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which was detected during medical consultation and without a history of growth&#46; Dermoscopy disclosed areas of peppering in the periphery&#44; irregular edges&#44; and a bluish-gray veil &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; No hardened or enlarged lymph nodes were found during palpation&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">An excisional biopsy with a 2-mm margin was performed&#44; considering the hypothesis of melanoma&#44; and the histopathological examination revealed multiple aggregates of melanophages in the reticular dermis &#40;Clark III&#41;&#44; better observed after counterstaining with Giemsa &#40;<a class="elsevierStyleCrossRefs" href="#fig0010">Figs&#46; 2 and 3</a>&#41;&#46; The diagnosis of tumoral melanosis was established and a choice was made for enlargement with margins measuring 2&#8239;cm in diameter&#46; Clinical examination and total body computed tomography did not disclose metastatic lesions&#46; An abdominal and lymph node ultrasonography was performed&#44; which did not disclose the presence of enlargement or signs of metastasis&#46; The patient was maintained under clinical follow-up every three months&#44; for three consecutive years&#44; with no signs of local recurrence of the lesion or metastasis&#44; confirmed by clinical and ultrasonographic examination&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Regression is a common occurrence in melanocytic neoplasias and is expected to occur in approximately 30&#37; of cases&#46; It usually occurs focally and seems to have little or no effect on the prognosis of an excised melanoma&#46; However&#44; extensive areas of regression are associated with a worse prognosis&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Since tumoral melanosis represents complete regression of atypical melanocytic cells&#44; they can also be found in lymph nodes with clinical signs of metastasis&#46; Tumoral melanosis has also been reported following treatment of metastatic melanoma with monoclonal antibodies &#40;e&#46;g&#46;&#44; dabrafenib&#47;trametinib&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Conflicting data have been reported in the literature on the prognostic effect of regression on melanoma&#46; It is suggested that partial regression in less than 50&#37;&#8211;75&#37; of tumor cells does not affect prognosis&#44; whereas complete or extensive regression above this percentage of tumor tissue is associated with metastatic disease&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The level of melanophage infiltrate is commonly correlated with the invasiveness of the previous lesion&#44; in addition to other histopathological signs&#44; such as solar elastosis in tumoral melanosis&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> In the present case&#44; although the melanophages are located in the dermis &#8211; without contact with the epidermis&#44; which makes it difficult to state that it was a primary lesion &#8211; it is believed that the patient had a thin melanoma that progressed into complete regression&#44; explaining the follow-up without recurrence or metastasis for a period of three years&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The present case highlights the importance of knowing the unusual histopathology of this lesion and calls attention for the necessity of a close follow-up&#44; even in cases with an apparent good evolution&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0040" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors&#8217; contributions</span><p id="par0045" class="elsevierStylePara elsevierViewall">Anna Carolina Miola&#58; Approval of the final version of the manuscript&#59; drafting and editing of the manuscript&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Ana Claudia Cavalcante Esposito&#58; Approval of the final version of the manuscript&#59; drafting and editing of the manuscript&#59; critical review of the literature&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Hamilton Ometto Stolf&#58; Approval of the final version of the manuscript&#59; drafting and editing of the manuscript&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Helio Amante Miot&#58; Approval of the final version of the manuscript&#59; drafting and editing of the manuscript&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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Case Letter
Tumoral melanosis without metastasis: a report after three years of follow-up
Anna Carolina Miolaa,
Corresponding author
anna.c.miola@unesp.br

Corresponding author.
, Ana Claudia Cavalcante Espositoa, Hamilton Ometto Stolfa,b, Helio Amante Miota
a Faculty of Medicine, Universidade Estadual Paulista, Botucatu, SP, Brazil
b Dermatology Discipline, Universidade Estadual de Campinas, Campinas, SP, Brazil
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Tumoral melanosis is a rare clinical manifestation of a completely regressed melanoma&#44; usually represented by a pigmented lesion clinically suspected of invasive melanoma&#46; The histopathological examination shows a dense dermal melanophage infiltrate but no atypical melanocytes&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The prognosis for this unusual entity is uncertain&#44; but metastases have been described during follow-up or even at the diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">This is the report of a white female patient&#44; aged 56 years&#44; with no previous history of sunburns and with a dark pigmented lesion on the back&#44; measuring 1&#46;2&#8239;cm in diameter and showing a hypopigmented halo&#44; which was detected during medical consultation and without a history of growth&#46; Dermoscopy disclosed areas of peppering in the periphery&#44; irregular edges&#44; and a bluish-gray veil &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; No hardened or enlarged lymph nodes were found during palpation&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">An excisional biopsy with a 2-mm margin was performed&#44; considering the hypothesis of melanoma&#44; and the histopathological examination revealed multiple aggregates of melanophages in the reticular dermis &#40;Clark III&#41;&#44; better observed after counterstaining with Giemsa &#40;<a class="elsevierStyleCrossRefs" href="#fig0010">Figs&#46; 2 and 3</a>&#41;&#46; The diagnosis of tumoral melanosis was established and a choice was made for enlargement with margins measuring 2&#8239;cm in diameter&#46; Clinical examination and total body computed tomography did not disclose metastatic lesions&#46; An abdominal and lymph node ultrasonography was performed&#44; which did not disclose the presence of enlargement or signs of metastasis&#46; The patient was maintained under clinical follow-up every three months&#44; for three consecutive years&#44; with no signs of local recurrence of the lesion or metastasis&#44; confirmed by clinical and ultrasonographic examination&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Regression is a common occurrence in melanocytic neoplasias and is expected to occur in approximately 30&#37; of cases&#46; It usually occurs focally and seems to have little or no effect on the prognosis of an excised melanoma&#46; However&#44; extensive areas of regression are associated with a worse prognosis&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Since tumoral melanosis represents complete regression of atypical melanocytic cells&#44; they can also be found in lymph nodes with clinical signs of metastasis&#46; Tumoral melanosis has also been reported following treatment of metastatic melanoma with monoclonal antibodies &#40;e&#46;g&#46;&#44; dabrafenib&#47;trametinib&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Conflicting data have been reported in the literature on the prognostic effect of regression on melanoma&#46; It is suggested that partial regression in less than 50&#37;&#8211;75&#37; of tumor cells does not affect prognosis&#44; whereas complete or extensive regression above this percentage of tumor tissue is associated with metastatic disease&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The level of melanophage infiltrate is commonly correlated with the invasiveness of the previous lesion&#44; in addition to other histopathological signs&#44; such as solar elastosis in tumoral melanosis&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> In the present case&#44; although the melanophages are located in the dermis &#8211; without contact with the epidermis&#44; which makes it difficult to state that it was a primary lesion &#8211; it is believed that the patient had a thin melanoma that progressed into complete regression&#44; explaining the follow-up without recurrence or metastasis for a period of three years&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The present case highlights the importance of knowing the unusual histopathology of this lesion and calls attention for the necessity of a close follow-up&#44; even in cases with an apparent good evolution&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0040" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors&#8217; contributions</span><p id="par0045" class="elsevierStylePara elsevierViewall">Anna Carolina Miola&#58; Approval of the final version of the manuscript&#59; drafting and editing of the manuscript&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Ana Claudia Cavalcante Esposito&#58; Approval of the final version of the manuscript&#59; drafting and editing of the manuscript&#59; critical review of the literature&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Hamilton Ometto Stolf&#58; Approval of the final version of the manuscript&#59; drafting and editing of the manuscript&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Helio Amante Miot&#58; Approval of the final version of the manuscript&#59; drafting and editing of the manuscript&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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Article information
ISSN: 03650596
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