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Patient was insulin-dependent diabetic and had a history of kidney transplant performed three years ago and in use of azathioprine and prednisone&#46; After dermatological evaluation&#44; it was decided to perform lesional skin scrapings and mycological culture of the lesion&#39;s secretion and the sputum&#44; as well as an incisional biopsy&#44; with the removal of two fragments for mycological and histopathological study&#46; Slides of direct secretion and sputum were prepared with addition of India ink upon which capsulated yeasts were observed&#46; In the mycological culture of all the samples&#44; there was a development of colonies of white to cream color of mucous aspect typical of <span class="elsevierStyleItalic">Cryptococcus</span> spp&#46; The species identification and antifungal susceptibility were performed in the Vitek 2-Compact&#46; The isolate was also identified by sequencing the D1&#47;D2 domain of the rDNA using the primers NL1 and NL4 being identified as <span class="elsevierStyleItalic">Cryptococcus neoformans</span> &#40;San Felice&#41; Vuill &#40;1901&#41;&#46; Histopathology revealed numerous yeast fungal structures&#44; best visualized by PAS staining &#40;periodic acid-Schiff&#41;&#44; with mucopolysaccharides capsules that stand out for Alcian Blue staining&#44; with scarce inflammatory infiltrate in between &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The patient was hospitalized and treated with amphotericin B associated with fluconazole&#46; After significant clinical improvement&#44; the patient was discharged on the use of fluconazol daily until complete resolution of the cutaneous condition &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">According to literature&#44; this mycosis is commonly diagnosed in patients with cellular immunosuppression&#44; such as HIV positive&#44; being the most frequent systemic mycosis in this group of patients and the third cause of opportunistic Central Nervous System &#40;CNS&#41; disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;4</span></a> In renal transplant patients&#44; cryptococcosis occurs in 0&#46;8&#8211;5&#37; of them&#44; depending on the type and intensity of immunosuppression&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> Infection is usually observed in the late postoperative period&#44; about four months after the introduction of immunosuppressive drugs&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Drug resistance&#44; when using fluconazole&#44; is likely to occur during prolonged suppressive treatments as in cases of <span class="elsevierStyleItalic">C&#46; neoformans</span> meningitis&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> For the treatment of renal transplant patients using immunosuppressive drugs&#44; drug interactions and side effects should be especially considered&#44; particularly the intrinsic nephrotoxicity of amphotericin B&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> There is still no consensus regarding dose adjustment&#44; time and duration of treatment&#44; as well as the need of maintenance therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">This report presents the medical history of a patient with cutaneous and pulmonary alterations&#44; which allowed the diagnosis of cryptococcosis and the appropriate treatment for it&#46; Through this report we could highlight the importance of the differential diagnosis of infectious conditions in renal transplant patients&#46;</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Financial support</span><p id="par0060" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Authors&#8217; 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Case Letter
Cutaneous and pulmonary cryptococcosis
Deborah Lucena Markmana,
Corresponding author
deborahlmarkman@gmail.com

Corresponding author.
, Pamella Paola Bezerra de Oliveiraa, Daniela Mayumi Takanob, Idalina Inês Fonseca Nogueira Cambuimc
a Department of Dermatology, Hospital Otávio de Freitas, Recife, PE, Brazil
b Department of Pathology, Universidade Federal de Pernambuco, Recife, PE, Brazil
c Mycology Laboratory, Hospital Otávio de Freitas, Recife, PE, Brazil
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Cryptococcus neoformans</span> is the etiological agent of cryptococcosis&#44; an infectious disease that affects humans&#44; domestic and wild animals&#46; This pathogen is often found in pigeon excreta&#44; possessing innumerable environmental sources&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The diagnosis can be performed by analysis of cerebrospinal fluid &#40;CSF&#41;&#44; urine sediment&#44; bronchoalveolar lavage fluid&#44; wound exudates&#44; floating node aspirate and suspected lesions biopsies&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Treatment of cryptococcosis in immunocompetent and immunocompromised humans&#44; consists of amphotericin B in combination with 5-flucitosin in disseminated infections&#59; or with fluconazole or itraconazole&#44; as an alternative for the treatment of cutaneous infections&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">A 36-year-old female patient presented an ulcerated plaque with hematic crust and erythematous infiltrated edges topped with pustules&#44; measuring approximately 3<span class="elsevierStyleHsp" style=""></span>cm length in the posterior region of the left ear &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The patient related the lesion appeared 4 months before the appointment&#44; accompanied by systemic symptoms such as intermittent fever&#44; productive cough&#44; and weight loss of approximately 5<span class="elsevierStyleHsp" style=""></span>kg in 15 days&#46; Chest X-ray showed evidence of hypotransparency in the middle segment of the right lung lobe&#46; Patient was insulin-dependent diabetic and had a history of kidney transplant performed three years ago and in use of azathioprine and prednisone&#46; After dermatological evaluation&#44; it was decided to perform lesional skin scrapings and mycological culture of the lesion&#39;s secretion and the sputum&#44; as well as an incisional biopsy&#44; with the removal of two fragments for mycological and histopathological study&#46; Slides of direct secretion and sputum were prepared with addition of India ink upon which capsulated yeasts were observed&#46; In the mycological culture of all the samples&#44; there was a development of colonies of white to cream color of mucous aspect typical of <span class="elsevierStyleItalic">Cryptococcus</span> spp&#46; The species identification and antifungal susceptibility were performed in the Vitek 2-Compact&#46; The isolate was also identified by sequencing the D1&#47;D2 domain of the rDNA using the primers NL1 and NL4 being identified as <span class="elsevierStyleItalic">Cryptococcus neoformans</span> &#40;San Felice&#41; Vuill &#40;1901&#41;&#46; Histopathology revealed numerous yeast fungal structures&#44; best visualized by PAS staining &#40;periodic acid-Schiff&#41;&#44; with mucopolysaccharides capsules that stand out for Alcian Blue staining&#44; with scarce inflammatory infiltrate in between &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The patient was hospitalized and treated with amphotericin B associated with fluconazole&#46; After significant clinical improvement&#44; the patient was discharged on the use of fluconazol daily until complete resolution of the cutaneous condition &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">According to literature&#44; this mycosis is commonly diagnosed in patients with cellular immunosuppression&#44; such as HIV positive&#44; being the most frequent systemic mycosis in this group of patients and the third cause of opportunistic Central Nervous System &#40;CNS&#41; disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;4</span></a> In renal transplant patients&#44; cryptococcosis occurs in 0&#46;8&#8211;5&#37; of them&#44; depending on the type and intensity of immunosuppression&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> Infection is usually observed in the late postoperative period&#44; about four months after the introduction of immunosuppressive drugs&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Drug resistance&#44; when using fluconazole&#44; is likely to occur during prolonged suppressive treatments as in cases of <span class="elsevierStyleItalic">C&#46; neoformans</span> meningitis&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> For the treatment of renal transplant patients using immunosuppressive drugs&#44; drug interactions and side effects should be especially considered&#44; particularly the intrinsic nephrotoxicity of amphotericin B&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> There is still no consensus regarding dose adjustment&#44; time and duration of treatment&#44; as well as the need of maintenance therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">This report presents the medical history of a patient with cutaneous and pulmonary alterations&#44; which allowed the diagnosis of cryptococcosis and the appropriate treatment for it&#46; Through this report we could highlight the importance of the differential diagnosis of infectious conditions in renal transplant patients&#46;</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Financial support</span><p id="par0060" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Authors&#8217; contributions</span><p id="par0040" class="elsevierStylePara elsevierViewall">Deborah Lucena Markman&#58; approval of the final version of the manuscript&#59; elaboration and writing of the manuscript&#59; effective participation in research orientation&#59; critical review of the literature&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Pamella Paola Bezerra de Oliveira&#58; elaboration and writing of the manuscript&#59; critical review of the literature&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Daniela Mayumi Takano&#58; approval of the final version of the manuscript&#59; effective participation in research orientation&#59; critical review of the manuscript&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Idalina In&#234;s Fonseca Nogueira Cambuim&#58; approval of the final version of the manuscript&#59; effective participation in research orientation&#59; critical review of the manuscript&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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