Case Letter
Anetoderma: an alert for antiphospholipid antibody syndrome
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"gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "pt" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta ‐ Caso clínico</span>" "titulo" => "Anetodermia: um alerta para a síndrome do anticorpo antifosfolípide" "tienePdf" => "pt" "tieneTextoCompleto" => "pt" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "123" "paginaFinal" => "125" ] ] "contieneTextoCompleto" => array:1 [ "pt" => true ] "contienePdf" => array:1 [ "pt" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 882 "Ancho" => 750 "Tamanyo" => 52082 ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Múltiplas pápulas hipopigmentadas com atrofia central em braço esquerdo.</p>" ] ] ] 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"LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 13 "formatos" => array:2 [ "EPUB" => 6 "PDF" => 7 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Letter</span>" "titulo" => "Spiky follicular mycosis fungoides and hidradenitis suppurativa-like lesions in a patient – complete remission with interferon alpha" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "121" "paginaFinal" => "123" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 841 "Ancho" => 751 "Tamanyo" => 64298 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Extensive scalp involvement, with numerous whitish and spiky hyperkeratotic follicular papules, and alopecia.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Mónica Garcia-Arpa, Miguel A. 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It still has an unknown etiology and may be associated with genetic causes, autoimmune mechanisms, infectious diseases, or elastophagocytosis. In addition, prothrombotic phenomena and the presence of antiphospholipid antibodies have been observed in these patients.</p><p id="par0010" class="elsevierStylePara elsevierViewall">This case report describes a patient with primary anetoderma and antiphospholipid syndrome (AS). In many cases of AS, anetoderma may be the first or the most evident manifestation of the disease. This association, however, is often overlooked, and the actions that could prevent an episode of thrombosis do not occur.</p><p id="par0015" class="elsevierStylePara elsevierViewall">The case of a 43-year-old male patient from Taciba, São Paulo, Brazil, with skin lesions on the arms and trunk for three years, is reported. He was previously epileptic and had history of deep venous thrombosis one year previously. He made continuous use of phenobarbital and carbamazepine. The dermatological examination showed rounded, hypochromic plaques with atrophic appearance and central flaccidity, distributed throughout the dorsal region and arms bilaterally (<a class="elsevierStyleCrossRefs" href="#fig0005">Figs. 1 and 2</a>). The hypothesis of anetoderma was made and the biopsy showed disorganized collagen fibers and ruptured elastic fibers in the superficial and middle dermis, as well as a mild superficial perivascular lymphomononuclear infiltrate in the dermis (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). Hemogram, electrolytes, and hepatic and renal function were normal. A laboratory investigation was performed for thrombotic disorders, with three antiphospholipid antibody reagents (anti-cardiolipin, lupus anticoagulant, and anti-β2-glycoprotein-I) and thus the diagnostic criteria for AS were met. Finally, erythrocyte sedimentation rate, C-reactive protein, and rheumatoid factor were normal; serologies for HIV, hepatitis, and VDRL were negative. The patient was referred to the rheumatology and hematology service where he remained under medical monitoring.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Anetoderma is a disorder in which loss of elastic fibers occurs in the papillary or reticular dermis. It presents as papules or rounded, hypopigmented plaques with a subcutaneous hernia sensation. Its etiopathogenesis remains uncertain, and it can be classified according to the triggering conditions as primary or secondary. Primary anetoderma affects previously healthy areas of skin, since secondary anetoderma occurs in regions affected by previous pathologies, such as acne or varicella. Association with infectious processes, drugs, and autoimmune disorders, among them AS, have been reported as causes of primary anetoderma.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">AS is an acquired thrombophilia characterized by the presence of antiphospholipid antibodies, thrombotic disorders, and/or recurrent fetal loss. Complications with strokes are common and cutaneous involvement is also common. The cutaneous manifestations include the following: anetoderma, necrotic ulcers type livedoid vasculopathy, extensive necrotic ulcers (pyoderma gangrenosum), periungual ulcerations, necrotizing purpura, digital gangrene, multiple linear subungual hemorrhages, disseminated superficial cutaneous necrosis, livedo reticularis, livedo racemosa, acrocyanosis, bluish finger syndrome, chronic pigmented purpura, and chronic urticaria. Thus, anetoderma can be considered a cutaneous manifestation of AS.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In the case reported, the patient had skin lesions compatible with anetoderma, which was confirmed by biopsy. Histopathology showed disorganized collagen fibers and ruptured elastic fibers in the superficial and middle dermis, and mild superficial perivascular lymphomononuclear infiltrate in the dermis. With the previous history of deep venous thrombosis in the lower limb, the possibility of AS was investigated and laboratory investigation was performed, evidencing antiphospholipid antibodies present and confirming the proposed diagnosis.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Recently, studies with patients with anetoderma showed that of nine patients affected, all nine had antiphospholipid antibodies and four met the criteria for the syndrome. In addition, of the nine patients studied, all had prothrombotic abnormalities. Therefore, the presence of an ischemic process followed by degeneration of the elastic fibers was suggested as the etiopathogenesis of the anetoderma in these cases.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Other possible explanations described include the increase of gelatinases in the skin of patients with anetoderma, or the presence of a common epitope between elastic fibers and phospholipids (β2-glycoprotein1).<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">There is no effective treatment for anetoderma. Although many modalities have already been used – intralesional injection of corticoid, penicillin G, salicylates, phenytoin, dapsone, and vitamin E – none of them has been proven satisfactory. In the described patient, intralesional corticosteroid injection was attempted, but without therapeutic response.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Finally, this case highlights the importance of clinical investigation of coagulation disorders in patients with anetoderma, so that thrombotic events can be predicted and poor outcomes can be avoided in these patients.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0055" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authors’ contribution</span><p id="par0060" class="elsevierStylePara elsevierViewall">Mariana Piraja Genta: Conception and planning of the study; composition of the manuscript; critical review of the literature.</p><p id="par0065" class="elsevierStylePara elsevierViewall">Marilda Aparecida Milanez Morgado de Abreu: Approval of the final version of the manuscript; conception and planning of the study; participation in the design of the study; intellectual participation in the propaedeutic and/or therapeutic conduct of the studied cases; critical review of the manuscript.</p><p id="par0070" class="elsevierStylePara elsevierViewall">Gisele Alborghetti Nai: Collection, analysis, and interpretation of data; participation in the orientation of the study.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0075" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:5 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Financial support" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Authors’ contribution" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Conflicts of interest" ] 3 => array:2 [ "identificador" => "xack455505" "titulo" => "Acknowledgment" ] 4 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-02-28" "fechaAceptado" => "2019-04-18" "NotaPie" => array:2 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">How to cite this article: Genta MP, Abreu MA, Nai GA. Anetoderma: an alert for antiphospholipid antibody syndrome. An Bras Dermatol. 2020;95:123–5.</p>" ] 1 => array:2 [ "etiqueta" => "☆☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Study conducted at the Hospital Regional de Presidente Prudente, Presidente Prudente, SP, Brazil.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 882 "Ancho" => 750 "Tamanyo" => 52082 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Multiple hypopigmented papules with central atrophy in the left arm.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 589 "Ancho" => 750 "Tamanyo" => 42675 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Multiple hypopigmented papules with central atrophy in the dorsum and upper limbs.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 971 "Ancho" => 750 "Tamanyo" => 159019 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Shortened and fragmented elastic fibers in the papillary dermis (Verhoeff-Van Gieson, ×400).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0030" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The skin and hypercoagulable states" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L.A. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 21 | 20 | 41 |
| 2024 October | 112 | 75 | 187 |
| 2024 September | 144 | 79 | 223 |
| 2024 August | 184 | 96 | 280 |
| 2024 July | 175 | 114 | 289 |
| 2024 June | 106 | 90 | 196 |
| 2024 May | 109 | 66 | 175 |
| 2024 April | 108 | 73 | 181 |
| 2024 March | 122 | 62 | 184 |
| 2024 February | 131 | 74 | 205 |
| 2024 January | 75 | 53 | 128 |
| 2023 December | 102 | 66 | 168 |
| 2023 November | 106 | 78 | 184 |
| 2023 October | 71 | 69 | 140 |
| 2023 September | 80 | 76 | 156 |
| 2023 August | 73 | 47 | 120 |
| 2023 July | 71 | 27 | 98 |
| 2023 June | 76 | 41 | 117 |
| 2023 May | 50 | 26 | 76 |
| 2023 April | 40 | 19 | 59 |
| 2023 March | 48 | 43 | 91 |
| 2023 February | 46 | 33 | 79 |
| 2023 January | 48 | 38 | 86 |
| 2022 December | 63 | 36 | 99 |
| 2022 November | 64 | 57 | 121 |
| 2022 October | 69 | 50 | 119 |
| 2022 September | 62 | 54 | 116 |
| 2022 August | 47 | 52 | 99 |
| 2022 July | 45 | 59 | 104 |
| 2022 June | 53 | 53 | 106 |
| 2022 May | 41 | 36 | 77 |
| 2022 April | 57 | 46 | 103 |
| 2022 March | 42 | 69 | 111 |
| 2022 February | 27 | 31 | 58 |
| 2022 January | 59 | 78 | 137 |
| 2021 December | 44 | 66 | 110 |
| 2021 November | 55 | 64 | 119 |
| 2021 October | 60 | 83 | 143 |
| 2021 September | 33 | 58 | 91 |
| 2021 August | 54 | 66 | 120 |
| 2021 July | 46 | 41 | 87 |
| 2021 June | 25 | 37 | 62 |
| 2021 May | 60 | 77 | 137 |
| 2021 April | 148 | 177 | 325 |
| 2021 March | 53 | 46 | 99 |
| 2021 February | 21 | 18 | 39 |
| 2021 January | 24 | 19 | 43 |
| 2020 December | 31 | 20 | 51 |
| 2020 November | 24 | 14 | 38 |
| 2020 October | 14 | 13 | 27 |
| 2020 September | 12 | 15 | 27 |
| 2020 August | 19 | 9 | 28 |
| 2020 July | 17 | 7 | 24 |
| 2020 June | 12 | 17 | 29 |
| 2020 May | 29 | 14 | 43 |
| 2020 April | 1 | 1 | 2 |
| 2020 March | 8 | 6 | 14 |
| 2020 January | 0 | 5 | 5 |
| 2019 December | 0 | 1 | 1 |
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