Research Letter
Evaluation of depression, stress and quality of life indexes in patients with atopic dermatitis
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quality of life indexes in patients with atopic dermatitis" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "627" "paginaFinal" => "629" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Cleide Rodrigues de Castro, Maria Elisa Bertocco Andrade, Renata Marli Gonçalves Pires, Mario Cezar Pires" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Cleide Rodrigues de" "apellidos" => "Castro" "email" => array:1 [ 0 => "cleiderodriguesdecastro@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Maria Elisa Bertocco" "apellidos" => "Andrade" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Renata Marli Gonçalves" "apellidos" => "Pires" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Mario Cezar" "apellidos" => "Pires" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Complexo Hospitalar Padre Bento de Guarulhos, Guarulhos, SP, Brazil" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Faculty of Medicine, Universidade de São Paulo, São Paulo, SP, Brazil" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 936 "Ancho" => 2167 "Tamanyo" => 116568 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Dermatology Life Quality Index (DLQI) Questionnaire.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Atopic Dermatitis (AD) is a recurrent chronic inflammatory dermatosis, characterized by pruritus, sleep disorders and multiple comorbidities, with significant psychological alterations and impact on mental health.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In many cases, there is loss of quality of life, with deep psychosocial and economic impact.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Some authors have described different degrees of depression and stress in patients with AD.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3</span></a> In this study, the authors evaluated depression, stress and quality of life indexes in adults with AD using:<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">•</span><p id="par0015" class="elsevierStylePara elsevierViewall">Beck depression inventory (Beck-BDI-II depression inventory - validated as of 15 years old)<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">•</span><p id="par0020" class="elsevierStylePara elsevierViewall">Inventory of stress symptoms for adults (ISSL - validated as of 15 years old) Classifies into 4 phases: alert (contact with aggressive stimulus); resistance (adaptation of the body); near exhaustion (depletion) and exhaustion (physical and/or psychological impairment)<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">•</span><p id="par0025" class="elsevierStylePara elsevierViewall">Dermatology life quality index (DLQI-BRA).</p></li></ul></p><p id="par0030" class="elsevierStylePara elsevierViewall">The analyzed variables were: age; gender; the visual scale of daytime and nighttime pruritus, the severity of AD (SCORAD - atopic dermatitis score) using Pearson's correlation with indexes of depression, stress and quality of life.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Statistical analysis was performed using the Adans Statistics Company (CONRE 8250-A).</p><p id="par0040" class="elsevierStylePara elsevierViewall">Thirty-one patients were included, of which 18 were women, 13 men, with a mean age of 29 years, and a standard deviation of 12.2 (minimum 15; maximum 54 years). Of the 31 patients, 7 (22.6%) had mild depressive symptoms, while 5 (16.1%) had mild to moderate; 18 (38.7%) had moderate to severe and 7 (22.6%) had severe symptoms (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Sleep pattern disorders had the highest score (1.74), followed by indecision (1.58), low self-esteem (1.42), and self-criticism (1.39). Suicidal thoughts or ideation had the lowest score (0.26), followed by pessimism (0.55) and loss of sexual interest (0.55).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">Of the 30 patients with symptoms of physical stress, 18 (60%) were in the resistance phase, while 11 (36.7%) were in the near-exhaustion phase and only 1 (3.3%) was in the alert phase (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Symptoms of psychological stress were manifested by 22 patients (73.3%), while 4 (13.3%) also reported physical symptoms and another 4 (13.3%) manifested both. There was no association between stress, depression and impaired quality of life with gender or age.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">The DLQI-BRA classification showed patients with significant quality of life impairment as follows: 7 (22.6%) showing mild impact, 6 (19.4%) moderate, 14 (45.2%) severe and 4 (12.9%) very severe impact (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). The correlation coefficient between daytime pruritus and physical stress was 0.385; with psychological stress, 0.369; with both, 0.412; with depression, 0.311; with quality of life, 0.127. A moderate correlation was observed with stress and depression, and a weak correlation with quality of life. The correlation between depression and anxiety was 0.608, considered moderate to strong.</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">The correlation coefficients of SCORAD with physical/psychological stress and depression were non-significant (-0.02 and -0.06 respectively, p-value 0.911 and 0.739). There was a weak positive correlation between the degree of severity and impaired quality of life (0.268, p-value = 0.145), which is in accordance with Carvalho et al.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Because it is a reference for the health network for dermatological diseases, most patients had moderate to severe disease; thus, it was concluded that the stress, depression and impaired quality of life indexes do not depend on AD severity.</p><p id="par0060" class="elsevierStylePara elsevierViewall">Psychosocial and emotional factors affect the course of the disease, as well as the response to therapeutic interventions. Other authors have obtained similar indexes of depression (around 15% for severe cases).<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3</span></a> Silverberg et al. stated that dermatologists should consider these associations when evaluating AD patients.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Unlike other authors, the present study found no association with suicidal thoughts or ideation (0.26).<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">The present study found a high prevalence of stress (96.8% of participants), with the majority (60.0%) in the resistance phase and a significant predominance of psychological symptoms (73.3%), which was more relevant than in other studies.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">The most common psychological symptoms were: sudden increase in motivation; enthusiasm; insecurity; feeling of incompetence; constant thinking on a single subject; excessive irritability; nightmares and fatigue. Classically, these findings are observed when living with greater vulnerability to psychological stress, as it occurs in AD crises. On the other hand, in our experience with atopic dermatitis patients we observe anticipatory distress and self demand, which in turn can lead to crises, creating a vicious circle (personal opinion of the authors).</p><p id="par0075" class="elsevierStylePara elsevierViewall">The authors conclude that individuals affected with atopic dermatitis often show symptoms of depression, stress and impaired quality of life. Itching is among the symptoms that were most often related to psychological distress and reduced quality of life. Thus, it is recommended that dermatologists, when treating patients with AD, also analyze aspects such as stress, depression and quality of life.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0080" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors’ contributions</span><p id="par0085" class="elsevierStylePara elsevierViewall">Cleide Rodrigues de Castro: Design and planning of the study; drafting and editing of the manuscript; collection, analysis, and interpretation of data; critical review of the literature; critical review of the manuscript.</p><p id="par0090" class="elsevierStylePara elsevierViewall">Maria Elisa Bertocco Andrade: Intellectual participation in the propaedeutic and/or therapeutic conduct of the studied cases.</p><p id="par0095" class="elsevierStylePara elsevierViewall">Renata Marli Gonçalves Pires: Critical review of the literature; critical review of the manuscript.</p><p id="par0100" class="elsevierStylePara elsevierViewall">Mario Cezar Pires: Approval of the final version of the manuscript; design and planning of the study; effective participation in research orientation; intellectual participation in the propaedeutic and/or therapeutic conduct of the studied cases; critical review of the literature; critical review of the manuscript.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0105" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Financial support" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Authors’ contributions" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Conflicts of interest" ] 3 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-12-07" "fechaAceptado" => "2020-09-01" "NotaPie" => array:2 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">How to cite this article: Castro CR, Andrade MEB, Pires RMG, Pires MC. Evaluation of depression, stress and quality of life indexes in patients with atopic dermatitis. An Bras Dermatol. 2021;96:627–9.</p>" ] 1 => array:2 [ "etiqueta" => "☆☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Study conducted at the Complexo Hospitalar Padre Bento de Guarulhos, Guarulhos, SP, Brazil.</p>" ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 716 "Ancho" => 2166 "Tamanyo" => 108613 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Beck II depression inventory.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1079 "Ancho" => 2152 "Tamanyo" => 122039 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Stress phases.</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 936 "Ancho" => 2167 "Tamanyo" => 116568 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Dermatology Life Quality Index (DLQI) Questionnaire.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Symptoms and diagnosis of anxiety and depression in atopic dermatitis in US adults" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.I. Silverberg" 1 => "J.M. Gelfand" 2 => "D.J. Margolis" 3 => "M. Boguniewicz" 4 => "L. Fonacier" 5 => "M.H. Grayson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/bjd.17683" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol." "fecha" => "2019" "volumen" => "181" "paginaInicial" => "554" "paginaFinal" => "565" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30838645" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Quality of life and characterization of patients with atopic dermatitis in Portugal – QUADEP study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D. Carvalho" 1 => "P. Aguiar" 2 => "P. Mendes-Bastos" 3 => "A. Palma-Carlos" 4 => "J. Freitas" 5 => "P. 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Lipp" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:3 [ "editores" => "M.E.Lipp" "titulo" => "Mecanismos neuropsicofisiológicos do stress: teoria e aplicações clínicas" "serieFecha" => "2003" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03650596/0000009600000005/v4_202110020832/S0365059621001574/v4_202110020832/en/main.assets" "Apartado" => array:4 [ "identificador" => "82768" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Research Letter" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009600000005/v4_202110020832/S0365059621001574/v4_202110020832/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059621001574?idApp=UINPBA00008Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 3 | 8 |
| 2024 October | 112 | 88 | 200 |
| 2024 September | 140 | 100 | 240 |
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| 2023 August | 58 | 34 | 92 |
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