding the pathological findings, the main assessment to guide the therapeutic approach is related to the analysis of the risk of developing secondary neoplasms, which is low for secondary carcinomas and high for benign neoplasms.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In this regard, the main reported benign neoplasms are trichoblastoma (TB) and syringocystadenoma papilliferum (SCAP), followed by trichilemmoma, sebaceous adenoma, desmoplastic trichilemmoma, apocrine adenoma, and poroma.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,18,23</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Trichoblastoma is defined as a trichogenic tumor, formed by the proliferation of follicular germ cells.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> On histological examination, trichoblastoma shows small cells of round to oval morphology, grouped and separated by a fibrous stroma, in a stratified squamous epithelium and areas of necrosis with calcification.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Syringocystadenoma papilliferum is a neoplasia of the apocrine and eccrine sweat glands and manifests as isolated patches or as multiple nodules containing vesicles or exudate.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> Histopathologically, the SCAP is characterized as an apocrine adnexal tumor with papillary projections and cystic ducts, which are covered by columnar or cuboidal cells with basophilic cytoplasm, often having a connection with the epidermis.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">As for malignant neoplasms, basal cell carcinoma (BCC) is the most frequently reported, although its occurrence is considered rare.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> BCC has significant histological similarities to trichoblastoma so assumptions indicate an overestimation of its actual incidence as a secondary neoplasm.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> The differentiation relies on the presence of a myxoid stroma in addition to retraction of the stroma around the basaloid cell clusters, findings typical of basal cell carcinoma.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">Regarding the genetic perspective, several studies have indicated a relationship between the appearance of nevus sebaceous, alone or as a multisystemic syndrome, and mutations in the <span class="elsevierStyleItalic">HRAS</span>, <span class="elsevierStyleItalic">KRAS,</span> and <span class="elsevierStyleItalic">NRAS</span> genes, so that the amino acid glycine is replaced by the amino acid arginine, which in turn leads to activation of the MAPK and PI3K-AKT pathways,<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7,16</span></a> with a consequent increase in cell proliferation in mutated cells,<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6,7</span></a> which was confirmed through the genetic analysis of blood cells and tissues from unaffected areas, corroborating the theory of genetic mosaicism.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15,25</span></a><a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> below depicts the most recurrent neoplasms in medical literature associated with nevus sebaceous.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,12,23</span></a></p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Treatment</span><p id="par0080" class="elsevierStylePara elsevierViewall">As with other epidermal nevi, nevus sebaceous can be permanently treated with full-thickness excision<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> in patients who complain of aesthetic and psychological discomfort.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> Lesion removal for prophylactic purposes is still widely debated.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> Seeking to highlight and evaluate this discussion, the article by Wali, Felton, and McPherson, published in 2018, addresses research carried out through a questionnaire sent to dermatologists and plastic surgeons in the United Kingdom aiming to determine the best current intervention for the management of nevus sebaceous. <a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> However, the results differed between the two groups of specialists, so while more than 90% of plastic surgeons considered the prophylactic excision to be the best course of action, only a third of dermatologists had the same opinion.<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> Moreover, plastic surgeons more commonly recommended that the excision be performed in childhood, in contrast to dermatologists, who chose to wait until adulthood.<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">In addition to the excision, other methods are frequently used to treat and improve Jadassohn lesions, such as curettage, cauterization, cryotherapy, photodynamic therapy,<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15,25,27</span></a> topical salicylic acid, topical and systemic retinoids, topical application of vitamin D analog, laser treatment, and dermabrasion.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,15,25</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">In individuals with greater system impairment due to Schimmelpenning-Feuerstein-Mims syndrome, a multidisciplinary approach to treatment is recommended, with the collaboration of a dermatologist, pediatrician, neurologist, ophthalmologist, geneticist,<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> or any other subspecialist, if necessary.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,7</span></a> The use of dermoscopy to monitor possible complications is also indicated.<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16,28</span></a></p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conclusion</span><p id="par0095" class="elsevierStylePara elsevierViewall">Although the Schimmelpenning-Feuerstein-Mims syndrome constitutes a rare manifestation, it is important to note that its diagnosis should be considered in children born with nevus sebaceous, when it is also associated with abnormalities at the systemic level, thus requiring correct evaluation and management, aiming at minimizing its extracutaneous complications. Moreover, even though there is no consensus on the best therapeutic approach for nevus sebaceous, surgical removal is often reported as a viable alternative, considering the aesthetic aspect and patient well-being regarding self-esteem, in addition to the risk of lesion malignancy, even though it is extremely low.</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Financial support</span><p id="par0100" class="elsevierStylePara elsevierViewall">This research did not receive any specific funding from public, private or non-profit funding agencies.</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Authors’ contributions</span><p id="par0105" class="elsevierStylePara elsevierViewall">Manoel Pereira da Silva Neto: Approval of the final version of the manuscript; design and planning of the study; effective participation in research orientation; drafting and editing of the manuscript; critical review of the literature; critical review of the manuscript.</p><p id="par0110" class="elsevierStylePara elsevierViewall">Barbara Rodovalho de Assis: Approval of the final version of the manuscript; drafting and editing of the manuscript; critical review of the literature; critical review of the manuscript.</p><p id="par0115" class="elsevierStylePara elsevierViewall">Gustavo Rodrigues Andrade: Approval of the final version of the manuscript; drafting and editing of the manuscript; critical review of the literature; critical review of the manuscript.</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflicts of interest</span><p id="par0120" class="elsevierStylePara elsevierViewall">The authors have no conflict of interest in this article.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:15 [ 0 => array:3 [ "identificador" => "xres1763870" "titulo" => "Abstract" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objective" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Method" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Discussion" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1551039" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 3 => array:2 [ "identificador" => "sec0010" "titulo" => "Objective" ] 4 => array:2 [ "identificador" => "sec0015" "titulo" => "Method" ] 5 => array:2 [ "identificador" => "sec0020" "titulo" => "Historical background" ] 6 => array:2 [ "identificador" => "sec0025" "titulo" => "Case report" ] 7 => array:2 [ "identificador" => "sec0030" "titulo" => "Epidemiology" ] 8 => array:3 [ "identificador" => "sec0035" "titulo" => "Clinical presentation" "secciones" => array:1 [ 0 => array:2 [ "identificador" => "sec0040" "titulo" => "Histopathological findings" ] ] ] 9 => array:2 [ "identificador" => "sec0045" "titulo" => "Treatment" ] 10 => array:2 [ "identificador" => "sec0050" "titulo" => "Conclusion" ] 11 => array:2 [ "identificador" => "sec0055" "titulo" => "Financial support" ] 12 => array:2 [ "identificador" => "sec0060" "titulo" => "Authors’ contributions" ] 13 => array:2 [ "identificador" => "sec0065" "titulo" => "Conflicts of interest" ] 14 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2021-09-09" "fechaAceptado" => "2021-11-25" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1551039" "palabras" => array:5 [ 0 => "Hamartoma" 1 => "Mosaicism" 2 => "Neurocutaneous syndromes" 3 => "Nevus, sebaceous of Jadassohn" 4 => "Skin" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Nevus sebaceous of Jadassohn is defined as a rare congenital malformation characterized as a non-hereditary hamartoma of the adnexal structures of the skin. Its etiology is not yet well understood, but it is believed to be related to post-zygotic mutations in the <span class="elsevierStyleItalic">HRAS</span>, <span class="elsevierStyleItalic">NRAS</span> and <span class="elsevierStyleItalic">KRAS</span> genes.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">To describe the clinical manifestation of nevus sebaceous, as well as the main management techniques addressed in the medical literature. Moreover, the present study discusses a case report of a congenital linear nevus in the left retroauricular region found in a male patient, without extracutaneous manifestations.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Method</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">A narrative review of the literature was carried out.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Discussion</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Nevus sebaceous occurs as lesions with a linear or oval appearance, with a smooth or verrucous texture, generally alopecic and with very variable color. Moreover, nevus sebaceous is one of the components of the so-called linear nevus syndrome or Schimmelpenning-Feuerstein-Mims syndrome, which is associated with multisystemic complications. The treatment of the lesions is still controversial; however, most experts indicate surgical excision as the most frequently adopted treatment method, in addition to multidisciplinary follow-up when the diagnosis of Schimmelpenning-Feuerstein-Mims syndrome is established.</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusion</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">The linear nevus syndrome constitutes a rare manifestation; however, its diagnosis should be considered in children born with nevus sebaceous. There is no consensus yet on the best therapy, but surgical removal has shown to be a viable option.</p></span>" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objective" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Method" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Discussion" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Conclusion" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Study conducted at the Instituto de Cirurgia Plástica Manoel Pereira and Hospital São Marcos, Uberaba, MG, Brazil.</p>" ] ] "multimedia" => array:9 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1806 "Ancho" => 1500 "Tamanyo" => 396912 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0030" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Linear lesion with a slightly reddish and brownish color and a verrucous appearance.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2400 "Ancho" => 1500 "Tamanyo" => 374067 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0035" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Pre-surgical marking.</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1627 "Ancho" => 1500 "Tamanyo" => 285868 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0040" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Lesion excision.</p>" ] ] 3 => array:8 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1242 "Ancho" => 1500 "Tamanyo" => 251914 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0045" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Primary closure.</p>" ] ] 4 => array:8 [ "identificador" => "fig0025" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 848 "Ancho" => 1500 "Tamanyo" => 342245 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0050" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Panoramic histopathological view showing mild hyperkeratosis, accompanied by acanthosis and papillomatosis (Hematoxylin & eosin, ×40).</p>" ] ] 5 => array:8 [ "identificador" => "fig0030" "etiqueta" => "Figure 6" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr6.jpeg" "Alto" => 848 "Ancho" => 1500 "Tamanyo" => 376248 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0055" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Hyperplasia of sebaceous glands localized close to the epidermis (Hematoxylin & eosin, ×40).</p>" ] ] 6 => array:8 [ "identificador" => "fig0035" "etiqueta" => "Figure 7" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr7.jpeg" "Alto" => 848 "Ancho" => 1500 "Tamanyo" => 416370 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0060" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Detail of sebaceous glands hyperplasia (Hematoxylin & eosin, ×40).</p>" ] ] 7 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0065" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="6" align="left" valign="middle"><span class="elsevierStyleBold">Skeletal</span></td><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Kyphoscoliosis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Craniofacial defects \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Limb deformities \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hip dislocation \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Frontal bulge \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hypophosphatemic rickets \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " rowspan="12" align="left" valign="middle"><span class="elsevierStyleBold">Neurological</span></td><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Agenesis of the corpus callosum \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Agyria, microgyria or cortical pachygyria \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Generalized brain atrophy \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Seizures \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Intellectual disability \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Cognitive impairment \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Cerebral vessel dysplasia \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pineal hamartoma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Left thalamic hamartoma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hemimegaloencephaly \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Cerebral heterotopia \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Dandy-Walker syndrome \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " rowspan="6" align="left" valign="middle"><span class="elsevierStyleBold">Ocular</span></td><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Coloboma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Optic nerve defects \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Strabismus \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Epibulbar lipodermoid \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Microphthalmia \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Corneal opacity \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " rowspan="9" align="left" valign="middle"><span class="elsevierStyleBold">Genitourinary tract</span></td><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Cryptorchidism \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hydronephrosis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hypospadias \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Nephroblastomatosis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Ureteropelvic junction obstruction \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Cystic kidney \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Horseshoe kidney \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Duplicated renal collecting system \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Testicular and paratesticular tumors \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " rowspan="3" align="left" valign="middle"><span class="elsevierStyleBold">Cardiovascular</span></td><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Coarctation of the aorta \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Ventricular septal defect \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Aortic hypoplasia \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " rowspan="4" align="left" valign="middle"><span class="elsevierStyleBold">Intraoral</span></td><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tooth aplasia \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Bone cysts \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hypoplastic enamel \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hemihyperplasia of the tongue \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " rowspan="2" align="left" valign="middle"><span class="elsevierStyleBold">Lymphatic system</span></td><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lymphedema \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Chylothorax \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Extracutaneous clinical manifestations of the nevus sebaceous syndrome.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,11,22</span></a></p>" ] ] 8 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0070" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Benign \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Malignant \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sebaceous adenoma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Adnexal carcinoma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Seborrheic keratosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Apocrine carcinoma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pigmented eccrine poroma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Basal cell carcinoma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hidradenoma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Squamous cell carcinoma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Infundibuloma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mucoepidermoid carcinoma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Osteoma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sebaceous carcinoma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Proliferation of basaloid cells \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Keratoacanthoma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sebaceoma (Sebaceous epithelioma) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="5" align="left" valign="middle"></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Syringocystadenoma papilliferum \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Trichoblastoma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Desmoplastic trichilemmoma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Verruca vulgaris \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Main secondary neoplasms.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,12,23</span></a></p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:28 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neoplasias axiais" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T. McCalmont" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Dermatologia" "fecha" => "2015" "volumen" => "2" "paginaInicial" => "1850" "paginaFinal" => "1852" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nevus Sebaceus. StatPearls [Internet]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Baigrie" 1 => "T. Troxell" 2 => "C. Cook" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2022" "editorial" => "StatPearls Publishing" "editorialLocalizacion" => "Treasure Island (FL)" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Schimmelpenning syndrome with large nevus sebaceous and multiple epidermal nevi" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R.F. Dwiyana" 1 => "M.N. Hazari" 2 => "I.A. Diana" 3 => "S.P. Gondokaryono" 4 => "R.M.R.A. Effendi" 5 => "H. Gunawan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000509992" "Revista" => array:6 [ "tituloSerie" => "Case Rep Dermatol" "fecha" => "2020" "volumen" => "12" "paginaInicial" => "186" "paginaFinal" => "191" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33250735" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nevus sebaceous of Jadassohn with eight secondary tumors of follicular, sebaceous, and sweat gland differentiation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Y. Liu" 1 => "M. Valdebran" 2 => "J. Chen" 3 => "A. Elbendary" 4 => "F. Wu" 5 => "M. Xu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/DAD.0000000000000603" "Revista" => array:6 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "2016" "volumen" => "38" "paginaInicial" => "861" "paginaFinal" => "866" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27097338" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Do you know this syndrome? Schimmelpenning-Feuerstein-Mims syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.P. Lena" 1 => "R.N. Kondo" 2 => "T. Nicolacópulos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "An Bras Dermatol" "fecha" => "2019" "volumen" => "94" "paginaInicial" => "227" "paginaFinal" => "229" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Somatic KRAS mutation in an infant with linear nevus sebaceous syndrome associated with lymphatic malformations: a case report and literature review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Lihua" 1 => "G. Feng" 2 => "M. Shanshan" 3 => "X. Jialu" 4 => "J. Kewen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Medicine (Baltimore)" "fecha" => "2017" "volumen" => "96" "paginaInicial" => "e8016" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systematised naevus sebaceus resulting from post-zygotic mutation in HRAS" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.K. Hsu" 1 => "R. Saito" 2 => "A. Nanda" 3 => "E. Rashidghamat" 4 => "H. Al-Ajmi" 5 => "J.Y. Lee" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/ajd.12399" "Revista" => array:6 [ "tituloSerie" => "Australas J Dermatol" "fecha" => "2017" "volumen" => "58" "paginaInicial" => "58" "paginaFinal" => "60" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26400620" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nevo Sebáceo de Jadassohn em Recém-Nascido [Nevus Sebaceous of Jadassohn in the Newborn]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Meireles" 1 => "M. Pereira" 2 => "M.J. Costa" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.20344/amp.12164" "Revista" => array:5 [ "tituloSerie" => "Acta Med Port" "fecha" => "2020" "volumen" => "33" "paginaInicial" => "288" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32238245" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lesões Névicas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Almeida" 1 => "A. D’acri" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Oncologia Cutânea" "fecha" => "2017" "volumen" => "1" "paginaInicial" => "68" "paginaFinal" => "69" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nevus sebaceous at an unusual location: a rare presentation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.K. Gu" 1 => "X.J. Zhang" 2 => "L.T. Zhang" 3 => "F.K. Ma" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Chin Med J (Engl)" "fecha" => "2017" "volumen" => "130" "paginaInicial" => "2897" "paginaFinal" => "2898" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gustav Schimmelpenning and the syndrome bearing his name" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R. Happle" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000079589" "Revista" => array:6 [ "tituloSerie" => "Dermatology" "fecha" => "2004" "volumen" => "209" "paginaInicial" => "84" "paginaFinal" => "87" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15316159" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nevus sebaceus with syringocystadenoma papilliferum, prurigo nodularis, apocrine cystadenoma, basaloid follicular proliferation, and sebaceoma: case report and review of nevus sebaceus-associated conditions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Basu" 1 => "C.P. Erickson" 2 => "A. Calame" 3 => "P.R. Cohen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Dermatol Online J" "fecha" => "2020" "volumen" => "26" "paginaInicial" => "1" "paginaFinal" => "6" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fitzpatrick’s dermatology" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Kang" 1 => "M. Amagi" 2 => "A.L. Bruckner" 3 => "A.H. Enk" 4 => "D.J. Margolis" 5 => "A.J. McMichael" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "edicion" => "9th ed." "fecha" => "2019" "editorial" => "McGraw-Hill Education" "editorialLocalizacion" => "New York" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of central precocious puberty with a rare presentation of Schimmelpenning-Feuerstein-Mims syndrome in a Peruvian Girl" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.A.L.S. Torre" 1 => "C.M. Águila-Villar" 2 => "L.R.L. Lama" 3 => "O. Nuñez-Almache" 4 => "E.M. Chávez-Tejada" 5 => "O.A. Espinoza-Robles" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Case Rep Endocrinol" "fecha" => "2020" "volumen" => "2020" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nevus sebaceus of Jadassohn — high frequency ultrasound imaging and videodermoscopy examination. Case presentation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Bezugly" 1 => "T. Sedova" 2 => "P. Belkov" 3 => "D. Enikeev" 4 => "R. Voloshin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.15386/mpr-1658" "Revista" => array:6 [ "tituloSerie" => "Med Pharm Rep" "fecha" => "2021" "volumen" => "94" "paginaInicial" => "112" "paginaFinal" => "117" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33629058" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Syringocystadenoma papilliferum and trichoblastoma arising in the nevus sebaceous" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "F. Wang" 1 => "Y. Wu" 2 => "Z. Zheng" 3 => "Y. Bai" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4103/IJPM.IJPM_613_16" "Revista" => array:6 [ "tituloSerie" => "Indian J Pathol Microbiol" "fecha" => "2018" "volumen" => "61" "paginaInicial" => "106" "paginaFinal" => "108" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29567896" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Basal cell carcinoma within nevus sebaceous of the trunk" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "I.T. Watson" 1 => "A. DeCrescenzo" 2 => "S.Y. Paek" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Proc (Bayl Univ Med Cent)" "fecha" => "2019" "volumen" => "32" "paginaInicial" => "392" "paginaFinal" => "393" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Secondary neoplasms arising from nevus sebaceus: a retrospective study of 450 cases in Taiwan" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.C. Hsu" 1 => "J.Y. Liau" 2 => "J.L. Hong" 3 => "Y. Cheng" 4 => "Y.H. Liao" 5 => "J.S. Chen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/1346-8138.13070" "Revista" => array:6 [ "tituloSerie" => "J Dermatol" "fecha" => "2016" "volumen" => "43" "paginaInicial" => "175" "paginaFinal" => "180" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26361884" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Microcystic adnexal carcinoma originating in a nevus sebaceous: a case report of a 16-year-old boy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Hashem" 1 => "N. Tynngård" 2 => "K. Lundmark" 3 => "L. Falk" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2340/00015555-3272" "Revista" => array:6 [ "tituloSerie" => "Acta Derm Venereol" "fecha" => "2019" "volumen" => "99" "paginaInicial" => "1182" "paginaFinal" => "1183" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31386165" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Basal cell carcinoma on a nevus sebaceous of Jadassohn: a case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "B. Paninson" 1 => "B.M. Trope" 2 => "J.C. Moschini" 3 => "M.A. Jeunon-Sousa" 4 => "M. Ramos-E-Silva" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Aesthet Dermatol" "fecha" => "2019" "volumen" => "12" "paginaInicial" => "40" "paginaFinal" => "43" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31531170" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Malignant melanoma arising in sebaceous naevus (of Jadassohn): a case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.J. Robinson" 1 => "A.P. Brown" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3109/2000656X.2016.1147741" "Revista" => array:6 [ "tituloSerie" => "J Plast Surg Hand Surg" "fecha" => "2016" "volumen" => "50" "paginaInicial" => "249" "paginaFinal" => "250" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26934428" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A patient with Schimmelpenning syndrome and mosaic KRAS mutation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Bj Mitchell" 1 => "Gf Rogers" 2 => "Bc Wood" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/SCS.0000000000004887" "Revista" => array:6 [ "tituloSerie" => "J Craniofac Surg" "fecha" => "2019" "volumen" => "30" "paginaInicial" => "184" "paginaFinal" => "185" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30394973" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Eccrine poroma arising within nevus sebaceous" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.K. Seo" 1 => "M.K. Shin" 2 => "K.H. Jeong" 3 => "M.H. Lee" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5021/ad.2020.32.6.516" "Revista" => array:6 [ "tituloSerie" => "Ann Dermatol" "fecha" => "2020" "volumen" => "32" "paginaInicial" => "516" "paginaFinal" => "518" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33911796" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pigmented trichoblastoma of nose: an unusual occurrence" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D.C. Sathyaki" 1 => "M. Riyas" 2 => "M.S. Roy" 3 => "R.J. Swarup" 4 => "N. Raghu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Clin Diagn Res" "fecha" => "2017" "volumen" => "11" "paginaInicial" => "09" "paginaFinal" => "10" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Carbon dioxide laser versus erbium: YAG laser in treatment of epidermal verrucous nevus: a comparative randomized clinical study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.A.R. Osman" 1 => "A.N. Kassab" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/09546634.2016.1255305" "Revista" => array:6 [ "tituloSerie" => "J Dermatolog Treat" "fecha" => "2017" "volumen" => "28" "paginaInicial" => "452" "paginaFinal" => "457" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27796132" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Management of naevus sebaceous: a national survey of UK dermatologists and plastic surgeons" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G.N. Wali" 1 => "S.J. Felton" 2 => "T. McPherson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/ced.13422" "Revista" => array:6 [ "tituloSerie" => "Clin Exp Dermatol" "fecha" => "2018" "volumen" => "43" "paginaInicial" => "589" "paginaFinal" => "591" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29460979" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nevus sebaceus on the face: experience with photodynamic therapy in adults and children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "O.M. Moreno-Arrones" 1 => "B. Perez-Garcia" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4103/ijdvl.IJDVL_424_17" "Revista" => array:5 [ "tituloSerie" => "Indian J Dermatol Venereol Leprol" "fecha" => "2019" "volumen" => "85" "paginaInicial" => "440" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30409923" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dermoscopic clues for sebaceous carcinoma arising in nevus sebaceous" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Pradhan" 1 => "H. Xiao" 2 => "H.L. Yang" 3 => "Y.P. Ran" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/CM9.0000000000000956" "Revista" => array:6 [ "tituloSerie" => "Chin Med J" "fecha" => "2020" "volumen" => "133" "paginaInicial" => "2121" "paginaFinal" => "2122" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32769491" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03650596/0000009700000005/v1_202208290604/S0365059622001143/v1_202208290604/en/main.assets" "Apartado" => array:4 [ "identificador" => "80632" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Review" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009700000005/v1_202208290604/S0365059622001143/v1_202208290604/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059622001143?idApp=UINPBA00008Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 26 | 6 | 32 |
| 2024 October | 246 | 137 | 383 |
| 2024 September | 279 | 201 | 480 |
| 2024 August | 266 | 111 | 377 |
| 2024 July | 256 | 178 | 434 |
| 2024 June | 184 | 119 | 303 |
| 2024 May | 157 | 150 | 307 |
| 2024 April | 158 | 104 | 262 |
| 2024 March | 130 | 89 | 219 |
| 2024 February | 160 | 89 | 249 |
| 2024 January | 111 | 80 | 191 |
| 2023 December | 96 | 65 | 161 |
| 2023 November | 117 | 74 | 191 |
| 2023 October | 118 | 75 | 193 |
| 2023 September | 138 | 96 | 234 |
| 2023 August | 118 | 45 | 163 |
| 2023 July | 116 | 50 | 166 |
| 2023 June | 110 | 48 | 158 |
| 2023 May | 83 | 32 | 115 |
| 2023 April | 78 | 24 | 102 |
| 2023 March | 105 | 73 | 178 |
| 2023 February | 100 | 37 | 137 |
| 2023 January | 70 | 53 | 123 |
| 2022 December | 135 | 50 | 185 |
| 2022 November | 140 | 59 | 199 |
| 2022 October | 222 | 73 | 295 |
| 2022 September | 304 | 112 | 416 |
| 2022 August | 300 | 98 | 398 |
| 2022 July | 26 | 31 | 57 |
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