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Algumas têm conteúdo hemorrágico e um ponto central onde ocorreu a picada.</p> <p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Fotografia: Sílvia Mitiko Nishima.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Vidal Haddad Jr, Cecília Guimarães Ferreira Fonseca, Adriana Lúcia Mendes" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Vidal" "apellidos" => "Haddad Jr" ] 1 => array:2 [ "nombre" => "Cecília Guimarães Ferreira" "apellidos" => "Fonseca" ] 2 => array:2 [ "nombre" => "Adriana Lúcia" "apellidos" => "Mendes" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0365059620302312" "doi" => "10.1016/j.abd.2020.05.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => 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class="elsevierStyleSimplePara elsevierViewall">Blisters on the hands of a patient who identified the stings as being from horseflies. Some have hemorrhagic content and a central point where the bite occurred. Photography: Sílvia Mitiko Nishima.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Insect bites and bite wounds are quite common and, in most cases, have mild repercussions on human skin. The statistics on the incidence of injuries caused by insects are not available, as most victims experience local reactions that are not reported.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The risk factors for insect bites and stings are mainly related to environmental exposure, which occurs mainly in hot and humid places. Insect females bite to obtain hormonal maturation factors for their eggs and found it in the victims' blood.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The most exposed people are children, people with large body exposure area, male individuals, people who have consumed alcohol, and pregnant women.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,3</span></a> Some mosquitoes may also be drawn to the variation in the odor of sweat of menstruating women.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,3</span></a> The regions of the body most affected are the extensor faces of the lower and upper limbs; bites on the palms, soles, and face are less common.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">During the insect bite, potentially antigenic substances are introduced into human skin, which causes predisposed (especially atopic) individuals to experience exacerbated local inflammatory reactions. Another important fact is that flies and mosquitoes that suck human blood have anticoagulant substances in their saliva, which prevents obstruction of their digestive tract.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Most bite reactions disappear spontaneously, and systemic allergic reactions that require emergency care are rare.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3–5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The typical clinical picture of a bite from a sucking dipterus shows erythematous papules of varying sizes; the number of lesions is dependent on the victim's exposure. Itching is intense and results in abrasions and secondary infections.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Immunocompromised individuals (people with HIV, cancer patients) may experience more severe local allergic reactions and some systemic signs, such as fever, malaise, headache, and lymphadenopathy.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The stings persist for approximately two weeks, and progress to hypo- or hyperchromic macules that disappear after a few months.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">If the patient is not atopic and sensitized, the symptoms of mosquito bites are mild. In turn, bites of black flies and horseflies cause local inflammation due to the fact that they are “chewers,” destroying the tissue and causing small hemorrhages at the bite sites. The horseflies of the Tabanidae family cause painful injuries, due to the insertion of the frontal stylus in the epidermis; their saliva contains allergens and pharmacologically active compounds that inhibit the body’s innate immune responses, causing anticoagulation, and impairing platelet formation, vasodilation, and anti-inflammatory processes (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). In addition, horsefly stings can transmit infectious diseases caused by helminths, viruses, and bacteria, a fact that is little known but real, and obscured by painful stings and spoliation of blood, which harms the herds of horses and cattle.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Case reports</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Patient 1</span><p id="par0040" class="elsevierStylePara elsevierViewall">A 70-year-old retired fisherman from São Sebastião, state of São Paulo, who had arterial hypertension, and using losartan, hydrochlorothiazide, and amlodipine, was referred. He reported the appearance of a blister in his hand 15 days after an insect bite that he did not see; he denied the use of any substance or medication on the spot. He sought an emergency care unit; he informed he had been prescribed and was treated with antiallergic and benzathine penicillin, but new bullous lesions with hemorrhagic content were observed (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). He denied pain, itching, or any other associated manifestation. In a new consultation, he was evaluated by a dermatologist, who recommended emptying of the blisters, as well as the use of prednisone, ciprofloxacin, sulfadiazine, and antiseptic soap, without improvement. The lesions disappeared after 15 days.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Patient 2</span><p id="par0045" class="elsevierStylePara elsevierViewall">A female patient, university professor of Biology, stung by horseflies during fieldwork – the insects were identified by the patient. The bites evolved into blisters with hemorrhagic content whose appearance made her seek help from a dermatologist. She presented blisters with hemorrhagic content of various diameters on her hands (<a class="elsevierStyleCrossRefs" href="#fig0015">Figs. 3 and 4</a>), which were treated with emptying of the liquid content and topical antibiotic in the resulting exulcerations, evolving with total cure in one week. The conditions of the location where the bites occurred and the absence of hospital care made it impossible to perform the histopathological examination, which would also be useful for the final diagnosis. The patient managed to collect the liquid from one blister, which was subsequently examined; cytology results demonstrated a large number of red blood cells.</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0050" class="elsevierStylePara elsevierViewall">Blisters and vesicles are not uncommon in bug bites. They appear in predisposed individuals, especially in atopic patients. The content of the lesions is usually citrine, reflecting the plasma present in the lesions. This is often observed in mosquito bites, whose sucking device is thin and introduces sensitizing substances into the victim. In the case of a simulid (black fly) or tabanid (horsefly) bite, the site is "chewed" by the sucking device, which severely injures the skin and causes minor bleeding, partly due to the hemorrhagic substances in the insects’ saliva. Tabanids (horseflies, mosquitoes) are flies measuring 6–33<span class="elsevierStyleHsp" style=""></span>mm, usually dark in color; they can also be yellowish. They have a large suction device, being more common in humid areas where cattle and equines, their main victims, are bred. The sting, which is very painful, causes bleeding and infections. If there is an overlapping allergic reaction, blisters are formed on the papules of acute prurigo, which may have hemorrhagic content due to the anticoagulant action of these insects’ saliva.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6,7</span></a> This can lead to diagnostic confusion with other causes of hemorrhagic blisters, such as autoimmune bullous diseases, polymorphic erythema, milker’s nodule, ORF, and other bullous diseases, which have a different clinical evolution. This occurs when the patient does not notice the bite or the insect which caused the lesion. Horseflies, which were associated with one of the described cases, are insects that can sensitize and cause hemorrhagic blisters on the hands of patients. Due to the similarity and atypical aspect of the lesions, these same insects may have also been implicated in the first case.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Financial support</span><p id="par0060" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Authors’ contributions</span><p id="par0065" class="elsevierStylePara elsevierViewall">Vidal Haddad Jr: Approval of the final version of the manuscript; conception and planning of the study, elaboration and writing of the manuscript, obtaining, analyzing, and interpreting the data; effective participation in research orientation, intellectual participation in propaedeutic and/or therapeutic conduct of studied cases; critical review of the literature, critical review of the manuscript.</p><p id="par0070" class="elsevierStylePara elsevierViewall">Cecília Guimarães Ferreira Fonseca: Elaboration and writing of the manuscript, obtaining, analyzing, and interpreting the data; critical review of the literature.</p><p id="par0075" class="elsevierStylePara elsevierViewall">Adriana Lúcia Mendes: Elaboration and writing of the manuscript; obtaining, analyzing, and interpreting the data; intellectual participation in propaedeutic and/or therapeutic conduct of studied cases, critical review of the manuscript, critical review of the literature.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conflicts of interest</span><p id="par0080" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres1418417" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1297626" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 3 => array:3 [ "identificador" => "sec0010" "titulo" => "Case reports" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Patient 1" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Patient 2" ] ] ] 4 => array:2 [ "identificador" => "sec0025" "titulo" => "Discussion" ] 5 => array:2 [ "identificador" => "sec0030" "titulo" => "Financial support" ] 6 => array:2 [ "identificador" => "sec0035" "titulo" => "Authors’ contributions" ] 7 => array:2 [ "identificador" => "sec0040" "titulo" => "Conflicts of interest" ] 8 => array:2 [ "identificador" => "xack494582" "titulo" => "Acknowledgements" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2020-03-02" "fechaAceptado" => "2020-05-15" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1297626" "palabras" => array:4 [ 0 => "Anticoagulants" 1 => "Diptera" 2 => "Hypersensitivity" 3 => "Insect bites and stings" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Insect bites and bite wounds are quite common and most often have mild repercussions in humans. Statistics on the incidence of accidents caused by insects are not available, and the skin reactions after the bites are not always known. The authors present two cases of patients with hemorrhagic blisters on their hands after tabanidae bites and discuss the factors that cause the problem and the importance of the differential diagnosis of blisters with hemorrhagic content on human skin.</p></span>" ] ] "NotaPie" => array:2 [ 0 => array:2 [ "etiqueta" => "⋆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">How to cite this article: Haddad Jr V, Fonseca CGF, Mendes AL. Acute bullous hemorrhagic prurigo: a diagnostic challenge. An Bras Dermatol. 2020</p>" ] 1 => array:2 [ "etiqueta" => "⋆⋆" "nota" => "<p class="elsevierStyleNotepara" id="npar1005">Study conducted at the Department of Infectious Diseases, Dermatology, Diagnostic Imaging and Radiotherapy, Faculty of Medicine, Universidade Estadual Paulista.</p>" ] ] "multimedia" => array:4 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 661 "Ancho" => 905 "Tamanyo" => 76073 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Horsefly or mosquito of the Tabanidae family, whose oral apparatus causes extensive lesions on human skin and can cause important allergic conditions. Photography: Vidal Haddad Junior.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 830 "Ancho" => 1305 "Tamanyo" => 92538 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Blisters of hemorrhagic content on the hands of a patient who reported insect bites, but did not identify the aggressor. Note the extent of the lesions. Photography: Cecília Guimarães Ferreira Fonseca.</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 766 "Ancho" => 905 "Tamanyo" => 73932 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Blisters on the hands of a patient who identified the stings as being from horseflies. Some have hemorrhagic content and a central point where the bite occurred. Photography: Sílvia Mitiko Nishima.</p>" ] ] 3 => array:8 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 965 "Ancho" => 905 "Tamanyo" => 76136 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0020" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The blisters after one week, less tense, but still with the hemorrhagic content. Photography: Sílvia Mitiko Nishima.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:7 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Insect allergy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H. Lee" 1 => "S. Halverson" 2 => "R. Mackey" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.pop.2016.04.010" "Revista" => array:6 [ "tituloSerie" => "Prim Care." 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