array:24 [
  "pii" => "S0365059620301343"
  "issn" => "03650596"
  "doi" => "10.1016/j.abd.2019.08.033"
  "estado" => "S300"
  "fechaPublicacion" => "2020-07-01"
  "aid" => "206"
  "copyright" => "Sociedade Brasileira de Dermatologia"
  "copyrightAnyo" => "2020"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by/4.0/"
  "subdocumento" => "sco"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "pt" => array:19 [
      "pii" => "S2666275220302071"
      "issn" => "26662752"
      "doi" => "10.1016/j.abdp.2020.05.012"
      "estado" => "S300"
      "fechaPublicacion" => "2020-07-01"
      "aid" => "206"
      "copyright" => "Sociedade Brasileira de Dermatologia"
      "documento" => "article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by/4.0/"
      "subdocumento" => "sco"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "pt" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta &#8211; Caso cl&#237;nico</span>"
        "titulo" => "Forma espor&#225;dica de epiderm&#243;lise bolhosa simples com pigmenta&#231;&#227;o moteada"
        "tienePdf" => "pt"
        "tieneTextoCompleto" => "pt"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "536"
            "paginaFinal" => "538"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "pt" => true
        ]
        "contienePdf" => array:1 [
          "pt" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0010"
            "etiqueta" => "Figura 2"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr2.jpeg"
                "Alto" => 642
                "Ancho" => 1007
                "Tamanyo" => 52235
              ]
            ]
            "descripcion" => array:1 [
              "pt" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Bolhas dessecadas e ves&#237;culas no p&#233; esquerdo&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Fl&#225;via Regina Ferreira, Carolina Fernandes Pereira, Juliana Carvalho Moretto, Mariana Patriota Naville"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "Fl&#225;via Regina"
                "apellidos" => "Ferreira"
              ]
              1 => array:2 [
                "nombre" => "Carolina Fernandes"
                "apellidos" => "Pereira"
              ]
              2 => array:2 [
                "nombre" => "Juliana Carvalho"
                "apellidos" => "Moretto"
              ]
              3 => array:2 [
                "nombre" => "Mariana Patriota"
                "apellidos" => "Naville"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "pt"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S0365059620301343"
          "doi" => "10.1016/j.abd.2019.08.033"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620301343?idApp=UINPBA00008Z"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220302071?idApp=UINPBA00008Z"
      "url" => "/26662752/0000009500000004/v2_202008070652/S2666275220302071/v2_202008070652/pt/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0365059620301252"
    "issn" => "03650596"
    "doi" => "10.1016/j.abd.2019.10.006"
    "estado" => "S300"
    "fechaPublicacion" => "2020-07-01"
    "aid" => "197"
    "copyright" => "Sociedade Brasileira de Dermatologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by/4.0/"
    "subdocumento" => "sco"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>"
      "titulo" => "Rare presentation of Rothmund-Thomson syndrome with novel compound heterozygous mutations of the RECQL4 gene"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "538"
          "paginaFinal" => "540"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1413
              "Ancho" => 2079
              "Tamanyo" => 268529
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Two novel heterozygous variants in the RECQL4 gene confirmed by gene sequencing&#46; One was in the splice site&#44; c&#46;1391-2A&#62;C from her father&#44; and also was seen in her sister&#46; The other was a deletion mutation&#44; c&#46;2492&#95;2493delAT &#40;p&#46;His831Argfs&#41; from her mother&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Xinyue Zhang, Songmei Geng, Yi Zheng"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Xinyue"
              "apellidos" => "Zhang"
            ]
            1 => array:2 [
              "nombre" => "Songmei"
              "apellidos" => "Geng"
            ]
            2 => array:2 [
              "nombre" => "Yi"
              "apellidos" => "Zheng"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "pt" => array:9 [
        "pii" => "S2666275220302083"
        "doi" => "10.1016/j.abdp.2020.05.013"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "pt"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220302083?idApp=UINPBA00008Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620301252?idApp=UINPBA00008Z"
    "url" => "/03650596/0000009500000004/v3_202008041755/S0365059620301252/v3_202008041755/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0365059620301306"
    "issn" => "03650596"
    "doi" => "10.1016/j.abd.2019.12.005"
    "estado" => "S300"
    "fechaPublicacion" => "2020-07-01"
    "aid" => "202"
    "copyright" => "Sociedade Brasileira de Dermatologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by/4.0/"
    "subdocumento" => "sco"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:9 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Research Letter</span>"
      "titulo" => "Cutaneous metastases from primary solid and hematopoietic neoplasms at a referral hospital in Colombia&#58; a cross-sectional study"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "533"
          "paginaFinal" => "535"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Mar&#237;a Fernanda Ord&#243;&#241;ez-Rubiano, Victoria Luc&#237;a D&#225;vila-Osorio, Paula Celeste Rubiano-Mojica, &#193;ngela Marcela Mari&#241;o-&#193;lvarez"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Mar&#237;a Fernanda"
              "apellidos" => "Ord&#243;&#241;ez-Rubiano"
            ]
            1 => array:2 [
              "nombre" => "Victoria Luc&#237;a"
              "apellidos" => "D&#225;vila-Osorio"
            ]
            2 => array:2 [
              "nombre" => "Paula Celeste"
              "apellidos" => "Rubiano-Mojica"
            ]
            3 => array:2 [
              "nombre" => "&#193;ngela Marcela"
              "apellidos" => "Mari&#241;o-&#193;lvarez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "pt" => array:9 [
        "pii" => "S2666275220302058"
        "doi" => "10.1016/j.abdp.2019.12.003"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "pt"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220302058?idApp=UINPBA00008Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620301306?idApp=UINPBA00008Z"
    "url" => "/03650596/0000009500000004/v3_202008041755/S0365059620301306/v3_202008041755/en/main.assets"
  ]
  "en" => array:17 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>"
    "titulo" => "Sporadic form of epidermolysis bullosa simplex with mottled pigmentation"
    "tieneTextoCompleto" => true
    "saludo" => "Dear Editor&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "536"
        "paginaFinal" => "538"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Fl&#225;via Regina Ferreira, Carolina Fernandes Pereira, Juliana Carvalho Moretto, Mariana Patriota Naville"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "Fl&#225;via Regina"
            "apellidos" => "Ferreira"
            "email" => array:1 [
              0 => "dermagica@uol.com.br"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "Carolina Fernandes"
            "apellidos" => "Pereira"
          ]
          2 => array:2 [
            "nombre" => "Juliana Carvalho"
            "apellidos" => "Moretto"
          ]
          3 => array:2 [
            "nombre" => "Mariana Patriota"
            "apellidos" => "Naville"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Dermatology Service&#44; Hospital Universit&#225;rio de Taubat&#233;&#44; Taubat&#233;&#44; SP&#44; Brazil"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 642
            "Ancho" => 1007
            "Tamanyo" => 52235
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Close-up&#46; Desiccated blisters and vesicles on the left foot&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Epidermolysis bullosa &#40;EB&#41; composes a group of hereditary bullous disorders in which the blisters arise spontaneously or are triggered by minimal trauma&#46; Koebner suggested this denomination in 1886&#46; EB is divided into four major types &#40;simplex&#44; junctional&#44; dystrophic&#44; and Kindler syndrome&#41; and several distinct clinical phenotypes&#44; according to the level of skin cleavage&#44; as well as clinical and molecular characteristics&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Epidermolysis bullosa simplex with mottled pigmentation &#40;EBS-MP&#41; is an uncommon subtype of epidermolysis bullosa simplex &#40;EBS&#59; Online Mendelian Inheritance in Man &#91;OMIM&#93; No&#46; 131960&#41;&#46; It is characterized by non-cicatricial blisters&#44; mainly at the distal extremities&#44; and progressive mottled hyperpigmentation&#46; Until 2013&#44; only 15 families and eight sporadic cases had been reported&#44; according to the data from the Hospital Infantil Universit&#225;rio Ni&#241;o Jesus&#44; in Madrid&#44; which motivated this report&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The patient was a 2-year-old girl&#44; phototype III&#44; with a history of blistering skin since birth&#46; On dermatological examination she had desiccated blisters on the feet&#44; as well as hyper- and hypochromic macules scattered over the tegument with mottled appearance &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46; Normochromic papules on the dorsal region of the fingers and onychodystrophy were also seen&#46; The blisters appeared spontaneously or after minimal trauma&#44; according to the mother&#39;s report&#44; and were located mainly at the distal extremities of the limbs&#46; At two months of age&#44; the hyper- and hypochromic macules began&#46; The mother also referred episodes of oral mucositis&#46; Immunomapping result &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41; coupled with the patient&#39;s clinical and laboratory findings confirmed the diagnosis of EBS-MP&#46; This is probably a sporadic case since family history fo EB or other bullous disese is negative&#46; The patient is under outpatient clinic follow-up&#46; Family orientations were conducted in order to reduce the occurrence of new blisters and improve the coexistence of the patient with her genodermatosis&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">First described in 1979 by Fischer and Gedd-Dahl&#44; EBS-MP begins in childhood and has a genetic origin&#46; It is a basal EBS caused by a mutation in the KRT5 gene that encodes cytokeratin 5&#46; It occurs most commonly due to a punctual heterozygous p24L mutation in the non-helical V1 domain of cytokeratin 5&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The diagnosis of this dermatosis is based on typical clinical findings&#44; family history&#44; immunomapping&#44; and&#47;or transmission electron microscopy&#44; as well as molecular&#47;mutation analysis when possible&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Clinically&#44; it is characterized by non-cicatricial blisters&#44; mainly at the distal extremities&#44; as well as progressive mottled hyperpigmentation&#44; which does not occur at the site of the blisters and often disappears in adulthood&#46; Some cases may be accompanied by hypopigmented macules&#44; as could be seen in this patient&#46; There are also reports of palmar and plantar focal hyperkeratosis&#46; Small acral verrucous papules&#44; onychodystrophy&#44; and mild involvement of the oral mucosa can be observed during childhood&#46; Uncommon findings include photosensitivity and dental disorders &#40;caries&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The differential diagnosis of EBS-MP includes other types of EBS &#40;mainly the herpetiformis type of Dowling-Meara&#41;&#44; Kindler syndrome&#44; Naegeli-Franceschetti-Jadassohn &#40;NFJ&#41; ectodermal dysplasia&#44; other forms of dyschromia&#44; Dowling-Degos disease&#44; and even atypical cases of Darier&#39;s disease with mutations in ATP2A2&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2&#8211;4</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Due to the clinical hypothesis of EB and to determine the level of skin cleavage&#44; immunomapping or transmission electron microscopy should be performed&#46; The immunomapping has diagnostic accuracy similar to transmission electron microscopy&#44; with the advantage of simple and fast execution and reading&#46; It is associated with the use of monoclonal antibodies and may be considered an indirect immunofluorescence technique&#46; In the EBS&#44; the skin cleavage occurs in the basal layer &#40;intra-epidermal&#41;&#44; and fluorescence deposition on the blister floor &#40;dermal side&#41; is seen with all antigenic markers &#40;bullous pemphigoid antigen&#44; laminin&#44; collagens IV and VII&#41;&#44; as observed in this case&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Ultrastructural analysis of the pigmented areas in this form of EBS demonstrates abundant mature melanosomes within the basal cells&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Thus&#44; this report details a rare case of a possibly sporadic EBS-MP&#46; The authors emphasize the rarity of this subtype of EBS and its remarkable clinical characteristics favoring future diagnoses&#44; and highlight its benign character&#44; with no scarring or deforming lesions and regression of hyperpigmentation in adulthood&#46;</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Financial support</span><p id="par0075" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Authors&#8217; contributions</span><p id="par0055" class="elsevierStylePara elsevierViewall">Fl&#225;via Regina Ferreira&#58; Approval of final version of the manuscript&#59; conception and planning of the study&#59; drafting and editing of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Carolina Fernandes Pereira&#58; Approval of final version of the manuscript&#59; conception and planning of the study&#59; drafting and editing of the manuscript&#59; critical review of the literature&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Juliana Carvalho Moretto&#58; Approval of final version of the manuscript&#59; conception and planning of the study&#59; drafting and editing of the manuscript&#59; critical review of the literature&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Mariana Patriota Naville&#58; Approval of final version of the manuscript&#59; conception and planning of the study&#59; drafting and editing of the manuscript&#59; critical review of the literature&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0080" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:4 [
        0 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Financial support"
        ]
        1 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Authors&#8217; contributions"
        ]
        2 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Conflicts of interest"
        ]
        3 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2019-05-01"
    "fechaAceptado" => "2019-08-20"
    "NotaPie" => array:2 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">How to cite this article&#58; Ferreira FR&#44; Pereira CF&#44; Moretto JC&#44; Naville MP&#46; Sporadic form of epidermolysis bullosa simplex with mottled pigmentation&#46; An Bras Dermatol&#46; 2020&#59;95&#58;536&#8211;8&#46;</p>"
      ]
      1 => array:2 [
        "etiqueta" => "&#9734;&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Study conducted at the Hospital Universit&#225;rio de Taubat&#233;&#44; Taubat&#233;&#44; SP&#44; Brazil&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2678
            "Ancho" => 1007
            "Tamanyo" => 175262
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Disseminated hyper- and hypochromic macules scattered over the tegument with mottled appearance&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 642
            "Ancho" => 1007
            "Tamanyo" => 52235
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Close-up&#46; Desiccated blisters and vesicles on the left foot&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 924
            "Ancho" => 1074
            "Tamanyo" => 127785
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Immunomapping&#58; fluorescence deposition on the blister floor &#40;dermal side&#41; observed with all antigenic markers &#40;bullous pemphigoid antigen&#44; laminin&#44; collagens IV and VII&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:5 [
            0 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inherited epidermolysis bullosa&#58; updated recommendations on diagnosis and classification"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;D&#46; Fine"
                            1 => "L&#46; Bruckner-Tuderman"
                            2 => "R&#46;A&#46; Eady"
                            3 => "E&#46;A&#46; Bauer"
                            4 => "J&#46;W&#46; Bauer"
                            5 => "C&#46; Has"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2014.01.903"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2014"
                        "volumen" => "70"
                        "paginaInicial" => "1103"
                        "paginaFinal" => "1126"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24690439"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidermolysis bullosa simplex with mottled pigmentation&#58; a family report and review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46; Echeverr&#237;a-Garc&#237;a"
                            1 => "A&#46; Vicente"
                            2 => "&#193;&#46; Hern&#225;ndez"
                            3 => "J&#46;M&#46; Mascar&#243;"
                            4 => "I&#46; Colmenero"
                            5 => "A&#46; Terr&#243;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1525-1470.2012.01748.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Dermatol"
                        "fecha" => "2013"
                        "volumen" => "30"
                        "paginaInicial" => "e125"
                        "paginaFinal" => "e131"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22640275"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recurrent p&#46;N767S mutation in the ATP2A2 gene in a Japanese family with haemorrhagic Darier disease clinically mimicking epidermolysis bullosa simplex with mottled pigmentation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Hamada"
                            1 => "S&#46; Yasumoto"
                            2 => "T&#46; Karashima"
                            3 => "N&#46; Ishii"
                            4 => "H&#46; Shimada"
                            5 => "Y&#46; Kawano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2007.08086.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2007"
                        "volumen" => "157"
                        "paginaInicial" => "605"
                        "paginaFinal" => "608"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17635506"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Updated review of genetic reticulate pigmentary disorders"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Zhang"
                            1 => "M&#46; Li"
                            2 => "Z&#46; Yao"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/bjd.15575"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2017"
                        "volumen" => "177"
                        "paginaInicial" => "945"
                        "paginaFinal" => "959"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28407215"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunomapping in the diagnosis of hereditary epidermolysis bullosa dystrophica"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;C&#46;F&#46; Alves"
                            1 => "M&#46;C&#46;M&#46;R&#46; Machado"
                            2 => "N&#46;C&#46; Cymbalista"
                            3 => "Z&#46;N&#46;P&#46; Oliveira"
                            4 => "M&#46;N&#46; Sotto"
                            5 => "M&#46;G&#46; Prianti"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "An Bras Dermatol"
                        "fecha" => "2001"
                        "volumen" => "76"
                        "paginaInicial" => "551"
                        "paginaFinal" => "560"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/03650596/0000009500000004/v3_202008041755/S0365059620301343/v3_202008041755/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "82769"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case Letter"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009500000004/v3_202008041755/S0365059620301343/v3_202008041755/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620301343?idApp=UINPBA00008Z"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Case Letter
Sporadic form of epidermolysis bullosa simplex with mottled pigmentation
Flávia Regina Ferreira
Corresponding author
dermagica@uol.com.br

Corresponding author.
, Carolina Fernandes Pereira, Juliana Carvalho Moretto, Mariana Patriota Naville
Dermatology Service, Hospital Universitário de Taubaté, Taubaté, SP, Brazil
Read
6072
Times
was read the article
3039
Total PDF
3033
Total HTML
Share statistics
 array:24 [
  "pii" => "S0365059620301343"
  "issn" => "03650596"
  "doi" => "10.1016/j.abd.2019.08.033"
  "estado" => "S300"
  "fechaPublicacion" => "2020-07-01"
  "aid" => "206"
  "copyright" => "Sociedade Brasileira de Dermatologia"
  "copyrightAnyo" => "2020"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by/4.0/"
  "subdocumento" => "sco"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "pt" => array:19 [
      "pii" => "S2666275220302071"
      "issn" => "26662752"
      "doi" => "10.1016/j.abdp.2020.05.012"
      "estado" => "S300"
      "fechaPublicacion" => "2020-07-01"
      "aid" => "206"
      "copyright" => "Sociedade Brasileira de Dermatologia"
      "documento" => "article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by/4.0/"
      "subdocumento" => "sco"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "pt" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta &#8211; Caso cl&#237;nico</span>"
        "titulo" => "Forma espor&#225;dica de epiderm&#243;lise bolhosa simples com pigmenta&#231;&#227;o moteada"
        "tienePdf" => "pt"
        "tieneTextoCompleto" => "pt"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "536"
            "paginaFinal" => "538"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "pt" => true
        ]
        "contienePdf" => array:1 [
          "pt" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0010"
            "etiqueta" => "Figura 2"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr2.jpeg"
                "Alto" => 642
                "Ancho" => 1007
                "Tamanyo" => 52235
              ]
            ]
            "descripcion" => array:1 [
              "pt" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Bolhas dessecadas e ves&#237;culas no p&#233; esquerdo&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Fl&#225;via Regina Ferreira, Carolina Fernandes Pereira, Juliana Carvalho Moretto, Mariana Patriota Naville"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "Fl&#225;via Regina"
                "apellidos" => "Ferreira"
              ]
              1 => array:2 [
                "nombre" => "Carolina Fernandes"
                "apellidos" => "Pereira"
              ]
              2 => array:2 [
                "nombre" => "Juliana Carvalho"
                "apellidos" => "Moretto"
              ]
              3 => array:2 [
                "nombre" => "Mariana Patriota"
                "apellidos" => "Naville"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "pt"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S0365059620301343"
          "doi" => "10.1016/j.abd.2019.08.033"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620301343?idApp=UINPBA00008Z"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220302071?idApp=UINPBA00008Z"
      "url" => "/26662752/0000009500000004/v2_202008070652/S2666275220302071/v2_202008070652/pt/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0365059620301252"
    "issn" => "03650596"
    "doi" => "10.1016/j.abd.2019.10.006"
    "estado" => "S300"
    "fechaPublicacion" => "2020-07-01"
    "aid" => "197"
    "copyright" => "Sociedade Brasileira de Dermatologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by/4.0/"
    "subdocumento" => "sco"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>"
      "titulo" => "Rare presentation of Rothmund-Thomson syndrome with novel compound heterozygous mutations of the RECQL4 gene"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "538"
          "paginaFinal" => "540"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1413
              "Ancho" => 2079
              "Tamanyo" => 268529
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Two novel heterozygous variants in the RECQL4 gene confirmed by gene sequencing&#46; One was in the splice site&#44; c&#46;1391-2A&#62;C from her father&#44; and also was seen in her sister&#46; The other was a deletion mutation&#44; c&#46;2492&#95;2493delAT &#40;p&#46;His831Argfs&#41; from her mother&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Xinyue Zhang, Songmei Geng, Yi Zheng"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Xinyue"
              "apellidos" => "Zhang"
            ]
            1 => array:2 [
              "nombre" => "Songmei"
              "apellidos" => "Geng"
            ]
            2 => array:2 [
              "nombre" => "Yi"
              "apellidos" => "Zheng"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "pt" => array:9 [
        "pii" => "S2666275220302083"
        "doi" => "10.1016/j.abdp.2020.05.013"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "pt"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220302083?idApp=UINPBA00008Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620301252?idApp=UINPBA00008Z"
    "url" => "/03650596/0000009500000004/v3_202008041755/S0365059620301252/v3_202008041755/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0365059620301306"
    "issn" => "03650596"
    "doi" => "10.1016/j.abd.2019.12.005"
    "estado" => "S300"
    "fechaPublicacion" => "2020-07-01"
    "aid" => "202"
    "copyright" => "Sociedade Brasileira de Dermatologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by/4.0/"
    "subdocumento" => "sco"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:9 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Research Letter</span>"
      "titulo" => "Cutaneous metastases from primary solid and hematopoietic neoplasms at a referral hospital in Colombia&#58; a cross-sectional study"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "533"
          "paginaFinal" => "535"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Mar&#237;a Fernanda Ord&#243;&#241;ez-Rubiano, Victoria Luc&#237;a D&#225;vila-Osorio, Paula Celeste Rubiano-Mojica, &#193;ngela Marcela Mari&#241;o-&#193;lvarez"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Mar&#237;a Fernanda"
              "apellidos" => "Ord&#243;&#241;ez-Rubiano"
            ]
            1 => array:2 [
              "nombre" => "Victoria Luc&#237;a"
              "apellidos" => "D&#225;vila-Osorio"
            ]
            2 => array:2 [
              "nombre" => "Paula Celeste"
              "apellidos" => "Rubiano-Mojica"
            ]
            3 => array:2 [
              "nombre" => "&#193;ngela Marcela"
              "apellidos" => "Mari&#241;o-&#193;lvarez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "pt" => array:9 [
        "pii" => "S2666275220302058"
        "doi" => "10.1016/j.abdp.2019.12.003"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "pt"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220302058?idApp=UINPBA00008Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620301306?idApp=UINPBA00008Z"
    "url" => "/03650596/0000009500000004/v3_202008041755/S0365059620301306/v3_202008041755/en/main.assets"
  ]
  "en" => array:17 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>"
    "titulo" => "Sporadic form of epidermolysis bullosa simplex with mottled pigmentation"
    "tieneTextoCompleto" => true
    "saludo" => "Dear Editor&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "536"
        "paginaFinal" => "538"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Fl&#225;via Regina Ferreira, Carolina Fernandes Pereira, Juliana Carvalho Moretto, Mariana Patriota Naville"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "Fl&#225;via Regina"
            "apellidos" => "Ferreira"
            "email" => array:1 [
              0 => "dermagica@uol.com.br"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "Carolina Fernandes"
            "apellidos" => "Pereira"
          ]
          2 => array:2 [
            "nombre" => "Juliana Carvalho"
            "apellidos" => "Moretto"
          ]
          3 => array:2 [
            "nombre" => "Mariana Patriota"
            "apellidos" => "Naville"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Dermatology Service&#44; Hospital Universit&#225;rio de Taubat&#233;&#44; Taubat&#233;&#44; SP&#44; Brazil"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 642
            "Ancho" => 1007
            "Tamanyo" => 52235
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Close-up&#46; Desiccated blisters and vesicles on the left foot&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Epidermolysis bullosa &#40;EB&#41; composes a group of hereditary bullous disorders in which the blisters arise spontaneously or are triggered by minimal trauma&#46; Koebner suggested this denomination in 1886&#46; EB is divided into four major types &#40;simplex&#44; junctional&#44; dystrophic&#44; and Kindler syndrome&#41; and several distinct clinical phenotypes&#44; according to the level of skin cleavage&#44; as well as clinical and molecular characteristics&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Epidermolysis bullosa simplex with mottled pigmentation &#40;EBS-MP&#41; is an uncommon subtype of epidermolysis bullosa simplex &#40;EBS&#59; Online Mendelian Inheritance in Man &#91;OMIM&#93; No&#46; 131960&#41;&#46; It is characterized by non-cicatricial blisters&#44; mainly at the distal extremities&#44; and progressive mottled hyperpigmentation&#46; Until 2013&#44; only 15 families and eight sporadic cases had been reported&#44; according to the data from the Hospital Infantil Universit&#225;rio Ni&#241;o Jesus&#44; in Madrid&#44; which motivated this report&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The patient was a 2-year-old girl&#44; phototype III&#44; with a history of blistering skin since birth&#46; On dermatological examination she had desiccated blisters on the feet&#44; as well as hyper- and hypochromic macules scattered over the tegument with mottled appearance &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46; Normochromic papules on the dorsal region of the fingers and onychodystrophy were also seen&#46; The blisters appeared spontaneously or after minimal trauma&#44; according to the mother&#39;s report&#44; and were located mainly at the distal extremities of the limbs&#46; At two months of age&#44; the hyper- and hypochromic macules began&#46; The mother also referred episodes of oral mucositis&#46; Immunomapping result &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41; coupled with the patient&#39;s clinical and laboratory findings confirmed the diagnosis of EBS-MP&#46; This is probably a sporadic case since family history fo EB or other bullous disese is negative&#46; The patient is under outpatient clinic follow-up&#46; Family orientations were conducted in order to reduce the occurrence of new blisters and improve the coexistence of the patient with her genodermatosis&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">First described in 1979 by Fischer and Gedd-Dahl&#44; EBS-MP begins in childhood and has a genetic origin&#46; It is a basal EBS caused by a mutation in the KRT5 gene that encodes cytokeratin 5&#46; It occurs most commonly due to a punctual heterozygous p24L mutation in the non-helical V1 domain of cytokeratin 5&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The diagnosis of this dermatosis is based on typical clinical findings&#44; family history&#44; immunomapping&#44; and&#47;or transmission electron microscopy&#44; as well as molecular&#47;mutation analysis when possible&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Clinically&#44; it is characterized by non-cicatricial blisters&#44; mainly at the distal extremities&#44; as well as progressive mottled hyperpigmentation&#44; which does not occur at the site of the blisters and often disappears in adulthood&#46; Some cases may be accompanied by hypopigmented macules&#44; as could be seen in this patient&#46; There are also reports of palmar and plantar focal hyperkeratosis&#46; Small acral verrucous papules&#44; onychodystrophy&#44; and mild involvement of the oral mucosa can be observed during childhood&#46; Uncommon findings include photosensitivity and dental disorders &#40;caries&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The differential diagnosis of EBS-MP includes other types of EBS &#40;mainly the herpetiformis type of Dowling-Meara&#41;&#44; Kindler syndrome&#44; Naegeli-Franceschetti-Jadassohn &#40;NFJ&#41; ectodermal dysplasia&#44; other forms of dyschromia&#44; Dowling-Degos disease&#44; and even atypical cases of Darier&#39;s disease with mutations in ATP2A2&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2&#8211;4</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Due to the clinical hypothesis of EB and to determine the level of skin cleavage&#44; immunomapping or transmission electron microscopy should be performed&#46; The immunomapping has diagnostic accuracy similar to transmission electron microscopy&#44; with the advantage of simple and fast execution and reading&#46; It is associated with the use of monoclonal antibodies and may be considered an indirect immunofluorescence technique&#46; In the EBS&#44; the skin cleavage occurs in the basal layer &#40;intra-epidermal&#41;&#44; and fluorescence deposition on the blister floor &#40;dermal side&#41; is seen with all antigenic markers &#40;bullous pemphigoid antigen&#44; laminin&#44; collagens IV and VII&#41;&#44; as observed in this case&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Ultrastructural analysis of the pigmented areas in this form of EBS demonstrates abundant mature melanosomes within the basal cells&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Thus&#44; this report details a rare case of a possibly sporadic EBS-MP&#46; The authors emphasize the rarity of this subtype of EBS and its remarkable clinical characteristics favoring future diagnoses&#44; and highlight its benign character&#44; with no scarring or deforming lesions and regression of hyperpigmentation in adulthood&#46;</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Financial support</span><p id="par0075" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Authors&#8217; contributions</span><p id="par0055" class="elsevierStylePara elsevierViewall">Fl&#225;via Regina Ferreira&#58; Approval of final version of the manuscript&#59; conception and planning of the study&#59; drafting and editing of the manuscript&#59; collection&#44; analysis&#44; and interpretation of data&#59; intellectual participation in the propaedeutic and&#47;or therapeutic conduct of the studied cases&#59; critical review of the literature&#59; critical review of the manuscript&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Carolina Fernandes Pereira&#58; Approval of final version of the manuscript&#59; conception and planning of the study&#59; drafting and editing of the manuscript&#59; critical review of the literature&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Juliana Carvalho Moretto&#58; Approval of final version of the manuscript&#59; conception and planning of the study&#59; drafting and editing of the manuscript&#59; critical review of the literature&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Mariana Patriota Naville&#58; Approval of final version of the manuscript&#59; conception and planning of the study&#59; drafting and editing of the manuscript&#59; critical review of the literature&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0080" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:4 [
        0 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Financial support"
        ]
        1 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Authors&#8217; contributions"
        ]
        2 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Conflicts of interest"
        ]
        3 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2019-05-01"
    "fechaAceptado" => "2019-08-20"
    "NotaPie" => array:2 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">How to cite this article&#58; Ferreira FR&#44; Pereira CF&#44; Moretto JC&#44; Naville MP&#46; Sporadic form of epidermolysis bullosa simplex with mottled pigmentation&#46; An Bras Dermatol&#46; 2020&#59;95&#58;536&#8211;8&#46;</p>"
      ]
      1 => array:2 [
        "etiqueta" => "&#9734;&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Study conducted at the Hospital Universit&#225;rio de Taubat&#233;&#44; Taubat&#233;&#44; SP&#44; Brazil&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2678
            "Ancho" => 1007
            "Tamanyo" => 175262
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Disseminated hyper- and hypochromic macules scattered over the tegument with mottled appearance&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 642
            "Ancho" => 1007
            "Tamanyo" => 52235
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Close-up&#46; Desiccated blisters and vesicles on the left foot&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 924
            "Ancho" => 1074
            "Tamanyo" => 127785
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Immunomapping&#58; fluorescence deposition on the blister floor &#40;dermal side&#41; observed with all antigenic markers &#40;bullous pemphigoid antigen&#44; laminin&#44; collagens IV and VII&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:5 [
            0 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inherited epidermolysis bullosa&#58; updated recommendations on diagnosis and classification"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;D&#46; Fine"
                            1 => "L&#46; Bruckner-Tuderman"
                            2 => "R&#46;A&#46; Eady"
                            3 => "E&#46;A&#46; Bauer"
                            4 => "J&#46;W&#46; Bauer"
                            5 => "C&#46; Has"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2014.01.903"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2014"
                        "volumen" => "70"
                        "paginaInicial" => "1103"
                        "paginaFinal" => "1126"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24690439"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidermolysis bullosa simplex with mottled pigmentation&#58; a family report and review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46; Echeverr&#237;a-Garc&#237;a"
                            1 => "A&#46; Vicente"
                            2 => "&#193;&#46; Hern&#225;ndez"
                            3 => "J&#46;M&#46; Mascar&#243;"
                            4 => "I&#46; Colmenero"
                            5 => "A&#46; Terr&#243;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1525-1470.2012.01748.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Dermatol"
                        "fecha" => "2013"
                        "volumen" => "30"
                        "paginaInicial" => "e125"
                        "paginaFinal" => "e131"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22640275"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recurrent p&#46;N767S mutation in the ATP2A2 gene in a Japanese family with haemorrhagic Darier disease clinically mimicking epidermolysis bullosa simplex with mottled pigmentation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Hamada"
                            1 => "S&#46; Yasumoto"
                            2 => "T&#46; Karashima"
                            3 => "N&#46; Ishii"
                            4 => "H&#46; Shimada"
                            5 => "Y&#46; Kawano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2007.08086.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2007"
                        "volumen" => "157"
                        "paginaInicial" => "605"
                        "paginaFinal" => "608"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17635506"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Updated review of genetic reticulate pigmentary disorders"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Zhang"
                            1 => "M&#46; Li"
                            2 => "Z&#46; Yao"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/bjd.15575"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2017"
                        "volumen" => "177"
                        "paginaInicial" => "945"
                        "paginaFinal" => "959"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28407215"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunomapping in the diagnosis of hereditary epidermolysis bullosa dystrophica"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;C&#46;F&#46; Alves"
                            1 => "M&#46;C&#46;M&#46;R&#46; Machado"
                            2 => "N&#46;C&#46; Cymbalista"
                            3 => "Z&#46;N&#46;P&#46; Oliveira"
                            4 => "M&#46;N&#46; Sotto"
                            5 => "M&#46;G&#46; Prianti"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "An Bras Dermatol"
                        "fecha" => "2001"
                        "volumen" => "76"
                        "paginaInicial" => "551"
                        "paginaFinal" => "560"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/03650596/0000009500000004/v3_202008041755/S0365059620301343/v3_202008041755/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "82769"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case Letter"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009500000004/v3_202008041755/S0365059620301343/v3_202008041755/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620301343?idApp=UINPBA00008Z"
]
Article information
ISSN: 03650596
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 20 14 34
2024 October 101 70 171
2024 September 169 86 255
2024 August 152 105 257
2024 July 129 119 248
2024 June 151 107 258
2024 May 105 77 182
2024 April 106 85 191
2024 March 81 74 155
2024 February 74 83 157
2024 January 46 60 106
2023 December 65 65 130
2023 November 64 80 144
2023 October 68 73 141
2023 September 114 68 182
2023 August 79 42 121
2023 July 49 38 87
2023 June 51 50 101
2023 May 44 18 62
2023 April 37 15 52
2023 March 59 53 112
2023 February 46 33 79
2023 January 40 35 75
2022 December 51 27 78
2022 November 60 50 110
2022 October 81 54 135
2022 September 52 63 115
2022 August 41 47 88
2022 July 34 57 91
2022 June 50 46 96
2022 May 32 68 100
2022 April 36 40 76
2022 March 40 75 115
2022 February 18 35 53
2022 January 61 91 152
2021 December 37 76 113
2021 November 43 56 99
2021 October 54 76 130
2021 September 37 52 89
2021 August 36 44 80
2021 July 39 46 85
2021 June 29 63 92
2021 May 42 71 113
2021 April 93 256 349
2021 March 36 49 85
2021 February 17 21 38
2021 January 21 20 41
2020 December 22 20 42
2020 November 24 13 37
2020 October 17 17 34
2020 September 23 18 41
2020 August 10 11 21
2020 July 30 12 42
2020 June 14 10 24
2020 May 3 5 8
Show all

Follow this link to access the full text of the article

Idiomas
Anais Brasileiros de Dermatologia
en pt
Cookies policy Política de cookies
To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.