Plasmacytoid dendritic cells in dermatology | Anais Brasileiros de Dermatologia

array:24 ["pii" => "S0365059620303202" "issn" => "03650596" "doi" => "10.1016/j.abd.2020.08.006" "estado" => "S300" "fechaPublicacion" => "2021-01-01" "aid" => "299" "copyright" => "Sociedade Brasileira de Dermatologia" "copyrightAnyo" => "2021" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "rev" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "pt" => array:19 [ "pii" => "S2666275220303659" "issn" => "26662752" "doi" => "10.1016/j.abdp.2020.08.006" "estado" => "S300" "fechaPublicacion" => "2021-01-01" "aid" => "299" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "rev" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "pt" => array:12 [ "idiomaDefecto" => true "cabecera" => "Revisão" "titulo" => "Células dendríticas plasmocitoides na dermatologia" "tienePdf" => "pt" "tieneTextoCompleto" => "pt" "tieneResumen" => "pt" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "76" "paginaFinal" => "81" ] ] "contieneResumen" => array:1 [ "pt" => true ] "contieneTextoCompleto" => array:1 [ "pt" => true ] "contienePdf" => array:1 [ "pt" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1640 "Ancho" => 2917 "Tamanyo" => 222770 ] ] "descripcion" => array:1 [ "pt" => "Células dendríticas plasmocitoides (pDCs): conexão de relevância entre as imunidades inata e adaptativa. Adaptado de Mitchell et al., 2018 e Swiecki et al., 2015.<a class="elsevierStyleCrossRefs" href="#bib0260">9,10</a> APRIL, ligante indutor de proliferação; AFF, fator de ativação da célula B da família fator de necrose tumoral alfa; CD, grupo de diferenciação; ICOSL, ligante coestimulador induzível; IDO, indoleamina‐2,3‐dioxigenase; IFN‐α, interferon alfa; IL, interleucina; MHC, complexo de histocompatibilidade; NK, natural killer; pDC, célula dendrítica plasmocitoide; TGF‐β, fator de transformação do crescimento beta; TH, linfócito T‐helper; TRAIL, ligante indutor de apoptose relacionado ao fator de necrose tumoral alfa; Treg, linfócito T‐regulatório." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Natasha Favoretto Dias de Oliveira, Claudia Giuli Santi, Celina Wakisaka Maruta, Valeria Aoki" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Natasha Favoretto" "apellidos" => "Dias de Oliveira" ] 1 => array:2 [ "nombre" => "Claudia Giuli" "apellidos" => "Santi" ] 2 => array:2 [ "nombre" => "Celina Wakisaka" "apellidos" => "Maruta" ] 3 => array:2 [ "nombre" => "Valeria" "apellidos" => "Aoki" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0365059620303202" "doi" => "10.1016/j.abd.2020.08.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620303202?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220303659?idApp=UINPBA00008Z" "url" => "/26662752/0000009600000001/v2_202102130748/S2666275220303659/v2_202102130748/pt/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S0365059620303044" "issn" => "03650596" "doi" => "10.1016/j.abd.2020.01.009" "estado" => "S300" "fechaPublicacion" => "2021-01-01" "aid" => "290" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "Tropical/Infectoparasitary Dermatology" "titulo" => "Diagnosis of cutaneous tuberculosis (lymph node scrofuloderma) using the Xpert MTB/RIF® method" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "82" "paginaFinal" => "84" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 599 "Ancho" => 1255 "Tamanyo" => 76283 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Materials for analysis by the Xpert MTB/RIF® method. (A), GeneXpert® device. (B), Buffer solution for treatment of the sample and cartridge for containing the material and reagents to be processed in the device." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Lilian Lemos Costa, John Verrinder Veasey" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Lilian Lemos" "apellidos" => "Costa" ] 1 => array:2 [ "nombre" => "John Verrinder" "apellidos" => "Veasey" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275220303568" "doi" => "10.1016/j.abdp.2020.01.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220303568?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620303044?idApp=UINPBA00008Z" "url" => "/03650596/0000009600000001/v3_202102051036/S0365059620303044/v3_202102051036/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0365059620302981" "issn" => "03650596" "doi" => "10.1016/j.abd.2020.08.004" "estado" => "S300" "fechaPublicacion" => "2021-01-01" "aid" => "284" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "Dermatopathology" "titulo" => "A case report and literature review of cutaneous intravascular large B-cell lymphoma presenting clinically as panniculitis: a difficult diagnosis, but a good prognosis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "72" "paginaFinal" => "75" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1374 "Ancho" => 900 "Tamanyo" => 332006 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Tumor cells in the lumens of vessel in the subcutaneous adipous tissue (A: Hematoxylin & eosin, ×100) and muscular tissue (B: Hematoxylin & eosin, ×400)." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Deniz Bayçelebi, Levent Yıldız, Nilgün Şentürk" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Deniz" "apellidos" => "Bayçelebi" ] 1 => array:2 [ "nombre" => "Levent" "apellidos" => "Yıldız" ] 2 => array:2 [ "nombre" => "Nilgün" "apellidos" => "Şentürk" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275220303490" "doi" => "10.1016/j.abdp.2020.08.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220303490?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620302981?idApp=UINPBA00008Z" "url" => "/03650596/0000009600000001/v3_202102051036/S0365059620302981/v3_202102051036/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "Review" "titulo" => "Plasmacytoid dendritic cells in dermatology" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "76" "paginaFinal" => "81" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Natasha Favoretto Dias de Oliveira, Claudia Giuli Santi, Celina Wakisaka Maruta, Valeria Aoki" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Natasha Favoretto" "apellidos" => "Dias de Oliveira" "email" => array:1 [ 0 => "natasha.favoretto@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Claudia Giuli" "apellidos" => "Santi" ] 2 => array:2 [ "nombre" => "Celina Wakisaka" "apellidos" => "Maruta" ] 3 => array:2 [ "nombre" => "Valeria" "apellidos" => "Aoki" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Department of Dermatology, Faculty of Medicine, Universidade de São Paulo, São Paulo, SP, Brazil" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1406 "Ancho" => 2500 "Tamanyo" => 232037 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Plasmacytoid dendritic cells (pDCs): relevant link between innate and adaptive immunity. Adapted from Mitchell et al., 2018 and Swiecki et al., 2015.<a class="elsevierStyleCrossRefs" href="#bib0045">9,10</a> pDC, plasmacytoid dendritic cell; MHC, major histocompatibility complex; CD, cluster of differentiation; Treg, T-regulatory lymphocyte; TH, T-helper lymphocyte; TGF-β, transforming growth factor beta; IL, interleukin; IDO, indoleamine-2,3-dioxygenase; ICOSL, inducible costimulator ligand; TRAIL, tumor necrosis factor-related apoptosis-inducing ligand; IFN-α, interferon alpha; BAFF, B cell-activating factor of the TNF family; APRIL, a proliferation-inducing ligand; NK, natural killer." ] ] ] "textoCompleto" => "IntroductionPlasmacytoid dendritic cells (pDCs) are part of dendritic cells family and develop from hematopoietic stem cells in the bone marrow. Lennert and Remmele first mentioned this then new cell type in 1958, detected in the paracortical region of reactive lymph nodes and named them lymphoblasts<a class="elsevierStyleCrossRef" href="#bib0005">1</a>; since the late 1980s, pDCs received several denominations over time (plasmacytoid T-cells, plasmacytoid monocytes).<a class="elsevierStyleCrossRefs" href="#bib0010">2–5</a>Characteristically, pDCs exhibit alpha chain receptor interleukin-3 (CD123) and blood derived dendritic cell antigen-2 (BDCA-2 or CD303), and are key mediators of innate immunity; they are the most potent producers of type 1 interferon (IFN) (IFN-a, IFN-b, IFN-l, IFN-w, and IFN-t), secreting a thousand times more IFN-α and IFN-β than other cell types.<a class="elsevierStyleCrossRef" href="#bib0030">6</a>pDCs are activated through Toll-like receptors (TLRs) 7 and 9, starting a signal that induces the expression of multiple immunomodulatory and pro-inflammatory molecules encoding genes, such as IFN-α. TLR7 responds to single-stranded RNA (rich in guanosine or uridine) found in viruses (as influenza and respiratory syncytial virus), while TLR 9 detects single-stranded DNA molecules containing unmethylated CpG motifs (CpG ODN) commonly found in virus genome like herpes simplex (HSV). Thus, pDCs detect viral infections through the recognition of viral nucleic acids and are important mediators of antiviral immunity.<a class="elsevierStyleCrossRef" href="#bib0030">6</a>pDCs are a relevant link between innate and adaptive immunity (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). They produce type 1 IFN in response to viral infections, promoting an antiviral state through IFN-stimulated genes expression and infected cells apoptosis. In addition to IFN, interleukin (IL)-12 and IL-18 activate natural killer (NK) cells, leading to IFN-γ secretion and lysis of target cells. IFN production by pDCs also induce macrophage and dendritic cells stimulation. Through expression of major histocompatibility complexes (MHC) and co-stimulatory molecules (as CD80, CD86, CD40), pDCs promote adaptive immunity by acting as antigen-presenting cells for both CD4+ and CD8+ T-lymphocytes. pDC expression of IDO (indoleamine-2,3-dioxygenase) and ICOSL (inducible costimulatory ligand) lead to T-regulatory (Treg) response, while pDCs production of TGF-β and IL-6 promotes T-helper (Th) 17 commitment. Production of IFN-I and IL-12 by the pDCs stimulates TCD8+ activity and polarization of TCD4+ cells into Th1. pDCs production of IFN-I, IL-6, B cell-activating factor of the TNF family (BAFF), and a proliferation-inducing ligand (APRIL) lead to expansion and stimulation of antibody-producing plasma cells. TNF-related apoptosis-inducing ligand (TRAIL) and granzyme B give pDCs the capacity to kill tumor cells, induce apoptosis of infected TCD4+ cells, and suppress T-cell proliferation. In addition, pDCs themselves stimulate plasmacytoid cells differentiation, through type 1 IFN and IL-6.<a class="elsevierStyleCrossRefs" href="#bib0030">6–10</a><elsevierMultimedia ident="fig0005"></elsevierMultimedia>pDCs are not usually present in normal skin; they infiltrate the skin in healing processes and in several conditions, such as viral infections, inflammatory, autoimmune, and neoplastic diseases.<a class="elsevierStyleCrossRefs" href="#bib0010">2,3</a> Review of the literature regarding the presence of pDCs and dermatologic diseases are below described.Cutaneous lupus erythematosusIn lupus erythematosus (LE), pDCs are the main producers of IFN-α. Circulating pDCs are known to be reduced in patients with systemic lupus erythematosus (SLE), since they migrate and infiltrate target tissues, such as the skin. Several studies have shown large amounts of IFN-α producing pDCs in chronic discoid lupus lesions.<a class="elsevierStyleCrossRefs" href="#bib0055">11–13</a>Tomasini et al. found differences in pDCs' distribution among different types of lupus: superficial expression in skin specimens of subacute lupus and discoid lupus, and distribution around deep vessels in cases of tumid lupus and multicentric reticulohistiocytosis.<a class="elsevierStyleCrossRef" href="#bib0015">3</a> They also found a positive relation between intensity of the inflammatory infiltrate and amount of pDCs.Additionally, the number of pDCs in LE and dermatomyositis (DM) lesions directly correlated with the expression of myxovirusresistance protein (MxA), a protein induced by IFN-α/β, suggesting that pDCs are an important IFN-α source in such diseases.<a class="elsevierStyleCrossRefs" href="#bib0055">11,14,15</a> McNiff et al. verified that pDCs were preferably detected at the epidermis in patients with dermatomyositis when compared to patients with lupus, where the location was mainly in the dermis, suggesting that in LE circulating immune complexes migrate through the vessels before skin deposition.<a class="elsevierStyleCrossRef" href="#bib0055">11</a>Lichen planusVries et al. observed abundant CD123+ pDCs in lichen planus (LP) skin fragments, arranged the band-like lymphocytic infiltrate at the dermo-epidermal junction. In addition, they demonstrated replication of herpes virus 7 in plasmacytoid dendritic cells in active LP lesions, followed by its decrease in clinical remission.<a class="elsevierStyleCrossRefs" href="#bib0080">16,17</a>Wang et al. described increased plasmacytoid dendritic cells infiltration in oral LP, proposing them as mediators of the innate immune response in this disease.<a class="elsevierStyleCrossRef" href="#bib0090">18</a>Lichen striatusBadr et al. found pDCs in the inflammatory infiltrate of lichen striatus (LS), suggesting that these cells play a role in the pathogenesis of the disease. Additionally, there is a perieccrine distribution of pDCs in LS, which may be a useful criterium to histologically differentiate LS from LP.<a class="elsevierStyleCrossRef" href="#bib0095">19</a>Atopic dermatitisIn patients with atopic dermatitis (AD), there was an increase in circulating pDCs in comparison to controls; moreover, recruitment of pDCs in AD lesions was much lower than the amount found in other dermatoses, such as LE and psoriasis. The poor recruitment of pDCs, resulting in reduced production of type 1 IFN in AD lesions, could explain enhanced susceptibility of patients with AD to viral infections, such as herpes simplex or poxvirus infections.<a class="elsevierStyleCrossRefs" href="#bib0100">20,21</a>Polymorphic light eruptionRossi et al., in contrast to previous studies, demonstrated significant increase of dermal pDCs in patients with polymorphic light eruption when compared to healthy controls, probably due to the photo provocation testing.<a class="elsevierStyleCrossRefs" href="#bib0110">22,23</a>PsoriasisNestle et al. found large amounts of pDCs in the dermal T-lymphocyte infiltrate of psoriatic plaques, absent in the skin of healthy donors and AD patients.<a class="elsevierStyleCrossRef" href="#bib0120">24</a> Additionally, pDCs were also found in the skin adjacent to the plaques, even without apparent lesions. They also demonstrated reduction in pDCs in the peripheral blood of patients with psoriasis when compared to healthy individuals, suggesting that the accumulation of pDCs in the skin of patients with psoriasis occurs due to the redistribution pDCs from the blood to the skin.<a class="elsevierStyleCrossRef" href="#bib0120">24</a> In animal models, the authors demonstrated production of IFN-α by pDCs in the injured skin, and its influence on theAnother study in psoriasis showed that heliotherapy provided not only clinical improvement, but also reduction of pDCs number and expression of MxA, a marker for IFN-α in lesional skin, strengthening the role of pDCs in psoriasis.<a class="elsevierStyleCrossRef" href="#bib0125">25</a>Chemerin is a chemotactic factor for serum pDCs. Albanesi et al. demonstrated a strong expression of chemerin and the presence of pDCs in the dermis of skin adjacent to psoriatic lesions.<a class="elsevierStyleCrossRef" href="#bib0130">26</a> There was a low expression of chemerin and few pDCs in chronic psoriatic plaques, suggesting that the expression of chemerin occurs in the early stages of psoriasis lesions and is temporally correlated with the presence of pDCs.Pityriasis lichenoidesThe pathophysiology of pityriasis lichenoides (PL) is not fully understood. MxA expression was demonstrated in PL lesions, establishing local production of type 1 IFN.<a class="elsevierStyleCrossRefs" href="#bib0135">27,28</a>Karouni et al. demonstrated the presence of pDCs in the skin of PL patients in both forms, pityriasis lichenoides et varioliformis acuta (PLEVA) and pityriasis lichenoides chronica (PLC).<a class="elsevierStyleCrossRef" href="#bib0145">29</a> Furthermore, they found intense and diffuse expression of MxA, demonstrating its activation and production of type 1 IFN. The authors suggest that viral infections, autoantigens, trauma, antigens against drugs and tumors – previously associated with cases of PL – could also contribute to the recruitment and activation of pDCs, as demonstrated in other interface dermatitis, such as LP, LS, LE, and DM.<a class="elsevierStyleCrossRef" href="#bib0145">29</a>Graft vs. host diseaseMalard et al. showed the presence of pDCs in skin fragments of patients with acute graft-versus-host disease (GVHD), as well as a strong expression of MxA, signaling local production of type 1 IFN.<a class="elsevierStyleCrossRef" href="#bib0150">30</a> Previously, the same group reported a reduction in serum levels of pDCs in patients with acute GVHD, suggesting pDCs' infiltration into the GVHD target tissues.<a class="elsevierStyleCrossRefs" href="#bib0150">30,31</a> However, the presence of CD123+ cells in the oral mucosa of patients with chronic GVHD was not superior when compared to controls in the study carried out by Botari et al., which suggests an early participation of pDCs in GVHD.<a class="elsevierStyleCrossRef" href="#bib0160">32</a>WartsThe demonstration of the presence of activated pDCs in inflamed viral warts was based on the intense expression of MxA, contrary to the data by Tomasini et al.<a class="elsevierStyleCrossRefs" href="#bib0015">3,33</a> The opposite results may be related to the different histological criteria for inflamed warts used by the two groups.<a class="elsevierStyleCrossRef" href="#bib0165">33</a>Tassone et al. evaluated patients with WHIM syndrome (warts, hypogammaglobulinemia, infections, and myelokathexis), who have refractory warts; the authors pointed out reduction in pDCs in peripheral blood and in skin lesions, and absence of type 1 IFN production, assessed through the expression of MxA, suggesting inability of antiviral activity of pDCs via TLR9.<a class="elsevierStyleCrossRef" href="#bib0170">34</a>Fungal diseasesPagliari et al. evaluated the role of pDCs in three deep mycoses (chromoblastomycosis [CBM], lobomycosis, and paracoccidioidomycosis [PCM]).<a class="elsevierStyleCrossRef" href="#bib0175">35</a> pDCs were found in 37% of the skin fragments of patients with CBM and in 50% of specimens of patients with PCM, but were absent in patients with lobomycosis. The authors hypothesize that pDCs would be a secondary source of cytokines, relevant to antifungal activity in cases of CBM and PCM. In lobomycosis, the absence of pDCs implies that such are not involved in the antifungal immune response.LeprosyMassone et al. described the absence of CD123 expression in skin biopsy fragments of leprosy patients, except for focal expression in two cases of erythema nodosum leprosum, implying in noninvolvementof pDCs in the immune response against Mycobacterium leprae.<a class="elsevierStyleCrossRef" href="#bib0180">36</a> Hirai et al., on the other hand, found pDCs in the inflammatory infiltrate and around the vessels in the skin of leprosy patients, emphasizing enhanced number of pDCs in tuberculoid leprosy, when compared to lepromatous leprosy.<a class="elsevierStyleCrossRef" href="#bib0185">37</a>Skin tumorsThe presence of pDCs in skin tumors has been evaluated by several authors. Abbas et al. identified the presence of pDCs in 100% of cases of keratoacanthoma (KC) and 90% of squamous cell carcinoma (SCC).<a class="elsevierStyleCrossRef" href="#bib0190">38</a> In KC, pDCs were more abundant, representing a greater proportion of the inflammatory infiltrate, with greater activity, suggesting a possible role of pDCS in the pathogenesis of KC regression. Recently, Fraga et al. corroborated the abundant presence of pDCs in both KC and SCC, without significant differences.<a class="elsevierStyleCrossRef" href="#bib0195">39</a>Imiquimod, a selective TLR7 agonist via transcription factor NF-kB activation and production of inflammatory cytokines, such as type 1 IFN, is used as treatment for some skin tumors.<a class="elsevierStyleCrossRef" href="#bib0200">40</a> Basal cell carcinomas (BCCs) treated with imiquimod showed activated pDCs producing IFN-α in the peritumoral infiltrate.<a class="elsevierStyleCrossRef" href="#bib0205">41</a> Subsequently, Ogawa et al. demonstrated correlation between the amount of pDCs recruited in actinic keratosis (AK) lesions and the therapeutic effect of imiquimod in these cases.<a class="elsevierStyleCrossRef" href="#bib0200">40</a>The presence of pDCs has also been described in melanoma, mainly located around the vessels and close to tumor cells, both in primary cases and in metastases. However, these pDCs are not activated, there is a lack of TLR7 and TLR9 signaling in the tumor environment, there is no production of type 1 IFN, and they have been associated with tumor growth. In contrast, regressive melanomas have activated pDCs, indicating possible antitumor activity. Treatment of skin tumors (AK, superficial BCC, Bowen's disease and even lentigo maligna melanoma) with imiquimod (TLR7 and TLR9 agonist) activates the pDCs to produce type 1 IFN.<a class="elsevierStyleCrossRef" href="#bib0210">42</a>Similarly, Karouni et al. described that pDCs are present in 90% of cases of Kaposi's sarcoma (KS), with reduced MxA expression, indicating suppression by Kaposi's sarcoma-associated herpesvirus (KSHV), through viral proteins that would inhibit the signaling pathways of pDCs activation.Main findings of pDCs in skin diseases are summarized in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>.<a class="elsevierStyleCrossRef" href="#bib0215">43</a><elsevierMultimedia ident="tbl0005"></elsevierMultimedia>ConclusionsIt is currently known that pDCs are the link between innate and adaptive immunity. These cells are not skin residents, and therefore their presence in the skin suggest a role (either central or adjuvant) in inflammatory, autoimmune, neoplastic and infectious processes. More studies are needed regarding such cells,which may lead to novel therapeutic targets.Financial supportThis study was financed by FUNADERSP (Dermatology Support Fund of the State of São Paulo-Sebastião Sampaio) – Project 52-2017.Authors’ contributionsNatasha Favoretto Dias de Oliveira: Approval of the final version of the manuscript; design and planning of the study; drafting and editing of the manuscript; collection, analysis, and interpretation of data; critical review of the literature.Claudia Giuli Santi: Approval of the final version of the manuscript; design and planning of the study; collection, analysis, and interpretation of data; effective participation in research orientation; critical review of the manuscript.Celina Wakisaka Maruta: Approval of the final version of the manuscript; design and planning of the study; collection, analysis, and interpretation of data; effective participation in research orientation; critical review of the manuscript.Valeria Aoki: Approval of the final version of the manuscript; design and planning of the study; collection, analysis, and interpretation of data; effective participation in research orientation; critical review of the literature; critical review of the manuscript.Conflicts of interestNone declared." "textoCompletoSecciones" => array:1 [ "secciones" => array:20 [ 0 => array:3 [ "identificador" => "xres1461416" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1331600" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 3 => array:2 [ "identificador" => "sec0010" "titulo" => "Cutaneous lupus erythematosus" ] 4 => array:2 [ "identificador" => "sec0015" "titulo" => "Lichen planus" ] 5 => array:2 [ "identificador" => "sec0020" "titulo" => "Lichen striatus" ] 6 => array:2 [ "identificador" => "sec0025" "titulo" => "Atopic dermatitis" ] 7 => array:2 [ "identificador" => "sec0030" "titulo" => "Polymorphic light eruption" ] 8 => array:2 [ "identificador" => "sec0035" "titulo" => "Psoriasis" ] 9 => array:2 [ "identificador" => "sec0040" "titulo" => "Pityriasis lichenoides" ] 10 => array:2 [ "identificador" => "sec0045" "titulo" => "Graft vs. host disease" ] 11 => array:2 [ "identificador" => "sec0050" "titulo" => "Warts" ] 12 => array:2 [ "identificador" => "sec0055" "titulo" => "Fungal diseases" ] 13 => array:2 [ "identificador" => "sec0060" "titulo" => "Leprosy" ] 14 => array:2 [ "identificador" => "sec0065" "titulo" => "Skin tumors" ] 15 => array:2 [ "identificador" => "sec0070" "titulo" => "Conclusions" ] 16 => array:2 [ "identificador" => "sec0075" "titulo" => "Financial support" ] 17 => array:2 [ "identificador" => "sec0080" "titulo" => "Authors’ contributions" ] 18 => array:2 [ "identificador" => "sec0085" "titulo" => "Conflicts of interest" ] 19 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2020-07-03" "fechaAceptado" => "2020-08-10" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1331600" "palabras" => array:5 [ 0 => "Adaptive immunity" 1 => "Dendritic cells" 2 => "Dermatological diseases" 3 => "Dermatology" 4 => "Innate immunity" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "Plasmacytoid dendritic cells are part of the dendritic cells family and are a relevant link between innate and adaptive immunity. They are the most potent producers of type 1 interferon, generating antiviral response, stimulating macrophages and dendritic cells and inducing activation and migration of natural killer cells. Plasmacytoid dendritic cells also exert a role as antigen-presenting cells, promote T-lymphocyte responses, immunoregulation, plasma cells differentiation and antibody secretion. Even though plasmacytoid dendritic cells are not usually present in normal skin, their presence is detected in healing processes, viral infections, and inflammatory, autoimmune, and neoplastic diseases. In recent years, the presence of plasmacytoid dendritic cells in several dermatological diseases has been described, enhancing their potential role in the pathogenesis of such conditions. Future studies on the role of plasmacytoid dendritic cells in dermatology may lead to new therapeutic targets." ] ] "NotaPie" => array:2 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "How to cite this article: Dias de Oliveira NF, Santi CG, Maruta CW, Aoki V. Plasmacytoid dendritic cells in dermatology. An Bras Dermatol. 2021;96:76–81." ] 1 => array:2 [ "etiqueta" => "☆☆" "nota" => "Study conducted at the Department of Dermatology, Faculty of Medicine, Universidade de São Paulo, São Paulo, SP, Brasil." ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1406 "Ancho" => 2500 "Tamanyo" => 232037 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Plasmacytoid dendritic cells (pDCs): relevant link between innate and adaptive immunity. Adapted from Mitchell et al., 2018 and Swiecki et al., 2015.<a class="elsevierStyleCrossRefs" href="#bib0045">9,10</a> pDC, plasmacytoid dendritic cell; MHC, major histocompatibility complex; CD, cluster of differentiation; Treg, T-regulatory lymphocyte; TH, T-helper lymphocyte; TGF-β, transforming growth factor beta; IL, interleukin; IDO, indoleamine-2,3-dioxygenase; ICOSL, inducible costimulator ligand; TRAIL, tumor necrosis factor-related apoptosis-inducing ligand; IFN-α, interferon alpha; BAFF, B cell-activating factor of the TNF family; APRIL, a proliferation-inducing ligand; NK, natural killer." ] ] 1 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "pDCs, plasmacytoid dendritic cells; SLE, systemic lupus erythematosus; DL, discoid lupus; SAL, subacute lupus; TL, tumid lupus; MRH, multicentric reticulohistiocytosis; DM, dermatomyositis; AD, atopic dermatitis; PLE, polymorphic light eruption; PL, pityriasis lichenoides; PLEVA, pityriasis lichenoides et varioliformis acuta; PLC, pityriasis lichenoides chronica; GVHD, graft vs. host disease; WHIM, warts, hypogammaglobulinemia, infections, and myelokathexis; CBM, chromoblastomycosis; PCM, paracoccidioidomycosis; SCC, squamous cell carcinoma; AK, actinic keratosis; BCC, basal cell carcinoma; KS, Kaposi's sarcoma; KSHV, Kaposi's sarcoma-associated herpesvirus." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dermatological diseases \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">pDCs \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " rowspan="5" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lupus erythematosus</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">SLE: reduced circulating pDCs<a class="elsevierStyleCrossRefs" href="#bib0015">3,11–13</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">DL: large amounts of IFN-α producing pDCs<a class="elsevierStyleCrossRefs" href="#bib0015">3,11–13</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">SAL, DL: superficial distribution<a class="elsevierStyleCrossRef" href="#bib0015">3</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TL, MHR: distribution around deep vessels<a class="elsevierStyleCrossRef" href="#bib0015">3</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">pDCs localized preferably in the epidermis in patients with DM and in the dermis in cases of lupus<a class="elsevierStyleCrossRef" href="#bib0055">11</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lichen planus</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">pDCs arranged similarly to the band-like lymphocytic infiltrate at the dermo-epidermal junction<a class="elsevierStyleCrossRefs" href="#bib0080">16,17</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">pDCs increased in oral lichen planus<a class="elsevierStyleCrossRef" href="#bib0090">18</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lichen striatus</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">pDCs present in the inflammatoryinfiltrate \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Perieccrine distribution of pDCs<a class="elsevierStyleCrossRef" href="#bib0095">19</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Atopic dermatitis</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Increased circulating pDCs compared to controls \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lower recruitment of pDCs in AD lesions compared to other dermatoses, such as lupus erythematosus and psoriasis<a class="elsevierStyleCrossRefs" href="#bib0100">20,21</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Polymorphic light eruption</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Wackernagel et al.:<a class="elsevierStyleCrossRef" href="#bib0110">22</a> absent pDCs \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Rossi et al.:<a class="elsevierStyleCrossRef" href="#bib0115">23</a> increased pDCs in PLE lesions, mainly dermal. The authors attribute the difference to the methodology witch included of a photoprovocation testing. \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " rowspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Psoriasis</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">pDCs present in the T lymphocyte infiltrate in the dermis of psoriatic plaques and in the perilesional skin<a class="elsevierStyleCrossRef" href="#bib0120">24</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Reduction of pDCs in the peripheral blood of patients with psoriasis<a class="elsevierStyleCrossRef" href="#bib0120">24</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Heliotherapy: reduction of pDCs amount and MxA expression<a class="elsevierStyleCrossRef" href="#bib0125">25</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Strong chemerin expression and presence of pDCs in the perilesional skin dermis<a class="elsevierStyleCrossRef" href="#bib0130">26</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pityriasis lichenoides</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Strong MxA expression in PL lesions (local production of type 1 IFN)<a class="elsevierStyleCrossRefs" href="#bib0135">27,28</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Presence of pDCs on the skin in all cases (PLEVA and PLC)<a class="elsevierStyleCrossRef" href="#bib0145">29</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " rowspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Graft vs. host disease</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Presence of pDCs in skin fragments of patients with acute GVHD, strong expression of MxA, signaling local production of type 1 IFN<a class="elsevierStyleCrossRef" href="#bib0150">30</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Reduction of serum pDCs in patients with acute GVHD<a class="elsevierStyleCrossRef" href="#bib0155">31</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Presence of CD123+ cells in the oral mucosa of patients with chronic GVHD was not superior<a class="elsevierStyleCrossRef" href="#bib0160">32</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Warts</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Saadeh et al.:<a class="elsevierStyleCrossRef" href="#bib0165">33</a> activated pDCs in inflamed viral warts, contrary to what was found by Tomasini et al.<a class="elsevierStyleCrossRef" href="#bib0015">3</a> (possible differences in histologic criteria for inflamed warts). \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Reduction in pDCs in peripheral blood and in skin lesions, absence of type 1 IFN production (MxA without expression) in patients with WHIM syndrome<a class="elsevierStyleCrossRef" href="#bib0170">34</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fungal diseases \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">pDCs found in 37% of the skin fragments of patients with CBM and in 50% of the specimens from patients with PCM, but absent in cases of lobomycosis<a class="elsevierStyleCrossRef" href="#bib0175">35</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Leprosy</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Massone et al.:<a class="elsevierStyleCrossRef" href="#bib0180">36</a> absence of CD123 expression, except for focal expression in two cases of erythema nodosum leprosum \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hirai et al.:<a class="elsevierStyleCrossRef" href="#bib0185">37</a> pDCs in the inflammatory infiltrate and around the vessels. Higher number of pDCs in tuberculoid cases compared to virchowian cases. \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " rowspan="6" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Skin tumors</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Keratoacanthoma: presence of pDCs in 100% of cases<a class="elsevierStyleCrossRef" href="#bib0190">38</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">SCC: presence of pDCs in 90% of cases<a class="elsevierStyleCrossRef" href="#bib0190">38</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">AK: correlation between the amount of pDCs recruited in the lesions during treatment with imiquimod and the therapeutic effect of the drug<a class="elsevierStyleCrossRef" href="#bib0200">40</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BCC: presence of activated pDCs producing IFN-α in the peritumoral infiltrate during treatment with imiquimod<a class="elsevierStyleCrossRef" href="#bib0205">41</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Melanoma: pDCs arranged around the vessels and close to the tumor cells, but not activated. Presence associated with tumor growth. pDCs activated in cases of regressive melanoma<a class="elsevierStyleCrossRef" href="#bib0210">42</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">KS: pDCs present in 90% of cases, but reduced expression of MxA (possible suppression of pDCs by KSHV)<a class="elsevierStyleCrossRef" href="#bib0215">43</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2514513.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Skin diseases and plasmacytoid dendritic cells (pDCs)." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:43 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "[Karyometric research on lymph node cells in man. I. Germinoblasts, lymphoblasts & lymphocytes]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "K. Lennert" 1 => "W. Remmele" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Acta Haematol." "fecha" => "1958" "volumen" => "19" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasmacytoid dendritic cells: physiologic roles and pathologic states" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.G. Jegalian" 1 => "F. Facchetti" 2 => "E.S. Jaffe" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/PAP.0b013e3181bb6bc2" "Revista" => array:6 [ "tituloSerie" => "Adv Anat Pathol." "fecha" => "2009" "volumen" => "16" "paginaInicial" => "392" "paginaFinal" => "404" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19851130" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasmacytoid dendritic cells: an overview of their presence and distribution in different inflammatory skin diseases, with special emphasis on Jessner’s lymphocytic infiltrate of the skin and cutaneous lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Tomasini" 1 => "T. Mentzel" 2 => "M. Hantschke" 3 => "A. Cerri" 4 => "B. Paredes" 5 => "A. Rütten" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1600-0560.2010.01587.x" "Revista" => array:6 [ "tituloSerie" => "J Cutan Pathol." "fecha" => "2010" "volumen" => "37" "paginaInicial" => "1132" "paginaFinal" => "1139" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20659210" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunohistology and aetiology of histiocytic necrotizing lymphadenitis. Report of three instructive cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.C. Feller" 1 => "K. Lennert" 2 => "H. Stein" 3 => "H.D. Bruhn" 4 => "H.H. Wuthe" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2559.1983.tb02299.x" "Revista" => array:6 [ "tituloSerie" => "Histopathology." "fecha" => "1983" "volumen" => "7" "paginaInicial" => "825" "paginaFinal" => "839" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6229466" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasmacytoid T cells. Immunohistochemical evidence for their monocyte/macrophage origin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "F. Facchetti" 1 => "C. de Wolf-Peeters" 2 => "D.Y. Mason" 3 => "K. Pulford" 4 => "J.J. van den Oord" 5 => "V.J. Desmet" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Pathol." "fecha" => "1988" "volumen" => "133" "paginaInicial" => "15" "paginaFinal" => "21" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3052093" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Gilliet" 1 => "W. Cao" 2 => "Y.J. Liu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nri2358" "Revista" => array:6 [ "tituloSerie" => "Nat Rev Immunol" "fecha" => "2008" "volumen" => "8" "paginaInicial" => "594" "paginaFinal" => "606" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18641647" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Update on the role of plasmacytoid dendritic cells in inflammatory/autoimmune skin diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Saadeh" 1 => "M. Kurban" 2 => "O. Abbas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/exd.12957" "Revista" => array:6 [ "tituloSerie" => "Exp Dermatol." "fecha" => "2016" "volumen" => "25" "paginaInicial" => "415" "paginaFinal" => "421" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26837058" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "T regulatory cells and plasmocytoid dentritic cells in hansen disease: a new insight into pathogenesis?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Massone" 1 => "E. Nunzi" 2 => "R. RibeiroRodrigues" 3 => "C. Talhari" 4 => "S. Talhari" 5 => "A.P. Schettini" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/DAD.0b013e3181b7fc56" "Revista" => array:6 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "2010" "volumen" => "32" "paginaInicial" => "251" "paginaFinal" => "256" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20075708" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasmacytoid dendritic cell in immunity and cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Mitchell" 1 => "S. Chintala" 2 => "M. Dey" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jneuroim.2018.06.012" "Revista" => array:6 [ "tituloSerie" => "J Neuroimmunol." "fecha" => "2018" "volumen" => "322" "paginaInicial" => "63" "paginaFinal" => "73" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30049538" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The multifaceted biology of plasmacytoid dendritic cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Swiecki" 1 => "M. Colonna" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nri3865" "Revista" => array:6 [ "tituloSerie" => "Nat Rev Immunol." "fecha" => "2015" "volumen" => "15" "paginaInicial" => "471" "paginaFinal" => "485" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26160613" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasmacytoid dendritic cells are present in cutaneous dermatomyositis lesions in a pattern distinct from lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.M. McNiff" 1 => "D.H. Kaplan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1600-0560.2007.00848.x" "Revista" => array:6 [ "tituloSerie" => "J Cutan Pathol." "fecha" => "2008" "volumen" => "35" "paginaInicial" => "452" "paginaFinal" => "456" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18005168" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.L. Rowland" 1 => "J.M. Riggs" 2 => "S. Gilfillan" 3 => "M. Bugatti" 4 => "W. Vermi" 5 => "R. Kolbeck" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1084/jem.20132620" "Revista" => array:6 [ "tituloSerie" => "J Exp Med." "fecha" => "2014" "volumen" => "211" "paginaInicial" => "1977" "paginaFinal" => "1991" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25180065" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasmacytoid dendritic cells in hypertrophic discoid lupus erythematosus: an objective evaluation of their diagnostic value" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N.M. Walsh" 1 => "J. Lai" 2 => "J.G. Hanly" 3 => "P.J. Green" 4 => "F. Bosisio" 5 => "J. Garcias-Ladaria" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/cup.12416" "Revista" => array:6 [ "tituloSerie" => "J Cutan Pathol." "fecha" => "2015" "volumen" => "42" "paginaInicial" => "32" "paginaFinal" => "38" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25367375" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasmacytoid dendritic cells (natural interferon-alpha/beta-producing cells) accumulate in cutaneous lupus erythematosus lesions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L. Farkas" 1 => "K. Beiske" 2 => "F. Lund-Johansen" 3 => "P. Brandtzaeg" 4 => "F.L. Jahnsen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0002-9440(10)61689-6" "Revista" => array:5 [ "tituloSerie" => "Am J Pathol." "fecha" => "2001" "volumen" => "159" "paginaInicial" => "237" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11438470" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Type I interferon-associated skin recruitment of CXCR31 lymphocytes in dermatomyositis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Wenzel" 1 => "R. Schmidt" 2 => "J. Proelss" 3 => "S. Zahn" 4 => "T. Bieber" 5 => "T. Tutling" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2230.2006.02150.x" "Revista" => array:6 [ "tituloSerie" => "Clin Exp Dermatol." "fecha" => "2006" "volumen" => "31" "paginaInicial" => "576" "paginaFinal" => "582" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16716166" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lichen planus is associated with human herpesvirus type 7 replication and infiltration of plasmacytoid dendritic cells" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H.J. de Vries" 1 => "J. van Marle" 2 => "M.B. Teunissen" 3 => "D. Picavet" 4 => "F. Zorgdrager" 5 => "J.D. Bos" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2005.06999.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol." "fecha" => "2006" "volumen" => "154" "paginaInicial" => "361" "paginaFinal" => "364" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16433811" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lichen planus remission is associated with a decrease of human herpes virus type 7 protein expression in plasmacytoid dendritic cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "H.J. de Vries" 1 => "M.B. Teunissen" 2 => "F. Zorgdrager" 3 => "D. Picavet" 4 => "M. Cornelissen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00403-007-0750-0" "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol Res." "fecha" => "2007" "volumen" => "299" "paginaInicial" => "213" "paginaFinal" => "219" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17404748" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased infiltration of CD11 c+/CD123+ dendritic cell subsets and upregulation of TLR/IFN-α signaling participate in pathogenesis of oral lichen planus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y. Wang" 1 => "S. Shang" 2 => "Q. Sun" 3 => "J. Chen" 4 => "G. Du" 5 => "H. Nie" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.oooo.2017.12.003" "Revista" => array:6 [ "tituloSerie" => "Oral Surg Oral Med Oral Pathol Oral Radiol." "fecha" => "2018" "volumen" => "125" "paginaInicial" => "459" "paginaFinal" => "467" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29429903" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasmacytoid Dendritic Cells and Type I Interferon Signature in Lichen Striatus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D. Badr" 1 => "R. Abadi" 2 => "M. Kurban" 3 => "O. Abbas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/pde.12824" "Revista" => array:6 [ "tituloSerie" => "Pediatr Dermatol." "fecha" => "2016" "volumen" => "33" "paginaInicial" => "301" "paginaFinal" => "306" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26935593" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of dendritic cell subtypes in the pathophysiology of atopic dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "N. Novak" 1 => "T. Bieber" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2005.04.060" "Revista" => array:7 [ "tituloSerie" => "J Am Acad Dermatol." "fecha" => "2005" "volumen" => "53" "numero" => "2 Suppl 2" "paginaInicial" => "S171" "paginaFinal" => "6" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16021172" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasmacytoid dendritic cells: a new cutaneous dendritic cell subset with distinct role in inflammatory skin diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Wollenberg" 1 => "M. Wagner" 2 => "S. Günther" 3 => "A. Towarowski" 4 => "E. Tuma" 5 => "M. Moderer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1523-1747.2002.19515.x" "Revista" => array:6 [ "tituloSerie" => "J Invest Dermatol." "fecha" => "2002" "volumen" => "119" "paginaInicial" => "1096" "paginaFinal" => "1102" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12445198" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasmacytoid dendritic cells are absent in skin lesions of polymorphic light eruption" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Wackernagel" 1 => "C. Massone" 2 => "G. Hoefler" 3 => "E. Steinbauer" 4 => "H. Kerl" 5 => "P. Wolf" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1600-0781.2007.00267.x" "Revista" => array:6 [ "tituloSerie" => "Photodermatol Photoimmunol Photomed." "fecha" => "2007" "volumen" => "23" "paginaInicial" => "24" "paginaFinal" => "28" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17254032" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous infiltration of plasmacytoid dendritic cells and T regulatory cells in skin lesions of polymorphic light eruption" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.T. Rossi" 1 => "M. Arisi" 2 => "S. Lonardi" 3 => "L. Lorenzi" 4 => "M. Ungari" 5 => "F. Serana" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jdv.14866" "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol." "fecha" => "2018" "volumen" => "32" "paginaInicial" => "985" "paginaFinal" => "991" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29430717" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F.O. Nestle" 1 => "C. Conrad" 2 => "A. Tun-Kyi" 3 => "B. Homey" 4 => "M. Gombert" 5 => "O. Boyman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1084/jem.20050500" "Revista" => array:6 [ "tituloSerie" => "J Exp Med." "fecha" => "2005" "volumen" => "202" "paginaInicial" => "135" "paginaFinal" => "143" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15998792" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sun exposure rapidly reduces plasmacytoid dendritic cells and inflammatory dermal dendritic cells in psoriatic skin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "I. Heier" 1 => "E. Søyland" 2 => "A.L. Krogstad" 3 => "C. Rodríguez-Gallego" 4 => "M.S. Nenseter" 5 => "F.L. Jahnsen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2011.10430.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol." "fecha" => "2011" "volumen" => "165" "paginaInicial" => "792" "paginaFinal" => "801" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21623747" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Albanesi" 1 => "C. Scarponi" 2 => "S. Pallotta" 3 => "R. Daniele" 4 => "D. Bosisio" 5 => "S. Madonna" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1084/jem.20080129" "Revista" => array:6 [ "tituloSerie" => "J Exp Med." "fecha" => "2009" "volumen" => "206" "paginaInicial" => "249" "paginaFinal" => "258" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19114666" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of cytotoxic skin-homing CD8+ lymphocytes in cutaneous cytotoxic T-cell lymphoma and pityriasis lichenoides" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Wenzel" 1 => "I. Gütgemann" 2 => "M. Distelmaier" 3 => "M. Uerlich" 4 => "S. Mikus" 5 => "T. Bieber" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2005.05.042" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol." "fecha" => "2005" "volumen" => "53" "paginaInicial" => "422" "paginaFinal" => "427" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16112347" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human MxA protein: an interferon- induced dynamin-like GTPase with broad antiviral activity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "O. Haller" 1 => "G. Kochs" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1089/jir.2010.0076" "Revista" => array:6 [ "tituloSerie" => "J Interferon Cytokine Res." "fecha" => "2011" "volumen" => "31" "paginaInicial" => "79" "paginaFinal" => "87" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21166595" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Possible role of plasmacytoid dendritic cells in pityriasis lichenoides" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Karouni" 1 => "J.A. Rahal" 2 => "M. Kurban" 3 => "A.G. Kibbi" 4 => "O. Abbas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/ced.13351" "Revista" => array:6 [ "tituloSerie" => "Clin Exp Dermatol." "fecha" => "2018" "volumen" => "43" "paginaInicial" => "404" "paginaFinal" => "409" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29349807" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased plasmacytoid dendritic cells and RORγt-expressing immune effectors in cutaneous acute graft-versus-host disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Malard" 1 => "C. Bossard" 2 => "E. Brissot" 3 => "P. Chevallier" 4 => "T. Guillaume" 5 => "J. Delaunay" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1189/jlb.0513295" "Revista" => array:6 [ "tituloSerie" => "J Leukoc Biol." "fecha" => "2013" "volumen" => "94" "paginaInicial" => "1337" "paginaFinal" => "1343" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23990625" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of plasmacytoid dendritic cells on outcome after reduced-intensity conditioning allogeneic stem cell transplantation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Mohty" 1 => "D. Blaise" 2 => "C. Faucher" 3 => "V.J. Bardou" 4 => "J.A. Gastaut" 5 => "P. Viens" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.leu.2403558" "Revista" => array:6 [ "tituloSerie" => "Leukemia." "fecha" => "2005" "volumen" => "19" "paginaInicial" => "1" "paginaFinal" => "6" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15526026" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Oral chronic graft-versus-host disease: analysis of dendritic cells subpopulations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C.M. Botari" 1 => "A.J. Nunes" 2 => "M.P. Souza" 3 => "E.S. Orti-Raduan" 4 => "A.G. Salvio" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1590/abd1806-4841.20142464" "Revista" => array:6 [ "tituloSerie" => "An Bras Dermatol." "fecha" => "2014" "volumen" => "89" "paginaInicial" => "632" "paginaFinal" => "637" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25054751" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0165" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasmacytoid dendritic cells and type I interferon in the immunological response against warts" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Saadeh" 1 => "M. Kurban" 2 => "O. Abbas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/ced.13187" "Revista" => array:6 [ "tituloSerie" => "Clin Exp Dermatol." "fecha" => "2017" "volumen" => "42" "paginaInicial" => "857" "paginaFinal" => "862" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28736973" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0170" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Defect of plasmacytoid dendritic cells in warts, hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Tassone" 1 => "D. Moratto" 2 => "W. Vermi" 3 => "M. De Francesco" 4 => "L.D. Notarangelo" 5 => "F. Porta" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Blood." "fecha" => "2010" "volumen" => "116" "paginaInicial" => "4870" "paginaFinal" => "4873" ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0175" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasmacytoid dendritic cells in cutaneous lesions of patients with chromoblastomycosis, lacaziosis, and paracoccidioidomycosis: a comparative analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Pagliari" 1 => "L. Kanashiro-Galo" 2 => "A.A. Silva" 3 => "T.C. Barboza" 4 => "P.R. Criado" 5 => "M.I. Duarte" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/mmy/myt026" "Revista" => array:6 [ "tituloSerie" => "Med Mycol." "fecha" => "2014" "volumen" => "52" "paginaInicial" => "397" "paginaFinal" => "402" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24782102" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0180" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "T regulatory cells and plasmocytoid dendritic cells in Hansen disease: a new insight into pathogenesis?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Massone" 1 => "E. Nunzi" 2 => "R. Ribeiro-Rodrigues" 3 => "C. Talhari" 4 => "S. Talhari" 5 => "A.P. Schettini" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/DAD.0b013e3181b7fc56" "Revista" => array:6 [ "tituloSerie" => "Am J Dermatopathol." "fecha" => "2010" "volumen" => "32" "paginaInicial" => "251" "paginaFinal" => "256" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20075708" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0185" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Langerhans cells (CD1a and CD207), dermal dendrocytes (FXIIIa) and plasmacytoid dendritic cells (CD123) in skin lesions of leprosy patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K.E. Hirai" 1 => "T.L. Aarão" 2 => "L.M. Silva" 3 => "J.R. de Sousa" 4 => "J. de Souza" 5 => "L.B. Dias Jr" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.micpath.2015.11.013" "Revista" => array:6 [ "tituloSerie" => "Microb Pathog." "fecha" => "2016" "volumen" => "91" "paginaInicial" => "18" "paginaFinal" => "25" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26639680" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0190" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasmacytoid dendritic cell involvement in the host response against keratoacanthoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "O. Abbas" 1 => "L. Hussein" 2 => "M. Kurban" 3 => "A.G. Kibbi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2014.02.007" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol." "fecha" => "2014" "volumen" => "70" "paginaInicial" => "1142" "paginaFinal" => "1145" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24831321" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0195" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasmacytoid dendritic cells in keratoacanthoma and squamous cell carcinoma: A blinded study of CD123 as a diagnostic marker" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G.R. Fraga" 1 => "P. Chow" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/cup.13573" "Revista" => array:6 [ "tituloSerie" => "J Cutan Pathol." "fecha" => "2020" "volumen" => "47" "paginaInicial" => "17" "paginaFinal" => "21" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31449667" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0200" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recruitment of plasmacytoid dendritic cells to skin regulates treatment responsiveness of actinic keratosis to imiquimod" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Y. Ogawa" 1 => "T. Kawamura" 2 => "T. Matsuzawa" 3 => "R. Aoki" 4 => "S. Shimada" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jdermsci.2014.07.004" "Revista" => array:6 [ "tituloSerie" => "J Dermatol Sci." "fecha" => "2014" "volumen" => "76" "paginaInicial" => "67" "paginaFinal" => "69" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25088809" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0205" "etiqueta" => "41" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G. Stary" 1 => "C. Bangert" 2 => "M. Tauber" 3 => "R. Strohal" 4 => "T. Kopp" 5 => "G. Stingl" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1084/jem.20070021" "Revista" => array:6 [ "tituloSerie" => "J Exp Med." "fecha" => "2007" "volumen" => "204" "paginaInicial" => "1441" "paginaFinal" => "1451" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17535975" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0210" "etiqueta" => "42" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasmacytoid dendritic cells in melanoma: can we revert bad into good?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Di Domizio" 1 => "O. Demaria" 2 => "M. Gilliet" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/jid.2014.155" "Revista" => array:6 [ "tituloSerie" => "J Invest Dermatol." "fecha" => "2014" "volumen" => "134" "paginaInicial" => "1797" "paginaFinal" => "1800" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24924760" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0215" "etiqueta" => "43" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasmacytoid dendritic cells in skin lesions of classic Kaposi’s sarcoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Karouni" 1 => "M. Kurban" 2 => "O. Abbas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00403-016-1671-6" "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol Res." "fecha" => "2016" "volumen" => "308" "paginaInicial" => "487" "paginaFinal" => "492" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27372661" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03650596/0000009600000001/v3_202102051036/S0365059620303202/v3_202102051036/en/main.assets" "Apartado" => array:4 [ "identificador" => "80632" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Review" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009600000001/v3_202102051036/S0365059620303202/v3_202102051036/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620303202?idApp=UINPBA00008Z"]

Statistics

Review

Plasmacytoid dendritic cells in dermatology

Natasha Favoretto Dias de Oliveira

Corresponding author

natasha.favoretto@gmail.com

Corresponding author.

, Claudia Giuli Santi, Celina Wakisaka Maruta, Valeria Aoki

Department of Dermatology, Faculty of Medicine, Universidade de São Paulo, São Paulo, SP, Brazil

Read

7659

Times
was read the article

3192

Total PDF

4467

Total HTML

Share statistics

 array:24 [
  "pii" => "S0365059620303202"
  "issn" => "03650596"
  "doi" => "10.1016/j.abd.2020.08.006"
  "estado" => "S300"
  "fechaPublicacion" => "2021-01-01"
  "aid" => "299"
  "copyright" => "Sociedade Brasileira de Dermatologia"
  "copyrightAnyo" => "2021"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by/4.0/"
  "subdocumento" => "rev"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "pt" => array:19 [
      "pii" => "S2666275220303659"
      "issn" => "26662752"
      "doi" => "10.1016/j.abdp.2020.08.006"
      "estado" => "S300"
      "fechaPublicacion" => "2021-01-01"
      "aid" => "299"
      "copyright" => "Sociedade Brasileira de Dermatologia"
      "documento" => "article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by/4.0/"
      "subdocumento" => "rev"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "pt" => array:12 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Revis&#227;o</span>"
        "titulo" => "C&#233;lulas dendr&#237;ticas plasmocitoides na dermatologia"
        "tienePdf" => "pt"
        "tieneTextoCompleto" => "pt"
        "tieneResumen" => "pt"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "76"
            "paginaFinal" => "81"
          ]
        ]
        "contieneResumen" => array:1 [
          "pt" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "pt" => true
        ]
        "contienePdf" => array:1 [
          "pt" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1640
                "Ancho" => 2917
                "Tamanyo" => 222770
              ]
            ]
            "descripcion" => array:1 [
              "pt" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">C&#233;lulas dendr&#237;ticas plasmocitoides &#40;pDCs&#41;&#58; conex&#227;o de relev&#226;ncia entre as imunidades inata e adaptativa&#46; Adaptado de Mitchell et al&#46;&#44; 2018 e Swiecki et al&#46;&#44; 2015&#46;<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">9&#44;10</span></a></p> <p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">APRIL&#44; ligante indutor de prolifera&#231;&#227;o&#59; AFF&#44; fator de ativa&#231;&#227;o da c&#233;lula B da fam&#237;lia fator de necrose tumoral alfa&#59; CD&#44; grupo de diferencia&#231;&#227;o&#59; ICOSL&#44; ligante coestimulador induz&#237;vel&#59; IDO&#44; indoleamina&#8208;2&#44;3&#8208;dioxigenase&#59; IFN&#8208;&#945;&#44; interferon alfa&#59; IL&#44; interleucina&#59; MHC&#44; complexo de histocompatibilidade&#59; NK&#44; <span class="elsevierStyleItalic">natural killer</span>&#59; pDC&#44; c&#233;lula dendr&#237;tica plasmocitoide&#59; TGF&#8208;&#946;&#44; fator de transforma&#231;&#227;o do crescimento beta&#59; TH&#44; linf&#243;cito T&#8208;<span class="elsevierStyleItalic">helper</span>&#59; TRAIL&#44; ligante indutor de apoptose relacionado ao fator de necrose tumoral alfa&#59; Treg&#44; linf&#243;cito T&#8208;regulat&#243;rio&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Natasha Favoretto Dias de Oliveira, Claudia Giuli Santi, Celina Wakisaka Maruta, Valeria Aoki"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "Natasha Favoretto"
                "apellidos" => "Dias de Oliveira"
              ]
              1 => array:2 [
                "nombre" => "Claudia Giuli"
                "apellidos" => "Santi"
              ]
              2 => array:2 [
                "nombre" => "Celina Wakisaka"
                "apellidos" => "Maruta"
              ]
              3 => array:2 [
                "nombre" => "Valeria"
                "apellidos" => "Aoki"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "pt"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S0365059620303202"
          "doi" => "10.1016/j.abd.2020.08.006"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620303202?idApp=UINPBA00008Z"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220303659?idApp=UINPBA00008Z"
      "url" => "/26662752/0000009600000001/v2_202102130748/S2666275220303659/v2_202102130748/pt/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0365059620303044"
    "issn" => "03650596"
    "doi" => "10.1016/j.abd.2020.01.009"
    "estado" => "S300"
    "fechaPublicacion" => "2021-01-01"
    "aid" => "290"
    "copyright" => "Sociedade Brasileira de Dermatologia"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by/4.0/"
    "subdocumento" => "crp"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Tropical&#47;Infectoparasitary Dermatology</span>"
      "titulo" => "Diagnosis of cutaneous tuberculosis &#40;lymph node scrofuloderma&#41; using the Xpert MTB&#47;RIF&#174; method"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "82"
          "paginaFinal" => "84"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0015"
          "etiqueta" => "Figure 3"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr3.jpeg"
              "Alto" => 599
              "Ancho" => 1255
              "Tamanyo" => 76283
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0015"
              "detalle" => "Fig&#46; "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Materials for analysis by the Xpert MTB&#47;RIF&#174; method&#46; &#40;A&#41;&#44; GeneXpert&#174; device&#46; &#40;B&#41;&#44; Buffer solution for treatment of the sample and cartridge for containing the material and reagents to be processed in the device&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Lilian Lemos Costa, John Verrinder Veasey"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "Lilian Lemos"
              "apellidos" => "Costa"
            ]
            1 => array:2 [
              "nombre" => "John Verrinder"
              "apellidos" => "Veasey"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "pt" => array:9 [
        "pii" => "S2666275220303568"
        "doi" => "10.1016/j.abdp.2020.01.007"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "pt"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220303568?idApp=UINPBA00008Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620303044?idApp=UINPBA00008Z"
    "url" => "/03650596/0000009600000001/v3_202102051036/S0365059620303044/v3_202102051036/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0365059620302981"
    "issn" => "03650596"
    "doi" => "10.1016/j.abd.2020.08.004"
    "estado" => "S300"
    "fechaPublicacion" => "2021-01-01"
    "aid" => "284"
    "copyright" => "Sociedade Brasileira de Dermatologia"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by/4.0/"
    "subdocumento" => "crp"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Dermatopathology</span>"
      "titulo" => "A case report and literature review of cutaneous intravascular large B-cell lymphoma presenting clinically as panniculitis&#58; a difficult diagnosis&#44; but a good prognosis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "72"
          "paginaFinal" => "75"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0015"
          "etiqueta" => "Figure 3"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr3.jpeg"
              "Alto" => 1374
              "Ancho" => 900
              "Tamanyo" => 332006
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0015"
              "detalle" => "Figure "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Tumor cells in the lumens of vessel in the subcutaneous adipous tissue &#40;A&#58; Hematoxylin &#38; eosin&#44; &#215;100&#41; and muscular tissue &#40;B&#58; Hematoxylin &#38; eosin&#44; &#215;400&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Deniz Bay&#231;elebi, Levent Y&#305;ld&#305;z, Nilg&#252;n &#350;ent&#252;rk"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Deniz"
              "apellidos" => "Bay&#231;elebi"
            ]
            1 => array:2 [
              "nombre" => "Levent"
              "apellidos" => "Y&#305;ld&#305;z"
            ]
            2 => array:2 [
              "nombre" => "Nilg&#252;n"
              "apellidos" => "&#350;ent&#252;rk"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "pt" => array:9 [
        "pii" => "S2666275220303490"
        "doi" => "10.1016/j.abdp.2020.08.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "pt"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220303490?idApp=UINPBA00008Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620302981?idApp=UINPBA00008Z"
    "url" => "/03650596/0000009600000001/v3_202102051036/S0365059620302981/v3_202102051036/en/main.assets"
  ]
  "en" => array:19 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Review</span>"
    "titulo" => "Plasmacytoid dendritic cells in dermatology"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "76"
        "paginaFinal" => "81"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Natasha Favoretto Dias de Oliveira, Claudia Giuli Santi, Celina Wakisaka Maruta, Valeria Aoki"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "Natasha Favoretto"
            "apellidos" => "Dias de Oliveira"
            "email" => array:1 [
              0 => "natasha.favoretto@gmail.com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "Claudia Giuli"
            "apellidos" => "Santi"
          ]
          2 => array:2 [
            "nombre" => "Celina Wakisaka"
            "apellidos" => "Maruta"
          ]
          3 => array:2 [
            "nombre" => "Valeria"
            "apellidos" => "Aoki"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Department of Dermatology&#44; Faculty of Medicine&#44; Universidade de S&#227;o Paulo&#44; S&#227;o Paulo&#44; SP&#44; Brazil"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1406
            "Ancho" => 2500
            "Tamanyo" => 232037
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Plasmacytoid dendritic cells &#40;pDCs&#41;&#58; relevant link between innate and adaptive immunity&#46; Adapted from Mitchell et al&#46;&#44; 2018 and Swiecki et al&#46;&#44; 2015&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;10</span></a> pDC&#44; plasmacytoid dendritic cell&#59; MHC&#44; major histocompatibility complex&#59; CD&#44; cluster of differentiation&#59; Treg&#44; T-regulatory lymphocyte&#59; TH&#44; T-helper lymphocyte&#59; TGF-&#946;&#44; transforming growth factor beta&#59; IL&#44; interleukin&#59; IDO&#44; indoleamine-2&#44;3-dioxygenase&#59; ICOSL&#44; inducible costimulator ligand&#59; TRAIL&#44; tumor necrosis factor-related apoptosis-inducing ligand&#59; IFN-&#945;&#44; interferon alpha&#59; BAFF&#44; B cell-activating factor of the TNF family&#59; APRIL&#44; a proliferation-inducing ligand&#59; NK&#44; natural killer&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Plasmacytoid dendritic cells &#40;pDCs&#41; are part of dendritic cells family and develop from hematopoietic stem cells in the bone marrow&#46; Lennert and Remmele first mentioned this then new cell type in 1958&#44; detected in the paracortical region of reactive lymph nodes and named them lymphoblasts<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#59; since the late 1980s&#44; pDCs received several denominations over time &#40;plasmacytoid T-cells&#44; plasmacytoid monocytes&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Characteristically&#44; pDCs exhibit alpha chain receptor interleukin-3 &#40;CD123&#41; and blood derived dendritic cell antigen-2 &#40;BDCA-2 or CD303&#41;&#44; and are key mediators of innate immunity&#59; they are the most potent producers of type 1 interferon &#40;IFN&#41; &#40;IFN-a&#44; IFN-b&#44; IFN-l&#44; IFN-w&#44; and IFN-t&#41;&#44; secreting a thousand times more IFN-&#945; and IFN-&#946; than other cell types&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">pDCs are activated through Toll-like receptors &#40;TLRs&#41; 7 and 9&#44; starting a signal that induces the expression of multiple immunomodulatory and pro-inflammatory molecules encoding genes&#44; such as IFN-&#945;&#46; TLR7 responds to single-stranded RNA &#40;rich in guanosine or uridine&#41; found in viruses &#40;as influenza and respiratory syncytial virus&#41;&#44; while TLR 9 detects single-stranded DNA molecules containing unmethylated CpG motifs &#40;CpG ODN&#41; commonly found in virus genome like herpes simplex &#40;HSV&#41;&#46; Thus&#44; pDCs detect viral infections through the recognition of viral nucleic acids and are important mediators of antiviral immunity&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">pDCs are a relevant link between innate and adaptive immunity &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; They produce type 1 IFN in response to viral infections&#44; promoting an antiviral state through IFN-stimulated genes expression and infected cells apoptosis&#46; In addition to IFN&#44; interleukin &#40;IL&#41;-12 and IL-18 activate natural killer &#40;NK&#41; cells&#44; leading to IFN-&#947; secretion and lysis of target cells&#46; IFN production by pDCs also induce macrophage and dendritic cells stimulation&#46; Through expression of major histocompatibility complexes &#40;MHC&#41; and co-stimulatory molecules &#40;as CD80&#44; CD86&#44; CD40&#41;&#44; pDCs promote adaptive immunity by acting as antigen-presenting cells for both CD4&#43; and CD8&#43; T-lymphocytes&#46; pDC expression of IDO &#40;indoleamine-2&#44;3-dioxygenase&#41; and ICOSL &#40;inducible costimulatory ligand&#41; lead to T-regulatory &#40;Treg&#41; response&#44; while pDCs production of TGF-&#946; and IL-6 promotes T-helper &#40;Th&#41; 17 commitment&#46; Production of IFN-I and IL-12 by the pDCs stimulates TCD8&#43; activity and polarization of TCD4&#43; cells into Th1&#46; pDCs production of IFN-I&#44; IL-6&#44; B cell-activating factor of the TNF family &#40;BAFF&#41;&#44; and a proliferation-inducing ligand &#40;APRIL&#41; lead to expansion and stimulation of antibody-producing plasma cells&#46; TNF-related apoptosis-inducing ligand &#40;TRAIL&#41; and granzyme B give pDCs the capacity to kill tumor cells&#44; induce apoptosis of infected TCD4&#43; cells&#44; and suppress T-cell proliferation&#46; In addition&#44; pDCs themselves stimulate plasmacytoid cells differentiation&#44; through type 1 IFN and IL-6&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#8211;10</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">pDCs are not usually present in normal skin&#59; they infiltrate the skin in healing processes and in several conditions&#44; such as viral infections&#44; inflammatory&#44; autoimmune&#44; and neoplastic diseases&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> Review of the literature regarding the presence of pDCs and dermatologic diseases are below described&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Cutaneous lupus erythematosus</span><p id="par0030" class="elsevierStylePara elsevierViewall">In lupus erythematosus &#40;LE&#41;&#44; pDCs are the main producers of IFN-&#945;&#46; Circulating pDCs are known to be reduced in patients with systemic lupus erythematosus &#40;SLE&#41;&#44; since they migrate and infiltrate target tissues&#44; such as the skin&#46; Several studies have shown large amounts of IFN-&#945; producing pDCs in chronic discoid lupus lesions&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#8211;13</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Tomasini et al&#46; found differences in pDCs&#39; distribution among different types of lupus&#58; superficial expression in skin specimens of subacute lupus and discoid lupus&#44; and distribution around deep vessels in cases of tumid lupus and multicentric reticulohistiocytosis&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> They also found a positive relation between intensity of the inflammatory infiltrate and amount of pDCs&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Additionally&#44; the number of pDCs in LE and dermatomyositis &#40;DM&#41; lesions directly correlated with the expression of myxovirusresistance protein &#40;MxA&#41;&#44; a protein induced by IFN-&#945;&#47;&#946;&#44; suggesting that pDCs are an important IFN-&#945; source in such diseases&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;14&#44;15</span></a> McNiff et al&#46; verified that pDCs were preferably detected at the epidermis in patients with dermatomyositis when compared to patients with lupus&#44; where the location was mainly in the dermis&#44; suggesting that in LE circulating immune complexes migrate through the vessels before skin deposition&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Lichen planus</span><p id="par0045" class="elsevierStylePara elsevierViewall">Vries et al&#46; observed abundant CD123&#43; pDCs in lichen planus &#40;LP&#41; skin fragments&#44; arranged the band-like lymphocytic infiltrate at the dermo-epidermal junction&#46; In addition&#44; they demonstrated replication of herpes virus 7 in plasmacytoid dendritic cells in active LP lesions&#44; followed by its decrease in clinical remission&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16&#44;17</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Wang et al&#46; described increased plasmacytoid dendritic cells infiltration in oral LP&#44; proposing them as mediators of the innate immune response in this disease&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Lichen striatus</span><p id="par0055" class="elsevierStylePara elsevierViewall">Badr et al&#46; found pDCs in the inflammatory infiltrate of lichen striatus &#40;LS&#41;&#44; suggesting that these cells play a role in the pathogenesis of the disease&#46; Additionally&#44; there is a perieccrine distribution of pDCs in LS&#44; which may be a useful criterium to histologically differentiate LS from LP&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Atopic dermatitis</span><p id="par0060" class="elsevierStylePara elsevierViewall">In patients with atopic dermatitis &#40;AD&#41;&#44; there was an increase in circulating pDCs in comparison to controls&#59; moreover&#44; recruitment of pDCs in AD lesions was much lower than the amount found in other dermatoses&#44; such as LE and psoriasis&#46; The poor recruitment of pDCs&#44; resulting in reduced production of type 1 IFN in AD lesions&#44; could explain enhanced susceptibility of patients with AD to viral infections&#44; such as herpes simplex or poxvirus infections&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">20&#44;21</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Polymorphic light eruption</span><p id="par0065" class="elsevierStylePara elsevierViewall">Rossi et al&#46;&#44; in contrast to previous studies&#44; demonstrated significant increase of dermal pDCs in patients with polymorphic light eruption when compared to healthy controls&#44; probably due to the photo provocation testing&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#44;23</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Psoriasis</span><p id="par0070" class="elsevierStylePara elsevierViewall">Nestle et al&#46; found large amounts of pDCs in the dermal T-lymphocyte infiltrate of psoriatic plaques&#44; absent in the skin of healthy donors and AD patients&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> Additionally&#44; pDCs were also found in the skin adjacent to the plaques&#44; even without apparent lesions&#46; They also demonstrated reduction in pDCs in the peripheral blood of patients with psoriasis when compared to healthy individuals&#44; suggesting that the accumulation of pDCs in the skin of patients with psoriasis occurs due to the redistribution pDCs from the blood to the skin&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> In animal models&#44; the authors demonstrated production of IFN-&#945; by pDCs in the injured skin&#44; and its influence on the</p><p id="par0075" class="elsevierStylePara elsevierViewall">Another study in psoriasis showed that heliotherapy provided not only clinical improvement&#44; but also reduction of pDCs number and expression of MxA&#44; a marker for IFN-&#945; in lesional skin&#44; strengthening the role of pDCs in psoriasis&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Chemerin is a chemotactic factor for serum pDCs&#46; Albanesi et al&#46; demonstrated a strong expression of chemerin and the presence of pDCs in the dermis of skin adjacent to psoriatic lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> There was a low expression of chemerin and few pDCs in chronic psoriatic plaques&#44; suggesting that the expression of chemerin occurs in the early stages of psoriasis lesions and is temporally correlated with the presence of pDCs&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Pityriasis lichenoides</span><p id="par0085" class="elsevierStylePara elsevierViewall">The pathophysiology of pityriasis lichenoides &#40;PL&#41; is not fully understood&#46; MxA expression was demonstrated in PL lesions&#44; establishing local production of type 1 IFN&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">27&#44;28</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">Karouni et al&#46; demonstrated the presence of pDCs in the skin of PL patients in both forms&#44; pityriasis lichenoides et varioliformis acuta &#40;PLEVA&#41; and pityriasis lichenoides chronica &#40;PLC&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a> Furthermore&#44; they found intense and diffuse expression of MxA&#44; demonstrating its activation and production of type 1 IFN&#46; The authors suggest that viral infections&#44; autoantigens&#44; trauma&#44; antigens against drugs and tumors &#8211; previously associated with cases of PL &#8211; could also contribute to the recruitment and activation of pDCs&#44; as demonstrated in other interface dermatitis&#44; such as LP&#44; LS&#44; LE&#44; and DM&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a></p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Graft vs&#46; host disease</span><p id="par0095" class="elsevierStylePara elsevierViewall">Malard et al&#46; showed the presence of pDCs in skin fragments of patients with acute graft-versus-host disease &#40;GVHD&#41;&#44; as well as a strong expression of MxA&#44; signaling local production of type 1 IFN&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a> Previously&#44; the same group reported a reduction in serum levels of pDCs in patients with acute GVHD&#44; suggesting pDCs&#39; infiltration into the GVHD target tissues&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">30&#44;31</span></a> However&#44; the presence of CD123&#43; cells in the oral mucosa of patients with chronic GVHD was not superior when compared to controls in the study carried out by Botari et al&#46;&#44; which suggests an early participation of pDCs in GVHD&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a></p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Warts</span><p id="par0100" class="elsevierStylePara elsevierViewall">The demonstration of the presence of activated pDCs in inflamed viral warts was based on the intense expression of MxA&#44; contrary to the data by Tomasini et al&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;33</span></a> The opposite results may be related to the different histological criteria for inflamed warts used by the two groups&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">Tassone et al&#46; evaluated patients with WHIM syndrome &#40;warts&#44; hypogammaglobulinemia&#44; infections&#44; and myelokathexis&#41;&#44; who have refractory warts&#59; the authors pointed out reduction in pDCs in peripheral blood and in skin lesions&#44; and absence of type 1 IFN production&#44; assessed through the expression of MxA&#44; suggesting inability of antiviral activity of pDCs <span class="elsevierStyleItalic">via</span> TLR9&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a></p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Fungal diseases</span><p id="par0110" class="elsevierStylePara elsevierViewall">Pagliari et al&#46; evaluated the role of pDCs in three deep mycoses &#40;chromoblastomycosis &#91;CBM&#93;&#44; lobomycosis&#44; and paracoccidioidomycosis &#91;PCM&#93;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a> pDCs were found in 37&#37; of the skin fragments of patients with CBM and in 50&#37; of specimens of patients with PCM&#44; but were absent in patients with lobomycosis&#46; The authors hypothesize that pDCs would be a secondary source of cytokines&#44; relevant to antifungal activity in cases of CBM and PCM&#46; In lobomycosis&#44; the absence of pDCs implies that such are not involved in the antifungal immune response&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Leprosy</span><p id="par0115" class="elsevierStylePara elsevierViewall">Massone et al&#46; described the absence of CD123 expression in skin biopsy fragments of leprosy patients&#44; except for focal expression in two cases of erythema nodosum leprosum&#44; implying in noninvolvementof pDCs in the immune response against <span class="elsevierStyleItalic">Mycobacterium leprae&#46;</span><a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> Hirai et al&#46;&#44; on the other hand&#44; found pDCs in the inflammatory infiltrate and around the vessels in the skin of leprosy patients&#44; emphasizing enhanced number of pDCs in tuberculoid leprosy&#44; when compared to lepromatous leprosy&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a></p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Skin tumors</span><p id="par0120" class="elsevierStylePara elsevierViewall">The presence of pDCs in skin tumors has been evaluated by several authors&#46; Abbas et al&#46; identified the presence of pDCs in 100&#37; of cases of keratoacanthoma &#40;KC&#41; and 90&#37; of squamous cell carcinoma &#40;SCC&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a> In KC&#44; pDCs were more abundant&#44; representing a greater proportion of the inflammatory infiltrate&#44; with greater activity&#44; suggesting a possible role of pDCS in the pathogenesis of KC regression&#46; Recently&#44; Fraga et al&#46; corroborated the abundant presence of pDCs in both KC and SCC&#44; without significant differences&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">Imiquimod&#44; a selective TLR7 agonist <span class="elsevierStyleItalic">via</span> transcription factor NF-kB activation and production of inflammatory cytokines&#44; such as type 1 IFN&#44; is used as treatment for some skin tumors&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a> Basal cell carcinomas &#40;BCCs&#41; treated with imiquimod showed activated pDCs producing IFN-&#945; in the peritumoral infiltrate&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a> Subsequently&#44; Ogawa et al&#46; demonstrated correlation between the amount of pDCs recruited in actinic keratosis &#40;AK&#41; lesions and the therapeutic effect of imiquimod in these cases&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">The presence of pDCs has also been described in melanoma&#44; mainly located around the vessels and close to tumor cells&#44; both in primary cases and in metastases&#46; However&#44; these pDCs are not activated&#44; there is a lack of TLR7 and TLR9 signaling in the tumor environment&#44; there is no production of type 1 IFN&#44; and they have been associated with tumor growth&#46; In contrast&#44; regressive melanomas have activated pDCs&#44; indicating possible antitumor activity&#46; Treatment of skin tumors &#40;AK&#44; superficial BCC&#44; Bowen&#39;s disease and even lentigo maligna melanoma&#41; with imiquimod &#40;TLR7 and TLR9 agonist&#41; activates the pDCs to produce type 1 IFN&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">42</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">Similarly&#44; Karouni et al&#46; described that pDCs are present in 90&#37; of cases of Kaposi&#39;s sarcoma &#40;KS&#41;&#44; with reduced MxA expression&#44; indicating suppression by Kaposi&#39;s sarcoma-associated herpesvirus &#40;KSHV&#41;&#44; through viral proteins that would inhibit the signaling pathways of pDCs activation&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Main findings of pDCs in skin diseases are summarized in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">43</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Conclusions</span><p id="par0145" class="elsevierStylePara elsevierViewall">It is currently known that pDCs are the link between innate and adaptive immunity&#46; These cells are not skin residents&#44; and therefore their presence in the skin suggest a role &#40;either central or adjuvant&#41; in inflammatory&#44; autoimmune&#44; neoplastic and infectious processes&#46; More studies are needed regarding such cells&#44;which may lead to novel therapeutic targets&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Financial support</span><p id="par0150" class="elsevierStylePara elsevierViewall">This study was financed by <span class="elsevierStyleGrantSponsor" id="gs0005">FUNADERSP</span> &#40;Dermatology Support Fund of the State of S&#227;o Paulo-Sebasti&#227;o Sampaio&#41; &#8211; Project <span class="elsevierStyleGrantNumber" refid="gs0005">52-2017</span>&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Authors&#8217; contributions</span><p id="par0155" class="elsevierStylePara elsevierViewall">Natasha Favoretto Dias de Oliveira&#58; Approval of the final version of the manuscript&#59; design and planning of the study&#59; drafting and editing of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#59; critical review of the literature&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Claudia Giuli Santi&#58; Approval of the final version of the manuscript&#59; design and planning of the study&#59; collection&#44; analysis&#44; and interpretation of data&#59; effective participation in research orientation&#59; critical review of the manuscript&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Celina Wakisaka Maruta&#58; Approval of the final version of the manuscript&#59; design and planning of the study&#59; collection&#44; analysis&#44; and interpretation of data&#59; effective participation in research orientation&#59; critical review of the manuscript&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Valeria Aoki&#58; Approval of the final version of the manuscript&#59; design and planning of the study&#59; collection&#44; analysis&#44; and interpretation of data&#59; effective participation in research orientation&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflicts of interest</span><p id="par0175" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:20 [
        0 => array:3 [
          "identificador" => "xres1461416"
          "titulo" => "Abstract"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0005"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1331600"
          "titulo" => "Keywords"
        ]
        2 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        3 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Cutaneous lupus erythematosus"
        ]
        4 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Lichen planus"
        ]
        5 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Lichen striatus"
        ]
        6 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Atopic dermatitis"
        ]
        7 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Polymorphic light eruption"
        ]
        8 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Psoriasis"
        ]
        9 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Pityriasis lichenoides"
        ]
        10 => array:2 [
          "identificador" => "sec0045"
          "titulo" => "Graft vs&#46; host disease"
        ]
        11 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Warts"
        ]
        12 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "Fungal diseases"
        ]
        13 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Leprosy"
        ]
        14 => array:2 [
          "identificador" => "sec0065"
          "titulo" => "Skin tumors"
        ]
        15 => array:2 [
          "identificador" => "sec0070"
          "titulo" => "Conclusions"
        ]
        16 => array:2 [
          "identificador" => "sec0075"
          "titulo" => "Financial support"
        ]
        17 => array:2 [
          "identificador" => "sec0080"
          "titulo" => "Authors&#8217; contributions"
        ]
        18 => array:2 [
          "identificador" => "sec0085"
          "titulo" => "Conflicts of interest"
        ]
        19 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2020-07-03"
    "fechaAceptado" => "2020-08-10"
    "PalabrasClave" => array:1 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1331600"
          "palabras" => array:5 [
            0 => "Adaptive immunity"
            1 => "Dendritic cells"
            2 => "Dermatological diseases"
            3 => "Dermatology"
            4 => "Innate immunity"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:1 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Plasmacytoid dendritic cells are part of the dendritic cells family and are a relevant link between innate and adaptive immunity&#46; They are the most potent producers of type 1 interferon&#44; generating antiviral response&#44; stimulating macrophages and dendritic cells and inducing activation and migration of natural killer cells&#46; Plasmacytoid dendritic cells also exert a role as antigen-presenting cells&#44; promote T-lymphocyte responses&#44; immunoregulation&#44; plasma cells differentiation and antibody secretion&#46; Even though plasmacytoid dendritic cells are not usually present in normal skin&#44; their presence is detected in healing processes&#44; viral infections&#44; and inflammatory&#44; autoimmune&#44; and neoplastic diseases&#46; In recent years&#44; the presence of plasmacytoid dendritic cells in several dermatological diseases has been described&#44; enhancing their potential role in the pathogenesis of such conditions&#46; Future studies on the role of plasmacytoid dendritic cells in dermatology may lead to new therapeutic targets&#46;</p></span>"
      ]
    ]
    "NotaPie" => array:2 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">How to cite this article&#58; Dias de Oliveira NF&#44; Santi CG&#44; Maruta CW&#44; Aoki V&#46; Plasmacytoid dendritic cells in dermatology&#46; An Bras Dermatol&#46; 2021&#59;96&#58;76&#8211;81&#46;</p>"
      ]
      1 => array:2 [
        "etiqueta" => "&#9734;&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Study conducted at the Department of Dermatology&#44;&#8239;Faculty of Medicine&#44;&#8239;Universidade de S&#227;o Paulo&#44; S&#227;o Paulo&#44; SP&#44; Brasil&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1406
            "Ancho" => 2500
            "Tamanyo" => 232037
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Plasmacytoid dendritic cells &#40;pDCs&#41;&#58; relevant link between innate and adaptive immunity&#46; Adapted from Mitchell et al&#46;&#44; 2018 and Swiecki et al&#46;&#44; 2015&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;10</span></a> pDC&#44; plasmacytoid dendritic cell&#59; MHC&#44; major histocompatibility complex&#59; CD&#44; cluster of differentiation&#59; Treg&#44; T-regulatory lymphocyte&#59; TH&#44; T-helper lymphocyte&#59; TGF-&#946;&#44; transforming growth factor beta&#59; IL&#44; interleukin&#59; IDO&#44; indoleamine-2&#44;3-dioxygenase&#59; ICOSL&#44; inducible costimulator ligand&#59; TRAIL&#44; tumor necrosis factor-related apoptosis-inducing ligand&#59; IFN-&#945;&#44; interferon alpha&#59; BAFF&#44; B cell-activating factor of the TNF family&#59; APRIL&#44; a proliferation-inducing ligand&#59; NK&#44; natural killer&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0010"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">pDCs&#44; plasmacytoid dendritic cells&#59; SLE&#44; systemic lupus erythematosus&#59; DL&#44; discoid lupus&#59; SAL&#44; subacute lupus&#59; TL&#44; tumid lupus&#59; MRH&#44; multicentric reticulohistiocytosis&#59; DM&#44; dermatomyositis&#59; AD&#44; atopic dermatitis&#59; PLE&#44; polymorphic light eruption&#59; PL&#44; pityriasis lichenoides&#59; PLEVA&#44; pityriasis lichenoides et varioliformis acuta&#59; PLC&#44; pityriasis lichenoides chronica&#59; GVHD&#44; graft <span class="elsevierStyleItalic">vs</span>&#46; host disease&#59; WHIM&#44; warts&#44; hypogammaglobulinemia&#44; infections&#44; and myelokathexis&#59; CBM&#44; chromoblastomycosis&#59; PCM&#44; paracoccidioidomycosis&#59; SCC&#44; squamous cell carcinoma&#59; AK&#44; actinic keratosis&#59; BCC&#44; basal cell carcinoma&#59; KS&#44; Kaposi&#39;s sarcoma&#59; KSHV&#44; Kaposi&#39;s sarcoma-associated herpesvirus&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dermatological diseases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">pDCs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " rowspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lupus erythematosus</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SLE&#58; reduced circulating pDCs<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;11&#8211;13</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DL&#58; large amounts of IFN-&#945; producing pDCs<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;11&#8211;13</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SAL&#44; DL&#58; superficial distribution<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TL&#44; MHR&#58; distribution around deep vessels<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">pDCs localized preferably in the epidermis in patients with DM and in the dermis in cases of lupus<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lichen planus</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">pDCs arranged similarly to the band-like lymphocytic infiltrate at the dermo-epidermal junction<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16&#44;17</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">pDCs increased in oral lichen planus<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lichen striatus</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">pDCs present in the inflammatoryinfiltrate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Perieccrine distribution of pDCs<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Atopic dermatitis</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Increased circulating pDCs compared to controls&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lower recruitment of pDCs in AD lesions compared to other dermatoses&#44; such as lupus erythematosus and psoriasis<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">20&#44;21</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Polymorphic light eruption</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Wackernagel et al&#46;&#58;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> absent pDCs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Rossi et al&#46;&#58;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> increased pDCs in PLE lesions&#44; mainly dermal&#46; The authors attribute the difference to the methodology witch included of a photoprovocation testing&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " rowspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Psoriasis</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">pDCs present in the T lymphocyte infiltrate in the dermis of psoriatic plaques and in the perilesional skin<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Reduction of pDCs in the peripheral blood of patients with psoriasis<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Heliotherapy&#58; reduction of pDCs amount and MxA expression<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Strong chemerin expression and presence of pDCs in the perilesional skin dermis<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pityriasis lichenoides</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Strong MxA expression in PL lesions &#40;local production of type 1 IFN&#41;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">27&#44;28</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presence of pDCs on the skin in all cases &#40;PLEVA and PLC&#41;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Graft <span class="elsevierStyleItalic">vs&#46;</span> host disease</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presence of pDCs in skin fragments of patients with acute GVHD&#44; strong expression of MxA&#44; signaling local production of type 1 IFN<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Reduction of serum pDCs in patients with acute GVHD<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presence of CD123&#43; cells in the oral mucosa of patients with chronic GVHD was not superior<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Warts</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Saadeh et al&#46;&#58;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a> activated pDCs in inflamed viral warts&#44; contrary to what was found by Tomasini et al&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> &#40;possible differences in histologic criteria for inflamed warts&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Reduction in pDCs in peripheral blood and in skin lesions&#44; absence of type 1 IFN production &#40;MxA without expression&#41; in patients with WHIM syndrome<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fungal diseases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">pDCs found in 37&#37; of the skin fragments of patients with CBM and in 50&#37; of the specimens from patients with PCM&#44; but absent in cases of lobomycosis<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Leprosy</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Massone et al&#46;&#58;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> absence of CD123 expression&#44; except for focal expression in two cases of erythema nodosum leprosum&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hirai et al&#46;&#58;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> pDCs in the inflammatory infiltrate and around the vessels&#46; Higher number of pDCs in tuberculoid cases compared to virchowian cases&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " rowspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Skin tumors</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Keratoacanthoma&#58; presence of pDCs in 100&#37; of cases<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SCC&#58; presence of pDCs in 90&#37; of cases<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AK&#58; correlation between the amount of pDCs recruited in the lesions during treatment with imiquimod and the therapeutic effect of the drug<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BCC&#58; presence of activated pDCs producing IFN-&#945; in the peritumoral infiltrate during treatment with imiquimod<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Melanoma&#58; pDCs arranged around the vessels and close to the tumor cells&#44; but not activated&#46; Presence associated with tumor growth&#46; pDCs activated in cases of regressive melanoma<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">42</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">KS&#58; pDCs present in 90&#37; of cases&#44; but reduced expression of MxA &#40;possible suppression of pDCs by KSHV&#41;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">43</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2514513.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Skin diseases and plasmacytoid dendritic cells &#40;pDCs&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:43 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#91;Karyometric research on lymph node cells in man&#46; I&#46; Germinoblasts&#44; lymphoblasts &#38; lymphocytes&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46; Lennert"
                            1 => "W&#46; Remmele"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Acta Haematol&#46;"
                        "fecha" => "1958"
                        "volumen" => "19"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Plasmacytoid dendritic cells&#58; physiologic roles and pathologic states"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;G&#46; Jegalian"
                            1 => "F&#46; Facchetti"
                            2 => "E&#46;S&#46; Jaffe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/PAP.0b013e3181bb6bc2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Adv Anat Pathol&#46;"
                        "fecha" => "2009"
                        "volumen" => "16"
                        "paginaInicial" => "392"
                        "paginaFinal" => "404"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19851130"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Plasmacytoid dendritic cells&#58; an overview of their presence and distribution in different inflammatory skin diseases&#44; with special emphasis on Jessner&#8217;s lymphocytic infiltrate of the skin and cutaneous lupus erythematosus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Tomasini"
                            1 => "T&#46; Mentzel"
                            2 => "M&#46; Hantschke"
                            3 => "A&#46; Cerri"
                            4 => "B&#46; Paredes"
                            5 => "A&#46; R&#252;tten"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0560.2010.01587.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Pathol&#46;"
                        "fecha" => "2010"
                        "volumen" => "37"
                        "paginaInicial" => "1132"
                        "paginaFinal" => "1139"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20659210"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunohistology and aetiology of histiocytic necrotizing lymphadenitis&#46; Report of three instructive cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46;C&#46; Feller"
                            1 => "K&#46; Lennert"
                            2 => "H&#46; Stein"
                            3 => "H&#46;D&#46; Bruhn"
                            4 => "H&#46;H&#46; Wuthe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2559.1983.tb02299.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Histopathology&#46;"
                        "fecha" => "1983"
                        "volumen" => "7"
                        "paginaInicial" => "825"
                        "paginaFinal" => "839"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6229466"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Plasmacytoid T cells&#46; Immunohistochemical evidence for their monocyte&#47;macrophage origin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F&#46; Facchetti"
                            1 => "C&#46; de Wolf-Peeters"
                            2 => "D&#46;Y&#46; Mason"
                            3 => "K&#46; Pulford"
                            4 => "J&#46;J&#46; van den Oord"
                            5 => "V&#46;J&#46; Desmet"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Pathol&#46;"
                        "fecha" => "1988"
                        "volumen" => "133"
                        "paginaInicial" => "15"
                        "paginaFinal" => "21"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3052093"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Plasmacytoid dendritic cells&#58; sensing nucleic acids in viral infection and autoimmune diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Gilliet"
                            1 => "W&#46; Cao"
                            2 => "Y&#46;J&#46; Liu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/nri2358"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Rev Immunol"
                        "fecha" => "2008"
                        "volumen" => "8"
                        "paginaInicial" => "594"
                        "paginaFinal" => "606"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18641647"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Update on the role of plasmacytoid dendritic cells in inflammatory&#47;autoimmune skin diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46; Saadeh"
                            1 => "M&#46; Kurban"
                            2 => "O&#46; Abbas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/exd.12957"
                      "Revista" => array:6 [
                        "tituloSerie" => "Exp Dermatol&#46;"
                        "fecha" => "2016"
                        "volumen" => "25"
                        "paginaInicial" => "415"
                        "paginaFinal" => "421"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26837058"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "T regulatory cells and plasmocytoid dentritic cells in hansen disease&#58; a new insight into pathogenesis&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Massone"
                            1 => "E&#46; Nunzi"
                            2 => "R&#46; Ribeiro&#173;Rodrigues"
                            3 => "C&#46; Talhari"
                            4 => "S&#46; Talhari"
                            5 => "A&#46;P&#46; Schettini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/DAD.0b013e3181b7fc56"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Dermatopathol"
                        "fecha" => "2010"
                        "volumen" => "32"
                        "paginaInicial" => "251"
                        "paginaFinal" => "256"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20075708"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Plasmacytoid dendritic cell in immunity and cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46; Mitchell"
                            1 => "S&#46; Chintala"
                            2 => "M&#46; Dey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jneuroim.2018.06.012"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neuroimmunol&#46;"
                        "fecha" => "2018"
                        "volumen" => "322"
                        "paginaInicial" => "63"
                        "paginaFinal" => "73"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30049538"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The multifaceted biology of plasmacytoid dendritic cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Swiecki"
                            1 => "M&#46; Colonna"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/nri3865"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Rev Immunol&#46;"
                        "fecha" => "2015"
                        "volumen" => "15"
                        "paginaInicial" => "471"
                        "paginaFinal" => "485"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26160613"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Plasmacytoid dendritic cells are present in cutaneous dermatomyositis lesions in a pattern distinct from lupus erythematosus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;M&#46; McNiff"
                            1 => "D&#46;H&#46; Kaplan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0560.2007.00848.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Pathol&#46;"
                        "fecha" => "2008"
                        "volumen" => "35"
                        "paginaInicial" => "452"
                        "paginaFinal" => "456"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18005168"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early&#44; transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;L&#46; Rowland"
                            1 => "J&#46;M&#46; Riggs"
                            2 => "S&#46; Gilfillan"
                            3 => "M&#46; Bugatti"
                            4 => "W&#46; Vermi"
                            5 => "R&#46; Kolbeck"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1084/jem.20132620"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Exp Med&#46;"
                        "fecha" => "2014"
                        "volumen" => "211"
                        "paginaInicial" => "1977"
                        "paginaFinal" => "1991"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25180065"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Plasmacytoid dendritic cells in hypertrophic discoid lupus erythematosus&#58; an objective evaluation of their diagnostic value"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46;M&#46; Walsh"
                            1 => "J&#46; Lai"
                            2 => "J&#46;G&#46; Hanly"
                            3 => "P&#46;J&#46; Green"
                            4 => "F&#46; Bosisio"
                            5 => "J&#46; Garcias-Ladaria"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/cup.12416"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Pathol&#46;"
                        "fecha" => "2015"
                        "volumen" => "42"
                        "paginaInicial" => "32"
                        "paginaFinal" => "38"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25367375"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Plasmacytoid dendritic cells &#40;natural interferon-alpha&#47;beta-producing cells&#41; accumulate in cutaneous lupus erythematosus lesions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46; Farkas"
                            1 => "K&#46; Beiske"
                            2 => "F&#46; Lund-Johansen"
                            3 => "P&#46; Brandtzaeg"
                            4 => "F&#46;L&#46; Jahnsen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0002-9440(10)61689-6"
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Pathol&#46;"
                        "fecha" => "2001"
                        "volumen" => "159"
                        "paginaInicial" => "237"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11438470"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Type I interferon-associated skin recruitment of CXCR31 lymphocytes in dermatomyositis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Wenzel"
                            1 => "R&#46; Schmidt"
                            2 => "J&#46; Proelss"
                            3 => "S&#46; Zahn"
                            4 => "T&#46; Bieber"
                            5 => "T&#46; Tutling"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2230.2006.02150.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Dermatol&#46;"
                        "fecha" => "2006"
                        "volumen" => "31"
                        "paginaInicial" => "576"
                        "paginaFinal" => "582"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16716166"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lichen planus is associated with human herpesvirus type 7 replication and infiltration of plasmacytoid dendritic cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46;J&#46; de Vries"
                            1 => "J&#46; van Marle"
                            2 => "M&#46;B&#46; Teunissen"
                            3 => "D&#46; Picavet"
                            4 => "F&#46; Zorgdrager"
                            5 => "J&#46;D&#46; Bos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2005.06999.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol&#46;"
                        "fecha" => "2006"
                        "volumen" => "154"
                        "paginaInicial" => "361"
                        "paginaFinal" => "364"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16433811"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lichen planus remission is associated with a decrease of human herpes virus type 7 protein expression in plasmacytoid dendritic cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "H&#46;J&#46; de Vries"
                            1 => "M&#46;B&#46; Teunissen"
                            2 => "F&#46; Zorgdrager"
                            3 => "D&#46; Picavet"
                            4 => "M&#46; Cornelissen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00403-007-0750-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol Res&#46;"
                        "fecha" => "2007"
                        "volumen" => "299"
                        "paginaInicial" => "213"
                        "paginaFinal" => "219"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17404748"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased infiltration of CD11 c<span class="elsevierStyleSup">&#43;</span>&#47;CD123<span class="elsevierStyleSup">&#43;</span> dendritic cell subsets and upregulation of TLR&#47;IFN-&#945; signaling participate in pathogenesis of oral lichen planus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Wang"
                            1 => "S&#46; Shang"
                            2 => "Q&#46; Sun"
                            3 => "J&#46; Chen"
                            4 => "G&#46; Du"
                            5 => "H&#46; Nie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.oooo.2017.12.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Oral Surg Oral Med Oral Pathol Oral Radiol&#46;"
                        "fecha" => "2018"
                        "volumen" => "125"
                        "paginaInicial" => "459"
                        "paginaFinal" => "467"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29429903"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Plasmacytoid Dendritic Cells and Type I Interferon Signature in Lichen Striatus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Badr"
                            1 => "R&#46; Abadi"
                            2 => "M&#46; Kurban"
                            3 => "O&#46; Abbas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/pde.12824"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Dermatol&#46;"
                        "fecha" => "2016"
                        "volumen" => "33"
                        "paginaInicial" => "301"
                        "paginaFinal" => "306"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26935593"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of dendritic cell subtypes in the pathophysiology of atopic dermatitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "N&#46; Novak"
                            1 => "T&#46; Bieber"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2005.04.060"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2005"
                        "volumen" => "53"
                        "numero" => "2 Suppl 2"
                        "paginaInicial" => "S171"
                        "paginaFinal" => "6"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16021172"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Plasmacytoid dendritic cells&#58; a new cutaneous dendritic cell subset with distinct role in inflammatory skin diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Wollenberg"
                            1 => "M&#46; Wagner"
                            2 => "S&#46; G&#252;nther"
                            3 => "A&#46; Towarowski"
                            4 => "E&#46; Tuma"
                            5 => "M&#46; Moderer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1523-1747.2002.19515.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol&#46;"
                        "fecha" => "2002"
                        "volumen" => "119"
                        "paginaInicial" => "1096"
                        "paginaFinal" => "1102"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12445198"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Plasmacytoid dendritic cells are absent in skin lesions of polymorphic light eruption"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Wackernagel"
                            1 => "C&#46; Massone"
                            2 => "G&#46; Hoefler"
                            3 => "E&#46; Steinbauer"
                            4 => "H&#46; Kerl"
                            5 => "P&#46; Wolf"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0781.2007.00267.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Photodermatol Photoimmunol Photomed&#46;"
                        "fecha" => "2007"
                        "volumen" => "23"
                        "paginaInicial" => "24"
                        "paginaFinal" => "28"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17254032"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous infiltration of plasmacytoid dendritic cells and T regulatory cells in skin lesions of polymorphic light eruption"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;T&#46; Rossi"
                            1 => "M&#46; Arisi"
                            2 => "S&#46; Lonardi"
                            3 => "L&#46; Lorenzi"
                            4 => "M&#46; Ungari"
                            5 => "F&#46; Serana"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/jdv.14866"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol&#46;"
                        "fecha" => "2018"
                        "volumen" => "32"
                        "paginaInicial" => "985"
                        "paginaFinal" => "991"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29430717"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;O&#46; Nestle"
                            1 => "C&#46; Conrad"
                            2 => "A&#46; Tun-Kyi"
                            3 => "B&#46; Homey"
                            4 => "M&#46; Gombert"
                            5 => "O&#46; Boyman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1084/jem.20050500"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Exp Med&#46;"
                        "fecha" => "2005"
                        "volumen" => "202"
                        "paginaInicial" => "135"
                        "paginaFinal" => "143"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15998792"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sun exposure rapidly reduces plasmacytoid dendritic cells and inflammatory dermal dendritic cells in psoriatic skin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "I&#46; Heier"
                            1 => "E&#46; S&#248;yland"
                            2 => "A&#46;L&#46; Krogstad"
                            3 => "C&#46; Rodr&#237;guez-Gallego"
                            4 => "M&#46;S&#46; Nenseter"
                            5 => "F&#46;L&#46; Jahnsen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2011.10430.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol&#46;"
                        "fecha" => "2011"
                        "volumen" => "165"
                        "paginaInicial" => "792"
                        "paginaFinal" => "801"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21623747"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Albanesi"
                            1 => "C&#46; Scarponi"
                            2 => "S&#46; Pallotta"
                            3 => "R&#46; Daniele"
                            4 => "D&#46; Bosisio"
                            5 => "S&#46; Madonna"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1084/jem.20080129"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Exp Med&#46;"
                        "fecha" => "2009"
                        "volumen" => "206"
                        "paginaInicial" => "249"
                        "paginaFinal" => "258"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19114666"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of cytotoxic skin-homing CD8&#43; lymphocytes in cutaneous cytotoxic T-cell lymphoma and pityriasis lichenoides"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Wenzel"
                            1 => "I&#46; G&#252;tgemann"
                            2 => "M&#46; Distelmaier"
                            3 => "M&#46; Uerlich"
                            4 => "S&#46; Mikus"
                            5 => "T&#46; Bieber"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2005.05.042"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2005"
                        "volumen" => "53"
                        "paginaInicial" => "422"
                        "paginaFinal" => "427"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16112347"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human MxA protein&#58; an interferon- induced dynamin-like GTPase with broad antiviral activity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "O&#46; Haller"
                            1 => "G&#46; Kochs"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1089/jir.2010.0076"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Interferon Cytokine Res&#46;"
                        "fecha" => "2011"
                        "volumen" => "31"
                        "paginaInicial" => "79"
                        "paginaFinal" => "87"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21166595"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Possible role of plasmacytoid dendritic cells in pityriasis lichenoides"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Karouni"
                            1 => "J&#46;A&#46; Rahal"
                            2 => "M&#46; Kurban"
                            3 => "A&#46;G&#46; Kibbi"
                            4 => "O&#46; Abbas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ced.13351"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Dermatol&#46;"
                        "fecha" => "2018"
                        "volumen" => "43"
                        "paginaInicial" => "404"
                        "paginaFinal" => "409"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29349807"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased plasmacytoid dendritic cells and ROR&#947;t-expressing immune effectors in cutaneous acute graft-versus-host disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46; Malard"
                            1 => "C&#46; Bossard"
                            2 => "E&#46; Brissot"
                            3 => "P&#46; Chevallier"
                            4 => "T&#46; Guillaume"
                            5 => "J&#46; Delaunay"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1189/jlb.0513295"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Leukoc Biol&#46;"
                        "fecha" => "2013"
                        "volumen" => "94"
                        "paginaInicial" => "1337"
                        "paginaFinal" => "1343"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23990625"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of plasmacytoid dendritic cells on outcome after reduced-intensity conditioning allogeneic stem cell transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Mohty"
                            1 => "D&#46; Blaise"
                            2 => "C&#46; Faucher"
                            3 => "V&#46;J&#46; Bardou"
                            4 => "J&#46;A&#46; Gastaut"
                            5 => "P&#46; Viens"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.leu.2403558"
                      "Revista" => array:6 [
                        "tituloSerie" => "Leukemia&#46;"
                        "fecha" => "2005"
                        "volumen" => "19"
                        "paginaInicial" => "1"
                        "paginaFinal" => "6"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15526026"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral chronic graft-versus-host disease&#58; analysis of dendritic cells subpopulations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46;M&#46; Botari"
                            1 => "A&#46;J&#46; Nunes"
                            2 => "M&#46;P&#46; Souza"
                            3 => "E&#46;S&#46; Orti-Raduan"
                            4 => "A&#46;G&#46; Salvio"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1590/abd1806-4841.20142464"
                      "Revista" => array:6 [
                        "tituloSerie" => "An Bras Dermatol&#46;"
                        "fecha" => "2014"
                        "volumen" => "89"
                        "paginaInicial" => "632"
                        "paginaFinal" => "637"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25054751"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Plasmacytoid dendritic cells and type I interferon in the immunological response against warts"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46; Saadeh"
                            1 => "M&#46; Kurban"
                            2 => "O&#46; Abbas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ced.13187"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Dermatol&#46;"
                        "fecha" => "2017"
                        "volumen" => "42"
                        "paginaInicial" => "857"
                        "paginaFinal" => "862"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28736973"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Defect of plasmacytoid dendritic cells in warts&#44; hypogammaglobulinemia&#44; infections&#44; myelokathexis &#40;WHIM&#41; syndrome patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Tassone"
                            1 => "D&#46; Moratto"
                            2 => "W&#46; Vermi"
                            3 => "M&#46; De Francesco"
                            4 => "L&#46;D&#46; Notarangelo"
                            5 => "F&#46; Porta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Blood&#46;"
                        "fecha" => "2010"
                        "volumen" => "116"
                        "paginaInicial" => "4870"
                        "paginaFinal" => "4873"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Plasmacytoid dendritic cells in cutaneous lesions of patients with chromoblastomycosis&#44; lacaziosis&#44; and paracoccidioidomycosis&#58; a comparative analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Pagliari"
                            1 => "L&#46; Kanashiro-Galo"
                            2 => "A&#46;A&#46; Silva"
                            3 => "T&#46;C&#46; Barboza"
                            4 => "P&#46;R&#46; Criado"
                            5 => "M&#46;I&#46; Duarte"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/mmy/myt026"
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Mycol&#46;"
                        "fecha" => "2014"
                        "volumen" => "52"
                        "paginaInicial" => "397"
                        "paginaFinal" => "402"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24782102"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "T regulatory cells and plasmocytoid dendritic cells in Hansen disease&#58; a new insight into pathogenesis&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Massone"
                            1 => "E&#46; Nunzi"
                            2 => "R&#46; Ribeiro-Rodrigues"
                            3 => "C&#46; Talhari"
                            4 => "S&#46; Talhari"
                            5 => "A&#46;P&#46; Schettini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/DAD.0b013e3181b7fc56"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Dermatopathol&#46;"
                        "fecha" => "2010"
                        "volumen" => "32"
                        "paginaInicial" => "251"
                        "paginaFinal" => "256"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20075708"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Langerhans cells &#40;CD1a and CD207&#41;&#44; dermal dendrocytes &#40;FXIIIa&#41; and plasmacytoid dendritic cells &#40;CD123&#41; in skin lesions of leprosy patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46;E&#46; Hirai"
                            1 => "T&#46;L&#46; Aar&#227;o"
                            2 => "L&#46;M&#46; Silva"
                            3 => "J&#46;R&#46; de Sousa"
                            4 => "J&#46; de Souza"
                            5 => "L&#46;B&#46; Dias Jr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.micpath.2015.11.013"
                      "Revista" => array:6 [
                        "tituloSerie" => "Microb Pathog&#46;"
                        "fecha" => "2016"
                        "volumen" => "91"
                        "paginaInicial" => "18"
                        "paginaFinal" => "25"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26639680"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Plasmacytoid dendritic cell involvement in the host response against keratoacanthoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "O&#46; Abbas"
                            1 => "L&#46; Hussein"
                            2 => "M&#46; Kurban"
                            3 => "A&#46;G&#46; Kibbi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2014.02.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2014"
                        "volumen" => "70"
                        "paginaInicial" => "1142"
                        "paginaFinal" => "1145"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24831321"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Plasmacytoid dendritic cells in keratoacanthoma and squamous cell carcinoma&#58; A blinded study of CD123 as a diagnostic marker"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46;R&#46; Fraga"
                            1 => "P&#46; Chow"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/cup.13573"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Pathol&#46;"
                        "fecha" => "2020"
                        "volumen" => "47"
                        "paginaInicial" => "17"
                        "paginaFinal" => "21"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31449667"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recruitment of plasmacytoid dendritic cells to skin regulates treatment responsiveness of actinic keratosis to imiquimod"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Y&#46; Ogawa"
                            1 => "T&#46; Kawamura"
                            2 => "T&#46; Matsuzawa"
                            3 => "R&#46; Aoki"
                            4 => "S&#46; Shimada"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jdermsci.2014.07.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatol Sci&#46;"
                        "fecha" => "2014"
                        "volumen" => "76"
                        "paginaInicial" => "67"
                        "paginaFinal" => "69"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25088809"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tumoricidal activity of TLR7&#47;8-activated inflammatory dendritic cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46; Stary"
                            1 => "C&#46; Bangert"
                            2 => "M&#46; Tauber"
                            3 => "R&#46; Strohal"
                            4 => "T&#46; Kopp"
                            5 => "G&#46; Stingl"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1084/jem.20070021"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Exp Med&#46;"
                        "fecha" => "2007"
                        "volumen" => "204"
                        "paginaInicial" => "1441"
                        "paginaFinal" => "1451"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17535975"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Plasmacytoid dendritic cells in melanoma&#58; can we revert bad into good&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Di Domizio"
                            1 => "O&#46; Demaria"
                            2 => "M&#46; Gilliet"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/jid.2014.155"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol&#46;"
                        "fecha" => "2014"
                        "volumen" => "134"
                        "paginaInicial" => "1797"
                        "paginaFinal" => "1800"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24924760"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Plasmacytoid dendritic cells in skin lesions of classic Kaposi&#8217;s sarcoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Karouni"
                            1 => "M&#46; Kurban"
                            2 => "O&#46; Abbas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00403-016-1671-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol Res&#46;"
                        "fecha" => "2016"
                        "volumen" => "308"
                        "paginaInicial" => "487"
                        "paginaFinal" => "492"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27372661"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/03650596/0000009600000001/v3_202102051036/S0365059620303202/v3_202102051036/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "80632"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Review"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009600000001/v3_202102051036/S0365059620303202/v3_202102051036/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620303202?idApp=UINPBA00008Z"
]

Article information

ISSN: 03650596
Original language: English

DOI:10.1016/j.abd.2020.08.006

The statistics are updated each day

Year/Month	Html	Pdf	Total

2024 November	25	8	33
2024 October	119	79	198
2024 September	158	88	246
2024 August	181	121	302
2024 July	153	128	281
2024 June	144	81	225
2024 May	192	56	248
2024 April	135	79	214
2024 March	142	77	219
2024 February	119	87	206
2024 January	83	55	138
2023 December	150	66	216
2023 November	126	79	205
2023 October	97	79	176
2023 September	120	98	218
2023 August	89	48	137
2023 July	101	64	165
2023 June	74	35	109
2023 May	102	28	130
2023 April	64	20	84
2023 March	112	44	156
2023 February	71	39	110
2023 January	64	71	135
2022 December	77	45	122
2022 November	106	53	159
2022 October	124	71	195
2022 September	68	69	137
2022 August	61	42	103
2022 July	57	59	116
2022 June	59	58	117
2022 May	53	54	107
2022 April	124	60	184
2022 March	65	77	142
2022 February	42	42	84
2022 January	56	87	143
2021 December	44	50	94
2021 November	56	60	116
2021 October	72	90	162
2021 September	51	69	120
2021 August	64	59	123
2021 July	44	47	91
2021 June	42	57	99
2021 May	76	110	186
2021 April	162	248	410
2021 March	207	95	302
2021 February	75	29	104
2021 January	47	17	64
2020 December	11	12	23
2020 November	3	2	5

Show all

Indexed in:

Follow us:

Subscribe:

Statistics

Indexed in:

Follow us:

Subscribe:

Statistics

Subscribe to our newsletter