array:24 [
  "pii" => "S0365059622000812"
  "issn" => "03650596"
  "doi" => "10.1016/j.abd.2020.11.018"
  "estado" => "S300"
  "fechaPublicacion" => "2022-07-01"
  "aid" => "561"
  "copyright" => "Sociedade Brasileira de Dermatologia"
  "copyrightAnyo" => "2022"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by/4.0/"
  "subdocumento" => "sco"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "pt" => array:19 [
      "pii" => "S2666275222000996"
      "issn" => "26662752"
      "doi" => "10.1016/j.abdp.2022.06.010"
      "estado" => "S300"
      "fechaPublicacion" => "2022-07-01"
      "aid" => "561"
      "copyright" => "Sociedade Brasileira de Dermatologia"
      "documento" => "article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by/4.0/"
      "subdocumento" => "sco"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "pt" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta &#8208; Caso cl&#237;nico</span>"
        "titulo" => "Ectima gangrenoso em pacientes neutrop&#234;nicos e a import&#226;ncia do raspado e da bi&#243;psia cut&#226;nea precoce para exame direto"
        "tienePdf" => "pt"
        "tieneTextoCompleto" => "pt"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "534"
            "paginaFinal" => "536"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "pt" => true
        ]
        "contienePdf" => array:1 [
          "pt" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0010"
            "etiqueta" => "Figura 2"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr2.jpeg"
                "Alto" => 672
                "Ancho" => 900
                "Tamanyo" => 92308
              ]
            ]
            "descripcion" => array:1 [
              "pt" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Placa eritematosa &#250;nica&#44; com centro necr&#243;tico&#44; na regi&#227;o tor&#225;cica anterior&#44; pr&#243;xima ao cateter de Hickman&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Yung Gonzaga, Thiago Jeunon, Jorge Machado, Marcio Nucci"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "Yung"
                "apellidos" => "Gonzaga"
              ]
              1 => array:2 [
                "nombre" => "Thiago"
                "apellidos" => "Jeunon"
              ]
              2 => array:2 [
                "nombre" => "Jorge"
                "apellidos" => "Machado"
              ]
              3 => array:2 [
                "nombre" => "Marcio"
                "apellidos" => "Nucci"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "pt"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S0365059622000812"
          "doi" => "10.1016/j.abd.2020.11.018"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059622000812?idApp=UINPBA00008Z"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275222000996?idApp=UINPBA00008Z"
      "url" => "/26662752/0000009700000004/v1_202207280537/S2666275222000996/v1_202207280537/pt/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0365059622000629"
    "issn" => "03650596"
    "doi" => "10.1016/j.abd.2020.10.023"
    "estado" => "S300"
    "fechaPublicacion" => "2022-07-01"
    "aid" => "542"
    "copyright" => "Sociedade Brasileira de Dermatologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by/4.0/"
    "subdocumento" => "sco"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>"
      "titulo" => "Exophytic botryomycosis&#58; An unusual clinical presentation"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "536"
          "paginaFinal" => "538"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0015"
          "etiqueta" => "Figure 3"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr3.jpeg"
              "Alto" => 1100
              "Ancho" => 1508
              "Tamanyo" => 355241
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0015"
              "detalle" => "Figure "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Granular basophilic bodies&#44; grains &#40;Hematoxylin &#38; eosin&#44; x100&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Lina Paola Gonz&#225;lez-Cardona, Adriana Mercedes Alejo Villamil, Carolina Cort&#233;s Correa, Elkin Omar Pe&#241;aranda Contreras"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Lina Paola"
              "apellidos" => "Gonz&#225;lez-Cardona"
            ]
            1 => array:2 [
              "nombre" => "Adriana Mercedes"
              "apellidos" => "Alejo Villamil"
            ]
            2 => array:2 [
              "nombre" => "Carolina"
              "apellidos" => "Cort&#233;s Correa"
            ]
            3 => array:2 [
              "nombre" => "Elkin Omar"
              "apellidos" => "Pe&#241;aranda Contreras"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "pt" => array:9 [
        "pii" => "S2666275222000789"
        "doi" => "10.1016/j.abdp.2022.05.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "pt"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275222000789?idApp=UINPBA00008Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059622000629?idApp=UINPBA00008Z"
    "url" => "/03650596/0000009700000004/v1_202206290808/S0365059622000629/v1_202206290808/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0365059622000708"
    "issn" => "03650596"
    "doi" => "10.1016/j.abd.2020.10.025"
    "estado" => "S300"
    "fechaPublicacion" => "2022-07-01"
    "aid" => "550"
    "copyright" => "Sociedade Brasileira de Dermatologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by/4.0/"
    "subdocumento" => "sco"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>"
      "titulo" => "Acquired generalized idiopathic anhidrosis &#8210; rare case in a Brazilian patient"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "532"
          "paginaFinal" => "534"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1292
              "Ancho" => 2508
              "Tamanyo" => 226734
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0010"
              "detalle" => "Figure "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Minor&#39;s test demonstrating preserved sweating only in the axillary region after strenuous physical activity&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Ma&#237;sa Aparecida Matico Utsumi Okada, Let&#237;cia Santos Dexheimer, Renan Rangel Bonamigo, Renata Heck"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Ma&#237;sa Aparecida Matico Utsumi"
              "apellidos" => "Okada"
            ]
            1 => array:2 [
              "nombre" => "Let&#237;cia Santos"
              "apellidos" => "Dexheimer"
            ]
            2 => array:2 [
              "nombre" => "Renan Rangel"
              "apellidos" => "Bonamigo"
            ]
            3 => array:2 [
              "nombre" => "Renata"
              "apellidos" => "Heck"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "pt" => array:9 [
        "pii" => "S2666275222000935"
        "doi" => "10.1016/j.abdp.2022.06.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "pt"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275222000935?idApp=UINPBA00008Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059622000708?idApp=UINPBA00008Z"
    "url" => "/03650596/0000009700000004/v1_202206290808/S0365059622000708/v1_202206290808/en/main.assets"
  ]
  "en" => array:17 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>"
    "titulo" => "Ecthyma gangrenosum in neutropenic patients and the importance of an early skin biopsy for direct examination"
    "tieneTextoCompleto" => true
    "saludo" => "Dear Editor&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "534"
        "paginaFinal" => "536"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Yung Gonzaga, Thiago Jeunon, Jorge Machado, Marcio Nucci"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "Yung"
            "apellidos" => "Gonzaga"
            "email" => array:1 [
              0 => "yungbmg@hotmail.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Thiago"
            "apellidos" => "Jeunon"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Jorge"
            "apellidos" => "Machado"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Marcio"
            "apellidos" => "Nucci"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Instituto Nacional de C&#226;ncer&#44; Rio de Janeiro&#44; RJ&#44; Brazil"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Private clinic&#44; Rio de Janeiro&#44; RJ&#44; Brazil"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Universidade Federal do Rio de Janeiro&#44; Rio de Janeiro&#44; RJ&#44; Brazil"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:8 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 576
            "Ancho" => 900
            "Tamanyo" => 73951
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0015"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Thick&#44; non-septate hyaline hyphae&#44; branching at a right angle&#46; Direct examination&#46; KOH 20&#37; and Parker&#39;s ink&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Ecthyma Gangrenosum &#40;EG&#41; was once considered pathognomonic for sepsis caused by <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> However&#44; other agents have been described in oncohaematological patients&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Skin biopsies are often not performed&#44; and treatment is usually empirical&#46; This report describes three cases of neutropenic patients with EG who underwent skin biopsy with direct examination&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Patient 1&#58; Male&#44; 36 years old&#44; with acute lymphoblastic leukemia&#44; presented with febrile neutropenia &#40;FN&#41; during chemotherapy&#44; and treatment with cefepime was started&#46; After ten days&#44; he once again had a fever&#44; with the appearance of erythematous lesions with a necrotic center on the face and chest&#46; He had neutropenia &#40;10&#47;mm<span class="elsevierStyleSup">3</span>&#41; and thrombocytopenia &#40;24&#44;000&#47; mm<span class="elsevierStyleSup">3</span>&#41;&#46; Blood cultures and a skin biopsy were collected&#44; and liposomal amphotericin B and voriconazole were started&#46; Direct examination identified septate hyaline hyphae &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; which were later also detected in the histopathological examination&#46; <span class="elsevierStyleItalic">Fusarium spp</span>&#46; was identified in blood and skin cultures&#46; The patient did not survive depicting of the treatment&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Patient 2&#58; Male&#44; 47 years old&#44; had FN during chemotherapy for acute myeloid leukemia&#44; and treatment with cefepime was started&#46; After fourteen days&#44; he once again had a fever&#44; with the appearance of a single erythematous lesion with a necrotic center&#44; on the chest &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; He had neutropenia &#40;40&#47;&#160;mm<span class="elsevierStyleSup">3</span>&#41; and thrombocytopenia &#40;44&#44;000&#47;&#160;mm<span class="elsevierStyleSup">3</span>&#41;&#46; Blood cultures and a skin biopsy were collected&#46; Direct examination revealed non-septate hyaline hyphae &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#44; which were later seen in the histopathological examination&#46; Antifungal treatment with liposomal amphotericin B was started&#46; Subsequently&#44; <span class="elsevierStyleItalic">Syncephalastrum spp</span>&#46; was identified in the skin culture&#46; The patient remained afebrile&#44; with neutrophilic recovery&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Patient 3&#58; Male&#44; 36 years old&#44; had FN during chemotherapy for acute myeloid leukemia&#44; and treatment with cefepime was started&#46; After four days&#44; he had a fever&#44; and arterial hypotension&#44; with the appearance of an erythematous lesion with a necrotic center on the back region&#46; Antibiotic therapy was expanded to include polymyxin B&#44; amikacin&#44; and meropenem&#46; He had neutropenia &#40;170&#47;&#160;mm<span class="elsevierStyleSup">3</span>&#41; and thrombocytopenia &#40;2&#44;000&#47;&#160;mm<span class="elsevierStyleSup">3</span>&#41;&#46; A skin biopsy was collected&#44; and a direct examination identified the presence of gram-negative rods&#46; No specimen was sent for histopathological examination&#46; Subsequently&#44; multidrug-resistant <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> was identified in the skin and blood cultures&#46; The antimicrobial regimen was maintained until a clinical resolution was attained&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The present report describes three cases of neutropenic patients who developed EG&#46; All had a similar clinical presentation&#44; with fever recurrence and the appearance of lesions during antibiotic therapy&#46; In the first patient&#44; direct examination suggested the diagnosis of fusariosis&#44; directing the combined antifungal treatment&#46; The cause of death was attributed to the absence of immune reconstitution&#46; In the second patient&#44; the direct examination suggested the diagnosis of mucormycosis&#44; directing the change of the antifungal agent for liposomal amphotericin B&#46; In the third patient&#44; the direct examination suggested the diagnosis of bacterial sepsis&#44; directing the expansion of the antibiotic regimen without the association of antifungal agents&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Typically&#44; the EG agent is identified in blood and skin cultures&#46; However&#44; as these results are not promptly available&#44; the treatment is usually the empirical expansion of the anti-infective regimen&#46; The disadvantages of this approach are exposure to toxic drugs and increased costs&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The skin biopsy is a safe procedure in thrombocytopenic patients&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Direct examination helped to identify the agent before the results of cultures were obtained&#44; which later confirmed what had already been detected&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In summary&#44; we suggest performing an early skin biopsy with direct examination in neutropenic patients with EG&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0045" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors&#39; contributions</span><p id="par0050" class="elsevierStylePara elsevierViewall">Yung Gonzaga&#58; Approval of the final version of the manuscript&#59; critical review of the literature&#59; collection&#44; analysis&#44; and interpretation of data&#59; effective participation in research orientation&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the manuscript&#59; drafting and editing of the manuscript&#59; statistical analysis&#59; design and planning of the study&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Thiago Jeunon&#58; Approval of the final version of the manuscript&#59; critical review of the literature&#59; collection&#44; analysis&#44; and interpretation of data&#59; effective participation in research orientation&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the manuscript&#59; drafting and editing of the manuscript&#59; statistical analysis&#59; design and planning of the study&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Jorge Machado&#58; Approval of the final version of the manuscript&#59; critical review of the literature&#59; collection&#44; analysis&#44; and interpretation of data&#59; effective participation in research orientation&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the manuscript&#59; drafting and editing of the manuscript&#59; statistical analysis&#59; design and planning of the study&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Marcio Nucci&#58; Approval of the final version of the manuscript&#59; critical review of the literature&#59; collection&#44; analysis&#44; and interpretation of data&#59; effective participation in research orientation&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the manuscript&#59; drafting and editing of the manuscript&#59; statistical analysis&#59; design and planning of the study&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0070" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:4 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Financial support"
        ]
        1 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Authors&#39; contributions"
        ]
        2 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Conflicts of interest"
        ]
        3 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2020-07-14"
    "fechaAceptado" => "2020-11-11"
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#8902;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Study conducted at the Instituto Nacional de C&#226;ncer&#44; Rio de Janeiro&#44; RJ&#44; Brazil&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1193
            "Ancho" => 750
            "Tamanyo" => 167263
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Septate hyaline hyphae with branching at an acute angle&#46; Direct examination&#44; KOH 20&#37;&#44; &#215;40&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 672
            "Ancho" => 900
            "Tamanyo" => 92308
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0010"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Single erythematous lesion with necrotic center in the anterior thoracic region&#44; close to the Hickman catheter&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 576
            "Ancho" => 900
            "Tamanyo" => 73951
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0015"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Thick&#44; non-septate hyaline hyphae&#44; branching at a right angle&#46; Direct examination&#46; KOH 20&#37; and Parker&#39;s ink&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:3 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ecthyma gangrenosum complicating Pseudomonas bacteremia&#46; Rare survival"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Pickarrd"
                            1 => "R&#46; Llamas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Fla Med Assoc&#46;"
                        "fecha" => "1970"
                        "volumen" => "57"
                        "paginaInicial" => "34"
                        "paginaFinal" => "35"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5445814"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ecthyma gangrenosum and ecthyma-like lesions&#58; review article"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Vaiman"
                            1 => "T&#46; Lazarovitch"
                            2 => "L&#46; Heller"
                            3 => "G&#46; Lotan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur J Clin Microbiol Infec Dis&#46;"
                        "fecha" => "2015"
                        "volumen" => "34"
                        "paginaInicial" => "633"
                        "paginaFinal" => "639"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low risk of hemorrhagic complications after obtaining diagnostic skin biopsy specimens in a cohort of thrombocytopenic inpatients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F&#46;D&#46; Xia"
                            1 => "H&#46; Khosravi"
                            2 => "M&#46;A&#46; Waul"
                            3 => "D&#46; Butler"
                            4 => "C&#46; Joyce"
                            5 => "A&#46; Mostaghimi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2016.12.033"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2017"
                        "volumen" => "76"
                        "paginaInicial" => "1004"
                        "paginaFinal" => "1005"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28411767"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/03650596/0000009700000004/v1_202206290808/S0365059622000812/v1_202206290808/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "82769"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case Letter"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009700000004/v1_202206290808/S0365059622000812/v1_202206290808/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059622000812?idApp=UINPBA00008Z"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Case Letter
Ecthyma gangrenosum in neutropenic patients and the importance of an early skin biopsy for direct examination
Yung Gonzagaa,
Corresponding author
yungbmg@hotmail.com

Corresponding author.
, Thiago Jeunonb, Jorge Machadoa, Marcio Nuccic
a Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brazil
b Private clinic, Rio de Janeiro, RJ, Brazil
c Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
Read
4380
Times
was read the article
1888
Total PDF
2492
Total HTML
Share statistics
 array:24 [
  "pii" => "S0365059622000812"
  "issn" => "03650596"
  "doi" => "10.1016/j.abd.2020.11.018"
  "estado" => "S300"
  "fechaPublicacion" => "2022-07-01"
  "aid" => "561"
  "copyright" => "Sociedade Brasileira de Dermatologia"
  "copyrightAnyo" => "2022"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by/4.0/"
  "subdocumento" => "sco"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "pt" => array:19 [
      "pii" => "S2666275222000996"
      "issn" => "26662752"
      "doi" => "10.1016/j.abdp.2022.06.010"
      "estado" => "S300"
      "fechaPublicacion" => "2022-07-01"
      "aid" => "561"
      "copyright" => "Sociedade Brasileira de Dermatologia"
      "documento" => "article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by/4.0/"
      "subdocumento" => "sco"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "pt" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta &#8208; Caso cl&#237;nico</span>"
        "titulo" => "Ectima gangrenoso em pacientes neutrop&#234;nicos e a import&#226;ncia do raspado e da bi&#243;psia cut&#226;nea precoce para exame direto"
        "tienePdf" => "pt"
        "tieneTextoCompleto" => "pt"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "534"
            "paginaFinal" => "536"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "pt" => true
        ]
        "contienePdf" => array:1 [
          "pt" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0010"
            "etiqueta" => "Figura 2"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr2.jpeg"
                "Alto" => 672
                "Ancho" => 900
                "Tamanyo" => 92308
              ]
            ]
            "descripcion" => array:1 [
              "pt" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Placa eritematosa &#250;nica&#44; com centro necr&#243;tico&#44; na regi&#227;o tor&#225;cica anterior&#44; pr&#243;xima ao cateter de Hickman&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Yung Gonzaga, Thiago Jeunon, Jorge Machado, Marcio Nucci"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "Yung"
                "apellidos" => "Gonzaga"
              ]
              1 => array:2 [
                "nombre" => "Thiago"
                "apellidos" => "Jeunon"
              ]
              2 => array:2 [
                "nombre" => "Jorge"
                "apellidos" => "Machado"
              ]
              3 => array:2 [
                "nombre" => "Marcio"
                "apellidos" => "Nucci"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "pt"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S0365059622000812"
          "doi" => "10.1016/j.abd.2020.11.018"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059622000812?idApp=UINPBA00008Z"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275222000996?idApp=UINPBA00008Z"
      "url" => "/26662752/0000009700000004/v1_202207280537/S2666275222000996/v1_202207280537/pt/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0365059622000629"
    "issn" => "03650596"
    "doi" => "10.1016/j.abd.2020.10.023"
    "estado" => "S300"
    "fechaPublicacion" => "2022-07-01"
    "aid" => "542"
    "copyright" => "Sociedade Brasileira de Dermatologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by/4.0/"
    "subdocumento" => "sco"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>"
      "titulo" => "Exophytic botryomycosis&#58; An unusual clinical presentation"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "536"
          "paginaFinal" => "538"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0015"
          "etiqueta" => "Figure 3"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr3.jpeg"
              "Alto" => 1100
              "Ancho" => 1508
              "Tamanyo" => 355241
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0015"
              "detalle" => "Figure "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Granular basophilic bodies&#44; grains &#40;Hematoxylin &#38; eosin&#44; x100&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Lina Paola Gonz&#225;lez-Cardona, Adriana Mercedes Alejo Villamil, Carolina Cort&#233;s Correa, Elkin Omar Pe&#241;aranda Contreras"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Lina Paola"
              "apellidos" => "Gonz&#225;lez-Cardona"
            ]
            1 => array:2 [
              "nombre" => "Adriana Mercedes"
              "apellidos" => "Alejo Villamil"
            ]
            2 => array:2 [
              "nombre" => "Carolina"
              "apellidos" => "Cort&#233;s Correa"
            ]
            3 => array:2 [
              "nombre" => "Elkin Omar"
              "apellidos" => "Pe&#241;aranda Contreras"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "pt" => array:9 [
        "pii" => "S2666275222000789"
        "doi" => "10.1016/j.abdp.2022.05.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "pt"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275222000789?idApp=UINPBA00008Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059622000629?idApp=UINPBA00008Z"
    "url" => "/03650596/0000009700000004/v1_202206290808/S0365059622000629/v1_202206290808/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0365059622000708"
    "issn" => "03650596"
    "doi" => "10.1016/j.abd.2020.10.025"
    "estado" => "S300"
    "fechaPublicacion" => "2022-07-01"
    "aid" => "550"
    "copyright" => "Sociedade Brasileira de Dermatologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by/4.0/"
    "subdocumento" => "sco"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>"
      "titulo" => "Acquired generalized idiopathic anhidrosis &#8210; rare case in a Brazilian patient"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "532"
          "paginaFinal" => "534"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1292
              "Ancho" => 2508
              "Tamanyo" => 226734
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0010"
              "detalle" => "Figure "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Minor&#39;s test demonstrating preserved sweating only in the axillary region after strenuous physical activity&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Ma&#237;sa Aparecida Matico Utsumi Okada, Let&#237;cia Santos Dexheimer, Renan Rangel Bonamigo, Renata Heck"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Ma&#237;sa Aparecida Matico Utsumi"
              "apellidos" => "Okada"
            ]
            1 => array:2 [
              "nombre" => "Let&#237;cia Santos"
              "apellidos" => "Dexheimer"
            ]
            2 => array:2 [
              "nombre" => "Renan Rangel"
              "apellidos" => "Bonamigo"
            ]
            3 => array:2 [
              "nombre" => "Renata"
              "apellidos" => "Heck"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "pt" => array:9 [
        "pii" => "S2666275222000935"
        "doi" => "10.1016/j.abdp.2022.06.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "pt"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275222000935?idApp=UINPBA00008Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059622000708?idApp=UINPBA00008Z"
    "url" => "/03650596/0000009700000004/v1_202206290808/S0365059622000708/v1_202206290808/en/main.assets"
  ]
  "en" => array:17 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>"
    "titulo" => "Ecthyma gangrenosum in neutropenic patients and the importance of an early skin biopsy for direct examination"
    "tieneTextoCompleto" => true
    "saludo" => "Dear Editor&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "534"
        "paginaFinal" => "536"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Yung Gonzaga, Thiago Jeunon, Jorge Machado, Marcio Nucci"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "Yung"
            "apellidos" => "Gonzaga"
            "email" => array:1 [
              0 => "yungbmg@hotmail.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Thiago"
            "apellidos" => "Jeunon"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Jorge"
            "apellidos" => "Machado"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Marcio"
            "apellidos" => "Nucci"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Instituto Nacional de C&#226;ncer&#44; Rio de Janeiro&#44; RJ&#44; Brazil"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Private clinic&#44; Rio de Janeiro&#44; RJ&#44; Brazil"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Universidade Federal do Rio de Janeiro&#44; Rio de Janeiro&#44; RJ&#44; Brazil"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:8 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 576
            "Ancho" => 900
            "Tamanyo" => 73951
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0015"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Thick&#44; non-septate hyaline hyphae&#44; branching at a right angle&#46; Direct examination&#46; KOH 20&#37; and Parker&#39;s ink&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Ecthyma Gangrenosum &#40;EG&#41; was once considered pathognomonic for sepsis caused by <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> However&#44; other agents have been described in oncohaematological patients&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Skin biopsies are often not performed&#44; and treatment is usually empirical&#46; This report describes three cases of neutropenic patients with EG who underwent skin biopsy with direct examination&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Patient 1&#58; Male&#44; 36 years old&#44; with acute lymphoblastic leukemia&#44; presented with febrile neutropenia &#40;FN&#41; during chemotherapy&#44; and treatment with cefepime was started&#46; After ten days&#44; he once again had a fever&#44; with the appearance of erythematous lesions with a necrotic center on the face and chest&#46; He had neutropenia &#40;10&#47;mm<span class="elsevierStyleSup">3</span>&#41; and thrombocytopenia &#40;24&#44;000&#47; mm<span class="elsevierStyleSup">3</span>&#41;&#46; Blood cultures and a skin biopsy were collected&#44; and liposomal amphotericin B and voriconazole were started&#46; Direct examination identified septate hyaline hyphae &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; which were later also detected in the histopathological examination&#46; <span class="elsevierStyleItalic">Fusarium spp</span>&#46; was identified in blood and skin cultures&#46; The patient did not survive depicting of the treatment&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Patient 2&#58; Male&#44; 47 years old&#44; had FN during chemotherapy for acute myeloid leukemia&#44; and treatment with cefepime was started&#46; After fourteen days&#44; he once again had a fever&#44; with the appearance of a single erythematous lesion with a necrotic center&#44; on the chest &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; He had neutropenia &#40;40&#47;&#160;mm<span class="elsevierStyleSup">3</span>&#41; and thrombocytopenia &#40;44&#44;000&#47;&#160;mm<span class="elsevierStyleSup">3</span>&#41;&#46; Blood cultures and a skin biopsy were collected&#46; Direct examination revealed non-septate hyaline hyphae &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#44; which were later seen in the histopathological examination&#46; Antifungal treatment with liposomal amphotericin B was started&#46; Subsequently&#44; <span class="elsevierStyleItalic">Syncephalastrum spp</span>&#46; was identified in the skin culture&#46; The patient remained afebrile&#44; with neutrophilic recovery&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Patient 3&#58; Male&#44; 36 years old&#44; had FN during chemotherapy for acute myeloid leukemia&#44; and treatment with cefepime was started&#46; After four days&#44; he had a fever&#44; and arterial hypotension&#44; with the appearance of an erythematous lesion with a necrotic center on the back region&#46; Antibiotic therapy was expanded to include polymyxin B&#44; amikacin&#44; and meropenem&#46; He had neutropenia &#40;170&#47;&#160;mm<span class="elsevierStyleSup">3</span>&#41; and thrombocytopenia &#40;2&#44;000&#47;&#160;mm<span class="elsevierStyleSup">3</span>&#41;&#46; A skin biopsy was collected&#44; and a direct examination identified the presence of gram-negative rods&#46; No specimen was sent for histopathological examination&#46; Subsequently&#44; multidrug-resistant <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> was identified in the skin and blood cultures&#46; The antimicrobial regimen was maintained until a clinical resolution was attained&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The present report describes three cases of neutropenic patients who developed EG&#46; All had a similar clinical presentation&#44; with fever recurrence and the appearance of lesions during antibiotic therapy&#46; In the first patient&#44; direct examination suggested the diagnosis of fusariosis&#44; directing the combined antifungal treatment&#46; The cause of death was attributed to the absence of immune reconstitution&#46; In the second patient&#44; the direct examination suggested the diagnosis of mucormycosis&#44; directing the change of the antifungal agent for liposomal amphotericin B&#46; In the third patient&#44; the direct examination suggested the diagnosis of bacterial sepsis&#44; directing the expansion of the antibiotic regimen without the association of antifungal agents&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Typically&#44; the EG agent is identified in blood and skin cultures&#46; However&#44; as these results are not promptly available&#44; the treatment is usually the empirical expansion of the anti-infective regimen&#46; The disadvantages of this approach are exposure to toxic drugs and increased costs&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The skin biopsy is a safe procedure in thrombocytopenic patients&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Direct examination helped to identify the agent before the results of cultures were obtained&#44; which later confirmed what had already been detected&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In summary&#44; we suggest performing an early skin biopsy with direct examination in neutropenic patients with EG&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0045" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors&#39; contributions</span><p id="par0050" class="elsevierStylePara elsevierViewall">Yung Gonzaga&#58; Approval of the final version of the manuscript&#59; critical review of the literature&#59; collection&#44; analysis&#44; and interpretation of data&#59; effective participation in research orientation&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the manuscript&#59; drafting and editing of the manuscript&#59; statistical analysis&#59; design and planning of the study&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Thiago Jeunon&#58; Approval of the final version of the manuscript&#59; critical review of the literature&#59; collection&#44; analysis&#44; and interpretation of data&#59; effective participation in research orientation&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the manuscript&#59; drafting and editing of the manuscript&#59; statistical analysis&#59; design and planning of the study&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Jorge Machado&#58; Approval of the final version of the manuscript&#59; critical review of the literature&#59; collection&#44; analysis&#44; and interpretation of data&#59; effective participation in research orientation&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the manuscript&#59; drafting and editing of the manuscript&#59; statistical analysis&#59; design and planning of the study&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Marcio Nucci&#58; Approval of the final version of the manuscript&#59; critical review of the literature&#59; collection&#44; analysis&#44; and interpretation of data&#59; effective participation in research orientation&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the manuscript&#59; drafting and editing of the manuscript&#59; statistical analysis&#59; design and planning of the study&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0070" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:4 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Financial support"
        ]
        1 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Authors&#39; contributions"
        ]
        2 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Conflicts of interest"
        ]
        3 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2020-07-14"
    "fechaAceptado" => "2020-11-11"
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#8902;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Study conducted at the Instituto Nacional de C&#226;ncer&#44; Rio de Janeiro&#44; RJ&#44; Brazil&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1193
            "Ancho" => 750
            "Tamanyo" => 167263
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Septate hyaline hyphae with branching at an acute angle&#46; Direct examination&#44; KOH 20&#37;&#44; &#215;40&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 672
            "Ancho" => 900
            "Tamanyo" => 92308
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0010"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Single erythematous lesion with necrotic center in the anterior thoracic region&#44; close to the Hickman catheter&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 576
            "Ancho" => 900
            "Tamanyo" => 73951
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0015"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Thick&#44; non-septate hyaline hyphae&#44; branching at a right angle&#46; Direct examination&#46; KOH 20&#37; and Parker&#39;s ink&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:3 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ecthyma gangrenosum complicating Pseudomonas bacteremia&#46; Rare survival"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Pickarrd"
                            1 => "R&#46; Llamas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Fla Med Assoc&#46;"
                        "fecha" => "1970"
                        "volumen" => "57"
                        "paginaInicial" => "34"
                        "paginaFinal" => "35"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5445814"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ecthyma gangrenosum and ecthyma-like lesions&#58; review article"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Vaiman"
                            1 => "T&#46; Lazarovitch"
                            2 => "L&#46; Heller"
                            3 => "G&#46; Lotan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur J Clin Microbiol Infec Dis&#46;"
                        "fecha" => "2015"
                        "volumen" => "34"
                        "paginaInicial" => "633"
                        "paginaFinal" => "639"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low risk of hemorrhagic complications after obtaining diagnostic skin biopsy specimens in a cohort of thrombocytopenic inpatients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F&#46;D&#46; Xia"
                            1 => "H&#46; Khosravi"
                            2 => "M&#46;A&#46; Waul"
                            3 => "D&#46; Butler"
                            4 => "C&#46; Joyce"
                            5 => "A&#46; Mostaghimi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2016.12.033"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2017"
                        "volumen" => "76"
                        "paginaInicial" => "1004"
                        "paginaFinal" => "1005"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28411767"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/03650596/0000009700000004/v1_202206290808/S0365059622000812/v1_202206290808/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "82769"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case Letter"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009700000004/v1_202206290808/S0365059622000812/v1_202206290808/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059622000812?idApp=UINPBA00008Z"
]
Article information
ISSN: 03650596
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 27 8 35
2024 October 135 76 211
2024 September 174 94 268
2024 August 173 127 300
2024 July 173 117 290
2024 June 140 103 243
2024 May 96 60 156
2024 April 137 93 230
2024 March 63 66 129
2024 February 85 85 170
2024 January 80 75 155
2023 December 70 50 120
2023 November 77 98 175
2023 October 77 69 146
2023 September 75 85 160
2023 August 57 39 96
2023 July 77 37 114
2023 June 61 43 104
2023 May 58 24 82
2023 April 42 24 66
2023 March 66 48 114
2023 February 56 34 90
2023 January 50 36 86
2022 December 42 30 72
2022 November 71 61 132
2022 October 82 67 149
2022 September 55 65 120
2022 August 69 56 125
2022 July 86 77 163
2022 June 38 41 79
Show all

Follow this link to access the full text of the article

Idiomas
Anais Brasileiros de Dermatologia
en pt
Cookies policy Política de cookies
To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.