array:24 [
  "pii" => "S0365059620301884"
  "issn" => "03650596"
  "doi" => "10.1016/j.abd.2020.02.013"
  "estado" => "S300"
  "fechaPublicacion" => "2020-09-01"
  "aid" => "243"
  "copyright" => "Sociedade Brasileira de Dermatologia"
  "copyrightAnyo" => "2020"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by/4.0/"
  "subdocumento" => "sco"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "pt" => array:19 [
      "pii" => "S2666275220302617"
      "issn" => "26662752"
      "doi" => "10.1016/j.abdp.2020.02.008"
      "estado" => "S300"
      "fechaPublicacion" => "2020-09-01"
      "aid" => "243"
      "copyright" => "Sociedade Brasileira de Dermatologia"
      "documento" => "article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by/4.0/"
      "subdocumento" => "sco"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "pt" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta &#8211; Caso cl&#237;nico</span>"
        "titulo" => "Melanoma maligno ap&#243;s tratamento para carcinoma de c&#233;lulas de Merkel"
        "tienePdf" => "pt"
        "tieneTextoCompleto" => "pt"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "662"
            "paginaFinal" => "664"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "pt" => true
        ]
        "contienePdf" => array:1 [
          "pt" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0015"
            "etiqueta" => "Figura 3"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr3.jpeg"
                "Alto" => 685
                "Ancho" => 905
                "Tamanyo" => 154862
              ]
            ]
            "descripcion" => array:1 [
              "pt" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">O exame histol&#243;gico evidenciou muitas c&#233;lulas at&#237;picas que se infiltravam irregularmente da epiderme &#224; derme &#40;Hematoxilina &#38; eosina&#44; 200&#215;&#41;&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Masato Ishikawa, Toshiyuki Yamamoto"
            "autores" => array:2 [
              0 => array:2 [
                "nombre" => "Masato"
                "apellidos" => "Ishikawa"
              ]
              1 => array:2 [
                "nombre" => "Toshiyuki"
                "apellidos" => "Yamamoto"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "pt"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S0365059620301884"
          "doi" => "10.1016/j.abd.2020.02.013"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620301884?idApp=UINPBA00008Z"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220302617?idApp=UINPBA00008Z"
      "url" => "/26662752/0000009500000005/v1_202010040634/S2666275220302617/v1_202010040634/pt/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0365059620301744"
    "issn" => "03650596"
    "doi" => "10.1016/j.abd.2020.02.007"
    "estado" => "S300"
    "fechaPublicacion" => "2020-09-01"
    "aid" => "229"
    "copyright" => "Sociedade Brasileira de Dermatologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by/4.0/"
    "subdocumento" => "sco"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>"
      "titulo" => "Purpura annularis telangiectodes of Majocchi"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "664"
          "paginaFinal" => "666"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 679
              "Ancho" => 905
              "Tamanyo" => 164760
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0010"
              "detalle" => "Fig&#46; "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Lymphohistiocytic infiltrate in the upper dermis&#44; as well as extravasation of red blood cells&#46; It is possible to see some lymphocyte exocytosis &#40;Hematoxylin &#38; eosin&#44; &#215;400&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Aline Soares Garcez, Vit&#243;ria Regina Pedreira de Almeida Rego, Thadeu Santos Silva"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Aline Soares"
              "apellidos" => "Garcez"
            ]
            1 => array:2 [
              "nombre" => "Vit&#243;ria Regina Pedreira de Almeida"
              "apellidos" => "Rego"
            ]
            2 => array:2 [
              "nombre" => "Thadeu Santos"
              "apellidos" => "Silva"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "pt" => array:9 [
        "pii" => "S2666275220302502"
        "doi" => "10.1016/j.abdp.2020.07.009"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "pt"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220302502?idApp=UINPBA00008Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620301744?idApp=UINPBA00008Z"
    "url" => "/03650596/0000009500000005/v2_202011080908/S0365059620301744/v2_202011080908/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0365059620301835"
    "issn" => "03650596"
    "doi" => "10.1016/j.abd.2020.02.010"
    "estado" => "S300"
    "fechaPublicacion" => "2020-09-01"
    "aid" => "238"
    "copyright" => "Sociedade Brasileira de Dermatologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by/4.0/"
    "subdocumento" => "sco"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>"
      "titulo" => "Onset of vitiligo in a patient with acquired secondary hypogonadism under treatment with testosterone gel 2&#37;&#58; inside the pathogenesis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "661"
          "paginaFinal" => "662"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 586
              "Ancho" => 905
              "Tamanyo" => 72577
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0005"
              "detalle" => "Figure "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Symmetric macules of vitiligo on the dorsomedial part of the hands&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Giovanni Paolino, Pietro Bearzi, Santo Raffaele Mercuri"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Giovanni"
              "apellidos" => "Paolino"
            ]
            1 => array:2 [
              "nombre" => "Pietro"
              "apellidos" => "Bearzi"
            ]
            2 => array:2 [
              "nombre" => "Santo Raffaele"
              "apellidos" => "Mercuri"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "pt" => array:9 [
        "pii" => "S2666275220302563"
        "doi" => "10.1016/j.abdp.2020.02.006"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "pt"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220302563?idApp=UINPBA00008Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620301835?idApp=UINPBA00008Z"
    "url" => "/03650596/0000009500000005/v2_202011080908/S0365059620301835/v2_202011080908/en/main.assets"
  ]
  "en" => array:17 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>"
    "titulo" => "Malignant melanoma after treatment for Merkel cell carcinoma"
    "tieneTextoCompleto" => true
    "saludo" => "Dear Editor&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "662"
        "paginaFinal" => "664"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Masato Ishikawa, Toshiyuki Yamamoto"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "Masato"
            "apellidos" => "Ishikawa"
            "email" => array:1 [
              0 => "ishimasa@fmu.ac.jp"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "Toshiyuki"
            "apellidos" => "Yamamoto"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Department of Dermatology&#44; Fukushima Medical University&#44; Fukushima&#44; Japan"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:8 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 685
            "Ancho" => 905
            "Tamanyo" => 154620
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0015"
            "detalle" => "Fig&#46; "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Histological examination showed many atypical cells infiltrating irregularly from the epidermis to the dermis &#40;Hematoxylin &#38; eosin&#44; &#215;200&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 98-year-old male was referred complaining of a mass on his left cheek&#46; He had never received immunosuppressive therapy&#46; Physical examination showed a solid&#44; dome-shaped&#44; reddish tumor&#44; 35&#8239;mm in diameter&#44; on his left cheek&#46; Microscopic examination of a biopsy specimen revealed an infiltrative tumor in the dermis&#46; The tumor was composed of sheets and trabeculae of atypical cells with scant cytoplasm&#44; and round nuclei with stippled chromatin &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Immunohistochemistry results revealed that the tumor cells stained positive for cytokeratin 20 and neuron specific enolase&#46; The patient underwent total resection of the tumor&#46; However&#44; because of the patient&#8217;s advanced age&#44; neither the patient nor his family wished further treatment&#44; including radiotherapy&#44; choosing follow-up visits only&#46; Two years later&#44; he presented again with erosion of the right hallux&#46; Physical examination showed widespread erosion of his right hallux&#44; which in part had a reddish nodule&#46; The nail had completely disappeared &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Histological examination revealed many atypical cells infiltrating irregularly from the epidermis to the dermis &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; These atypical cells were immunoreactive for MART-1 and HMB-45&#46; For the same reason as before&#44; the patient and his family wanted only local symptomatic treatments at a nearby hospital&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Merkel cell carcinoma &#40;MCC&#41; is a rare cutaneous neuroendocrine cancer that is known to be a highly aggressive malignancy with frequent metastasis and a high mortality rate&#46; A previous review article revealed increased risk of a second primary cancer after the diagnosis of MCC&#44; and cutaneous malignant melanoma &#40;MM&#41; is one of the most common cancers after MCC&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Miller and Rabkin reported that occurrences of MM and MCC were similarly increased with sun exposure and immunosuppression&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Considering that ultra violet &#40;UV&#41; rays attenuate systemic immune responses <span class="elsevierStyleItalic">via</span> the induction of regulatory T-cells&#44; systemic immunosuppression may be an essential factor in the development of both conditions in a patient&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> In the present case&#44; MCC occurred on the left cheek&#44; and MM occurred on the right hallux&#46; In Japan&#44; the majority of MM cases occur on the edges of limbs that are not directly affected by UV rays&#44; and external irritation has been considered one of the risk factors&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> However&#44; systemic immunosuppression associated with aging and&#47;or UV irradiation may be a common cause of both conditions in the present case&#46; According to previous articles&#44; several cases in which MCC and MM developed in a patient have been reported from countries other than Japan&#59; however&#44; to the best of the authors&#8217; knowledge&#44; this is the first report of its type from Japan&#46; Interestingly&#44; there was a report of a case of MCC that developed in a patient during treatment with immune checkpoint inhibitors for MM&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;5</span></a> Given the increase of immune checkpoint inhibitors used to treat MM&#44; the number of cases in which both MCC and MM develop in a patient may increase in Japan&#44; as well as around the world&#46;</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Financial support</span><p id="par0025" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Authors&#39; contributions</span><p id="par0015" class="elsevierStylePara elsevierViewall">Masato Ishikawa&#58; Drafting and editing of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Toshiyuki Yamamoto&#58; Approval of the final version of the manuscript&#59; conception and planning of the study&#59; critical review of the manuscript&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:4 [
        0 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Financial support"
        ]
        1 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Authors&#39; contributions"
        ]
        2 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Conflicts of interest"
        ]
        3 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2019-12-12"
    "fechaAceptado" => "2020-02-12"
    "NotaPie" => array:2 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">How to cite this article&#58; Ishikawa M&#44; Yamamoto T&#46; Malignant melanoma after treatment for Merkel cell carcinoma&#46; An Bras Dermatol&#46; 2020&#59; 95&#46; <span class="elsevierStyleInterRef" id="intr0005" href="https://doi.org/10.1016/j.abd.2020.02.013">https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1016&#47;j&#46;abd&#46;2020&#46;02&#46;013</span>&#46;</p>"
      ]
      1 => array:2 [
        "etiqueta" => "&#9734;&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Study conducted at the Fukushima Medical University&#44; Fukushima&#44; Japan&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 684
            "Ancho" => 905
            "Tamanyo" => 224242
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Fig&#46; "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Microscopic examination of a biopsy specimen from a mass on patient&#8217;s left cheek&#46; There was an infiltrative tumor in the dermis&#46; The tumor was composed of sheets and trabeculae of atypical cells with scant cytoplasm&#44; and round nuclei with stippled chromatin &#40;Hematoxylin &#38; eosin&#44; &#215;200&#41;&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1022
            "Ancho" => 899
            "Tamanyo" => 96065
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0010"
            "detalle" => "Fig&#46; "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Physical examination revealed widespread erosion of the right hallux&#44; which in part had a reddish nodule&#46; The nail had completely disappeared&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 685
            "Ancho" => 905
            "Tamanyo" => 154620
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0015"
            "detalle" => "Fig&#46; "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Histological examination showed many atypical cells infiltrating irregularly from the epidermis to the dermis &#40;Hematoxylin &#38; eosin&#44; &#215;200&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:5 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk of second cancers in Merkel cell carcinoma&#58; a meta-analysis of population based cohort studies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Saxena"
                            1 => "M&#46; Rubens"
                            2 => "V&#46; Ramamoorthy"
                            3 => "H&#46; Khan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "J Skin Cancer&#46;"
                        "fecha" => "2014"
                        "volumen" => "2014"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Merkel cell carcinoma and melanoma etiological similarities and differences"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;W&#46; Miller"
                            1 => "C&#46;S&#46; Rabkin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cancer Epidemiol Biomarkers Prev&#46;"
                        "fecha" => "1999"
                        "volumen" => "8"
                        "paginaInicial" => "153"
                        "paginaFinal" => "158"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of ultraviolet light on human serum 25-hydroxyvitamin D and systemic immune function"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;V&#46; Milliken"
                            1 => "H&#46; Wassall"
                            2 => "B&#46;J&#46; Lewis"
                            3 => "J&#46; Logie"
                            4 => "R&#46;N&#46; Barker"
                            5 => "H&#46; Macdonald"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Allergy Clin Immunol&#46;"
                        "fecha" => "2012"
                        "volumen" => "129"
                        "paginaInicial" => "1554"
                        "paginaFinal" => "1561"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prognosis and Statistical Investigation Committee of the Japanese Skin Cancer Society&#46; Statistical profiles of malignant melanoma and other skin cancers in Japan&#58; 2007 update"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46; Ishihara"
                            1 => "T&#46; Saida"
                            2 => "F&#46; Otsuka"
                            3 => "N&#46; Yamazaki"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Clin Oncol"
                        "fecha" => "2008"
                        "volumen" => "13"
                        "paginaInicial" => "33"
                        "paginaFinal" => "41"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Development of Merkel cell carcinoma and squamous cell carcinoma during treatment with pembrolizumab for metastatic mucosal melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46; Hajar"
                            1 => "E&#46;E&#46; Hill"
                            2 => "J&#46;J&#46; Leitenberger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Dermatol Surg&#46;"
                        "fecha" => "2019"
                        "volumen" => "1"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/03650596/0000009500000005/v2_202011080908/S0365059620301884/v2_202011080908/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "82769"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case Letter"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009500000005/v2_202011080908/S0365059620301884/v2_202011080908/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620301884?idApp=UINPBA00008Z"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Case Letter
Malignant melanoma after treatment for Merkel cell carcinoma
Masato Ishikawa
Corresponding author
ishimasa@fmu.ac.jp

Corresponding author.
, Toshiyuki Yamamoto
Department of Dermatology, Fukushima Medical University, Fukushima, Japan
Read
5618
Times
was read the article
2865
Total PDF
2753
Total HTML
Share statistics
 array:24 [
  "pii" => "S0365059620301884"
  "issn" => "03650596"
  "doi" => "10.1016/j.abd.2020.02.013"
  "estado" => "S300"
  "fechaPublicacion" => "2020-09-01"
  "aid" => "243"
  "copyright" => "Sociedade Brasileira de Dermatologia"
  "copyrightAnyo" => "2020"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by/4.0/"
  "subdocumento" => "sco"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "pt" => array:19 [
      "pii" => "S2666275220302617"
      "issn" => "26662752"
      "doi" => "10.1016/j.abdp.2020.02.008"
      "estado" => "S300"
      "fechaPublicacion" => "2020-09-01"
      "aid" => "243"
      "copyright" => "Sociedade Brasileira de Dermatologia"
      "documento" => "article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by/4.0/"
      "subdocumento" => "sco"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "pt" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta &#8211; Caso cl&#237;nico</span>"
        "titulo" => "Melanoma maligno ap&#243;s tratamento para carcinoma de c&#233;lulas de Merkel"
        "tienePdf" => "pt"
        "tieneTextoCompleto" => "pt"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "662"
            "paginaFinal" => "664"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "pt" => true
        ]
        "contienePdf" => array:1 [
          "pt" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0015"
            "etiqueta" => "Figura 3"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr3.jpeg"
                "Alto" => 685
                "Ancho" => 905
                "Tamanyo" => 154862
              ]
            ]
            "descripcion" => array:1 [
              "pt" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">O exame histol&#243;gico evidenciou muitas c&#233;lulas at&#237;picas que se infiltravam irregularmente da epiderme &#224; derme &#40;Hematoxilina &#38; eosina&#44; 200&#215;&#41;&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Masato Ishikawa, Toshiyuki Yamamoto"
            "autores" => array:2 [
              0 => array:2 [
                "nombre" => "Masato"
                "apellidos" => "Ishikawa"
              ]
              1 => array:2 [
                "nombre" => "Toshiyuki"
                "apellidos" => "Yamamoto"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "pt"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S0365059620301884"
          "doi" => "10.1016/j.abd.2020.02.013"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620301884?idApp=UINPBA00008Z"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220302617?idApp=UINPBA00008Z"
      "url" => "/26662752/0000009500000005/v1_202010040634/S2666275220302617/v1_202010040634/pt/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0365059620301744"
    "issn" => "03650596"
    "doi" => "10.1016/j.abd.2020.02.007"
    "estado" => "S300"
    "fechaPublicacion" => "2020-09-01"
    "aid" => "229"
    "copyright" => "Sociedade Brasileira de Dermatologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by/4.0/"
    "subdocumento" => "sco"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>"
      "titulo" => "Purpura annularis telangiectodes of Majocchi"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "664"
          "paginaFinal" => "666"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 679
              "Ancho" => 905
              "Tamanyo" => 164760
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0010"
              "detalle" => "Fig&#46; "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Lymphohistiocytic infiltrate in the upper dermis&#44; as well as extravasation of red blood cells&#46; It is possible to see some lymphocyte exocytosis &#40;Hematoxylin &#38; eosin&#44; &#215;400&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Aline Soares Garcez, Vit&#243;ria Regina Pedreira de Almeida Rego, Thadeu Santos Silva"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Aline Soares"
              "apellidos" => "Garcez"
            ]
            1 => array:2 [
              "nombre" => "Vit&#243;ria Regina Pedreira de Almeida"
              "apellidos" => "Rego"
            ]
            2 => array:2 [
              "nombre" => "Thadeu Santos"
              "apellidos" => "Silva"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "pt" => array:9 [
        "pii" => "S2666275220302502"
        "doi" => "10.1016/j.abdp.2020.07.009"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "pt"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220302502?idApp=UINPBA00008Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620301744?idApp=UINPBA00008Z"
    "url" => "/03650596/0000009500000005/v2_202011080908/S0365059620301744/v2_202011080908/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0365059620301835"
    "issn" => "03650596"
    "doi" => "10.1016/j.abd.2020.02.010"
    "estado" => "S300"
    "fechaPublicacion" => "2020-09-01"
    "aid" => "238"
    "copyright" => "Sociedade Brasileira de Dermatologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by/4.0/"
    "subdocumento" => "sco"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>"
      "titulo" => "Onset of vitiligo in a patient with acquired secondary hypogonadism under treatment with testosterone gel 2&#37;&#58; inside the pathogenesis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "661"
          "paginaFinal" => "662"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 586
              "Ancho" => 905
              "Tamanyo" => 72577
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0005"
              "detalle" => "Figure "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Symmetric macules of vitiligo on the dorsomedial part of the hands&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Giovanni Paolino, Pietro Bearzi, Santo Raffaele Mercuri"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Giovanni"
              "apellidos" => "Paolino"
            ]
            1 => array:2 [
              "nombre" => "Pietro"
              "apellidos" => "Bearzi"
            ]
            2 => array:2 [
              "nombre" => "Santo Raffaele"
              "apellidos" => "Mercuri"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "pt" => array:9 [
        "pii" => "S2666275220302563"
        "doi" => "10.1016/j.abdp.2020.02.006"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "pt"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220302563?idApp=UINPBA00008Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620301835?idApp=UINPBA00008Z"
    "url" => "/03650596/0000009500000005/v2_202011080908/S0365059620301835/v2_202011080908/en/main.assets"
  ]
  "en" => array:17 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>"
    "titulo" => "Malignant melanoma after treatment for Merkel cell carcinoma"
    "tieneTextoCompleto" => true
    "saludo" => "Dear Editor&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "662"
        "paginaFinal" => "664"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Masato Ishikawa, Toshiyuki Yamamoto"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "Masato"
            "apellidos" => "Ishikawa"
            "email" => array:1 [
              0 => "ishimasa@fmu.ac.jp"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "Toshiyuki"
            "apellidos" => "Yamamoto"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Department of Dermatology&#44; Fukushima Medical University&#44; Fukushima&#44; Japan"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:8 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 685
            "Ancho" => 905
            "Tamanyo" => 154620
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0015"
            "detalle" => "Fig&#46; "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Histological examination showed many atypical cells infiltrating irregularly from the epidermis to the dermis &#40;Hematoxylin &#38; eosin&#44; &#215;200&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 98-year-old male was referred complaining of a mass on his left cheek&#46; He had never received immunosuppressive therapy&#46; Physical examination showed a solid&#44; dome-shaped&#44; reddish tumor&#44; 35&#8239;mm in diameter&#44; on his left cheek&#46; Microscopic examination of a biopsy specimen revealed an infiltrative tumor in the dermis&#46; The tumor was composed of sheets and trabeculae of atypical cells with scant cytoplasm&#44; and round nuclei with stippled chromatin &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Immunohistochemistry results revealed that the tumor cells stained positive for cytokeratin 20 and neuron specific enolase&#46; The patient underwent total resection of the tumor&#46; However&#44; because of the patient&#8217;s advanced age&#44; neither the patient nor his family wished further treatment&#44; including radiotherapy&#44; choosing follow-up visits only&#46; Two years later&#44; he presented again with erosion of the right hallux&#46; Physical examination showed widespread erosion of his right hallux&#44; which in part had a reddish nodule&#46; The nail had completely disappeared &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Histological examination revealed many atypical cells infiltrating irregularly from the epidermis to the dermis &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; These atypical cells were immunoreactive for MART-1 and HMB-45&#46; For the same reason as before&#44; the patient and his family wanted only local symptomatic treatments at a nearby hospital&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Merkel cell carcinoma &#40;MCC&#41; is a rare cutaneous neuroendocrine cancer that is known to be a highly aggressive malignancy with frequent metastasis and a high mortality rate&#46; A previous review article revealed increased risk of a second primary cancer after the diagnosis of MCC&#44; and cutaneous malignant melanoma &#40;MM&#41; is one of the most common cancers after MCC&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Miller and Rabkin reported that occurrences of MM and MCC were similarly increased with sun exposure and immunosuppression&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Considering that ultra violet &#40;UV&#41; rays attenuate systemic immune responses <span class="elsevierStyleItalic">via</span> the induction of regulatory T-cells&#44; systemic immunosuppression may be an essential factor in the development of both conditions in a patient&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> In the present case&#44; MCC occurred on the left cheek&#44; and MM occurred on the right hallux&#46; In Japan&#44; the majority of MM cases occur on the edges of limbs that are not directly affected by UV rays&#44; and external irritation has been considered one of the risk factors&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> However&#44; systemic immunosuppression associated with aging and&#47;or UV irradiation may be a common cause of both conditions in the present case&#46; According to previous articles&#44; several cases in which MCC and MM developed in a patient have been reported from countries other than Japan&#59; however&#44; to the best of the authors&#8217; knowledge&#44; this is the first report of its type from Japan&#46; Interestingly&#44; there was a report of a case of MCC that developed in a patient during treatment with immune checkpoint inhibitors for MM&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;5</span></a> Given the increase of immune checkpoint inhibitors used to treat MM&#44; the number of cases in which both MCC and MM develop in a patient may increase in Japan&#44; as well as around the world&#46;</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Financial support</span><p id="par0025" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Authors&#39; contributions</span><p id="par0015" class="elsevierStylePara elsevierViewall">Masato Ishikawa&#58; Drafting and editing of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Toshiyuki Yamamoto&#58; Approval of the final version of the manuscript&#59; conception and planning of the study&#59; critical review of the manuscript&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:4 [
        0 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Financial support"
        ]
        1 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Authors&#39; contributions"
        ]
        2 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Conflicts of interest"
        ]
        3 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2019-12-12"
    "fechaAceptado" => "2020-02-12"
    "NotaPie" => array:2 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">How to cite this article&#58; Ishikawa M&#44; Yamamoto T&#46; Malignant melanoma after treatment for Merkel cell carcinoma&#46; An Bras Dermatol&#46; 2020&#59; 95&#46; <span class="elsevierStyleInterRef" id="intr0005" href="https://doi.org/10.1016/j.abd.2020.02.013">https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1016&#47;j&#46;abd&#46;2020&#46;02&#46;013</span>&#46;</p>"
      ]
      1 => array:2 [
        "etiqueta" => "&#9734;&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Study conducted at the Fukushima Medical University&#44; Fukushima&#44; Japan&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 684
            "Ancho" => 905
            "Tamanyo" => 224242
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Fig&#46; "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Microscopic examination of a biopsy specimen from a mass on patient&#8217;s left cheek&#46; There was an infiltrative tumor in the dermis&#46; The tumor was composed of sheets and trabeculae of atypical cells with scant cytoplasm&#44; and round nuclei with stippled chromatin &#40;Hematoxylin &#38; eosin&#44; &#215;200&#41;&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1022
            "Ancho" => 899
            "Tamanyo" => 96065
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0010"
            "detalle" => "Fig&#46; "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Physical examination revealed widespread erosion of the right hallux&#44; which in part had a reddish nodule&#46; The nail had completely disappeared&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 685
            "Ancho" => 905
            "Tamanyo" => 154620
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0015"
            "detalle" => "Fig&#46; "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Histological examination showed many atypical cells infiltrating irregularly from the epidermis to the dermis &#40;Hematoxylin &#38; eosin&#44; &#215;200&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:5 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk of second cancers in Merkel cell carcinoma&#58; a meta-analysis of population based cohort studies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Saxena"
                            1 => "M&#46; Rubens"
                            2 => "V&#46; Ramamoorthy"
                            3 => "H&#46; Khan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "J Skin Cancer&#46;"
                        "fecha" => "2014"
                        "volumen" => "2014"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Merkel cell carcinoma and melanoma etiological similarities and differences"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;W&#46; Miller"
                            1 => "C&#46;S&#46; Rabkin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cancer Epidemiol Biomarkers Prev&#46;"
                        "fecha" => "1999"
                        "volumen" => "8"
                        "paginaInicial" => "153"
                        "paginaFinal" => "158"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of ultraviolet light on human serum 25-hydroxyvitamin D and systemic immune function"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;V&#46; Milliken"
                            1 => "H&#46; Wassall"
                            2 => "B&#46;J&#46; Lewis"
                            3 => "J&#46; Logie"
                            4 => "R&#46;N&#46; Barker"
                            5 => "H&#46; Macdonald"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Allergy Clin Immunol&#46;"
                        "fecha" => "2012"
                        "volumen" => "129"
                        "paginaInicial" => "1554"
                        "paginaFinal" => "1561"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prognosis and Statistical Investigation Committee of the Japanese Skin Cancer Society&#46; Statistical profiles of malignant melanoma and other skin cancers in Japan&#58; 2007 update"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46; Ishihara"
                            1 => "T&#46; Saida"
                            2 => "F&#46; Otsuka"
                            3 => "N&#46; Yamazaki"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Clin Oncol"
                        "fecha" => "2008"
                        "volumen" => "13"
                        "paginaInicial" => "33"
                        "paginaFinal" => "41"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Development of Merkel cell carcinoma and squamous cell carcinoma during treatment with pembrolizumab for metastatic mucosal melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46; Hajar"
                            1 => "E&#46;E&#46; Hill"
                            2 => "J&#46;J&#46; Leitenberger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Dermatol Surg&#46;"
                        "fecha" => "2019"
                        "volumen" => "1"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/03650596/0000009500000005/v2_202011080908/S0365059620301884/v2_202011080908/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "82769"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case Letter"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009500000005/v2_202011080908/S0365059620301884/v2_202011080908/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620301884?idApp=UINPBA00008Z"
]
Article information
ISSN: 03650596
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 15 11 26
2024 October 80 71 151
2024 September 108 85 193
2024 August 121 104 225
2024 July 114 130 244
2024 June 107 80 187
2024 May 98 72 170
2024 April 146 88 234
2024 March 120 72 192
2024 February 94 81 175
2024 January 65 55 120
2023 December 59 62 121
2023 November 79 73 152
2023 October 69 79 148
2023 September 60 76 136
2023 August 42 42 84
2023 July 55 37 92
2023 June 51 39 90
2023 May 36 21 57
2023 April 28 15 43
2023 March 38 51 89
2023 February 37 28 65
2023 January 39 40 79
2022 December 48 26 74
2022 November 54 45 99
2022 October 53 45 98
2022 September 49 61 110
2022 August 40 42 82
2022 July 42 46 88
2022 June 34 49 83
2022 May 32 42 74
2022 April 40 67 107
2022 March 42 60 102
2022 February 29 33 62
2022 January 42 86 128
2021 December 35 46 81
2021 November 29 55 84
2021 October 44 79 123
2021 September 23 45 68
2021 August 33 50 83
2021 July 30 33 63
2021 June 26 47 73
2021 May 49 96 145
2021 April 130 229 359
2021 March 52 65 117
2021 February 25 18 43
2021 January 19 22 41
2020 December 19 19 38
2020 November 27 14 41
2020 October 18 10 28
2020 September 14 7 21
2020 August 10 11 21
2020 July 4 5 9
Show all

Follow this link to access the full text of the article

Idiomas
Anais Brasileiros de Dermatologia
en pt
Cookies policy Política de cookies
To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.