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associated with a coagulation disorder&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Brazil persists with high incidence rates of leprosy&#46; Between 2014 and 2018&#44; the average detection rate was 13&#46;64 new cases for every 100&#44;000 inhabitants&#46; The high rate of endemicity reinforces the importance of establishing management measures to attain early detection&#44; minimizing deformities and physical disabilities&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The authors describe a case of lepromatous leprosy &#40;LL&#41; that was diagnosed in the presence of LP&#44; despite having been previously assisted at other health services&#44; showing an unfavorable outcome&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Case report</span><p id="par0025" class="elsevierStylePara elsevierViewall">A 69-year-old man presented with an infectious condition in his left leg for 15 days&#44; 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superficial and deep foamy macrophages&#44; full of bacilli&#44; forming globia&#44; in addition to neutrophils around and inside the vessel walls and presence of bacilli in the vessel lumen&#44; leukocytoclasia and extravasation of red blood cells&#44; characterizing leukocytoclastic vasculitis&#44; compatible with LP &#40;<a class="elsevierStyleCrossRefs" href="#fig0020">Figs&#46; 4 and 5</a>&#41;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><elsevierMultimedia ident="fig0025"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">After the histopathological examination&#44; the dose of prednisone was adjusted to 1&#8239;mg&#47;kg&#47;day and thalidomide 100&#8239;mg&#47;day was introduced&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Despite repeated surgical debridement to remove devitalized tissues and the use of broad-spectrum antibiotics such as vancomycin and piperacillin&#47;tazobactam&#44; the lesions persisted with the secretion of purulent-fibrinous material&#44; suggestive of secondary infection&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The patient developed persistent fever and worsening of the general status&#46; Because he had a recurrent pleural effusion&#44; he was submitted to bronchoscopy&#44; with alveolar bronchial lavage analysis&#44; wich revealed a weakly positive GeneXpert&#46; The RIPE regimen was prescribed&#59; however&#44; the patient died of probable sepsis due to a cutaneous focus on the third day&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Discussion</span><p id="par0060" class="elsevierStylePara elsevierViewall">The diagnosis of leprosy is essentially clinical and should be preferably performed during primary case assistance&#46; An early diagnosis prevents sequelae and interrupts the transmission chain&#46; However&#44; the varied clinical spectrum of the disease&#44; depending on the individual immune response&#44; makes diagnosis difficult by non-dermatologists&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3&#44;6</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">LP is a reaction condition characterized by outbreaks of erythematous&#44; painful&#44; slightly infiltrated macules&#44; and hemorrhagic bullae that progress to ulceration&#46; Several factors can precipitate it&#44; such as infections&#44; drugs&#44; and pregnancy&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4</span></a> It usually tends to progress with the formation of atrophic stellar scars&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;7</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">It usually appears three to four years after disease onset in untreated or inadequately treated patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> The evolution pattern usually starts in the lower limbs&#44; ascending to the buttocks&#44; upper limbs&#44; hands&#44; and rarely the back and face&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> A triad of diagnostic criteria define LP&#58; skin ulceration&#44; vascular thrombosis&#44; and invasion of the blood vessel wall by Hansen&#39;s bacilli&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">The pathophysiology of occlusive thrombi is yet to be completely elucidated&#44; and it may be due to two mechanisms&#44; one of which is the result of immune-mediated events&#44; whereas the other is a direct effect of the presence of <span class="elsevierStyleItalic">Mycobacterium leprae</span> itself in the vessel&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Ischemia&#44; infarction&#44; and tissue necrosis can occur as a result of these events&#44; including disseminated intravascular coagulation&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">There have been reports of gastrointestinal alterations in the presence of LP&#44; with the presence of necrotizing and ulcerative lesions in the digestive tract&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Therefore&#44; the parenteral administration of corticoids is recommended&#46; A controversial issue is recommending the use of thalidomide in cases in which LP occurs together with erythema nodosum leprosum &#40;ENL&#41;&#46; However&#44; there is no consensus in the literature regarding the use or not of thalidomide in patients without previous ENL&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4&#44;7</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">The presence of pleural effusions in LP patients has been confirmed in autopsies&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;9</span></a> GeneXpert detects the rpoB gene more specifically for <span class="elsevierStyleItalic">M&#46; tuberculosis</span>&#59; however&#44; weakly positive samples can occur in cases of leprosy with a high bacillary index&#46; A study by the Federal Drug Administration lists <span class="elsevierStyleItalic">M&#46; leprae</span> as potentially causing a GeneXpert cross-reaction&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> Therefore&#44; it is questionnable whether the pleural effusion&#44; in this case&#44; is also a manifestation of LP&#44; or a co-infection with other mycobacteria&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">This case report describes an undiagnosed LL patient&#44; which initially went untreated and that evolved with LP&#46; The unfavorable outcome described herein is relevant&#44; as it reinforces the need for continuing education of professionals working at all levels of healthy care&#44; aiming at attaining an early diagnosis of leprosy and immediate access to adequate treatment&#44; as well as the management of complications&#46; Likewise&#44; the importance of the dermatologists in the care team for treating leprosy and other dermatoses in the hospital environment is emphasized&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Financial support</span><p id="par0095" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Authors&#39; contributions</span><p id="par0100" class="elsevierStylePara elsevierViewall">Juliana Viana Pinheiro&#58; Drafting and editing of the manuscript&#59; intellectual participation in propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Maria Araci de Andrade Pontes&#58; Approval of the final version of the manuscript&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Jos&#233; Urbano de Medeiros Neto&#58; Approval of the final version of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Heitor de S&#225; Gon&#231;alves&#58; Approval of the final version of the manuscript&#59; effective participation in research orientation&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflicts of interest</span><p id="par0120" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Hansen&#237;ase"
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                        0 => array:2 [
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                          "autores" => array:5 [
                            0 => "H&#46;S&#46; Goncalves"
                            1 => "G&#46;O&#46; Penna"
                            2 => "M&#46;A&#46;A&#46; Pontes"
                            3 => "M&#46;M&#46;A&#46; Stefani"
                            4 => "S&#46; Talhari"
                          ]
                        ]
                      ]
                    ]
                  ]
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                        "titulo" => "Tratado de Dermatologia"
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                        "paginaFinal" => "1542"
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                        "serieFecha" => "2018"
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              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Lucio&#8217;s phenomenon &#40;necrotizing erythema&#41; in pregnancy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "K&#46;A&#46; Helmer"
                            1 => "I&#46; Fleischfresser"
                            2 => "L&#46;D&#46; Kucharski-Esmanhoto"
                            3 => "J&#46; Fillus Neto"
                            4 => "J&#46;R&#46; Santamaria"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "An Bras Dermatol&#46;"
                        "fecha" => "2004"
                        "volumen" => "79"
                        "paginaInicial" => "205"
                        "paginaFinal" => "210"
                      ]
                    ]
                  ]
                ]
              ]
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            2 => array:3 [
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              "etiqueta" => "3"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fatal Lucio&#8217;s phenomenom&#58; an autopsy case report"
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                          "autores" => array:3 [
                            0 => "F&#46;P&#46;F&#46; Campos"
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                            2 => "A&#46;N&#46; Duarte Neto"
                          ]
                        ]
                      ]
                    ]
                  ]
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                        "tituloSerie" => "Autopsy Case Report&#46;"
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                        "paginaFinal" => "19"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "4"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Revisiting Lucio&#8217;s leprosy and Lucio&#8217;s phenomenon"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Cutan Iber Lat Am&#46;"
                        "fecha" => "2005"
                        "volumen" => "33"
                        "paginaInicial" => "125"
                        "paginaFinal" => "133"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Secretaria de Vigil&#226;ncia em Sa&#250;de"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
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                      ]
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                    0 => array:1 [
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                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Peregrination &#40;Via Crucis&#41; to a diagnosis of leprosy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
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                            1 => "E&#46;P&#46;A&#46;A&#46; Rocha"
                            2 => "M&#46;C&#46;G&#46; Guerra"
                            3 => "M&#46;W&#46;L&#46; Coriolano"
                            4 => "E&#46;M&#46;R&#46; de Vasconcelos"
                            5 => "E&#46;N&#46; de Alencar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Enferm UERJ&#46;"
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                        "volumen" => "23"
                        "paginaInicial" => "185"
                        "paginaFinal" => "190"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lucio&#8217;s phenomenon&#58; another case reported in Brazil"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46; Monteiro"
                            1 => "M&#46;A&#46;M&#46;M&#46; de Abreu"
                            2 => "M&#46;G&#46; Tiezzi"
                            3 => "E&#46;V&#46;M&#46; Roncada"
                            4 => "C&#46;C&#46;M&#46; de Oliveira"
                            5 => "L&#46;C&#46;M&#46; Ortigosa"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1590/s0365-05962012000200017"
                      "Revista" => array:6 [
                        "tituloSerie" => "An Bras Dermatol&#46;"
                        "fecha" => "2012"
                        "volumen" => "87"
                        "paginaInicial" => "296"
                        "paginaFinal" => "300"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22570037"
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                ]
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              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Lucio&#8217;s phenomenon &#8211; case report"
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                          "autores" => array:3 [
                            0 => "R&#46;R&#46;C&#46;S&#46;S&#46; Soares"
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                            2 => "S&#46; Ura"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Hansenol Int&#46;"
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                        "paginaInicial" => "47"
                        "paginaFinal" => "51"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
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                      "titulo" => "Lucio&#8217;s phenomenon &#40;necrotizing erythema&#41;"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Hansenol&#46; Int&#46;"
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                        "paginaInicial" => "60"
                        "paginaFinal" => "65"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0050"
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Case Report
Lucius phenomenon: the importance of a primary dermatological care
Juliana Viana Pinheiro
Corresponding author
comunicacaoartigo@gmail.com

Corresponding author.
, Maria Araci de Andrade Pontes, José Urbano de Medeiros Neto, Heitor de Sá Gonçalves
Centro de Referência Nacional em Dermatologia Sanitária Dona Libânia, Fortaleza, CE, Brazil
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Leprosy is transmitted by <span class="elsevierStyleItalic">Mycobacterium leprae</span>&#46; The clinical picture and reaction states are influenced by the individual&#39;s immune response&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> There are two well-described forms of the reactions&#58; type 1 and type 2&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Lucius phenomenon &#40;LP&#41; is a rare&#44; severe&#44; and diffuse manifestation&#46; Difficulty in the classification of this condition has been going on for years&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Some authors consider it a variant of the type 2 reaction and others as a third reaction pattern&#44; associated with a coagulation disorder&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Brazil persists with high incidence rates of leprosy&#46; Between 2014 and 2018&#44; the average detection rate was 13&#46;64 new cases for every 100&#44;000 inhabitants&#46; The high rate of endemicity reinforces the importance of establishing management measures to attain early detection&#44; minimizing deformities and physical disabilities&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The authors describe a case of lepromatous leprosy &#40;LL&#41; that was diagnosed in the presence of LP&#44; despite having been previously assisted at other health services&#44; showing an unfavorable outcome&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Case report</span><p id="par0025" class="elsevierStylePara elsevierViewall">A 69-year-old man presented with an infectious condition in his left leg for 15 days&#44; associated with fever and chills&#46; He had received amoxicillin and clavulanate&#44; after an evaluation at a Basic Health Unit&#46; He developed painless polygonal blisters&#44; with spontaneous rupture and formation of ulcerated plaques with a necrotic background&#44; initially on the lower limbs&#44; with an ascending pattern&#46; He sought care at an Emergency Unit&#44; where treatment was initiated with meropenem&#44; followed by ceftriaxone associated with clindamycin&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">He was admitted to the general ward of a referral hospital for contagious infectious diseases with a diagnostic hypothesis of pharmacoderma&#44; with impaired general status and fever&#46; He reported reduced tactile sensitivity&#44; predominantly on the limbs&#46; Then&#44; the antibiotic regimen was suspended&#44; and prednisone was introduced at a dose of 40&#8239;mg&#47;day&#44; and a dermatology assessment was requested&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">On physical examination&#44; there were ulcerated plaques with a necrotic background&#44; with the presence of fibrin and purulent secretion&#44; affecting the lower limbs&#44; abdomen&#44; buttocks&#44; upper limbs&#44; ear pinnae&#44; and upper lip&#44; bilateral palpable and painful lymph nodes in the inguinal regions and scrotal sac edema &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1&#8211;3</a>&#41;&#46; Bilateral madarosis and burn injuries on the fingers were important findings&#44; which raised the hypothesis of leprosy&#44; and bacilloscopy of a dermal infiltrate was requested&#44; which showed a bacilloscopic index of 5&#46; Once the diagnosis was confirmed&#44; standard polychemotherapy for lepromatous leprosy was started&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">The histopathological examination of the biopsies performed at two sites showed an extensive dermal infiltrate predominantly consisting of interstitial&#44; superficial and deep foamy macrophages&#44; full of bacilli&#44; forming globia&#44; in addition to neutrophils around and inside the vessel walls and presence of bacilli in the vessel lumen&#44; leukocytoclasia and extravasation of red blood cells&#44; characterizing leukocytoclastic vasculitis&#44; compatible with LP &#40;<a class="elsevierStyleCrossRefs" href="#fig0020">Figs&#46; 4 and 5</a>&#41;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><elsevierMultimedia ident="fig0025"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">After the histopathological examination&#44; the dose of prednisone was adjusted to 1&#8239;mg&#47;kg&#47;day and thalidomide 100&#8239;mg&#47;day was introduced&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Despite repeated surgical debridement to remove devitalized tissues and the use of broad-spectrum antibiotics such as vancomycin and piperacillin&#47;tazobactam&#44; the lesions persisted with the secretion of purulent-fibrinous material&#44; suggestive of secondary infection&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The patient developed persistent fever and worsening of the general status&#46; Because he had a recurrent pleural effusion&#44; he was submitted to bronchoscopy&#44; with alveolar bronchial lavage analysis&#44; wich revealed a weakly positive GeneXpert&#46; The RIPE regimen was prescribed&#59; however&#44; the patient died of probable sepsis due to a cutaneous focus on the third day&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Discussion</span><p id="par0060" class="elsevierStylePara elsevierViewall">The diagnosis of leprosy is essentially clinical and should be preferably performed during primary case assistance&#46; An early diagnosis prevents sequelae and interrupts the transmission chain&#46; However&#44; the varied clinical spectrum of the disease&#44; depending on the individual immune response&#44; makes diagnosis difficult by non-dermatologists&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3&#44;6</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">LP is a reaction condition characterized by outbreaks of erythematous&#44; painful&#44; slightly infiltrated macules&#44; and hemorrhagic bullae that progress to ulceration&#46; Several factors can precipitate it&#44; such as infections&#44; drugs&#44; and pregnancy&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4</span></a> It usually tends to progress with the formation of atrophic stellar scars&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;7</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">It usually appears three to four years after disease onset in untreated or inadequately treated patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> The evolution pattern usually starts in the lower limbs&#44; ascending to the buttocks&#44; upper limbs&#44; hands&#44; and rarely the back and face&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> A triad of diagnostic criteria define LP&#58; skin ulceration&#44; vascular thrombosis&#44; and invasion of the blood vessel wall by Hansen&#39;s bacilli&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">The pathophysiology of occlusive thrombi is yet to be completely elucidated&#44; and it may be due to two mechanisms&#44; one of which is the result of immune-mediated events&#44; whereas the other is a direct effect of the presence of <span class="elsevierStyleItalic">Mycobacterium leprae</span> itself in the vessel&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Ischemia&#44; infarction&#44; and tissue necrosis can occur as a result of these events&#44; including disseminated intravascular coagulation&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">There have been reports of gastrointestinal alterations in the presence of LP&#44; with the presence of necrotizing and ulcerative lesions in the digestive tract&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Therefore&#44; the parenteral administration of corticoids is recommended&#46; A controversial issue is recommending the use of thalidomide in cases in which LP occurs together with erythema nodosum leprosum &#40;ENL&#41;&#46; However&#44; there is no consensus in the literature regarding the use or not of thalidomide in patients without previous ENL&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4&#44;7</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">The presence of pleural effusions in LP patients has been confirmed in autopsies&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;9</span></a> GeneXpert detects the rpoB gene more specifically for <span class="elsevierStyleItalic">M&#46; tuberculosis</span>&#59; however&#44; weakly positive samples can occur in cases of leprosy with a high bacillary index&#46; A study by the Federal Drug Administration lists <span class="elsevierStyleItalic">M&#46; leprae</span> as potentially causing a GeneXpert cross-reaction&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> Therefore&#44; it is questionnable whether the pleural effusion&#44; in this case&#44; is also a manifestation of LP&#44; or a co-infection with other mycobacteria&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">This case report describes an undiagnosed LL patient&#44; which initially went untreated and that evolved with LP&#46; The unfavorable outcome described herein is relevant&#44; as it reinforces the need for continuing education of professionals working at all levels of healthy care&#44; aiming at attaining an early diagnosis of leprosy and immediate access to adequate treatment&#44; as well as the management of complications&#46; Likewise&#44; the importance of the dermatologists in the care team for treating leprosy and other dermatoses in the hospital environment is emphasized&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Financial support</span><p id="par0095" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Authors&#39; contributions</span><p id="par0100" class="elsevierStylePara elsevierViewall">Juliana Viana Pinheiro&#58; Drafting and editing of the manuscript&#59; intellectual participation in propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Maria Araci de Andrade Pontes&#58; Approval of the final version of the manuscript&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Jos&#233; Urbano de Medeiros Neto&#58; Approval of the final version of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Heitor de S&#225; Gon&#231;alves&#58; Approval of the final version of the manuscript&#59; effective participation in research orientation&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflicts of interest</span><p id="par0120" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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                    0 => array:2 [
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                            0 => "H&#46;S&#46; Goncalves"
                            1 => "G&#46;O&#46; Penna"
                            2 => "M&#46;A&#46;A&#46; Pontes"
                            3 => "M&#46;M&#46;A&#46; Stefani"
                            4 => "S&#46; Talhari"
                          ]
                        ]
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                        "titulo" => "Tratado de Dermatologia"
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              "etiqueta" => "2"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "The Lucio&#8217;s phenomenon &#40;necrotizing erythema&#41; in pregnancy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
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                            2 => "L&#46;D&#46; Kucharski-Esmanhoto"
                            3 => "J&#46; Fillus Neto"
                            4 => "J&#46;R&#46; Santamaria"
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                  ]
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                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "An Bras Dermatol&#46;"
                        "fecha" => "2004"
                        "volumen" => "79"
                        "paginaInicial" => "205"
                        "paginaFinal" => "210"
                      ]
                    ]
                  ]
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                          "autores" => array:3 [
                            0 => "F&#46;P&#46;F&#46; Campos"
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                        "paginaFinal" => "19"
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                      "titulo" => "Revisiting Lucio&#8217;s leprosy and Lucio&#8217;s phenomenon"
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                          "autores" => array:2 [
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                        "tituloSerie" => "Med Cutan Iber Lat Am&#46;"
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                        "volumen" => "33"
                        "paginaInicial" => "125"
                        "paginaFinal" => "133"
                      ]
                    ]
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              ]
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              "etiqueta" => "5"
              "referencia" => array:1 [
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                      "titulo" => "Secretaria de Vigil&#226;ncia em Sa&#250;de"
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                          ]
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                      ]
                    ]
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                        "tituloSerie" => "Rev Enferm UERJ&#46;"
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                        "paginaInicial" => "185"
                        "paginaFinal" => "190"
                      ]
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                      "titulo" => "Lucio&#8217;s phenomenon&#58; another case reported in Brazil"
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                        "volumen" => "87"
                        "paginaInicial" => "296"
                        "paginaFinal" => "300"
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                  ]
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                        "tituloSerie" => "Hansenol Int&#46;"
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                    ]
                  ]
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                      "titulo" => "Lucio&#8217;s phenomenon &#40;necrotizing erythema&#41;"
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                        "paginaFinal" => "65"
                      ]
                    ]
                  ]
                ]
              ]
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Article information
ISSN: 03650596
Original language: English
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2024 November 8 8 16
2024 October 138 70 208
2024 September 163 82 245
2024 August 153 121 274
2024 July 148 110 258
2024 June 130 68 198
2024 May 119 78 197
2024 April 114 88 202
2024 March 96 86 182
2024 February 94 87 181
2024 January 95 71 166
2023 December 77 61 138
2023 November 94 77 171
2023 October 76 72 148
2023 September 83 82 165
2023 August 54 33 87
2023 July 82 44 126
2023 June 91 50 141
2023 May 51 49 100
2023 April 44 19 63
2023 March 77 57 134
2023 February 53 31 84
2023 January 57 46 103
2022 December 75 38 113
2022 November 82 68 150
2022 October 90 76 166
2022 September 63 70 133
2022 August 49 62 111
2022 July 56 69 125
2022 June 49 57 106
2022 May 61 52 113
2022 April 59 65 124
2022 March 69 86 155
2022 February 119 73 192
2022 January 127 116 243
2021 December 31 41 72
2021 November 12 21 33
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