Research Letter
Brazilian Consensus on Psoriasis 2020 and Treatment Algorithm of the Brazilian Society of Dermatology
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Duarte" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Ricardo" "apellidos" => "Romiti" "email" => array:1 [ 0 => "rromiti@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "André Vicente E. de" "apellidos" => "Carvalho" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Gleison V." "apellidos" => "Duarte" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:2 [ "colaborador" => "Grupo de Trabalho do Consenso Brasileiro de Psoríase da Sociedade Brasileira de Dermatologia" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "fn0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Dermatology Department of Hospital das Clínicas da Universidade de São Paulo, SP, Brazil" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Hospital Moinhos de Vento de Porto Alegre, Porto Alegre, RS, Brazil" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Instituto Bahiano de Imunoterapias, Salvador, BA, Brazil" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1651 "Ancho" => 2925 "Tamanyo" => 356298 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Algorithm for the Treatment of Severe Psoriasis of the Brazilian Society of Dermatology, 2020.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The elucidation of pathophysiological mechanisms and the development of new treatments for psoriasis require periodic updates in the publication of consensuses, algorithms and treatment guides.</p><p id="par0010" class="elsevierStylePara elsevierViewall">In Brazil, the ethnic composition, increased longevity, in addition to climatic and insolation characteristics may imply unique epidemiological data and different regional prevalence rates of psoriasis, in addition to influence disease severity and therapeutic response. Recent data from the Brazilian Society of Dermatology estimate the prevalence of psoriasis in Brazil at 1.31%, with 1.15% (95% CI 0.90% to 1.43%) in women and 1.47% (95% CI 1.11% to 1.82%) in men (p = 0.22). An increase in the prevalence of psoriasis (p < 0.01) was identified in relation to age groups, which was 0.58% (95% CI 0.31% to 0.84%) under the age of 30; 1.39% (95% CI 1.10% to 1.74%) between 30 and 60 years old; and 2.29% (95% CI 1.71% to 2.84%) in individuals over 60 years. The geographical regions of the country differed in terms of disease prevalence (p = 0.02), with higher indicators in the South and Southeast regions, in contrast to the Midwest, North and Northeast regions.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">In parallel, 73.4% of Brazilian patients with moderate to severe psoriasis report impaired health-related quality of life.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The Brazilian Consensus on Psoriasis 2020 and the Treatment Algorithm of the Brazilian Society of Dermatology (SBD), created with the collaboration of experts from all regions of Brazil is shown below (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">In preparing this consensus, the stratification of the levels of evidence and their grade of recommendation was used, according to the project guidelines of the Brazilian Medical Association (AMB), described below:</p><p id="par0030" class="elsevierStylePara elsevierViewall">Grade of recommendation and strength of evidence<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">A: Experimental or observational studies of higher consistency.</p><p id="par0040" class="elsevierStylePara elsevierViewall">B: Experimental or observational studies of lower consistency.</p><p id="par0045" class="elsevierStylePara elsevierViewall">C: Case reports (uncontrolled studies).</p><p id="par0050" class="elsevierStylePara elsevierViewall">D: Opinion without critical evaluation consensus based, physiological studies or animal models.</p><p id="par0055" class="elsevierStylePara elsevierViewall">In this document, we use the Delphi tool to obtain answers to non-consensual questions in the literature, through the anonymous collection of data among specialists on the subject. The Delphi method is defined as “a data collection technique used to obtain consensus from a group of experts on a particular subject”.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Thus, a new treatment flowchart for severe psoriasis was validated and strategies were defined for the migration of therapies, designed for adoption in the Brazilian public or private health context, based on hearing the opinions of experts engaged in these health systems (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">Two rounds were held with the participation of 66 dermatologists who authored this consensus, from all regions of the country, with experience in the treatment of psoriasis. The online voting system (Survey Monkey®) was used, and the agreement of at least 70% of the experts was considered a consensus. The data obtained were statistically analyzed. The sample was obtained by appointment and submitted to a randomness test, which resulted in the non-rejection of randomness, with a significance of 5%. The results are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">Mediated by the Brazilian Society of Dermatology, this instrument represents progress in the standardization of conduct, whether in public or private care, based on what we have available or aspire for the treatment of severe psoriasis. The existence of dissensus stimulates further debate on controversial and unanswered topics in the medical literature.</p><p id="par0070" class="elsevierStylePara elsevierViewall">The high percentage of agreement in the other topics provides subsidies to professionals working in the area for the best therapeutic choices, instead of decisions based solely on the prescriber's experience. Such transparency is essential for everyone involved, whether managers of the supplementary health system or the Brazilian Unified Health System (SUS), physicians, patients, their families, and patient associations.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0075" class="elsevierStylePara elsevierViewall">Brazilian Society of Dermatology (SBD).</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors' contributions</span><p id="par0080" class="elsevierStylePara elsevierViewall">Ricardo Romiti: Design and planning of the study; data collection, or data analysis and interpretation; statistical analysis; drafting and editing of the manuscript or critical review of important intellectual content; collection, analysis, and interpretation of data; effective participation in research orientation; critical review of the literature; approval of the final version of the manuscript.</p><p id="par0085" class="elsevierStylePara elsevierViewall">André Vicente Esteves de Carvalho: Design and planning of the study; data collection, or data analysis and interpretation; statistical analysis; drafting and editing of the manuscript or critical review of important intellectual content; collection, analysis, and interpretation of data; effective participation in research orientation; critical review of the literature; approval of the final version of the manuscript.</p><p id="par0090" class="elsevierStylePara elsevierViewall">Gleison V Duarte: Design and planning of the study; data collection, or data analysis and interpretation; statistical analysis; drafting and editing of the manuscript or critical review of important intellectual content; collection, analysis, and interpretation of data; effective participation in research orientation; critical review of the literature; approval of the final version of the manuscript.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflict of interest</span><p id="par0095" class="elsevierStylePara elsevierViewall">Romiti R is/has served as a scientific consultant, speaker, or clinical study investigator for Abbvie, Boehringer-Ingelheim, Galderma, Janssen, Lilly, Leo-Pharma, Novartis, Pierre-Fabre, Pfizer, UCB, and TEVA.Carvalho AVE is/has served as a scientific consultant, speaker, or clinical study investigator for Abbvie, Boehringer-Ingelheim, Janssen, Lilly, Leo-Pharma, Novartis, and UCB.Duarte GV is/has served as a scientific consultant, speaker, or clinical study investigator for Abbvie, Bayer, Janssen, Leo-Pharma, Galderma, Novartis, Pfizer, and UCB.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Financial support" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Authors' contributions" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Conflict of interest" ] 3 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2021-02-20" "fechaAceptado" => "2021-03-07" "NotaPie" => array:3 [ 0 => array:3 [ "etiqueta" => "1" "nota" => "<p class="elsevierStyleNotepara" id="npar0015">The list of participants is available in Appendix <a class="elsevierStyleCrossRef" href="#sec0020">A</a>.</p>" "identificador" => "fn0005" ] 1 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">How to cite this article: Romiti R, Carvalho AVE, Duarte GV; Grupo de Trabalho do Consenso Brasileiro de Psoríase da Sociedade Brasileira de Dermatologia. Brazilian Consensus on Psoriasis 2020 and Treatment Algorithm of the Brazilian Society of Dermatology. An Bras Dermatol. 2021;96:778–81.</p>" ] 2 => array:2 [ "etiqueta" => "☆☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Study conducted at the Dermatology Department of Hospital das Clínicas da Universidade de São Paulo, São Paulo, SP; Hospital Moinhos de Vento de Porto Alegre, Porto Alegre, RS; Instituto Bahiano de Imunoterapias, Salvador, BA, Brazil.</p>" ] ] "apendice" => array:1 [ 0 => array:1 [ "seccion" => array:1 [ 0 => array:4 [ "apendice" => "<p id="par0100" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></p>" "etiqueta" => "Appendix A" "titulo" => "Members of the Working Group of the Brazilian Consensus on Psoriasis of the Brazilian Society of Dermatology" "identificador" => "sec0020" ] ] ] ] "multimedia" => array:4 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1783 "Ancho" => 3167 "Tamanyo" => 209973 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Geographical distribution of Brazilian experts participating in the Brazilian Consensus on Psoriasis 2020.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1651 "Ancho" => 2925 "Tamanyo" => 356298 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Algorithm for the Treatment of Severe Psoriasis of the Brazilian Society of Dermatology, 2020.</p>" ] ] 2 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Classification of respondents' opinions, per question, Brazil – 2020</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Consensus criterion: 70% of agreement or more.</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Questions \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Answers with the highest percentage of agreement \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Classification \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Q1: What is the criterion for changing from one therapy to another? \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Unavailability, intolerance, failure or absolute or relative contraindication \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Consensus \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Q2: What to do if the patient does not reach PASI 50 and DLQI < 5 (primary failure) with oral methotrexate at a dose of 15 mg/week within 8 weeks, with full access/availability?</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1. Medication change: 54% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowgroup " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Dissensus</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 MTX dose optimization up to 25 mg/week, regardless of administration route: 46% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Q3: If the patient does not reach PASI 75 and DLQI < 5 (secondary failure) with oral methotrexate at a dose of 15 mg/week within 8 weeks, what is the suggested approach when there is full access/availability? \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">MTX dose optimization up to 25 mg/week, regardless of administration route (oral/parenteral) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Consensus \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Q4: If the patient does not reach PASI 50 and DLQI < 5, acitretin failure should be considered after: \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12–16 weeks \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Consensus \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Q5: If the patient does not reach PASI 50 and DLQI < 5, primary failure of cyclosporine (up to 5 mg/kg) should be considered in: \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Up to 4 weeks \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Consensus \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Q6: What is the therapeutic goal to be achieved in patients using biologicals? \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PASI 90 or absolute PASI <3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Consensus \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Q7: What is your degree of agreement with the sentence: "In patients with primary failure with an immunobiological, the medication should be changed to another one with a different mechanism of action"? \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">70% of agreement \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Consensus \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Q8: What is your degree of agreement with the sentence: "Patients with secondary failure with a biological mechanism of action can benefit from a change to a drug of the same class"? \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">51% of agreement \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Dissensus \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Q9: From 1–10 what is your degree of agreement with the proposed flowchart? (1 = strongly disagree; 10 = strongly agree). \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">86.4% of agreement \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Consensus \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2749606.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Classification of respondents' opinions, per question, Brazil – 2020. Source: Study data.</p>" ] ] 3 => array:5 [ "identificador" => "tbl0010" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => false "mostrarDisplay" => true "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Authors of the Brazilian Consensus on Psoriasis 2020 \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Silvio Alencar Marques (SP), Luciane D. B. Miot (SP), Maria Cecilia de C. Bortoletto (SP), Arnóbio da Penha Pachêco (RN), Adriane Reichert Faria (PR), Caio Cesar S. de Castro (PR), Luciena C. Martins Ortigosa (SP), Xinaida Lima (CE), Sueli Carneiro (RJ), Marcelo Pinheiro (SP), Mayra Ianhez (GO), Monica Nunes de Souza Santos (AM), Roberta Buense Bedrikow (SP), Rosana Lazzarini (SP), João Carlos R. Avelleira (RJ), Aline Bressan (RJ), André Luís da Silva Hirayama (SP), Sineida B. Ferreira (PR), Adriana M. Porro (SP), Alexandre Gripp (RJ), Ivonise Follador (BA), Juliana Nakano (SP), Andréa Machado C. Ramos (MG), Aripuanã Terena (MG), Francisca Regina O. Carneiro (PA), Vivianne Lira da C. Costa (RN), Anber A. Tanaka (PR), Lincoln Fabricio (PR), Leticia Oba Galvão (DF), Gladys A. Martins (DF), Ricardo Romiti (SP), Clarice Kobata (SP), Michelle dos Santos Diniz (MG), Cacilda da Silva Souza (SP), Renata F. Magalhães (SP), Dimitri Luz (SP), André Vicente E. de Carvalho (RS), Jaquelini Silva (RS), Claudia Maia (RJ), Paulo A. Oldani Felix (RJ), Wagner Galvão (SP), Maria Victoria Suárez Restrepo (SP), Cynthia C. F. Mota (SP), Eduardo L. Martins (SP), Daniel H. Nunes (SC), Andreia Costa (SP), Mauricio Conti (SC), Esther B. Palitot (PB), Ana Carolina B Arruda (SP), Claudio Lerer (DF), Livia Souto (RJ), Roberto Souto (RJ), Jane Bonfá (RJ), Verônica Bogado (RJ), Sidney Augusto da C. Costa (RN), Domingos Jordão Neto (SP), Luiza O. Keiko (SP), Bruna Falcone (SP), Luna Azulay Abulafia (RJ), Aldejane Gurgel de A. Rodrigues (PE), Tania F. Cestari (RS), Juliana Bozza (RS), Marcelo Arnone (SP), Maria Denise F. Takahashi (SP), Heitor de Sá Gonçalves (CE), Paulo Eduardo de Sá Gonçalves (CE), Gleison V. Duarte (BA), Maria de Fátima S. Paim de Oliveira (BA). \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2749605.png" ] ] ] ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of psoriasis in Brazil – a geographical survey" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Romiti" 1 => "M. Amone" 2 => "A. Menter" 3 => "H.A. Miot" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Int J Dermatol." 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Sun" 2 => "Chih-An" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11739-014-1156-6" "Revista" => array:6 [ "tituloSerie" => "Intern Emerg Med" "fecha" => "2015" "volumen" => "10" "paginaInicial" => "373" "paginaFinal" => "383" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25430678" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03650596/0000009600000006/v2_202111180901/S0365059621002154/v2_202111180901/en/main.assets" "Apartado" => array:4 [ "identificador" => "82768" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Research Letter" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009600000006/v2_202111180901/S0365059621002154/v2_202111180901/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059621002154?idApp=UINPBA00008Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 7 | 0 | 7 |
| 2024 October | 140 | 72 | 212 |
| 2024 September | 159 | 78 | 237 |
| 2024 August | 172 | 114 | 286 |
| 2024 July | 175 | 110 | 285 |
| 2024 June | 145 | 64 | 209 |
| 2024 May | 128 | 69 | 197 |
| 2024 April | 185 | 94 | 279 |
| 2024 March | 130 | 65 | 195 |
| 2024 February | 132 | 82 | 214 |
| 2024 January | 99 | 71 | 170 |
| 2023 December | 76 | 58 | 134 |
| 2023 November | 151 | 98 | 249 |
| 2023 October | 115 | 83 | 198 |
| 2023 September | 177 | 84 | 261 |
| 2023 August | 72 | 38 | 110 |
| 2023 July | 82 | 25 | 107 |
| 2023 June | 100 | 33 | 133 |
| 2023 May | 81 | 28 | 109 |
| 2023 April | 67 | 15 | 82 |
| 2023 March | 87 | 48 | 135 |
| 2023 February | 68 | 34 | 102 |
| 2023 January | 62 | 59 | 121 |
| 2022 December | 63 | 35 | 98 |
| 2022 November | 96 | 62 | 158 |
| 2022 October | 105 | 64 | 169 |
| 2022 September | 64 | 70 | 134 |
| 2022 August | 53 | 43 | 96 |
| 2022 July | 48 | 62 | 110 |
| 2022 June | 58 | 53 | 111 |
| 2022 May | 53 | 68 | 121 |
| 2022 April | 61 | 61 | 122 |
| 2022 March | 72 | 73 | 145 |
| 2022 February | 46 | 43 | 89 |
| 2022 January | 108 | 109 | 217 |
| 2021 December | 181 | 103 | 284 |
| 2021 November | 152 | 107 | 259 |
| 2021 October | 44 | 57 | 101 |
| 2021 September | 14 | 16 | 30 |
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