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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 3-year-old girl presented with an asymptomatic lesion on the left upper arm of 2 years&#8217; duration&#46; The lesion started as a papule at the site of Bacillus Calmette-Gu&#233;rin &#40;BCG&#41; vaccination scar at the age of 1 year and gradually enlarged to its present size&#46; She had no constitutional symptoms and was otherwise well&#46; There was no history of contact with an active case of Tuberculosis &#40;TB&#41;&#46; General and systemic examinations were normal&#46; Cutaneous examination revealed an erythematous plaque measuring 5&#215;4&#160;cm with thick adherent scales and fingerlike extensions on the left deltoid region &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Clinical differential diagnoses considered were BCG vaccine-induced lupus vulgaris&#44; chromoblastomycosis&#44; psoriasis&#44; and discoid lupus erythematosus&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Routine hematological investigations showed a raised erythrocyte sedimentation rate&#46; Her chest X-Ray was normal&#46; Serology for HIV was negative&#46; A skin biopsy of the plaque revealed non-caseating epithelioid cell granulomas with a rim of lymphocytes in the upper and mid dermis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Acid-fast bacilli and periodic acid-Schiff staining of biopsy specimen were negative&#46; Cultures of the skin biopsy were also negative for mycobacteria and fungi&#46; Mycobacterium &#40;M&#41; tuberculosis complex DNA detection via Polymerase Chain Reaction &#40;PCR&#41; of the biopsy specimen was negative&#46; Interferon-gamma release assay using the Quantiferon TB gold test was also negative&#46; Based on the site of lesion&#44; clinical morphology&#44; and presence of epithelioid cell granulomas in histopathology&#44; the possibility of BCG vaccine-induced lupus vulgaris was considered and a trial of antitubercular therapy was commenced&#46; <span class="elsevierStyleItalic">M&#46; bovis</span> is inherently resistant to pyrazinamide and ethambutol is avoided in children due to its ophthalmologic side effects&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The child thus received a regimen consisting of rifampicin &#40;6&#160;mg&#47;kg&#47;day&#41; and isoniazid &#40;5&#160;mg&#47;kg&#47;day&#41; from the Pediatric Infectious Disease unit&#46; The lesion healed completely after 2 months of therapy &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; A final diagnosis of BCG vaccine-induced lupus vulgaris was thus made&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The BCG vaccine is composed of a live attenuated strain of <span class="elsevierStyleItalic">M&#46; bovis</span>&#46; It is routinely administered to all neonates in high endemic countries to prevent the more serious forms of tubercular infections such as meningoencephalitis and miliary tuberculosis in children&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Cutaneous complications of the BCG vaccine in the immunocompetent host include the common local reaction to the vaccine and uncommon reactions&#46; The local reaction occurs 2&#8211;6 weeks post-vaccination as a small papule that may discharge purulent material&#44; enlarge to form a shallow ulcer which scars&#46; The rare complications include BCG granuloma&#44; injection site keloids&#44; lupus vulgaris&#44; scrofuloderma&#44; tuberculids&#44; fixed drug eruption&#44; and BCG granulomas occurring during the course of Kawasaki disease&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">BCG vaccine-induced lupus vulgaris occurs in 5 per million vaccinations&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> It is commoner after multiple vaccinations and usually manifests after 1 year of vaccination&#46; Lupus vulgaris is a paucibacillary form of cutaneous tuberculosis that occurs either via hematogenous spread or direct inoculation&#46; A skin biopsy is helpful in obtaining a histopathological diagnosis&#46; Other confirmatory tests for tuberculosis may be inconclusive as in our patient&#46; A high index of suspicion is required for the diagnosis and a trial of antitubercular drugs is warranted&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0030" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors&#8217; contributions</span><p id="par0035" class="elsevierStylePara elsevierViewall">Nisha V Parmar&#58; Conception and planning of the study&#59; critical review of the literature&#59; obtaining&#44; analysis&#44; and interpretation of the data&#59; elaboration and writing of the manuscript&#59; critical review of the manuscript&#46; approval of the final version of the manuscript&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Amani AlFalasi&#58; Approval of the final version of the manuscript&#59; obtaining&#44; analysis&#44; and interpretation of the data&#59; critical review of the manuscript&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Alia AlMualla&#58; Approval of the final version of the manuscript&#59; obtaining&#44; analysis&#44; and interpretation of the data&#59; critical review of the manuscript&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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Case Letter
Bacillus Calmette-Guérin vaccine-induced lupus vulgaris in a 3-year-old child
Nisha V. Parmar
Corresponding author
parmarnish@gmail.com

Corresponding author.
, Amani Al Falasi, Alia Almualla
Dermatology Centre, Dubai Health Authority, Dubai, United Arab Emirates
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 3-year-old girl presented with an asymptomatic lesion on the left upper arm of 2 years&#8217; duration&#46; The lesion started as a papule at the site of Bacillus Calmette-Gu&#233;rin &#40;BCG&#41; vaccination scar at the age of 1 year and gradually enlarged to its present size&#46; She had no constitutional symptoms and was otherwise well&#46; There was no history of contact with an active case of Tuberculosis &#40;TB&#41;&#46; General and systemic examinations were normal&#46; Cutaneous examination revealed an erythematous plaque measuring 5&#215;4&#160;cm with thick adherent scales and fingerlike extensions on the left deltoid region &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Clinical differential diagnoses considered were BCG vaccine-induced lupus vulgaris&#44; chromoblastomycosis&#44; psoriasis&#44; and discoid lupus erythematosus&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Routine hematological investigations showed a raised erythrocyte sedimentation rate&#46; Her chest X-Ray was normal&#46; Serology for HIV was negative&#46; A skin biopsy of the plaque revealed non-caseating epithelioid cell granulomas with a rim of lymphocytes in the upper and mid dermis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Acid-fast bacilli and periodic acid-Schiff staining of biopsy specimen were negative&#46; Cultures of the skin biopsy were also negative for mycobacteria and fungi&#46; Mycobacterium &#40;M&#41; tuberculosis complex DNA detection via Polymerase Chain Reaction &#40;PCR&#41; of the biopsy specimen was negative&#46; Interferon-gamma release assay using the Quantiferon TB gold test was also negative&#46; Based on the site of lesion&#44; clinical morphology&#44; and presence of epithelioid cell granulomas in histopathology&#44; the possibility of BCG vaccine-induced lupus vulgaris was considered and a trial of antitubercular therapy was commenced&#46; <span class="elsevierStyleItalic">M&#46; bovis</span> is inherently resistant to pyrazinamide and ethambutol is avoided in children due to its ophthalmologic side effects&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The child thus received a regimen consisting of rifampicin &#40;6&#160;mg&#47;kg&#47;day&#41; and isoniazid &#40;5&#160;mg&#47;kg&#47;day&#41; from the Pediatric Infectious Disease unit&#46; The lesion healed completely after 2 months of therapy &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; A final diagnosis of BCG vaccine-induced lupus vulgaris was thus made&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The BCG vaccine is composed of a live attenuated strain of <span class="elsevierStyleItalic">M&#46; bovis</span>&#46; It is routinely administered to all neonates in high endemic countries to prevent the more serious forms of tubercular infections such as meningoencephalitis and miliary tuberculosis in children&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Cutaneous complications of the BCG vaccine in the immunocompetent host include the common local reaction to the vaccine and uncommon reactions&#46; The local reaction occurs 2&#8211;6 weeks post-vaccination as a small papule that may discharge purulent material&#44; enlarge to form a shallow ulcer which scars&#46; The rare complications include BCG granuloma&#44; injection site keloids&#44; lupus vulgaris&#44; scrofuloderma&#44; tuberculids&#44; fixed drug eruption&#44; and BCG granulomas occurring during the course of Kawasaki disease&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">BCG vaccine-induced lupus vulgaris occurs in 5 per million vaccinations&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> It is commoner after multiple vaccinations and usually manifests after 1 year of vaccination&#46; Lupus vulgaris is a paucibacillary form of cutaneous tuberculosis that occurs either via hematogenous spread or direct inoculation&#46; A skin biopsy is helpful in obtaining a histopathological diagnosis&#46; Other confirmatory tests for tuberculosis may be inconclusive as in our patient&#46; A high index of suspicion is required for the diagnosis and a trial of antitubercular drugs is warranted&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0030" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors&#8217; contributions</span><p id="par0035" class="elsevierStylePara elsevierViewall">Nisha V Parmar&#58; Conception and planning of the study&#59; critical review of the literature&#59; obtaining&#44; analysis&#44; and interpretation of the data&#59; elaboration and writing of the manuscript&#59; critical review of the manuscript&#46; approval of the final version of the manuscript&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Amani AlFalasi&#58; Approval of the final version of the manuscript&#59; obtaining&#44; analysis&#44; and interpretation of the data&#59; critical review of the manuscript&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Alia AlMualla&#58; Approval of the final version of the manuscript&#59; obtaining&#44; analysis&#44; and interpretation of the data&#59; critical review of the manuscript&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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Article information
ISSN: 03650596
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