What is your diagnosis?
Case for diagnosis. Dorsal nodule in a 10-year-old male
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Nódulo dorsal em menino de 10 anos" "tienePdf" => "pt" "tieneTextoCompleto" => "pt" "tieneResumen" => "pt" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "237" "paginaFinal" => "239" ] ] "contieneResumen" => array:1 [ "pt" => true ] "contieneTextoCompleto" => array:1 [ "pt" => true ] "contienePdf" => array:1 [ "pt" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1156 "Ancho" => 1505 "Tamanyo" => 219682 ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">(A), Nódulo solitário, redondo, medindo 3<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>cm, vermelho‐escuro, cupuliforme, firme, localizado na região dorsal. (B), Em pequeno aumento observam‐se massas de grandes células com bordas celulares distintas, separadas por finos e delicados septos de tecido conjuntivo. O tumor estava recoberto por epiderme normal (Hematoxilina & eosina, 40<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>). (C), O folículo piloso apresentava‐se encarcerado pelo tumor (Hematoxilina & eosina, 100<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>). (D), As células apresentavam abundante citoplasma granular eosinofílico e ocasionais glóbulos redondos profundamente eosinofílicos. Os núcleos eram vesiculares com cromatina pálida e um único nucléolo central. Um filete nervoso também era visível (Hematoxilina & eosina, 200<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Gongjun Xu, Xuefeng Fu, Jinxian Fang, Chiqing Huang" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Gongjun" "apellidos" => "Xu" ] 1 => array:2 [ "nombre" => "Xuefeng" "apellidos" => "Fu" ] 2 => array:2 [ "nombre" => "Jinxian" "apellidos" => "Fang" ] 3 => array:2 [ "nombre" => "Chiqing" "apellidos" => "Huang" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S036505962100009X" "doi" => "10.1016/j.abd.2020.08.009" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S036505962100009X?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275221000084?idApp=UINPBA00008Z" "url" => "/26662752/0000009600000002/v2_202104230742/S2666275221000084/v2_202104230742/pt/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S0365059621000040" "issn" => "03650596" "doi" => "10.1016/j.abd.2020.06.009" "estado" => "S300" "fechaPublicacion" => "2021-03-01" "aid" => "305" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">What is your diagnosis?</span>" "titulo" => "Case for diagnosis. Cutaneous small vessel vasculitis (anti-proteinase 3 positive), fever, hemoptysis, and lung cavitation in an adult" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "240" "paginaFinal" => "242" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 563 "Ancho" => 750 "Tamanyo" => 165912 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0020" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Histopathological examination of the skin showing intense diffuse inflammatory infiltrate in the dermis, red blood cells leakage, vascular walls infiltrated by neutrophils, and fibrinoid necrosis. Subepidermal vesicle, filled with red blood cells and neutrophils (Hematoxylin & eosin, ×10).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Luana Moraes Campos, Mariana Righetto de Ré, Priscila Neri Lacerda, Hélio Amante Miot" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Luana Moraes" "apellidos" => "Campos" ] 1 => array:2 [ "nombre" => "Mariana Righetto" "apellidos" => "de Ré" ] 2 => array:2 [ "nombre" => "Priscila Neri" "apellidos" => "Lacerda" ] 3 => array:2 [ "nombre" => "Hélio Amante" "apellidos" => "Miot" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275221000047" "doi" => "10.1016/j.abdp.2020.06.010" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275221000047?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059621000040?idApp=UINPBA00008Z" "url" => "/03650596/0000009600000002/v2_202104300920/S0365059621000040/v2_202104300920/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0365059621000088" "issn" => "03650596" "doi" => "10.1016/j.abd.2020.06.011" "estado" => "S300" "fechaPublicacion" => "2021-03-01" "aid" => "309" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">What is your diagnosis?</span>" "titulo" => "Case for diagnosis. Atypical Grover’s disease" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "234" "paginaFinal" => "236" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 765 "Ancho" => 750 "Tamanyo" => 59228 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Dermoscopy shows a pink background with dotted and glomerular vessels, and fine white scaling.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Pablo Vargas-Mora, Diego Orlandi, Irene Araya, Claudia Morales" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Pablo" "apellidos" => "Vargas-Mora" ] 1 => array:2 [ "nombre" => "Diego" "apellidos" => "Orlandi" ] 2 => array:2 [ "nombre" => "Irene" "apellidos" => "Araya" ] 3 => array:2 [ "nombre" => "Claudia" "apellidos" => "Morales" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275221000072" "doi" => "10.1016/j.abdp.2020.06.011" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275221000072?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059621000088?idApp=UINPBA00008Z" "url" => "/03650596/0000009600000002/v2_202104300920/S0365059621000088/v2_202104300920/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">What is your diagnosis?</span>" "titulo" => "Case for diagnosis. Dorsal nodule in a 10-year-old male" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "237" "paginaFinal" => "239" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Gongjun Xu, Xuefeng Fu, Jinxian Fang, Chiqing Huang" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Gongjun" "apellidos" => "Xu" "email" => array:1 [ 0 => "jxfxxgj2009@163.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Xuefeng" "apellidos" => "Fu" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Jinxian" "apellidos" => "Fang" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Chiqing" "apellidos" => "Huang" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Department of Dermatology, Jinhua Fifth Hospital, Jinhua, Zhejiang, China" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Dermatology, Jinhua Municipal Central Hospital, Jinhua, Zhejiang, China" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1104 "Ancho" => 1750 "Tamanyo" => 388302 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Photomicrographs of immunohistochemical studies. (A) S-100 was negative in the tumor cells, while the nerve fiber tract served as an internal positive control (Original magnification, ×200). (B) CD68, (C) vimentin, (D) Syn, and (E) NKI/C3 (CD63) were positive (Original magnification, ×100), and (F) NSE was weakly positive (Original magnification, ×200).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Case report</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 10-year-old male presented with a dorsal nodule, which rapidly increased in size after two months. The lesion was neither painful nor tender. On physical examination, a single, firm, subcutaneous nodular lesion with well-defined borders was noted on the back (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>a). The subcutaneous nodule was 3<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>cm and was adhered to the deep soft tissues. The biopsy revealed aggregates and sheets of large epithelioid and spindle cells, with distinct cellular borders separated by thin, delicate connective tissue septa. The cells had abundant eosinophilic granular cytoplasm and occasional deeply eosinophilic round globules. The nuclei were vesicular with pale chromatin and a single central nucleolus. The skin appendages were encased by the tumor (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a> b–d). IHC analysis revealed the tumor was positive for CD68, vimentin, and synaptophysin (Syn); weakly positive for NSE; and negative for SOX10, HMB45, Melan A, cytokeratin, SMA, EMA, CD163, CD56, and CD34. In the presence of positive internal and external controls, the tumor cells were negative for S-100 protein. The intracytoplasmic granules were diffuse and strongly positive for NKI/C3 (CD63) (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a> a–f). The Ki-67 index was less than 1%.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">What is your diagnosis?</span><p id="par0075" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">a)</span><p id="par0010" class="elsevierStylePara elsevierViewall">Tuberous xanthoma</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">b)</span><p id="par0015" class="elsevierStylePara elsevierViewall">Dermatofibroma</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">c)</span><p id="par0020" class="elsevierStylePara elsevierViewall">Leiomyomas</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">d)</span><p id="par0025" class="elsevierStylePara elsevierViewall">S-100-negative cutaneous granular cell tumor</p></li></ul></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Discussion</span><p id="par0030" class="elsevierStylePara elsevierViewall">Cutaneous GCTs mostly present as an asymptomatic, slow-growing, solitary nodule, with a multifocal location in 5%–14% of cases.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Histopathologically, GCTs are composed of sheets of large spindle, ovoid, and polygonal cells. At a higher magnification, the cells have abundant, finely granular cytoplasm and small bland nuclei with occasional nucleoli. GCTs show strong and diffuse positivity for the S-100 protein, NSE, CD68, NKI/C3, and vimentin. This staining pattern is suggestive of a Schwann cell origin. However, there is still much debate regarding the histogenesis of GCTs, include striated and smooth muscle cells, perineural fibroblasts, histiocytes, neurogenic cells, undifferentiated mesenchymal cells, and polyphyletic cells.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">A distinctive S-100 protein-negative variant of GCT has been observed. In 1991, an originally S-100-negative GCT was reported as a “primitive polypoid granular cell tumor”.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The tumor cells of the present lesion were negative for S-100 protein but stained strongly positive for Syn and weakly for NSE. This staining pattern is suggestive of a possible neuroendocrine origin. CD68 immunoreactivity indicates the presence of lysosomes rather than a marker of histiocytic lineage, as tumor cells are negative for CD163. The intracytoplasmic granules are diffusely and strongly positive for NKI/C3, with a large number of lysosomes in the cytoplasm of the tumor cells.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Some reports have suggested that the absence of S-100 expression may be due to an altered differentiation process in malignant GCTs.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Although the present case did not present malignant features clinically or histopathologically, an appropriate follow-up should be conducted to allow further characterization of the behavior of this rare neoplasm.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Financial support</span><p id="par0045" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Authors’contributions</span><p id="par0050" class="elsevierStylePara elsevierViewall">Gongjun Xu: Conception and planning of the study; elaboration and writing of the manuscript; critical review of the manuscript.</p><p id="par0055" class="elsevierStylePara elsevierViewall">Xuefeng Fu: Conception and planning of the study; elaboration and writing of the manuscript.</p><p id="par0060" class="elsevierStylePara elsevierViewall">Jinxian Fang: Design and planning of the study; preparation and writing of the manuscript.</p><p id="par0065" class="elsevierStylePara elsevierViewall">Chiqing Huang: Effective participation in research orientation; critical review of the literature.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflicts of interest</span><p id="par0070" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:9 [ 0 => array:3 [ "identificador" => "xres1505263" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1366019" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "sec0005" "titulo" => "Case report" ] 3 => array:2 [ "identificador" => "sec0010" "titulo" => "What is your diagnosis?" ] 4 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 5 => array:2 [ "identificador" => "sec0020" "titulo" => "Financial support" ] 6 => array:2 [ "identificador" => "sec0025" "titulo" => "Authors’contributions" ] 7 => array:2 [ "identificador" => "sec0030" "titulo" => "Conflicts of interest" ] 8 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2020-05-29" "fechaAceptado" => "2020-08-20" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1366019" "palabras" => array:4 [ 0 => "Benign" 1 => "Cutaneous" 2 => "Granular cell tumor" 3 => "S-100 negative" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Granular cell tumors (GCTs) are rare soft-tissue neoplasms. GCT immunohistochemistry is positive for S-100, NSE, and CD68. This report describes the case of a 10-year-old male who presented with a dorsal nodule. A biopsy revealed aggregates and sheets of large epithelioid and spindle cells. The cells had abundant eosinophilic granular cytoplasm. Immunohistochemical analysis was positive for CD68, NKI/C3, and synaptophysin; weakly positive for NSE; and negative for S-100, SOX10, HMB45, Melan A, cytokeratin, SMA, EMA, and CD163. The Ki-67 index was less than 1%. A diagnosis of an S-100 negative, cutaneous, benign GCT was determined.</p></span>" ] ] "NotaPie" => array:2 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">How to cite this article: Xu G, Fu X, Fang J, Huang C. Case for diagnosis. Dorsal nodule in a 10-year-old male. An Bras Dermatol. 2021;96:237–9.</p>" ] 1 => array:2 [ "etiqueta" => "☆☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Study conducted at the Department of Dermatology, Jinhua Fifth Hospital, Jinhua, China.</p>" ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1155 "Ancho" => 1500 "Tamanyo" => 210917 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) A solitary, round, 3<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>cm, dark-red-colored, dome-shaped, firm nodule on the back. (B) At low power, the biopsy showed aggregates and sheets of large cells with distinct cellular borders separated by thin, delicate connective tissue septa. The tumors were covered by a normal epidermis (Hematoxylin & eosin, ×40). (C) The folliculus pili were encased by the tumor (Hematoxylin & eosin, ×100). (D) The cells had abundant eosinophilic granular cytoplasm and occasional deeply eosinophilic round globules. The nuclei were vesicular, with pale chromatin and a single central nucleolus. A nerve fiber tract was also visible (Hematoxylin & eosin, ×200).</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1104 "Ancho" => 1750 "Tamanyo" => 388302 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Photomicrographs of immunohistochemical studies. (A) S-100 was negative in the tumor cells, while the nerve fiber tract served as an internal positive control (Original magnification, ×200). (B) CD68, (C) vimentin, (D) Syn, and (E) NKI/C3 (CD63) were positive (Original magnification, ×100), and (F) NSE was weakly positive (Original magnification, ×200).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:4 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary cutaneous malignant granular cell tumor: a case report in China and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T.T. Liu" 1 => "Y. Han" 2 => "S. Zheng" 3 => "B. Li" 4 => "Y.Q. Liu" 5 => "Y.X. Chen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s13000-015-0357-2" "Revista" => array:5 [ "tituloSerie" => "Diagn Pathol." "fecha" => "2015" "volumen" => "10" "paginaInicial" => "113" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26187381" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multiple plaques on the back: S-100 negative benign granular cell tumor" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "O. Arican" 1 => "H. Ciralik" 2 => "S. Sasmaz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1346-8138.2005.tb00803.x" "Revista" => array:6 [ "tituloSerie" => "J Dermatol." "fecha" => "2005" "volumen" => "32" "paginaInicial" => "585" "paginaFinal" => "588" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16335876" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primitive polypoid granular-cell tumor and other cutaneous granular-cell neoplasms of apparent nonneural origin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P.E. LeBoit" 1 => "R.J. Barr" 2 => "S. Burall" 3 => "J.S. Metcalf" 4 => "T.S. Yen" 5 => "M.R. Wick" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/00000478-199101000-00006" "Revista" => array:6 [ "tituloSerie" => "Am J Surg Pathol." "fecha" => "1991" "volumen" => "15" "paginaInicial" => "48" "paginaFinal" => "58" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1985501" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathergic pyoderma gangrenosum in a venous ulcer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P. Rosina" 1 => "S. Cunego" 2 => "C.Z. Franz" 3 => "F.S. D’Onghia" 4 => "G. Chieregato" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1365-4362.2002.01373_1.x" "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol." "fecha" => "2002" "volumen" => "41" "paginaInicial" => "166" "paginaFinal" => "167" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12010342" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03650596/0000009600000002/v2_202104300920/S036505962100009X/v2_202104300920/en/main.assets" "Apartado" => array:4 [ "identificador" => "80633" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "What is your Diagnosis?" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009600000002/v2_202104300920/S036505962100009X/v2_202104300920/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S036505962100009X?idApp=UINPBA00008Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 14 | 9 | 23 |
| 2024 October | 90 | 70 | 160 |
| 2024 September | 124 | 91 | 215 |
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| 2023 September | 64 | 64 | 128 |
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