Images in Dermatology
In vivo reflectance confocal microscopic findings in a case of trichofolliculoma
Read
4965
Timeswas read the article
2272
Total PDF
2693
Total HTML
Share statistics
array:24 [ "pii" => "S0365059621003184" "issn" => "03650596" "doi" => "10.1016/j.abd.2021.05.013" "estado" => "S300" "fechaPublicacion" => "2022-03-01" "aid" => "508" "copyright" => "Sociedade Brasileira de Dermatologia" "copyrightAnyo" => "2021" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "pt" => array:19 [ "pii" => "S2666275222000091" "issn" => "26662752" "doi" => "10.1016/j.abdp.2022.01.009" "estado" => "S300" "fechaPublicacion" => "2022-03-01" "aid" => "508" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "pt" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Imagens em Dermatologia</span>" "titulo" => "Achados de microscopia confocal de reflectância <span class="elsevierStyleItalic">in vivo</span> em caso de tricofoliculoma" "tienePdf" => "pt" "tieneTextoCompleto" => "pt" "tieneResumen" => "pt" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "236" "paginaFinal" => "239" ] ] "contieneResumen" => array:1 [ "pt" => true ] "contieneTextoCompleto" => array:1 [ "pt" => true ] "contienePdf" => array:1 [ "pt" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figura 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 556 "Ancho" => 1505 "Tamanyo" => 241811 ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">(A), Vários pequenos folículos pilosos abortivos irradiados, com vários graus de maturidade ao redor do folículo piloso primário central (Hematoxilina & eosina, 100×). (B), Alguns folículos capilares abortivos localizados sob a epiderme (Hematoxilina & eosina, 100×).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Isil Karaarslan, Gokturk Oraloglu, Banu Yaman" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Isil" "apellidos" => "Karaarslan" ] 1 => array:2 [ "nombre" => "Gokturk" "apellidos" => "Oraloglu" ] 2 => array:2 [ "nombre" => "Banu" "apellidos" => "Yaman" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0365059621003184" "doi" => "10.1016/j.abd.2021.05.013" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059621003184?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275222000091?idApp=UINPBA00008Z" "url" => "/26662752/0000009700000002/v1_202204130559/S2666275222000091/v1_202204130559/pt/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S036505962100310X" "issn" => "03650596" "doi" => "10.1016/j.abd.2021.03.011" "estado" => "S300" "fechaPublicacion" => "2022-03-01" "aid" => "501" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Images in Dermatology</span>" "titulo" => "Scanning electron microscopy of panitumumab-induced eyelash and hair alterations – Pili canaliculi" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "240" "paginaFinal" => "242" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1710 "Ancho" => 1667 "Tamanyo" => 396565 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Scanning electron microscopy - Hair examination - small (A) and medium magnification (B), showing grooves in the hair shaft (×45, ×250).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Debora Sarzi Sartori, Antônia Larangeira de Almeida, Gabriel Santana Pereira de Oliveira, Hiram Larangeira de Almeida Jr" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Debora" "apellidos" => "Sarzi Sartori" ] 1 => array:2 [ "nombre" => "Antônia" "apellidos" => "Larangeira de Almeida" ] 2 => array:2 [ "nombre" => "Gabriel" "apellidos" => "Santana Pereira de Oliveira" ] 3 => array:2 [ "nombre" => "Hiram Larangeira" "apellidos" => "de Almeida Jr" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275222000017" "doi" => "10.1016/j.abdp.2022.01.001" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275222000017?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S036505962100310X?idApp=UINPBA00008Z" "url" => "/03650596/0000009700000002/v2_202204021027/S036505962100310X/v2_202204021027/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S036505962100307X" "issn" => "03650596" "doi" => "10.1016/j.abd.2020.09.016" "estado" => "S300" "fechaPublicacion" => "2022-03-01" "aid" => "498" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Tropical/Infectoparasitary Dermatology</span>" "titulo" => "Necrotic erythema nodosum reaction associated with histological alterations of Lucio’s phenomenon" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "231" "paginaFinal" => "235" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 2510 "Ancho" => 2508 "Tamanyo" => 1031714 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">(A), Necrosis of the epidermis and dense inflammatory infiltrate in the dermis are observed (Hematoxylin & eosin, ×10). (B), Neutrophilic infiltrate on the wall and around the vessels (Hematoxylin & eosin, ×40). (C), Vacuolated macrophages containing large amounts of intact and fragmented bacilli (Wade, ×40).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Larissa Daniele Machado Góes, Patrícia Motta de Morais, Paula Frassinetti Bessa Rebello, Antônio Pedro Mendes Schettini" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Larissa Daniele Machado" "apellidos" => "Góes" ] 1 => array:2 [ "nombre" => "Patrícia Motta de" "apellidos" => "Morais" ] 2 => array:2 [ "nombre" => "Paula Frassinetti Bessa" "apellidos" => "Rebello" ] 3 => array:2 [ "nombre" => "Antônio Pedro Mendes" "apellidos" => "Schettini" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275221003131" "doi" => "10.1016/j.abdp.2021.12.011" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275221003131?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S036505962100307X?idApp=UINPBA00008Z" "url" => "/03650596/0000009700000002/v2_202204021027/S036505962100307X/v2_202204021027/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Images in Dermatology</span>" "titulo" => "In vivo reflectance confocal microscopic findings in a case of trichofolliculoma" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "236" "paginaFinal" => "239" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Isil Karaarslan, Gokturk Oraloglu, Banu Yaman" "autores" => array:3 [ 0 => array:3 [ "nombre" => "Isil" "apellidos" => "Karaarslan" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:4 [ "nombre" => "Gokturk" "apellidos" => "Oraloglu" "email" => array:1 [ 0 => "gokturkoraloglu@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 2 => array:3 [ "nombre" => "Banu" "apellidos" => "Yaman" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Department of Dermatology, Medical Faculty, Ege University, Izmir, Turkey" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Pathology, Medical Faculty, Ege University, Izmir, Turkey" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1125 "Ancho" => 3007 "Tamanyo" => 310374 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A), A skin-colored, firm, non-tender papule with a diameter of 4 × 5 mm. (B), Whitish-pinkish homogenous structureless area on dermoscopy.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Case report</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 66-year-old man was referred to our department because of an asymptomatic slowly growing papule on the chin with 1-year of duration. Physical examination revealed a skin-colored, firm, non-tender papule measuring 4 × 5 mm (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A). The dermoscopic picture was non-specific with a whitish-pinkish homogenous structureless area. Prominent follicular openings and linear vessels on erythematous background were present on both lesional and peri-lesional sun-damaged skin (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B). In Reflectance Confocal Microscopy (RCM) evaluation (Vivascope 3000 Handheld; Mavig GmbH, Munich, Germany), a honeycomb pattern with mild disarray was seen at the epidermal level. There were no atypical cells. There were some bright inflammatory cells. The epidermal thickness was attenuated, and at the Dermoepidermal Junction (DEJ) rings were few and far between. The authors observed squamous hyperplasia forming irregular finger-like protrusions around the hair follicle and papillomatous hyperplasia in the hair follicle epithelium was seen (<a class="elsevierStyleCrossRefs" href="#fig0010">Figs. 2 and 3</a>). At the dermal level, coarse collagen fibers beneath the follicles were observed. On histopathology, multiple radiate small abortive hair follicles of varying degrees of maturity around a few central dilated primary follicles filled with loose keratin were seen. The abortive hair follicles were secondary or tertiary follicles consistent with the diagnosis of a trichofolliculoma. The stroma between the follicles was cellular, vascularized with some lymphoid cells. Some of the abortive hair follicles located beneath the epidermis. The epidermis was thin and rete ridges were flattened (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Discussion</span><p id="par0010" class="elsevierStylePara elsevierViewall">Trichofolliculoma is a rare follicular hamartoma mostly seen as a solitary asymptomatic, skin-colored, dome-shaped papule or nodule and usually affects the face and the scalp. The morphologic features of the lesion are generally non-distinctive unless it has a centrally located small tuft of hairs or a central pore.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Histopathological appearance is characteristic of one or more primary central dilated follicle(s) and multiple secondary and tertiary hair follicles budding outward centrifugally from the central one.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Correct clinical diagnosis of solitary non-pigmented lesions may be difficult, and in vivo diagnostic techniques have great importance in such cases. Dermoscopy has been widely used for decades in the the differential diagnosis of skin lesions, in most of which dermoscopic features have been described in detail. However, dermoscopic features of trichofolliculoma have been reported in only 3 cases until now.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3–5</span></a> In these cases, central brown zone with several radial dark brown projections lying towards the periphery (“firework” pattern), fine peripheral serpiginous vascularization with centripetal disposition, and a white-pink central area with shiny white structures, dotted vessels and a central scale were the reported dermoscopic features. In the present case, a whitish pinkish homogenous structureless area was the only dermoscopic finding which was not helpful in the diagnosis.</p><p id="par0020" class="elsevierStylePara elsevierViewall">RCM is another in vivo technique that has been relatively recently developed. It has advantages with giving cellular details of the upper layers of the skin and can be considered as “optical biopsy” of the living tissue. To the best of our knowledge, there has been no report on RCM features of trichofolliculoma.</p><p id="par0025" class="elsevierStylePara elsevierViewall">In the present case, squamous hyperplasia forming irregular finger-like protrusions around the hair follicle and papillomatous hyperplasia in the hair follicle epithelium was the RCM findings that were concordant with histology. This case suggests that RCM may help incorrect in vivo diagnosis of trichofolliculoma in cases difficult to diagnose by morphology and dermoscopy.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Financial support</span><p id="par0030" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Authors' contributions</span><p id="par0035" class="elsevierStylePara elsevierViewall">Isil Karaarslan: Data collection, or analysis and interpretation of data; Manuscript or critical review of important intellectual content; Effective participation in the research guidance; Critical review of the literature; Final approval of the final version of the manuscript.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Gokturk Oraloglu: Data collection, or analysis and interpretation of data; Manuscript or critical review of important intellectual content; Critical review of the literature; Final approval of the final version of the manuscript.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Banu Yaman: Data collection, or analysis and interpretation of data; Manuscript or critical review of important intellectual content; Effective participation in the research guidance; Critical review of the literature; Final approval of the final version of the manuscript.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conflicts of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:8 [ 0 => array:3 [ "identificador" => "xres1688463" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1497321" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "sec0005" "titulo" => "Case report" ] 3 => array:2 [ "identificador" => "sec0010" "titulo" => "Discussion" ] 4 => array:2 [ "identificador" => "sec0015" "titulo" => "Financial support" ] 5 => array:2 [ "identificador" => "sec0020" "titulo" => "Authors' contributions" ] 6 => array:2 [ "identificador" => "sec0025" "titulo" => "Conflicts of interest" ] 7 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2021-04-07" "fechaAceptado" => "2021-05-14" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1497321" "palabras" => array:4 [ 0 => "Adnexal and skin appendage" 1 => "Confocal microscopy" 2 => "Dermoscopy" 3 => "Neoplasms" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Trichofolliculoma is a rare follicular hamartoma whose dermoscopic features have been scarcely reported. On the other hand, reflectance confocal microscopy features have not been described yet. In the present study, the authors report reflectance confocal microscopy features in a case of trichofolliculoma as squamous hyperplasia forming irregular finger-like protrusions around the hair follicle and papillomatous hyperplasia of the hair follicle epithelium, which correlated with histopathology. This case suggests that reflectance confocal microscopy may help incorrect in vivo diagnosis of trichofolliculoma in cases difficult to diagnose by morphology and dermoscopy.</p></span>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Study conducted at the Medical Faculty, Ege University, Izmir, Turkey.</p>" ] ] "multimedia" => array:4 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1125 "Ancho" => 3007 "Tamanyo" => 310374 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A), A skin-colored, firm, non-tender papule with a diameter of 4 × 5 mm. (B), Whitish-pinkish homogenous structureless area on dermoscopy.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1576 "Ancho" => 3007 "Tamanyo" => 383082 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">(A), Squamous hyperplasia forming irregular finger-like protrusions around the hair follicle (B), Papillomatous hyperplasia in the hair follicle epithelium on reflectance confocal microscopy.</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 4174 "Ancho" => 721 "Tamanyo" => 376506 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">VivaStack imaging of the dilated follicule with finger-like protrusions around the follicle.</p>" ] ] 3 => array:8 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1110 "Ancho" => 3007 "Tamanyo" => 616801 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0020" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">(A), Multiple radiate small abortive hair follicles of varying maturity degrees around central located primary follicle (Hematoxylin & eosin ×100). (B), Some abortive hair follicles located beneath the epidermis (Hematoxylin & eosin ×100).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adnexal neoplasms" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T.H. McCalmont" 1 => "L.B. Pincus" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:6 [ "editores" => "J.L.Bolognia, J.V.Schaffer, L.Cerroni" "titulo" => "Dermatology" "paginaInicial" => "1930" "paginaFinal" => "1953" "edicion" => "4<span class="elsevierStyleSup">th</span> ed" "serieFecha" => "2018" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Skin adnexal tumors in plain language: a practical approach for the general surgical pathologist" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E.H. Fulton" 1 => "J.R. Kaley" 2 => "J.M. Gardner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5858/arpa.2018-0189-RA" "Revista" => array:6 [ "tituloSerie" => "Arch Pathol Lab Med." "fecha" => "2019" "volumen" => "143" "paginaInicial" => "832" "paginaFinal" => "851" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30638401" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The “firework” pattern in dermoscopy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "V. Panasiti" 1 => "V. Roberti" 2 => "P. Lieto" 3 => "B. Visconti" 4 => "S. Calvieri" 5 => "E. Perrella" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Int J Dermatol." "fecha" => "2013" "volumen" => "52" "paginaInicial" => "1158" "paginaFinal" => "1159" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Trichofolliculomes: revue rétrospective de 8 cas [Trichofolliculoma: a retrospective review of 8 cases]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.H. Jégou-Penouil" 1 => "C. Bourseau-Quetier" 2 => "S. Cajanus" 3 => "J.L. Rigon" 4 => "M. Risbourg" 5 => "N. Kluger" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.annder.2015.01.014" "Revista" => array:6 [ "tituloSerie" => "Ann Dermatol Venereol." "fecha" => "2015" "volumen" => "142" "paginaInicial" => "183" "paginaFinal" => "188" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25683009" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dermoscopy of trichofolliculoma: a rare hair follicle hamartoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.C. Garcia-Garcia" 1 => "A. Villarreal-Martinez" 2 => "G.A. Guerrero-Gonzalez" 3 => "I. Miranda-Maldonado" 4 => "J. Ocampo-Candiani" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Eur Acad Dermatol Venereol." "fecha" => "2017" "volumen" => "31" "paginaInicial" => "123" "paginaFinal" => "124" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03650596/0000009700000002/v2_202204021027/S0365059621003184/v2_202204021027/en/main.assets" "Apartado" => array:4 [ "identificador" => "80631" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Images in Dermatology" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009700000002/v2_202204021027/S0365059621003184/v2_202204021027/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059621003184?idApp=UINPBA00008Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 20 | 7 | 27 |
| 2024 October | 145 | 64 | 209 |
| 2024 September | 194 | 75 | 269 |
| 2024 August | 176 | 108 | 284 |
| 2024 July | 197 | 115 | 312 |
| 2024 June | 136 | 74 | 210 |
| 2024 May | 88 | 76 | 164 |
| 2024 April | 84 | 102 | 186 |
| 2024 March | 87 | 86 | 173 |
| 2024 February | 81 | 83 | 164 |
| 2024 January | 64 | 65 | 129 |
| 2023 December | 55 | 71 | 126 |
| 2023 November | 77 | 84 | 161 |
| 2023 October | 65 | 77 | 142 |
| 2023 September | 65 | 81 | 146 |
| 2023 August | 59 | 35 | 94 |
| 2023 July | 61 | 47 | 108 |
| 2023 June | 66 | 52 | 118 |
| 2023 May | 45 | 26 | 71 |
| 2023 April | 41 | 18 | 59 |
| 2023 March | 44 | 51 | 95 |
| 2023 February | 40 | 29 | 69 |
| 2023 January | 44 | 52 | 96 |
| 2022 December | 51 | 37 | 88 |
| 2022 November | 73 | 55 | 128 |
| 2022 October | 83 | 74 | 157 |
| 2022 September | 55 | 77 | 132 |
| 2022 August | 36 | 64 | 100 |
| 2022 July | 43 | 65 | 108 |
| 2022 June | 68 | 84 | 152 |
| 2022 May | 79 | 78 | 157 |
| 2022 April | 98 | 81 | 179 |
| 2022 March | 124 | 93 | 217 |
| 2022 February | 24 | 31 | 55 |
| 2022 January | 25 | 55 | 80 |
Show all
