was read the article
array:24 [ "pii" => "S0365059620300234" "issn" => "03650596" "doi" => "10.1016/j.abd.2019.02.012" "estado" => "S300" "fechaPublicacion" => "2020-03-01" "aid" => "130" "copyright" => "Sociedade Brasileira de Dermatologia" "copyrightAnyo" => "2020" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3 "formatos" => array:2 [ "EPUB" => 1 "PDF" => 2 ] ] "Traduccion" => array:1 [ "pt" => array:19 [ "pii" => "S2666275220300564" "issn" => "26662752" "doi" => "10.1016/j.abdp.2019.02.012" "estado" => "S300" "fechaPublicacion" => "2020-03-01" "aid" => "130" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "pt" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Caso Clínico</span>" "titulo" => "PsAPASH: síndrome autoinflamatória rara, associada à hidradenite supurativa" "tienePdf" => "pt" "tieneTextoCompleto" => "pt" "tieneResumen" => "pt" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "203" "paginaFinal" => "206" ] ] "contieneResumen" => array:1 [ "pt" => true ] "contieneTextoCompleto" => array:1 [ "pt" => true ] "contienePdf" => array:1 [ "pt" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figura 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1126 "Ancho" => 805 "Tamanyo" => 87836 ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Lesão ulcerada cicatricial no membro inferior esquerdo de pioderma gangrenoso.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Raissa de Lima Gadelha, Renata da Silveira Rodrigues Paiva, Esther Bastos Palitot, Joanne Elizabeth Ferraz da Costa" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Raissa de Lima" "apellidos" => "Gadelha" ] 1 => array:2 [ "nombre" => "Renata da Silveira Rodrigues" "apellidos" => "Paiva" ] 2 => array:2 [ "nombre" => "Esther Bastos" "apellidos" => "Palitot" ] 3 => array:2 [ "nombre" => "Joanne Elizabeth Ferraz da" "apellidos" => "Costa" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0365059620300234" "doi" => "10.1016/j.abd.2019.02.012" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620300234?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220300564?idApp=UINPBA00008Z" "url" => "/26662752/0000009500000002/v1_202005231807/S2666275220300564/v1_202005231807/pt/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S0365059620300222" "issn" => "03650596" "doi" => "10.1016/j.abd.2019.05.005" "estado" => "S300" "fechaPublicacion" => "2020-03-01" "aid" => "129" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3 "formatos" => array:2 [ "EPUB" => 1 "PDF" => 2 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>" "titulo" => "Success in the use of oral propranolol in the treatment of infantile hemangioma in nasal tip – Report of two cases" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "207" "paginaFinal" => "209" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 692 "Ancho" => 1007 "Tamanyo" => 49715 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Before the treatment with oral propranolol, 6-month-old infant.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Mariana Carvalho Costa, Odil Garrido Campos de Andrade, Lethícia de Castro Pereira, Izelda Maria Carvalho Costa" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Mariana Carvalho" "apellidos" => "Costa" ] 1 => array:2 [ "nombre" => "Odil Garrido Campos de" "apellidos" => "Andrade" ] 2 => array:2 [ "nombre" => "Lethícia de Castro" "apellidos" => "Pereira" ] 3 => array:2 [ "nombre" => "Izelda Maria Carvalho" "apellidos" => "Costa" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275220300552" "doi" => "10.1016/j.abdp.2019.05.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220300552?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620300222?idApp=UINPBA00008Z" "url" => "/03650596/0000009500000002/v1_202004180640/S0365059620300222/v1_202004180640/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0365059620300271" "issn" => "03650596" "doi" => "10.1016/j.abd.2019.02.013" "estado" => "S300" "fechaPublicacion" => "2020-03-01" "aid" => "134" "copyright" => "Sociedade Brasileira de Dermatologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>" "titulo" => "Exuberant case of erythema elevatum diutinum in a patient infected with HIV and hepatitis B virus" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "200" "paginaFinal" => "202" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 884 "Ancho" => 1207 "Tamanyo" => 313146 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Anatomopathological examination of the skin biopsy demonstrating neutrophilic dermatitis, with marked leukocytoclasia and presence of fibrotic nodules surrounding the neutrophilic infiltrate, compatible with leukocytoclastic vasculitis (Hematoxylin & eosin, ×40).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Sayuri Aparecida Hirayama, Cezar Arthur Tavares Pinheiro, Isabelle Maffei Guarenti, Danise Senna Oliveira" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Sayuri Aparecida" "apellidos" => "Hirayama" ] 1 => array:2 [ "nombre" => "Cezar Arthur Tavares" "apellidos" => "Pinheiro" ] 2 => array:2 [ "nombre" => "Isabelle Maffei" "apellidos" => "Guarenti" ] 3 => array:2 [ "nombre" => "Danise Senna" "apellidos" => "Oliveira" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2666275220300783" "doi" => "10.1016/j.abdp.2019.02.013" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2666275220300783?idApp=UINPBA00008Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620300271?idApp=UINPBA00008Z" "url" => "/03650596/0000009500000002/v1_202004180640/S0365059620300271/v1_202004180640/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>" "titulo" => "PsAPASH: a rare and recent autoinflammatory syndrome associated with hidradenitis suppurativa" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "203" "paginaFinal" => "206" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Raissa de Lima Gadelha, Renata da Silveira Rodrigues Paiva, Esther Bastos Palitot, Joanne Elizabeth Ferraz da Costa" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Raissa de Lima" "apellidos" => "Gadelha" "email" => array:1 [ 0 => "raissalimagadelha@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Renata da Silveira Rodrigues" "apellidos" => "Paiva" ] 2 => array:2 [ "nombre" => "Esther Bastos" "apellidos" => "Palitot" ] 3 => array:2 [ "nombre" => "Joanne Elizabeth Ferraz da" "apellidos" => "Costa" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Department of Dermatology, Hospital Universitário Lauro Wanderley, João Pessoa, PB, Brazil" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1430 "Ancho" => 1074 "Tamanyo" => 161357 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Lesions suggestive of pyoderma gangrenosum in the left breast: ulcers with violaceous and undermined borders.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Suppurative hidradenitis is a chronic inflammatory skin disease with pathophysiology based on follicular occlusion of the pilosebaceous unit and innate deregulated immune response.<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1,2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Suppurative hidradenitis and acne may be essential components of the auto-inflammatory syndromes which are described: Pyoderma gangrenosum, Acne and Pyogenic Arthritis (PAPA), pyoderma gangrenosum, acne and hidradenitis suppurativa (PASH), Pyoderma gangrenosum, Acne, Pyogenic arthritis and Hidradenitis Suppurativa (PAPASH) and Pyoderma gangrenosum, Acne and Spondyloarthritis (PASS). Recently it was added to the spectrum the syndrome composed of Psoriatic Arthritis, Pyoderma gangrenosum, Acne and Hidradenitis Suppurativa (PsAPASH) and Pyoderma gangrenosum, Acne and ulcerative Colitis (PAC).<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Auto inflammatory syndromes are defined by an aberrant innate immune system and absence of circulating autoantibodies and autoreactive T-cells and it is believed that recurrent episodes of neutrophilic inflammation are mediated by interleukin 1.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a> The symptoms are usually severe and may not respond to standard treatments and thus have devastating physical and psychological consequences for the affected patients.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Case report</span><p id="par0020" class="elsevierStylePara elsevierViewall">A 22 year-old female patient reported painful lesions in the armpits 3 years later with dissemination to the groin and breasts. One year ago, acne lesions appeared in addition to lower limb ulcers and scaly lesions on the scalp appeared for 3 months and were referred to our HULW Dermatology service. He also reported joint pains in hands, wrists, knees and lumbar spine with morning stiffness of 30<span class="elsevierStyleHsp" style=""></span>min.</p><p id="par0025" class="elsevierStylePara elsevierViewall">At the examination he had Grade 2 acne on the face; abscesses, fistulae and fibrosis in armpits and groin compatible with Hurley's Grade III suppurative hidradenitis; scaly erythematous scaly plaques suggestive of psoriasis and pseudotinha amiantácea; and purulent painful nodules and ulcers with violaceous, protruding and undermined left breast tendrils suggestive of pyoderma gangrenosum (<a class="elsevierStyleCrossRefs" href="#fig0005">Figs. 1–4</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">The patient was medicated with capillary solution of salicylic acid and betamethasone dipropionate and antisecretory shampoo, in addition to clindamycin 300<span class="elsevierStyleHsp" style=""></span>mg every 8<span class="elsevierStyleHsp" style=""></span>h and metformin 500<span class="elsevierStyleHsp" style=""></span>mg twice daily.</p><p id="par0035" class="elsevierStylePara elsevierViewall">The anatomopathological fragment of the scalp revealed epidermis with psoriasiform acanthosis, paraaceratosis, hypogranulosis and intracranial microabscesses, a dermis with inflammatory infiltrate of the perivascular lymphohistiocytic, compatible with psoriasis. Already the fragment of the left breast showed cutaneous ulcer with dense and diffuse mixed inflammatory infiltrate, with abscessed foci, focal areas of necrosis and frequent leukocytoclasia.</p><p id="par0040" class="elsevierStylePara elsevierViewall">He presented laboratory tests, such as non-reactive FAN, VHS 54, Negative Rheumatoid Factor, serologic tests for Hepatitis B and C negative, PPD 0<span class="elsevierStyleHsp" style=""></span>mm, Chest X-Ray without changes. Based on the CASPAR criteria, it presents a diagnosis of psoriatic arthritis (peripheral arthritis, current psoriasis and negative rheumatoid factor), and was referred to the Rheumatology department for interdisciplinary follow-up.</p><p id="par0045" class="elsevierStylePara elsevierViewall">The patient did not present improvement with initial treatment and then started using Adalimumab in a scheme for hidradenitis suppurativa and presented an important improvement of the picture at the consultation after 2 months (<a class="elsevierStyleCrossRefs" href="#fig0025">Figs. 5 and 6</a>), evidenced by the decrease in Sartorius score (underarm, previous: 55, after 2 months: 49).</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia><elsevierMultimedia ident="fig0030"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">The schedule was performed with 4 syringes, subcutaneously, of Adalimumab (40<span class="elsevierStyleHsp" style=""></span>mg) at week 0 and 2 syringes at week 2 (induction phase), followed by 1 syringe every 7 days (maintenance phase). The same goes on regular quarterly monitoring in our service.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Discussion</span><p id="par0055" class="elsevierStylePara elsevierViewall">Suppurative hidradenitis is a chronic inflammatory disease of the skin, clinically defined by nodules and recurrent painful abscesses that lead to the formation of fistulas, nodules and scars. It occurs in 1% of the population, is more frequent in women and tends to resolve at menopause.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Locally recurring lesions may be excised or treated with a laser. Disseminated lesions, however, can be treated with radical surgery, topical or systemic antibiotics (tetracycline or clindamycin with rifampicin), oral retinoids, dapsone and biological agents (adalimumab and infliximab). Pain management, weight loss, tobacco abstinence and treatment of superinfections are also important recommendations for all patients.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Suppurative hidradenitis associated with autoinflammatory syndromes is often severe (Hurley II, III) and does not respond to many of the usual treatments.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Because of the likely common pathogenesis involving IL-1-induced inflammation, collective experiments to date indicate that IL-1 and TNF-targeted therapies represent the most successful treatment solution for prolonged remission. TNF-blocking agents, adalimumab and infliximab, have achieved good control of suppurative hidradenitis lesions and, thus, reinforce the role of a deregulated innate immune response in the disease pathogenesis.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">The autoinflammatory syndrome composed of the association of psoriatic arthritis, pyoderma gangrenosum, acne and hidradenitis suppurativa (PsAPASH) was described in 2015 and there was no other similar description in the literature.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> As in the case described, our patient was treated with Adalimumab and presented in remission of the disease.</p><p id="par0080" class="elsevierStylePara elsevierViewall">No genetic mutation associated with PsAPASH has yet been identified, but the other syndromes are associated with the genetic mutation in the coding region of PSTPIP1 as well as with increased repetitions of CCTG in the promoter region of PSTPIP1, leading to its deregulation and predisposition to cutaneous neutrophilic inflammation.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">Thus, it is very important that dermatologists know about autoinflammatory syndromic hidradenitis, including typical lesions of pyoderma gangrenosum, hidradenitis suppurativa, psoriasis and acne, and laboratory findings suggestive of systemic inflammation to establish clinical prevalence and early treatment.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Financial support</span><p id="par0090" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Authors’ contributions</span><p id="par0095" class="elsevierStylePara elsevierViewall">Raissa de Lima Gadelha: Statistical analysis; conception and planning of the study; elaboration and writing of the manuscript; obtaining, analysis, and interpretation of the data; intellectual participation in the propaedeutic and/or therapeutic conduct of the studied cases; critical review of the literature; critical review of the manuscript.</p><p id="par0100" class="elsevierStylePara elsevierViewall">Renata da Silveira Rodrigues Paiva: Approval of the final version of the manuscript; effective participation in research orientation; intellectual participation in the propaedeutic and/or therapeutic conduct of the studied cases.</p><p id="par0105" class="elsevierStylePara elsevierViewall">Esther Bastos Palitot: Approval of the final version of the manuscript; effective participation in research orientation; intellectual participation in the propaedeutic and/or therapeutic conduct of the studied cases.</p><p id="par0110" class="elsevierStylePara elsevierViewall">Joanne Elizabeth Ferraz da Costa: Approval of the final version of the manuscript; effective participation in research orientation; intellectual participation in the propaedeutic and/or therapeutic conduct of the studied cases.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflicts of interest</span><p id="par0115" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:9 [ 0 => array:3 [ "identificador" => "xres1327247" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1223476" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 3 => array:2 [ "identificador" => "sec0010" "titulo" => "Case report" ] 4 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 5 => array:2 [ "identificador" => "sec0020" "titulo" => "Financial support" ] 6 => array:2 [ "identificador" => "sec0025" "titulo" => "Authors’ contributions" ] 7 => array:2 [ "identificador" => "sec0030" "titulo" => "Conflicts of interest" ] 8 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2018-11-06" "fechaAceptado" => "2019-02-27" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1223476" "palabras" => array:4 [ 0 => "Acne vulgaris" 1 => "Arthritis, psoriatic" 2 => "Hidradenitis suppurativa" 3 => "Pyoderma gangrenosum" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Hidradenitis suppurativa is a chronic inflammatory skin disease, which affects 1% of the population, being more common in young, obese and smokers, and mainly affects armpits and groin, with formation of pustules, nodules, abscesses, scars and fistulas. Recently, its association with other autoimmune diseases such as psoriasis, psoriatic arthritis, pyoderma gangrenosum, pyogenic arthritis and ulcerative colitis have been reported. These associated forms are usually resistant to standard treatment, with immunobiologicals as promising therapy. The case of a rare form of association is reported, with only one case previously described in the literature: psoriasis arthritis, pyoderma gangrenosum, acne and hidradenitis suppurativa.</p></span>" ] ] "NotaPie" => array:2 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">How to cite this article: Gadelha RL, Paiva RSR, Palitot EB, Costa JEF. PsAPASH: a rare and recent autoinflammatory syndrome associated with hidradenitis suppurativa. An Bras Dermatol. 2020;95:203–6.</p>" ] 1 => array:2 [ "etiqueta" => "☆☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Study conducted at the Hospital Universitário Lauro Wanderley, Universidade Federal da Paraíba, João Pessoa, PB, Brazil.</p>" ] ] "multimedia" => array:6 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1429 "Ancho" => 1074 "Tamanyo" => 152726 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Injuries suggestive of hidradenitis suppurativa in the axilla: nodules, scars and fibrosis.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1430 "Ancho" => 1074 "Tamanyo" => 161357 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Lesions suggestive of pyoderma gangrenosum in the left breast: ulcers with violaceous and undermined borders.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1430 "Ancho" => 1074 "Tamanyo" => 312704 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Erythematous scaly lesions on the scalp suggestive of psoriasis.</p>" ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1126 "Ancho" => 805 "Tamanyo" => 87520 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Ulcerated cicatricial lesion in lower left limb of pyoderma gangrenosum.</p>" ] ] 4 => array:7 [ "identificador" => "fig0025" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 1430 "Ancho" => 1074 "Tamanyo" => 141701 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Lesions in the left axilla presenting improvement of the picture after 2 months of use of Adalimumabe SC.</p>" ] ] 5 => array:7 [ "identificador" => "fig0030" "etiqueta" => "Figure 6" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr6.jpeg" "Alto" => 1431 "Ancho" => 1074 "Tamanyo" => 143243 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Lesions in the left breast presenting improvement of the picture after 2 months of use of Adalimumabe SC.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:9 [ 0 => array:3 [ "identificador" => "bib0050" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "What's new in the physiopathology of acne?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.H. Suh" 1 => "H.H. Kwon" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/bjd.13634" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2015" "volumen" => "172" "paginaInicial" => "13" "paginaFinal" => "19" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25645151" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0055" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hidradenitis suppurativa: a review of cause and treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Yazdanyar" 1 => "G.B.E. Jemec" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/QCO.0b013e3283428d07" "Revista" => array:6 [ "tituloSerie" => "Curr Opin Infect Dis" "fecha" => "2011" "volumen" => "24" "paginaInicial" => "118" "paginaFinal" => "123" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21192260" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0060" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Autoinflammatory syndromes associated with hidradenitis suppurativa and/or acne" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Vinkel" 1 => "S.F. Thomsen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/ijd.13603" "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2017" "volumen" => "56" "paginaInicial" => "811" "paginaFinal" => "818" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28345207" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0065" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "PASS syndrome: an IL-1-driven autoinflammatory disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Leuenberger" 1 => "J. Berner" 2 => "J. Di Lucca" 3 => "L. Fischer" 4 => "N. Kaparos" 5 => "C. Conrad" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000443648" "Revista" => array:6 [ "tituloSerie" => "Dermatology" "fecha" => "2016" "volumen" => "232" "paginaInicial" => "254" "paginaFinal" => "258" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26919742" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0070" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Successful use of adalimumab to treat pyoderma gangrenosum, acne and suppurative hidradenitis (PASH syndrome) following colectomy in ulcerative colitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B. Murphy" 1 => "G. Morrison" 2 => "P. Podmore" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00384-014-2110-9" "Revista" => array:6 [ "tituloSerie" => "Int J Colorectal Dis" "fecha" => "2015" "volumen" => "30" "paginaInicial" => "1139" "paginaFinal" => "1140" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25564349" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0075" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk factors, clinical course and long-term prognosis in hidradenitis suppurativa: a cross-sectional study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C.B. Kromann" 1 => "I.E. Deckers" 2 => "S. Esmann" 3 => "J. Boer" 4 => "E.P. Prens" 5 => "G.B. Jemec" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/bjd.13090" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2014" "volumen" => "171" "paginaInicial" => "819" "paginaFinal" => "824" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24804604" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0080" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "PsAPASH: a new syndrome associated with hidradenitis suppurativa with response to tumor necrosis factor inhibition" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R. Saraceno" 1 => "G. Babino" 2 => "A. Chiricozzi" 3 => "A. Zangrilli" 4 => "S. Chimenti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2014.10.002" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2015" "volumen" => "72" "paginaInicial" => "e42" "paginaFinal" => "e44" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25497954" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0085" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Remission of refractory pyoderma gangrenosum, severe acne, and hidradenitis suppurativa (PASH) syndrome using targeted antibiotic therapy in 4 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "O. Join-Lambert" 1 => "S. Duchatelet" 2 => "M. Delage" 3 => "S. Miskinyte" 4 => "H. Coignard" 5 => "N. Lemarchand" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2015.07.040" "Revista" => array:7 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2015" "volumen" => "73" "numero" => "Suppl. 1" "paginaInicial" => "S66" "paginaFinal" => "S69" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26470620" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0090" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pyoderma gangrenosum, acne and suppurative hidradenitis syndrome following bowel bypass surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.V. Marzano" 1 => "R.S. Ishak" 2 => "A. Colombo" 3 => "F. Caroli" 4 => "C. Crosti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000343602" "Revista" => array:6 [ "tituloSerie" => "Dermatology" "fecha" => "2012" "volumen" => "225" "paginaInicial" => "215" "paginaFinal" => "219" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23171584" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03650596/0000009500000002/v1_202004180640/S0365059620300234/v1_202004180640/en/main.assets" "Apartado" => array:4 [ "identificador" => "80638" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case Report" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03650596/0000009500000002/v1_202004180640/S0365059620300234/v1_202004180640/en/main.pdf?idApp=UINPBA00008Z&text.app=https://clinics.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365059620300234?idApp=UINPBA00008Z" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 21 | 12 | 33 |
2024 October | 113 | 81 | 194 |
2024 September | 164 | 103 | 267 |
2024 August | 150 | 110 | 260 |
2024 July | 164 | 117 | 281 |
2024 June | 114 | 80 | 194 |
2024 May | 123 | 72 | 195 |
2024 April | 120 | 83 | 203 |
2024 March | 106 | 80 | 186 |
2024 February | 112 | 78 | 190 |
2024 January | 85 | 52 | 137 |
2023 December | 107 | 57 | 164 |
2023 November | 121 | 78 | 199 |
2023 October | 91 | 92 | 183 |
2023 September | 124 | 75 | 199 |
2023 August | 85 | 46 | 131 |
2023 July | 121 | 52 | 173 |
2023 June | 141 | 45 | 186 |
2023 May | 96 | 23 | 119 |
2023 April | 91 | 25 | 116 |
2023 March | 117 | 60 | 177 |
2023 February | 92 | 43 | 135 |
2023 January | 76 | 32 | 108 |
2022 December | 75 | 28 | 103 |
2022 November | 107 | 62 | 169 |
2022 October | 115 | 56 | 171 |
2022 September | 95 | 77 | 172 |
2022 August | 85 | 43 | 128 |
2022 July | 57 | 71 | 128 |
2022 June | 59 | 55 | 114 |
2022 May | 51 | 51 | 102 |
2022 April | 58 | 63 | 121 |
2022 March | 55 | 74 | 129 |
2022 February | 42 | 38 | 80 |
2022 January | 72 | 75 | 147 |
2021 December | 37 | 52 | 89 |
2021 November | 48 | 60 | 108 |
2021 October | 77 | 81 | 158 |
2021 September | 47 | 53 | 100 |
2021 August | 60 | 48 | 108 |
2021 July | 40 | 45 | 85 |
2021 June | 46 | 47 | 93 |
2021 May | 115 | 68 | 183 |
2021 April | 180 | 262 | 442 |
2021 March | 94 | 59 | 153 |
2021 February | 38 | 33 | 71 |
2021 January | 26 | 25 | 51 |
2020 December | 25 | 19 | 44 |
2020 November | 40 | 13 | 53 |
2020 October | 52 | 13 | 65 |
2020 September | 19 | 8 | 27 |
2020 August | 15 | 5 | 20 |
2020 July | 5 | 12 | 17 |
2020 June | 14 | 18 | 32 |
2020 May | 15 | 12 | 27 |
2020 April | 3 | 3 | 6 |
2020 March | 0 | 1 | 1 |
2020 February | 0 | 3 | 3 |