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and thickening and pain on palpation of the left ulnar and left external sciatic popliteal nerves&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The bacilloscopy of the ear and two trunk lesions was positive &#40;smear index&#58; 3&#46;33&#41;&#46; Histopathology of the plaque in the inguinal region showed an epidermis with hyperkeratosis&#59; in the dermis&#44; edema and a perivascular&#44; periadnexal&#44; and interstitial mild inflammatory infiltrate composed of lymphocytes&#44; histiocytes&#44; plasmocytes&#44; epithelioid cells&#44; and sparse giant Langhans cells&#44; involving the subcutaneous tissue&#44; adipocytes and septa&#46; Wade staining showed a large number of intracellular acid-fast bacilli&#44; grouped in globi&#44; fragmented and granular &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>A and <a class="elsevierStyleCrossRef" href="#fig0015">3</a> B&#41;&#46; PAS staining did not show thickening of the basal membrane&#44; and no mucin was observed in the Alcian blue staining&#46; 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of the patients with lepromatous leprosy&#59; in 23&#46;6&#37; of those with tuberculoid borderline&#59; in 18&#46;2&#37; of those with borderline forms&#59; and in 16&#46;4&#37; of those with borderline lepromatous type&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Positive ANA can be observed in 3&#37; to 34&#37; of leprosy patients&#46; Titers are generally low&#44; and the speckled and homogeneous patterns are the most common&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Rheumatoid factor&#44; anti-CCP&#44; ANCA&#44; anti-cardiolipin&#44; and antiphospholipids have been observed in varying percentages in patients with the different forms of leprosy&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#8211;8</span></a> Non-scarring alopecia&#44; especially in patients with the lepromatous leprosy&#44; has already been described&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">The different clinical manifestations of leprosy pose a diagnostic challenge&#44; since they can mimic other diseases&#44; including autoimmune disorders&#46; The difficulty of diagnosing leprosy early can increase the chance of transmission and cause deformities secondary to peripheral nerve involvement&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Financial support</span><p id="par0070" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Authors&#39; contributions</span><p id="par0075" class="elsevierStylePara elsevierViewall">Larissa Daniele Machado G&#243;es&#58; Elaboration and writing of the manuscript&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Juliana Alves Scrignoli&#58; Approval of the final version of the manuscript&#59; conception and planning of the study&#59; elaboration and writing of the manuscript&#59; obtaining&#44; analyzing&#44; and interpreting the data&#59; effective participation in research orientation&#59; intellectual participation in propaedeutic and&#47;or therapeutic conduct of studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Patr&#237;cia Morais&#58; Statistical analysis&#59; approval of the final version of the manuscript&#59; conception and planning of the study&#59; elaboration and writing of the manuscript&#59; obtaining&#44; analyzing&#44; and interpreting the data&#59; effective participation in research orientation&#59; intellectual participation in propaedeutic and&#47;or therapeutic conduct of studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Patr&#237;cia Morais&#58; Statistical analysis&#59; approval of the final version of the manuscript&#59; conception and planning of the study&#59; elaboration and writing of the manuscript&#59; obtaining&#44; analyzing&#44; and interpreting the data&#59; effective participation in research orientation&#59; intellectual participation in propaedeutic and&#47;or therapeutic conduct of studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflicts of interest</span><p id="par0095" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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What is your diagnosis?
Case for diagnosis. Infiltrated areas on the trunk
Larissa Daniele Machado Góesa,
Corresponding author
larissadaniele55@gmail.com

Corresponding author.
, Juliana Alves Scrignolib, Patrícia Moraisc, Carolina Talharia
a Tropical Dermatology Clinic, Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta, Manaus, AM, Brazil
b Rheumatology Service, Fundação Hospital Adriano Jorge, Manaus, AM, Brazil
c Dermatopathology Service, Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta, Manaus, AM, Brazil
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and thickening and pain on palpation of the left ulnar and left external sciatic popliteal nerves&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The bacilloscopy of the ear and two trunk lesions was positive &#40;smear index&#58; 3&#46;33&#41;&#46; Histopathology of the plaque in the inguinal region showed an epidermis with hyperkeratosis&#59; in the dermis&#44; edema and a perivascular&#44; periadnexal&#44; and interstitial mild inflammatory infiltrate composed of lymphocytes&#44; histiocytes&#44; plasmocytes&#44; epithelioid cells&#44; and sparse giant Langhans cells&#44; involving the subcutaneous tissue&#44; adipocytes and septa&#46; Wade staining showed a large number of intracellular acid-fast bacilli&#44; grouped in globi&#44; fragmented and granular &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>A and <a class="elsevierStyleCrossRef" href="#fig0015">3</a> B&#41;&#46; PAS staining did not show thickening of the basal membrane&#44; and no mucin was observed in the Alcian blue staining&#46; 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of the patients with lepromatous leprosy&#59; in 23&#46;6&#37; of those with tuberculoid borderline&#59; in 18&#46;2&#37; of those with borderline forms&#59; and in 16&#46;4&#37; of those with borderline lepromatous type&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Positive ANA can be observed in 3&#37; to 34&#37; of leprosy patients&#46; Titers are generally low&#44; and the speckled and homogeneous patterns are the most common&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Rheumatoid factor&#44; anti-CCP&#44; ANCA&#44; anti-cardiolipin&#44; and antiphospholipids have been observed in varying percentages in patients with the different forms of leprosy&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#8211;8</span></a> Non-scarring alopecia&#44; especially in patients with the lepromatous leprosy&#44; has already been described&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">The different clinical manifestations of leprosy pose a diagnostic challenge&#44; since they can mimic other diseases&#44; including autoimmune disorders&#46; The difficulty of diagnosing leprosy early can increase the chance of transmission and cause deformities secondary to peripheral nerve involvement&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Financial support</span><p id="par0070" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Authors&#39; contributions</span><p id="par0075" class="elsevierStylePara elsevierViewall">Larissa Daniele Machado G&#243;es&#58; Elaboration and writing of the manuscript&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Juliana Alves Scrignoli&#58; Approval of the final version of the manuscript&#59; conception and planning of the study&#59; elaboration and writing of the manuscript&#59; obtaining&#44; analyzing&#44; and interpreting the data&#59; effective participation in research orientation&#59; intellectual participation in propaedeutic and&#47;or therapeutic conduct of studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Patr&#237;cia Morais&#58; Statistical analysis&#59; approval of the final version of the manuscript&#59; conception and planning of the study&#59; elaboration and writing of the manuscript&#59; obtaining&#44; analyzing&#44; and interpreting the data&#59; effective participation in research orientation&#59; intellectual participation in propaedeutic and&#47;or therapeutic conduct of studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Patr&#237;cia Morais&#58; Statistical analysis&#59; approval of the final version of the manuscript&#59; conception and planning of the study&#59; elaboration and writing of the manuscript&#59; obtaining&#44; analyzing&#44; and interpreting the data&#59; effective participation in research orientation&#59; intellectual participation in propaedeutic and&#47;or therapeutic conduct of studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflicts of interest</span><p id="par0095" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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Article information
ISSN: 03650596
Original language: English
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2021 June 27 52 79
2021 May 47 94 141
2021 April 116 215 331
2021 March 56 70 126
2021 February 28 25 53
2021 January 30 21 51
2020 December 16 18 34
2020 November 41 13 54
2020 October 21 7 28
2020 September 13 10 23
2020 August 10 8 18
2020 July 26 10 36
2020 June 3 5 8
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