Tropical/Infectoparasitary Dermatology
Sporotrichosis refractory to conventional treatment: therapeutic success with potassium iodide
Read
7700
Timeswas read the article
3083
Total PDF
4617
Total HTML
Share statistics
array:24 [ "pii" => "S0365059621000192" "issn" => "03650596" "doi" => "10.1016/j.abd.2020.04.013" "estado" => "S300" "fechaPublicacion" => "2021-03-01" "aid" => "318" "copyright" => "Sociedade Brasileira de Dermatologia" "copyrightAnyo" => "2021" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "pt" => array:19 [ "pii" => "S2666275221000175" "issn" => "26662752" "doi" => "10.1016/j.abdp.2020.04.010" "estado" => "S300" "fechaPublicacion" => "2021-03-01" "aid" => "318" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "pt" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Dermatologia Tropical/Infectoparasitária</span>" "titulo" => "Esporotricose refratária ao tratamento convencional: sucesso terapêutico com iodeto de potássio" "tienePdf" => "pt" "tieneTextoCompleto" => "pt" "tieneResumen" => "pt" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "231" "paginaFinal" => "233" ] ] "contieneResumen" => array:1 [ "pt" => true ] "contieneTextoCompleto" => array:1 [ "pt" => true ] "contienePdf" => array:1 [ "pt" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 604 "Ancho" => 905 "Tamanyo" => 84938 ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Placa infiltrada com ulceração central circundada por múltiplas pápulas satélites com 75 dias de evolução.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Marcelo Rosandiski Lyra, Vanessa Sokoloski, Priscila Marques de Macedo, Anna Carolina Procópio de Azevedo" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Marcelo Rosandiski" "apellidos" => "Lyra" ] 1 => array:2 [ "nombre" => "Vanessa" "apellidos" => "Sokoloski" ] 2 => array:2 [ "nombre" => "Priscila Marques" "apellidos" => "de Macedo" ] 3 => array:2 [ "nombre" => "Anna Carolina Procópio de" "apellidos" => "Azevedo" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0365059621000192" "doi" => "10.1016/j.abd.2020.04.013" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059621000192?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275221000175?idApp=UINPBA00008Z" "url" => "/26662752/0000009600000002/v2_202104230742/S2666275221000175/v2_202104230742/pt/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S0365059621000088" "issn" => "03650596" "doi" => "10.1016/j.abd.2020.06.011" "estado" => "S300" "fechaPublicacion" => "2021-03-01" "aid" => "309" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">What is your diagnosis?</span>" "titulo" => "Case for diagnosis. Atypical Grover’s disease" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "234" "paginaFinal" => "236" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 765 "Ancho" => 750 "Tamanyo" => 59228 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Dermoscopy shows a pink background with dotted and glomerular vessels, and fine white scaling.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Pablo Vargas-Mora, Diego Orlandi, Irene Araya, Claudia Morales" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Pablo" "apellidos" => "Vargas-Mora" ] 1 => array:2 [ "nombre" => "Diego" "apellidos" => "Orlandi" ] 2 => array:2 [ "nombre" => "Irene" "apellidos" => "Araya" ] 3 => array:2 [ "nombre" => "Claudia" "apellidos" => "Morales" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275221000072" "doi" => "10.1016/j.abdp.2020.06.011" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275221000072?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059621000088?idApp=UINPBA00008Z" "url" => "/03650596/0000009600000002/v2_202104300920/S0365059621000088/v2_202104300920/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0365059621000180" "issn" => "03650596" "doi" => "10.1016/j.abd.2020.07.008" "estado" => "S300" "fechaPublicacion" => "2021-03-01" "aid" => "317" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Tropical/Infectoparasitary Dermatology</span>" "titulo" => "Gummatous cutaneous tuberculosis associated with the use of infliximab for Crohn's disease" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "228" "paginaFinal" => "230" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1515 "Ancho" => 905 "Tamanyo" => 87973 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Ulcerated nodules on the posterior region of the right thigh.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Lucas Campos Garcia, Everton Carlos Siviero do Vale, Maria de Lourdes Ferrari, Lauro Damasceno de Carvalho Faria" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Lucas Campos" "apellidos" => "Garcia" ] 1 => array:2 [ "nombre" => "Everton Carlos Siviero do" "apellidos" => "Vale" ] 2 => array:2 [ "nombre" => "Maria de Lourdes" "apellidos" => "Ferrari" ] 3 => array:2 [ "nombre" => "Lauro Damasceno de Carvalho" "apellidos" => "Faria" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275221000163" "doi" => "10.1016/j.abdp.2020.07.016" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275221000163?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059621000180?idApp=UINPBA00008Z" "url" => "/03650596/0000009600000002/v2_202104300920/S0365059621000180/v2_202104300920/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Tropical/Infectoparasitary Dermatology</span>" "titulo" => "Sporotrichosis refractory to conventional treatment: therapeutic success with potassium iodide" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "231" "paginaFinal" => "233" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Marcelo Rosandiski Lyra, Vanessa Sokoloski, Priscila Marques de Macedo, Anna Carolina Procópio de Azevedo" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Marcelo Rosandiski" "apellidos" => "Lyra" "email" => array:1 [ 0 => "marcelo.lyra@ini.fiocruz.br" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Vanessa" "apellidos" => "Sokoloski" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Priscila Marques" "apellidos" => "de Macedo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Anna Carolina Procópio de" "apellidos" => "Azevedo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Hospital Central Aristarcho Pessoa, Rio de Janeiro, RJ, Brazil" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 604 "Ancho" => 905 "Tamanyo" => 84938 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Infiltrated plaque with central ulceration surrounded by multiple satellite papules of 75 days evolution.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Sporotrichosis is a subcutaneous mycosis caused by dimorphic fungi of the genus <span class="elsevierStyleItalic">Sporothrix</span>. It usually occurs through traumatic inoculation of the fungus in the skin or mucous membranes. The increase in cases in the state of Rio de Janeiro is related to the feline zoonotic epidemic that began in 1998; the main species involved was <span class="elsevierStyleItalic">Sporothrix brasiliensis</span>.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The first choice for the treatment of lymphocutaneous sporotrichosis is itraconazole at a dose of 100 mg/day. Although robust experience attests to the safety and efficacy of itraconazole in the treatment of this disease, its metabolism depends on CYP3A4, which can lead to multiple drug interactions.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Terbinafine is a safe and effective alternative when itraconazole is contraindicated.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Saturated solution of potassium iodide (SSKI) was the first treatment for sporotrichosis through its immunological action, acting on the breakdown of granulomas, neutrophil chemotaxis, <span class="elsevierStyleItalic">Sporothrix</span> phagocytosis, and inhibition of biofilm in the yeast and filamentous phases.<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,5</span></a> It is also an alternative in cats refractory to itraconazole.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Cryosurgery has been successfully used in 199 patients with slow or refractory responses to itraconazole/terbinafine.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The authors report the case of a healthy 25-year-old woman with a left shoulder lesion of 75 days evolution (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). She reported contact with a sick cat. The culture for fungi confirmed the diagnosis of sporotrichosis (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). The clinical form was fixed cutaneous sporotrichosis.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">She was treated with itraconazole 200 mg/day for 11 months without good response; terbinafine 250 mg/day was added to the regimen for another seven months with partial improvement. Simultaneously, she received 11 cryosurgery sessions at monthly intervals; however, the lesion remained infiltrated, with a central crust (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Due to the therapeutic failure, the authors chose to associate SSKI 1.42 g/mL (started at 0.6 g/day, with a progressive increase every three days up to the dose of 2.1 g/day). Two months after the start of SSKI, the lesion was completely healed (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>).</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">The antifungal sensitivity profile of the clinical isolate molecularly identified as <span class="elsevierStyleItalic">S. brasiliensis</span>, performed using the CLSI M38-A2 method, showed the following minimum inhibitory concentrations (MIC): amphotericin B, 2.0 µg/mL; itraconazole, 1.0 µg/mL; terbinafine, 0.125 µg/mL. The experiments of this work were carried out at the Mycology Laboratory of the National Institute of Infectious Diseases Evandro Chagas INI - Fiocruz/RJ.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Cases of sporotrichosis refractory to conventional antifungal therapy are rare. Generally, patients with slow response evolve to cure after adjuvant cryosurgery.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">S. brasiliensis</span> was shown to be more susceptible to antifungals than <span class="elsevierStyleItalic">S. schenckii</span>.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Although rare, resistance to itraconazole/terbinafine has been described in the literature.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Despite the favorable sensitivity profile, the present case had therapeutic failure. It is likely that therapeutic failure is related to the host-fungus interaction rather than drug resistance.</p><p id="par0055" class="elsevierStylePara elsevierViewall">SSKI is no longer the first choice in the treatment of sporotrichosis due to several factors: lack of standardized commercial formulation, unknown mechanisms of action, metallic taste, and especially the advent of modern and safe antifungal drugs. Recently, alternative therapies with lower doses of SSKI have been proposed, with very promising results.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">The authors highlight SSKI as a safe and effective therapeutic alternative in the treatment of cutaneous sporotrichosis refractory to itraconazole/terbinafine, emphasizing that the immunomodulatory action of SSKI may have played an important role in curing this patient.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Financial support</span><p id="par0065" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Authors’ contributions</span><p id="par0070" class="elsevierStylePara elsevierViewall">Marcelo Rosandiski Lyra: Approval of the final version of the manuscript; design and planning of the study; drafting and editing of the manuscript; collection, analysis, and interpretation of data; effective participation in research orientation; intellectual participation in propaedeutic and/or therapeutic conduct of the studied cases; critical review of the literature; critical review of the manuscript.</p><p id="par0075" class="elsevierStylePara elsevierViewall">Vanessa Sokoloski: Design and planning of the study; drafting and editing of the manuscript; critical review of the literature; critical review of the manuscript.</p><p id="par0080" class="elsevierStylePara elsevierViewall">Priscila Marques de Macedo: Approval of the final version of the manuscript; drafting and editing of the manuscript; effective participation in research orientation; critical review of the literature; critical review of the manuscript.</p><p id="par0085" class="elsevierStylePara elsevierViewall">Anna Carolina Procópio de Azevedo: Statistical analysis; drafting and editing of the manuscript; collection, analysis, and interpretation of data; critical review of the manuscript.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conflicts of interest</span><p id="par0090" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:6 [ 0 => array:3 [ "identificador" => "xres1505261" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1366017" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "sec0005" "titulo" => "Financial support" ] 3 => array:2 [ "identificador" => "sec0010" "titulo" => "Authors’ contributions" ] 4 => array:2 [ "identificador" => "sec0015" "titulo" => "Conflicts of interest" ] 5 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-12-08" "fechaAceptado" => "2020-04-06" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1366017" "palabras" => array:5 [ 0 => "Cryosurgery" 1 => "Itraconazole" 2 => "Potassium iodide" 3 => "Sporothrix" 4 => "Sporotrichosis" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Sporotrichosis is a subcutaneous mycosis caused by dimorphic fungi of the genus <span class="elsevierStyleItalic">Sporothrix</span>. The authors report a case of fixed cutaneous sporotrichosis with therapeutic failure after 18 months of itraconazole and terbinafine associated with cryosurgery. The patient was cured after the introduction of saturated potassium iodide solution. <span class="elsevierStyleItalic">Sporothrix brasiliensis</span> was the identified species, presenting a susceptibility profile to itraconazole and terbinafine. This fact suggests that therapeutic failure is probably related to the host-fungus interaction rather than drug resistance. It is possible that the immunomodulatory action of the saturated potassium iodide solution may have played an important role in curing this patient.</p></span>" ] ] "NotaPie" => array:2 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">How to cite this article: Lyra MR, Sokoloski V, de Macedo PM, Azevedo ACP. Sporotrichosis refractory to conventional treatment: therapeutic success with potassium iodide. An Bras Dermatol. 2021;96:231–3.</p>" ] 1 => array:2 [ "etiqueta" => "☆☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Study conducted at the Laboratory of Clinical Research and Surveillance in Leishmaniasis, Instituto Nacional de Infectologia, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.</p>" ] ] "multimedia" => array:4 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 604 "Ancho" => 905 "Tamanyo" => 84938 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Infiltrated plaque with central ulceration surrounded by multiple satellite papules of 75 days evolution.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 547 "Ancho" => 1305 "Tamanyo" => 68031 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Sporothrix brasiliensis</span> – left, colony macromorphology in the filamentous phase in potato dextrose agar (PDA), after 14 days of incubation at 30 °C. On the right, microscopy of the filamentous phase, stained by cotton blue with lactophenol (× 400).* The experiments of this work were carried out at the Mycology Laboratory of the National Institute of Infectious Diseases Evandro Chagas INI - Fiocruz/RJ.</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 605 "Ancho" => 905 "Tamanyo" => 63793 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Infiltrated plaque with central sero-hematic crust after 18 months of treatment. Eleven months with itraconazole followed by seven months of terbinafine, combined with 11 sessions of cryosurgery at monthly intervals.</p>" ] ] 3 => array:8 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 602 "Ancho" => 905 "Tamanyo" => 64177 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0020" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Lesion completely healed after 20 months of evolution and two months of treatment with saturated solution of potassium iodide.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Phylogenetic Analysis Reveals a High Prevalence of <span class="elsevierStyleItalic">Sporothrix brasiliensis</span> in Feline Sporotrichosis Outbreaks" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.M. Rodrigues" 1 => "M.M. Teixeira" 2 => "G.S. de Hoog" 3 => "T.M.P. Schubach" 4 => "S.A. Pereira" 5 => "G.F. Fernandes" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pntd.0002281" "Revista" => array:5 [ "tituloSerie" => "PLOS Negl Trop Dis" "fecha" => "2013" "volumen" => "7" "paginaInicial" => "e2281" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23818999" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of cutaneous sporotrichosis with itraconazole—study of 645 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.B. Lima Barros" 1 => "A.O. Schubach" 2 => "R.V.C. Oliveira" 3 => "E.B. Martins" 4 => "J.L. Teixeira" 5 => "B. Wanke" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/cid/cir245" "Revista" => array:6 [ "tituloSerie" => "Clin Infect Dis" "fecha" => "2011" "volumen" => "52" "paginaInicial" => "e200" "paginaFinal" => "6" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21628477" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efetividade da Terbinafina na dosagem de 250 mg por dia no tratamento da esporotricose cutânea [Dissertação]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G.F. Valle" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2009" "editorial" => "Fundação Oswaldo Cruz – Instituto Nacional de Infectologia Evandro Chagas" "editorialLocalizacion" => "Rio de Janeiro" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bernardes-Engemann AR. Sporotrichosis: an update on epidemiology etiopathogenesis, laboratory and clinical therapeutics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Orofino-Costa" 1 => "P.M. Macedo" 2 => "A.M. Rodrigues" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1590/abd1806-4841.2017279" "Revista" => array:6 [ "tituloSerie" => "An Bras Dermatol" "fecha" => "2017" "volumen" => "92" "paginaInicial" => "606" "paginaFinal" => "620" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29166494" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Potassium iodide and miltefosine inhibit biofilms of Sporothrix schenckii species complex in yeast and filamentous forms" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.S.N. Brilhante" 1 => "M.L.Q.D. Silva" 2 => "V.S. Pereira" 3 => "J.S. Oliveira" 4 => "J.M. Maciel" 5 => "Silva INGD" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/mmy/myy119" "Revista" => array:7 [ "tituloSerie" => "Med Mycol" "fecha" => "2019" "volumen" => "57" "paginaInicial" => "764" "paginaFinal" => "772" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30462271" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S2213260020302435" "estado" => "S300" "issn" => "22132600" ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tratamento da esporotricose felina refratária com a associação de iodeto de potássio e itraconazol oral [Tese]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.F.D.B. Rocha" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2014" "editorial" => "Fundação Oswaldo Cruz – Instituto Nacional de Infectologia Evandro Chagas" "editorialLocalizacion" => "Rio de Janeiro" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cryosurgery for the treatment of cutaneous sporotrichosis: Experience with 199 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Fichman" 1 => "A. Valle" 2 => "D. Freitas" 3 => "F. Sampaio" 4 => "M. Lyra" 5 => "P. de Macedo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/bjd.17532" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2018" "volumen" => "180" "paginaInicial" => "1541" "paginaFinal" => "1542" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30560992" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "In vitro antifungal susceptibilities of five species of Sporothrix" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R. Marimon" 1 => "C. Serena" 2 => "J. Gené" 3 => "J. Cano" 4 => "J. Guarro" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/AAC.01012-07" "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2008" "volumen" => "52" "paginaInicial" => "732" "paginaFinal" => "734" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18039919" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Refractory sporotrichosis due to <span class="elsevierStyleItalic">Sporothrix brasiliensis</span> in humans appears to be unrelated to in vivo resistance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R. Almeida-Paes" 1 => "M. Oliveira" 2 => "D. Freitas" 3 => "A.C.F. do Valle" 4 => "M.C. Galhardo" 5 => "R. Zancope-Oliveira" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/mmy/myw103" "Revista" => array:6 [ "tituloSerie" => "Med Mycol" "fecha" => "2017" "volumen" => "55" "paginaInicial" => "507" "paginaFinal" => "517" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27771622" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "New posology of potassium iodide for the treatment of cutaneous sporotrichosis: study of efficacy and safety in 102 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P.M. Macedo" 1 => "L.M. Lopes-Bezerra" 2 => "A.R. Bernardes-Engemann" 3 => "R. Orofino-Costa" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jdv.12667" "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "2015" "volumen" => "29" "paginaInicial" => "719" "paginaFinal" => "724" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25229626" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03650596/0000009600000002/v2_202104300920/S0365059621000192/v2_202104300920/en/main.assets" "Apartado" => array:4 [ "identificador" => "80635" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Tropical/Infectoparasitary Dermatology" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009600000002/v2_202104300920/S0365059621000192/v2_202104300920/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059621000192?idApp=UINPBA00008Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 31 | 10 | 41 |
| 2024 October | 166 | 68 | 234 |
| 2024 September | 172 | 86 | 258 |
| 2024 August | 205 | 113 | 318 |
| 2024 July | 134 | 114 | 248 |
| 2024 June | 126 | 73 | 199 |
| 2024 May | 96 | 73 | 169 |
| 2024 April | 116 | 83 | 199 |
| 2024 March | 149 | 69 | 218 |
| 2024 February | 167 | 78 | 245 |
| 2024 January | 98 | 38 | 136 |
| 2023 December | 78 | 58 | 136 |
| 2023 November | 104 | 84 | 188 |
| 2023 October | 91 | 85 | 176 |
| 2023 September | 94 | 62 | 156 |
| 2023 August | 74 | 40 | 114 |
| 2023 July | 95 | 28 | 123 |
| 2023 June | 90 | 45 | 135 |
| 2023 May | 105 | 37 | 142 |
| 2023 April | 74 | 17 | 91 |
| 2023 March | 93 | 50 | 143 |
| 2023 February | 67 | 36 | 103 |
| 2023 January | 63 | 39 | 102 |
| 2022 December | 127 | 36 | 163 |
| 2022 November | 87 | 58 | 145 |
| 2022 October | 144 | 61 | 205 |
| 2022 September | 64 | 75 | 139 |
| 2022 August | 74 | 52 | 126 |
| 2022 July | 49 | 52 | 101 |
| 2022 June | 57 | 60 | 117 |
| 2022 May | 49 | 56 | 105 |
| 2022 April | 66 | 50 | 116 |
| 2022 March | 56 | 82 | 138 |
| 2022 February | 67 | 47 | 114 |
| 2022 January | 120 | 80 | 200 |
| 2021 December | 50 | 64 | 114 |
| 2021 November | 54 | 65 | 119 |
| 2021 October | 76 | 85 | 161 |
| 2021 September | 74 | 61 | 135 |
| 2021 August | 60 | 55 | 115 |
| 2021 July | 56 | 49 | 105 |
| 2021 June | 98 | 74 | 172 |
| 2021 May | 169 | 101 | 270 |
| 2021 April | 447 | 378 | 825 |
| 2021 March | 76 | 45 | 121 |
| 2021 February | 9 | 11 | 20 |
Show all
