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B, A histopatologia da segunda biópsia mostrou um quadro histopatológico semelhante ao da primeira biópsia (Hematoxilina & eosina, 200×).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Kang Tao, Ting Wang, Lian Zhang, Xi‐Chuan Yang, Zhi‐Fang Zhai" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Kang" "apellidos" => "Tao" ] 1 => array:2 [ "nombre" => "Ting" "apellidos" => "Wang" ] 2 => array:2 [ "nombre" => "Lian" "apellidos" => "Zhang" ] 3 => array:2 [ "nombre" => "Xi‐Chuan" "apellidos" => "Yang" ] 4 => array:2 [ "nombre" => "Zhi‐Fang" "apellidos" => "Zhai" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S036505962200085X" "doi" => "10.1016/j.abd.2021.12.001" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S036505962200085X?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275222001035?idApp=UINPBA00008Z" "url" => "/26662752/0000009700000004/v1_202207280537/S2666275222001035/v1_202207280537/pt/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S0365059622000903" "issn" => "03650596" "doi" => "10.1016/j.abd.2022.02.001" "estado" => "S300" "fechaPublicacion" => "2022-07-01" "aid" => "567" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Tropical/Infectoparasitary Dermatology</span>" "titulo" => "Rhino-orbito-cerebral mucormycosis caused by <span class="elsevierStyleItalic">Rhizopus microsporus var. microsporus</span> in a diabetic patient with COVID-19" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "501" "paginaFinal" => "504" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1876 "Ancho" => 2175 "Tamanyo" => 341383 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Rhizopus microsporus</span>. (A), Colony consisting of whitish “cotton-wool” mycelium and blackish granular aerial mycelium. (B), Microculture showing coenocytic hypha with rhizoids, sporangiophore and empty sporangia. The presence of sporangiospores is observed around the structure (Cotton blue, ×400).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Sandy Daniele Munhoz, Rute Facchini Lellis, Ana Paula Carvalho Reis, Gilda Maria Barbaro Del Negro, Maria Glória Teixeira Sousa, John Verrinder Veasey" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Sandy Daniele" "apellidos" => "Munhoz" ] 1 => array:2 [ "nombre" => "Rute Facchini" "apellidos" => "Lellis" ] 2 => array:2 [ "nombre" => "Ana Paula Carvalho" "apellidos" => "Reis" ] 3 => array:2 [ "nombre" => "Gilda Maria Barbaro" "apellidos" => "Del Negro" ] 4 => array:2 [ "nombre" => "Maria Glória Teixeira" "apellidos" => "Sousa" ] 5 => array:2 [ "nombre" => "John Verrinder" "apellidos" => "Veasey" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275222000807" "doi" => "10.1016/j.abdp.2022.05.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275222000807?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059622000903?idApp=UINPBA00008Z" "url" => "/03650596/0000009700000004/v1_202206290808/S0365059622000903/v1_202206290808/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0365059622000691" "issn" => "03650596" "doi" => "10.1016/j.abd.2022.01.002" "estado" => "S300" "fechaPublicacion" => "2022-07-01" "aid" => "549" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "fla" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Special Article</span>" "titulo" => "Compulsory notification of injuries in aesthetic procedures. Impact on patient safety" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "491" "paginaFinal" => "497" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1112 "Ancho" => 2508 "Tamanyo" => 118127 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Absolute number of deaths in liposuction in the period from 1987 to 2015.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,3</span></a></p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Érico Pampado Di Santis, Samira Yarak, Marcos Roberto Martins, Sergio Henrique Hirata" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Érico Pampado" "apellidos" => "Di Santis" ] 1 => array:2 [ "nombre" => "Samira" "apellidos" => "Yarak" ] 2 => array:2 [ "nombre" => "Marcos Roberto" "apellidos" => "Martins" ] 3 => array:2 [ "nombre" => "Sergio Henrique" "apellidos" => "Hirata" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275222000923" "doi" => "10.1016/j.abdp.2022.06.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275222000923?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059622000691?idApp=UINPBA00008Z" "url" => "/03650596/0000009700000004/v1_202206290808/S0365059622000691/v1_202206290808/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Tropical/Infectoparasitary Dermatology</span>" "titulo" => "Fatal <span class="elsevierStyleItalic">Balamuthia mandrillaris</span> infection with red plaques on the nasal dorsum as the first presentation" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "498" "paginaFinal" => "500" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Kang Tao, Ting Wang, Lian Zhang, Xi-Chuan Yang, Zhi-Fang Zhai" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Kang" "apellidos" => "Tao" ] 1 => array:2 [ "nombre" => "Ting" "apellidos" => "Wang" ] 2 => array:2 [ "nombre" => "Lian" "apellidos" => "Zhang" ] 3 => array:2 [ "nombre" => "Xi-Chuan" "apellidos" => "Yang" ] 4 => array:4 [ "nombre" => "Zhi-Fang" "apellidos" => "Zhai" "email" => array:1 [ 0 => "zhaizf1004@163.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Department of Dermatology and Venereology, Southwest Hospital, Army Medical University, Chongqing, China" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1499 "Ancho" => 1250 "Tamanyo" => 467270 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A), Clinical image showing a red well-circumscribed plaque on his nasal dorsum with slightly raised border and a few scales on the surface. (B), The histopathology examination of the first biopsy shows cutaneous mixed inflammatory cells infiltration, including lymphocytes, histocytes, eosinophils and multinuclear giant cells, with numerous granulomas observed. (Hematoxylin & eosin, ×100).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Balamuthia mandrillaris</span> infection is a rare and fatal disease caused by <span class="elsevierStyleItalic">B. mandrillaris</span> amoeba, which was first isolated from a pregnant mandrill monkey died from encephalitis in 1986.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> It causes Central Nervous System (CNS) disease called Granulomatous Amebic Encephalitis (GAE). Most patients rapidly developed fatal encephalitis, and the lethality rate was up to 90% in the United States from 1974 to 2016.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> The epidemiology of <span class="elsevierStyleItalic">B. mandrillaris</span> has been little known, and it can only be concluded that soil and polluted water exposures were mentioned frequently in the cases.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Case report</span><p id="par0010" class="elsevierStylePara elsevierViewall">Here, the authors reported a 15-year-old boy presented with a red plaque on the nasal dorsum over one month, with slight itching. He denied fever or taking any medicine lately. His family and travel history were normal, but he used to swim in the wild pond with ambiguous trauma on the nose. Dermatologic examination revealed a well-circumscribed red plaque with a slightly raised border and mild infiltration with a few scales on the surface (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A), involving about two-thirds of his nasal dorsum. No enlarged cervical lymph node was detected.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The biopsy was taken from the red plaque, and the histopathology showed mixed inflammatory cells infiltration with the predominance of lymphocytes, histocytes, eosinophils, and multinuclear giant cells, with numerous granulomas observed (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B). However, both Periodic Acid-Schiff (PAS) and acid-fast staining were negative, as well as fungal culture and atypical mycobacteriosis detection. Even so, oral Itraconazole was prescribed, 200 mg/day. A month later, he had a “cold” with a slight cough and an enlarged lesion involving almost the whole nasal dorsum (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>A). Computed Tomography (CT) scan of the lungs was negative, and a second biopsy showed a similar histological profile (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>B). As the investigation of <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> on lesion sample by PCR-reversed dot hybridization had been negative, the treatment was switched to oral clarithromycin 500 mg/day and doxycycline 200 mg/day, combined with Itraconazole 400 mg/day. Another month later, high-grade fever and repeated nosebleeds occurred. He got into a coma and was hospitalized in another hospital five days later. A cranial CT scan showed multiple abnormal low-density foci in bilateral frontal, parietal lobes, and right occipital lobes. His cerebrospinal fluid sample was sent to Guangzhou Vision medicals Inc. for pathogen detection via Next-Generation Sequence (NGS), which confirmed the presence of <span class="elsevierStyleItalic">B. mandrillaris</span> genomic sequences expressed as 88.17% of the whole parasites, which suggests that <span class="elsevierStyleItalic">B. mandrillaris</span> was the main pathogen. Though Itraconazole and Linezolid intravenously were given, he died about 2-weeks later, unfortunately. The authors confirmed that <span class="elsevierStyleItalic">B. mandrillaris</span> infection already existed in the embedding skin biopsy tissue from initial red plaques by NGS.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Discussion</span><p id="par0020" class="elsevierStylePara elsevierViewall">Only about 7 cases of <span class="elsevierStyleItalic">B. mandrillaris</span> infection were reported per year worldwide.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> The patients can be divided into two types by different clinical manifestations. One type is mainly from the United States, which presents with encephalitis without skin lesions, and usually dies within months.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,4</span></a> The other one is observed mainly in China<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> and Peru,<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> where the skin is usually involved first and then gradually develops into encephalitis. Up to 50% of cases were children.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Wang et al. reported 28 Chinese cases, most of them seemed to be less aggressive with higher survival rate (44%), which may be related to the timely treatment before infection developed into GAE. Similarly, the present case also presented with skin lesions, and it took about half a year before encephalitis. Unfortunately, the authors didn't diagnose in time and prevent the infection from rapidly worsening.</p><p id="par0025" class="elsevierStylePara elsevierViewall">It is difficult to diagnose <span class="elsevierStyleItalic">B. mandrillaris</span> infection early. Traumatic history and contact history of dirty water or soil should be of concern. Most cases showed a common indurate plaque without ulceration or pustule secretion.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Microscopically, the amoeba looks like histiocytes in morphology and is difficult to be identified. Conventional PAS and acid-fast staining are unhelpful, and the infection is easily misdiagnosed as lethal midline granuloma.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Immunohistochemical staining with anti<span class="elsevierStyleItalic">-Balamuthia</span> antibody is useful, while the antibody is not commercially available yet. The next-generation sequence technique is recommended, which can get a higher positive rate for more kinds of microbes, especially some rare pathogen, from different samples, such as tissues, blood, body fluids, and secretions.</p><p id="par0030" class="elsevierStylePara elsevierViewall">The treatment is troublesome for physicians, and there is no standard strategy till now. The miltefosine may benefit patients and should be considered in any treatment plan.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Besides, lincomycin, azithromycin, and interferon-γ may be useful.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Except for drug treatments, Doyle et al. reported a case successfully treated with excision of the infected brain tissue,<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> but it is not the first choice for most encephalitis. Clinically it is imperative for us to make early diagnoses and discover effective treatments to save more lives.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Financial support</span><p id="par0035" class="elsevierStylePara elsevierViewall">Our project was supported by the National Natural Science Foundation of China (Grant No.81773316).</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Authors' contributions</span><p id="par0040" class="elsevierStylePara elsevierViewall">Kang Tao: Conception and planning of the study; critical review of the literature; obtaining, analysis, and interpretation of the data; elaboration and writing of the manuscript; critical review of the manuscript; approval of the final version of the manuscript.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Ting Wang: Approval of the final version of the manuscript; obtaining, analysis, and interpretation of the data; critical review of the manuscript.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Lian Zhang: Approval of the final version of the manuscript; obtaining, analysis, and interpretation of the data; critical review of the manuscript.</p><p id="par0055" class="elsevierStylePara elsevierViewall">Xi-Chuan Yang: Approval of the final version of the manuscript; obtaining, analysis, and interpretation of the data; critical review of the manuscript.</p><p id="par0060" class="elsevierStylePara elsevierViewall">Zhi-Fang Zhai: Conception and planning of the study; critical review of the literature; obtaining, analysis, and interpretation of the data; elaboration and writing of the manuscript; critical review of the manuscript; approval of the final version of the manuscript.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflicts of interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:9 [ 0 => array:3 [ "identificador" => "xres1740647" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1535181" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 3 => array:2 [ "identificador" => "sec0010" "titulo" => "Case report" ] 4 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 5 => array:2 [ "identificador" => "sec0020" "titulo" => "Financial support" ] 6 => array:2 [ "identificador" => "sec0025" "titulo" => "Authors' contributions" ] 7 => array:2 [ "identificador" => "sec0030" "titulo" => "Conflicts of interest" ] 8 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2021-08-20" "fechaAceptado" => "2021-12-01" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1535181" "palabras" => array:5 [ 0 => "<span class="elsevierStyleItalic">Balamuthia mandrillaris</span>" 1 => "Amebiasis" 2 => "Encephalitis" 3 => "Granuloma" 4 => "Skin diseases" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Balamuthia mandrillaris</span> infection is a rare infectious disease around the world, with high rates of morbidity and mortality. Its early and correct diagnosis is a big challenge for us, and without it the delay in starting effective treatment can lead to the development of encephalitis. This is a report of a case of <span class="elsevierStyleItalic">Balamuthia mandrillaris</span> infection in a Chinese boy, with red plaques on the nasal dorsum as the first presentation, who finally developed into fatal encephalitis. The authors have reviewed the related literature and share the special skin features in order to favor the early diagnosis of the disease and increase the chances of survival.</p></span>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "⋆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Study conducted at the Department of Dermatology and Venereology, Southwest Hospital, Army Medical University, Chongqing, China.</p>" ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1499 "Ancho" => 1250 "Tamanyo" => 467270 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A), Clinical image showing a red well-circumscribed plaque on his nasal dorsum with slightly raised border and a few scales on the surface. (B), The histopathology examination of the first biopsy shows cutaneous mixed inflammatory cells infiltration, including lymphocytes, histocytes, eosinophils and multinuclear giant cells, with numerous granulomas observed. (Hematoxylin & eosin, ×100).</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1404 "Ancho" => 755 "Tamanyo" => 285434 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">(A), The red plaques enlarged and involved almost the whole nasal dorsum when the patient visited again; (B), The histopathology of the second biopsy showed a similar histological profile as the first biopsy (Hematoxylin & eosin, ×200).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leptomyxid ameba, a new agent of amebic meningoencephalitis in humans and animals" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G.S. 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