Case Letter
Pemphigus vegetans developing after Mohs micrographic surgery and cryotherapy
a Department of Dermatology, University of Illinois College of Medicine, Chicago, USA
b Department of Dermatology, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil
c Chicago Medical School, Rosalind Franklin University, Chicago, USA
d Department of Dermatology, School of Medicine, Northwestern University Feinberg, Chicago, USA
Read
5516
Timeswas read the article
2524
Total PDF
2992
Total HTML
Share statistics
array:24 [ "pii" => "S0365059621001306" "issn" => "03650596" "doi" => "10.1016/j.abd.2020.07.018" "estado" => "S300" "fechaPublicacion" => "2021-07-01" "aid" => "390" "copyright" => "Sociedade Brasileira de Dermatologia" "copyrightAnyo" => "2021" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "sco" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "pt" => array:19 [ "pii" => "S2666275221001326" "issn" => "26662752" "doi" => "10.1016/j.abdp.2020.07.026" "estado" => "S300" "fechaPublicacion" => "2021-07-01" "aid" => "390" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "sco" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "pt" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta ‐ Caso Clínico</span>" "titulo" => "Desenvolvimento de pênfigo vegetante após cirurgia micrográfica de Mohs e crioterapia" "tienePdf" => "pt" "tieneTextoCompleto" => "pt" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "520" "paginaFinal" => "523" ] ] "contieneTextoCompleto" => array:1 [ "pt" => true ] "contienePdf" => array:1 [ "pt" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figura 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1341 "Ancho" => 2006 "Tamanyo" => 440438 ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Cicatrização completa três semanas após o início da terapia imunossupressora com eritema residual nas duas lesões. Cicatriz linear no meio do tórax direito agora pode ser vista no centro.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Nathan Jetter, Felipe Bochnia Cerci, Karan Pandher, Aleksandar L. Krunic" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Nathan" "apellidos" => "Jetter" ] 1 => array:2 [ "nombre" => "Felipe Bochnia" "apellidos" => "Cerci" ] 2 => array:2 [ "nombre" => "Karan" "apellidos" => "Pandher" ] 3 => array:2 [ "nombre" => "Aleksandar L." "apellidos" => "Krunic" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0365059621001306" "doi" => "10.1016/j.abd.2020.07.018" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059621001306?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275221001326?idApp=UINPBA00008Z" "url" => "/26662752/0000009600000004/v1_202107170646/S2666275221001326/v1_202107170646/pt/main.assets" ] ] "itemSiguiente" => array:18 [ "pii" => "S0365059621001185" "issn" => "03650596" "doi" => "10.1016/j.abd.2020.06.026" "estado" => "S300" "fechaPublicacion" => "2021-07-01" "aid" => "378" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "sco" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>" "titulo" => "Pemphigus vulgaris aggravated by obsessive-compulsive behavior: the importance of adjuvant topical occlusive dressing" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "523" "paginaFinal" => "525" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1904 "Ancho" => 1674 "Tamanyo" => 270130 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Pemphigus vulgaris and obsessive-compulsive behavior. Evolution after 40 days of the established therapy.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Paula Basso Lima, Marilia Formentini Scotton Jorge, Luciana Patrícia Fernandes Abbade, Sílvio Alencar Marques" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Paula Basso" "apellidos" => "Lima" ] 1 => array:2 [ "nombre" => "Marilia Formentini Scotton" "apellidos" => "Jorge" ] 2 => array:2 [ "nombre" => "Luciana Patrícia Fernandes" "apellidos" => "Abbade" ] 3 => array:2 [ "nombre" => "Sílvio Alencar" "apellidos" => "Marques" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275221001193" "doi" => "10.1016/j.abdp.2020.06.027" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275221001193?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059621001185?idApp=UINPBA00008Z" "url" => "/03650596/0000009600000004/v4_202107160617/S0365059621001185/v4_202107160617/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S036505962100129X" "issn" => "03650596" "doi" => "10.1016/j.abd.2020.06.028" "estado" => "S300" "fechaPublicacion" => "2021-07-01" "aid" => "389" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "sco" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>" "titulo" => "Metastatic urothelial carcinoma" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "519" "paginaFinal" => "520" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2698 "Ancho" => 1674 "Tamanyo" => 889868 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Multiple erythemato-violaceous nodules on the trunk (A) and the scalp (B).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Elisabeth Gómez-Moyano, Silvestre Martínez Garcia, David Hernandez Alcaraz, Maria Ayala-Blanca" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Elisabeth" "apellidos" => "Gómez-Moyano" ] 1 => array:2 [ "nombre" => "Silvestre" "apellidos" => "Martínez Garcia" ] 2 => array:2 [ "nombre" => "David" "apellidos" => "Hernandez Alcaraz" ] 3 => array:2 [ "nombre" => "Maria" "apellidos" => "Ayala-Blanca" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275221001314" "doi" => "10.1016/j.abdp.2020.06.029" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275221001314?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S036505962100129X?idApp=UINPBA00008Z" "url" => "/03650596/0000009600000004/v4_202107160617/S036505962100129X/v4_202107160617/en/main.assets" ] "en" => array:17 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>" "titulo" => "Pemphigus vegetans developing after Mohs micrographic surgery and cryotherapy" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "520" "paginaFinal" => "523" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Nathan Jetter, Felipe Bochnia Cerci, Karan Pandher, Aleksandar L. Krunic" "autores" => array:4 [ 0 => array:3 [ "nombre" => "Nathan" "apellidos" => "Jetter" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:4 [ "nombre" => "Felipe Bochnia" "apellidos" => "Cerci" "email" => array:2 [ 0 => "cercihc@hotmail.com" 1 => "felipecerci@ufpr.br" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 2 => array:3 [ "nombre" => "Karan" "apellidos" => "Pandher" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "Aleksandar L." "apellidos" => "Krunic" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Department of Dermatology, University of Illinois College of Medicine, Chicago, USA" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Dermatology, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Chicago Medical School, Rosalind Franklin University, Chicago, USA" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Department of Dermatology, School of Medicine, Northwestern University Feinberg, Chicago, USA" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1662 "Ancho" => 2507 "Tamanyo" => 489512 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A), Vegetative, hyperkeratotic, eroded plaques on the right chest (Mohs surgery site). The site of primary closure has been superimposed with a white line. (B), Left temple/forehead (cryosurgery site). Sites of original trauma have been superimposed with orange circles.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Pemphigus vegetans (Pveg) is a subtype of pemphigus vulgaris (PV), characterized by flaccid blisters which become erosions and vegetating plaques, typically in the intertriginous areas, face, and scalp.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Histologically it presents as pseudoepitheliomatous hyperplasia (PEH) associated with suprabasal acantholysis.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Trauma-induced pemphigus is rare following surgical procedures, with only a few reports occurring after Mohs micrographic surgery (MMS).<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2–5</span></a> Herein, a patient who developed Pveg after MMS for squamous cell carcinoma (SCC) of his chest and after cryosurgery for actinic keratosis (AKs) at his temple and forehead is presented. To the authors’ knowledge, this is the first report of Pveg arising within either an MMS site or site treated by cryosurgery.</p><p id="par0015" class="elsevierStylePara elsevierViewall">An 81-year-old caucasian male presented with several months of an erythematous hyperkeratotic nodule on the right anterior chest. Biopsy confirmed well-differentiated SCC and the patient underwent MMS for tumor removal. Concomitantly he was submitted to cryosurgery on his left temple and forehead for AKs. The postoperative course, initially unremarkable, was complicated by poor wound healing, oozing and discharge from the wound sites, as well as maceration at the periphery. Wound cultures grew <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>, but the patient failed to respond to systemic and topical antibiotics. Two months after MMS, the patient was noted to have erosions and hyperkeratotic vegetating plaques expanding circumferentially from the procedure sites (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Biopsy from the chest demonstrated PEH and suprabasal acantholysis suggesting Pveg. Direct immunofluorescence showed deposits of IgG and C3 in the intercellular spaces of the epidermis, compatible with pemphigus (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Indirect immunofluorescence revealed autoantibodies against the epidermal cell surface at a titer of 1:40. ELISA showed anti-desmoglein (DSG) 1 antibody titer at 131.4 and anti-DSG3 antibody titer at 34.2 (>20 is positive for both).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The immunofluorescence and histopathology results along with the clinical presentation were consistent with Pveg. The patient was started on oral dexamethasone 0.15 mg/kg and azathioprine 150 mg daily and topical steroids, with complete resolution of the skin lesions in the due course (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Trauma-induced PV has been described after major general surgical procedures (abdominal, chest, orthopedic) and dental procedures.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Out of 36 cases of surgically induced-PV, thirteen were in patients without pre-existing pemphigus. The literature review revealed only 2 cases of PV and 2 cases of PF occurring after MMS, and one case of PF after cryosurgery for AKs.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2–5</span></a> In most cases of pemphigus following MMS, including this present case, the patients presented with unremarkable healing in the immediate postoperative period followed by the development of erosions, scaling, oozing, and desquamation after 4–5 weeks post-procedure simulating wound infection or contact dermatitis.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,4,5</span></a> All cases required a high index of suspicion with biopsy confirmation and immunofluorescence testing.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Several mechanisms have been proposed to explain the induction of pemphigus and Koebnerization of pre-existing pemphigus by surgical trauma, and the process is likely to be multifactorial.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Epidermal injury may expose DSG 1 and 3 and lead to new autoantibody formation in genetically susceptible patients or to activation of pre-existing antibodies already present in low (subclinical) titers.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2,4</span></a> Furthermore, surgical trauma may link antigens not related to pemphigus but capable of immune response to pemphigus antigens through the process of epitope spreading.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3</span></a> These factors could potentially explain the long latency period (15 weeks) for pemphigus induction in non-dermatology surgery procedures where there is much less injury to the epidermis. With MMS, cryosurgery or shave biopsies there is more damage to the skin layers and at the dermo-epidermal junction, producing higher concentrations of released antigens (DSG 1 and 3) leading to more efficient epitope spreading and faster and stronger immunological response.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3</span></a> Finally, SCC itself could develop an expression of DSG 1 and 3 and trigger an autoimmune response.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Pveg poses a further diagnostic challenge as it has histological similarities with SCC due to the presence of PEH. Besides being associated with suprabasal acantholysis, PEH in Pveg cases is of adnexal (follicular) origin, confined to the epidermis and dermis, with minimal atypia, rare mitoses, and absent individual keratinocyte necrosis.</p><p id="par0040" class="elsevierStylePara elsevierViewall">In patients who have known bullous disease reconstruction of MMS wounds should be simple, and 2<span class="elsevierStyleSup">nd</span> intention or partial closure should be considered.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Some authors recommend increasing oral immunosuppression in the immediate postoperative period.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In patients like ours who present without previous history of bullous disease, Pveg associated to the Mohs surgery and the criotherapy must have a high suspicion on the appearance of non-healing wounds or localized inflammation occurring several weeks after the procedure.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0050" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors’ contributions</span><p id="par0055" class="elsevierStylePara elsevierViewall">Nathan Jetter: Participation in the conception and planning of the study; obtaining, analyzing, and interpreting the data; writing; approval of its final version.</p><p id="par0060" class="elsevierStylePara elsevierViewall">Felipe Bochnia Cerci: Analyzing and interpreting the data; writing; approval of its final version.</p><p id="par0065" class="elsevierStylePara elsevierViewall">Karan Pandher: Participation in the conception and planning of the study; obtaining, analyzing, and interpreting the data; writing; approval of its final version.</p><p id="par0070" class="elsevierStylePara elsevierViewall">Aleksandar L. Krunic: Participation in the conception and planning of the study; obtaining analyzing and interpreting the data; critical review of the manuscript; approval of its final version.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0075" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Financial support" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Authors’ contributions" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Conflicts of interest" ] 3 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2020-05-12" "fechaAceptado" => "2020-07-03" "NotaPie" => array:2 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">How to cite this article: Jetter N, Cerci FB, Pandher K, Krunic AL. Pemphigus vegetans developing after Mohs micrographic surgery and cryotherapy. An Bras Dermatol. 2021;96:520–3.</p>" ] 1 => array:2 [ "etiqueta" => "☆☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Study conducted at the Department of Dermatology, School of Medicine, Northwestern University Feinberg, Chicago, USA.</p>" ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1662 "Ancho" => 2507 "Tamanyo" => 489512 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A), Vegetative, hyperkeratotic, eroded plaques on the right chest (Mohs surgery site). The site of primary closure has been superimposed with a white line. (B), Left temple/forehead (cryosurgery site). Sites of original trauma have been superimposed with orange circles.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1871 "Ancho" => 2500 "Tamanyo" => 462502 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Direct immunofluorescence on skin biospy demonstrating IgG fluorescence around keratinocytes (white arrows).</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1676 "Ancho" => 2507 "Tamanyo" => 613524 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Complete healing 3 weeks after initiation of immunosuppressive therapy with residual erythema. A linear scar in the middle of the right chest can now be seen in the center.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Trauma-induced pemphigus: a case series of 36 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Daneshpazhooh" 1 => "M. Fatehnejad" 2 => "Z. Rahbar" 3 => "K. Balighi" 4 => "N. Ghandi" 5 => "M. Ghiasi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Dtsch Dermatol Ges" "fecha" => "2016" "volumen" => "14" "paginaInicial" => "166" "paginaFinal" => "171" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mohs micrographic surgery-induced pemphigus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.G. Duick" 1 => "B. Zaks" 2 => "R.L. Moy" 3 => "R.P. Kaplan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1524-4725.2001.00247.x" "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg" "fecha" => "2001" "volumen" => "27" "paginaInicial" => "895" "paginaFinal" => "897" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11722529" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pemphigus vulgaris and koebner phenomenon" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "H. Nazik" 1 => "P. Ozturk" 2 => "M. Mulayim" 3 => "E. Koyuncu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Sci" "fecha" => "2019" "volumen" => "8" "paginaInicial" => "464" "paginaFinal" => "465" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pemphigus foliaceus masquerading as postoperative wound infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.M. Rotunda" 1 => "A.R. Bhupathy" 2 => "R. Dye" 3 => "T.T. Soriano" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1524-4725.2005.31047" "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg" "fecha" => "2005" "volumen" => "31" "paginaInicial" => "226" "paginaFinal" => "231" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15762220" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pemphigus foliaceus demonstrating pathergy after mohs micrographic surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S.N. Tolkachjov" 1 => "M. Frith" 2 => "L.D. Cooper" 3 => "C.B. Harmon" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/DSS.0000000000001452" "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg" "fecha" => "2018" "volumen" => "44" "paginaInicial" => "1352" "paginaFinal" => "1353" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29293109" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03650596/0000009600000004/v4_202107160617/S0365059621001306/v4_202107160617/en/main.assets" "Apartado" => array:4 [ "identificador" => "82769" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case Letter" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009600000004/v4_202107160617/S0365059621001306/v4_202107160617/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059621001306?idApp=UINPBA00008Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 17 | 8 | 25 |
| 2024 October | 96 | 68 | 164 |
| 2024 September | 142 | 81 | 223 |
| 2024 August | 163 | 117 | 280 |
| 2024 July | 124 | 105 | 229 |
| 2024 June | 91 | 59 | 150 |
| 2024 May | 86 | 70 | 156 |
| 2024 April | 93 | 99 | 192 |
| 2024 March | 95 | 62 | 157 |
| 2024 February | 85 | 79 | 164 |
| 2024 January | 67 | 64 | 131 |
| 2023 December | 62 | 66 | 128 |
| 2023 November | 70 | 73 | 143 |
| 2023 October | 57 | 89 | 146 |
| 2023 September | 78 | 75 | 153 |
| 2023 August | 54 | 32 | 86 |
| 2023 July | 57 | 34 | 91 |
| 2023 June | 72 | 59 | 131 |
| 2023 May | 48 | 19 | 67 |
| 2023 April | 35 | 18 | 53 |
| 2023 March | 59 | 35 | 94 |
| 2023 February | 52 | 35 | 87 |
| 2023 January | 43 | 32 | 75 |
| 2022 December | 44 | 29 | 73 |
| 2022 November | 78 | 44 | 122 |
| 2022 October | 120 | 51 | 171 |
| 2022 September | 61 | 56 | 117 |
| 2022 August | 42 | 48 | 90 |
| 2022 July | 40 | 61 | 101 |
| 2022 June | 46 | 49 | 95 |
| 2022 May | 38 | 63 | 101 |
| 2022 April | 52 | 43 | 95 |
| 2022 March | 68 | 66 | 134 |
| 2022 February | 42 | 49 | 91 |
| 2022 January | 58 | 76 | 134 |
| 2021 December | 49 | 58 | 107 |
| 2021 November | 57 | 67 | 124 |
| 2021 October | 88 | 87 | 175 |
| 2021 September | 82 | 78 | 160 |
| 2021 August | 99 | 79 | 178 |
| 2021 July | 110 | 55 | 165 |
| 2021 June | 60 | 65 | 125 |
| 2021 May | 12 | 21 | 33 |
Show all
